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Blood Substitutes - Present and Future Perspectives - E. Tsuchida (Elsevier, 1998) WW PDF

409 Pages·1998·21.36 MB·English
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Blood Substitutes Present and Future Perspectives Cover illustration taken from Chapter 6 'Overview of the Effects of Diaspirin Crosslinked Hemoglobin (DCLHb) on Oxygenation, Perfusion of the Microcirculation, and Clinical Studies' by K.E. Burhop and T.H. Schmitz. Blood Substitutes Present and Future Perspectives edited by Eishun Tsuchida Department of Polymer Chemistry Waseda University Tokyo, Japan 1998 ELSEVIER Amsterdam - Lausanne - New York - Oxford - Shannon - Singapore - Tokyo ELSEVIER SCIENCE S.A. Avenue de la Gare 50 1001 Lausanne 1, Switzerland © 1998 Elsevier Science S.A. All rights reserved. This work and the individual contributions contained in it are protected under copyright by Elsevier Science S.A., and the following terms and conditions apply to its use: Photocopying Single photocopies of single chapters may be made for personal use as allowed by national copyright laws. Permission of the publisher and payment of a fee is required for all other photocopying, including multiple or systematic copying, copying for advertising or promotional purposes, resale, and all forms of document delivery. Special rates are available for educational institutions that wish to make photocopies for non-profit educational classroom use. Permissions may be sought directly from Elsevier Science Rights & Permissions Department, PO Box 800, Oxford OX5 IDX, UK; phone: (+44) 1865 843830, fax: (+44) 1865 853333, e-mail: permissions® elsevier.co.uk. You may also contact Rights & Permissions directly through Elsevier's home page (http:// www.elsevier.nl), selecting first 'Customer Support', then 'General Information', then 'Permissions Query Form'. In the USA, users may clear permissions and make payments through the Copyright Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, USA; phone: (978) 7508400, fax: (978) 7504744, and in the UK through the Copyright Licensing Agency Rapid Clearance Service (CLARCS), 90 Tottenham Court Road, London WIP OLP, UK; phone: (+44) 171 436 5931; fax: (+44) 171 436 3986. Other countries may have a local reprographic rights agency for payments. Derivative Works Subscribers may reproduce tables of contents for internal circulation within their institutions. Permission of the publisher is required for resale or distribution of such material outside the institution. Permission of the publisher is required for all other derivative works, including compilations and translations. Electronic Storage or Usage Permission of the publisher is required to store or use electronically any material contained in this work, including any chapter or part of a chapter. Contact the publisher at the address indicated. Except as outlined above, no part of this work may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior written permission of the pubhsher. Address permissions requests to: Elsevier Science Rights & Permissions Department, at the mail, fax and e-mail addresses noted above. Notice No responsibility is assumed by the Publisher for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions or ideas contained in the material herein. Because of rapid advances in the medical sciences, in particular, independent verification of diagnoses and drug dosages should be made. First edition 1998 Library of Congress Cataloging in Publication Data A catalog record from the Library of Congress has been applied for. ISBN: 0 444 20524 1 Transferred to digital printing 2005 Printed and bound by Antony Rowe Ltd, Eastbourne PREFACE This book contains the selected papers presented at the seventh International Symposium on Blood Substitutes (7th ISBS) held at Ibuka Memorial Hall, the International Conference Center of Waseda University in Tokyo on 7-10 September 1997. In keeping with the scientific design of the 7th ISBS Symposium, chapters have been carefully selected and organized to showcase the advancements in recent research. Furthermore, the newest developments after 7th ISBS are also included. The first highlight is "The Current Status of Blood Substitutes" including up-to-date clinical results of leading companies which are manufacturing hemoglobin-based or perfluorocarbon-based blood substitutes. The following chapter is the report of a roundtable discussion, "The Target and Assessment of Clinical Tests." I believe that readers will enjoy this chapter which expresses real targets of the products and issues of clinical trials, which also reflects the high activity in this area. I wish to thank Prof. M. Takaori who edited this report as a chairperson. Before the submission of the chapter, he asked all speakers to check their statements and discussions and revise them more comprehensively for readers. Indeed, the good use of hemoglobin-based materials as hemoglobin formulation is remarkable, but the development of oxygen infusion should be more important. The following chapters are advanced techniques to evaluate the oxygen carrying efficacy in vitro and in vivo including microcirculation measurements. "Development in Encapsulated Hemoglobin," will focus on encapsulated hemoglobins as one of the prime candidates for use in the next generation of hemoglobin-based oxygen carriers. The book covers issues of hemoglobin toxicity and side effects such as vasoconstric- tion in more detail using carefully designed in vivo and ex vivo techniques. "Platelet Substitutes" introduce a new subject area to the session lineup at ISBS Symposia, and they are also included in this book. Of course, this book is also a collection of various new types of red cell