Bone Metastases: A translational and clinical approach PDF
Preview Bone Metastases: A translational and clinical approach
Bone Metastases Cancer Metastasis – Biology and Treatment VOLUME 12 SeriesEditors RichardJ.Ablin,Ph.D.,UniversityofArizona,CollegeofMedicineandTheArizonaCancer Center,AZ,U.S.A. WenG.Jiang,M.D.,WalesCollegeofMedicine,CardiffUniversity,Cardiff,U.K. AdvisoryEditorialBoard HaroldF.Dvorak,M.D. PhilGold,M.D.,Ph.D. DannyWelch, Ph.D. HiroshiKobayashi,M.D.,Ph.D. RobertE.Mansel,M.S.,FRCS. KlausPantel,Ph.D. Forfurthervolumes: http://www.springer.com/series/5761 Bone Metastases A Translational and Clinical Approach Edited by Dimitrios Kardamakis, M D, PhD, DM RT DepartmentofRadiationOncology,UniversityofPatrasMedicalSchool,Patras,Greece Vassilios Vassiliou, M D, PhD DepartmentofRadiationOncology,UniversityofPatrasMedicalSchool,Patras,Greece and Edward Chow, M B B S, PhD, FRCPC Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre,UniversityofToronto,Toronto,Ontario,Canada Editors Dr.DimitriosKardamakis,MD,PhD,DMRT Dr.VassiliosVassiliou,MD,PhD UniversityofPatras UniversityofPatras MedicalSchool MedicalSchool Dept.ofRadiationOncology Dept.ofRadiationOncology 26504Patras 26504Patras Greece Greece [email protected] [email protected] Dr.EdwardChow,MBBS,PhD,FRCPC UniversityofToronto SunnybrookHealthSciencesCentre Dept.ofRadiationOncology 2075BayviewAvenue Toronto,OntarioM4N3M5 Canada [email protected] ISBN 978-1-4020-9818-5 e-ISBN 978-1-4020-9819-2 DOI10.1007/978-1-4020-9819-2 LibraryofCongressControlNumber:2009920108 (cid:2)c SpringerScience+BusinessMediaB.V.2009 Nopartofthisworkmaybereproduced,storedinaretrievalsystem,ortransmitted inanyformorbyanymeans,electronic,mechanical,photocopying,microfilming,recording orotherwise,withoutwrittenpermissionfromthePublisher,withtheexception ofanymaterialsuppliedspecificallyforthepurposeofbeingentered andexecutedonacomputersystem,forexclusiveusebythepurchaserofthework. Printedonacid-freepaper 9 8 7 6 5 4 3 2 1 springer.com ToKaterinaandAnastasis,whosesupport andpatiencemakeitpossible DimitriosKardamakis Tomyfamilyfortheinvaluable helptheyhaveoffered andtocancerpatientsandresearcherswhostruggle againstcancerintheireverydaylife VassiliosVassiliou Tomycolleaguesandmypatientswhoteachandguideme EdwardChow Preface by Editors Bonemetastasesarecommonintheeventofmalignancyandafterliverandlungs, bone is the third most common site of distant metastases. Metastatic bone dis- easeisinevitablyassociatedwithseverecomplicationssuchaspain,impairedmo- bility, pathological fractures, spinal cord or root compression and hypercalcemia. Thesecomplicationsdeteriorateseverelytheclinicalandphysicalstatusofpatients, affect negatively their quality of life and can also be life threatening. The under- standing of the pathophysiology of bone metastases and the investigation and ap- plication of newer diagnostic and therapeutic modalities is therefore of uttermost importance. “Bone metastases: A translational and clinical approach” is intended to serve both as an introductory and reference book that focuses on the field of metastatic bone disease. All invited contributing authors are expert researchers who have prominentpublicationsinthefieldofbonemetastasesorrelatedtopics.Morespecif- ically, the book describes thoroughly the molecular and cellular mechanisms in- volvedintheformationofbonemetastases,commentsontheroleofangiogenesis, presents the newer advances made in the understanding of the clinical picture and symptoms of patients, analyses the role of bone markers in research and clinical practice and deals with all aspects of imaging modalities applied for the detection and evaluation of bone metastases. Furthermore, it covers extensively the use of radiotherapy, surgery and systemic treatments for the management of metastatic bonedisease,givingspecialattentiontotheroleandindicationsofeachtherapeu- tic mode. New therapeutic approaches such as the combination of radiotherapy or radiopharmaceuticalswithbisphosphonatesarealsocommentedupon.Finally,two chapters are dedicated to the assessment of the therapeutic response by applying clinical,radiologicalandbiochemicalparametersormethods. Overallthetextbookpresentsthoroughlyallaspectsofmetastaticbonedisease, providingcomprehensiveandconciseinformationthatservesasareferenceforre- searchers,oncologists,orthopaedicsurgeons,cliniciansandmedicalstudentsalike. Moreover it can serve as a guide for the clinical and therapeutic management of patientswithmetastaticbonedisease. The editors would like to thank all contributing authors for their scholarly ef- forts and complement them for their outstanding work. We also thank Dr Richard Ablin and Wen Jiang, editors of the book series on Cancer Metastasis: Biology vii viii PrefacebyEditors andTreatment,forinvitingustoeditavolumefortheaforementionedbookseries. Finally,theassistancefromthePublishingEditorDr.ChristinaMirandaAlvesdos Santosandherassistant,Ms.MelaniaRuizEsparzawasmorethanvaluable. Patras DimitriosKardamakis Patras VassiliosVassiliou Toronto,ON EdwardChow Contents PartI FundamentalConceptsofBoneMetastases 1 BONEANATOMY,PHYSIOLOGYANDFUNCTION............. 3 Vassiliki Tzelepi, Athanassios C. Tsamandas, Vassiliki Zolota andChrisoulaD.Scopa 2 PATHOPHYSIOLOGYOFBONEMETASTASES ................ 31 G.DavidRoodman 3 ANGIOGENESISANDBONEMETASTASIS:IMPLICATIONS FORDIAGNOSIS,PREVENTIONANDTREATMENT ........... 51 PelagiaG.TsoutsouandMichaelI.Koukourakis 4 NATURALHISTORY,PROGNOSIS,CLINICALFEATURES ANDCOMPLICATIONSOFMETASTATICBONEDISEASE ..... 77 VassiliosVassiliou,EdwardChowandDimitriosKardamakis 5 BONE BIOMARKERS IN RESEARCH ANDCLINICALPRACTICE ................................... 93 JanetE.BrownandEdwardChow PartII ImagingModalities 6 RADIOLOGICEVALUATIONOFSKELETALMETASTASES: ROLE OF PLAIN RADIOGRAPHS AND COMPUTED TOMOGRAPHY ..............................................119 ChristinaKalogeropoulou,AnnaKarachaliouandPeterZampakis ix x Contents 7 THE CONTRIBUTION OF NUCLEAR MEDICINE INTHEDIAGNOSISOFBONEMETASTASES ..................137 AndorW.J.M.Glaudemans,MarnixG.E.H.Lam,NielsC.Veltman, RudiA.J.O.DierckxandAlbertoSignore 8 MAGNETICRESONANCEIMAGINGOFMETASTATICBONE DISEASE .....................................................163 Ekaterini Solomou, Alexandra Kazantzi, Odysseas Romanos andDimitriosKardamakis PartIII TherapeuticStrategies 9 RADIOTHERAPYANDBONEMETASTASES ...................185 JanW.H.LeerandYvetteM.vanderLinden 10 BIPHOSPHONATESINTHEMANAGEMENTOFMETASTATIC BONEDISEASE...............................................195 FredSaadandArifHussain 11 COMBINEDRADIOTHERAPYANDBISPHOSPHONATES: STATEOFART ...............................................233 VassiliosVassiliouandDimitriosKardamakis 12 BIPHOSPHONATESINTHETREATMENTOFBONE METASTASES–OSTEONECROSISOFTHEJAW ...............251 CesarAugustoMigliorati 13 SURGICALMANAGEMENTOFBONEMETASTASES ..........263 MarkkuNousiainen,CariM.Whyne,AlbertJ.M.Yee,JoelFinkelstein andMichaelFord 14 THE ROLE OF CHEMOTHERAPY IN THE TREATMENT OFBONEMETASTASES ......................................287 ThomasMakatsorisandHaralabosP.Kalofonos 15 HORMONOTHERAPYOFBONEMETASTASES ................299 KonstantinosKamposiorasandEvangelosBriasoulis 16 RADIONUCLIDETHERAPY...................................321 GiovanniStorto
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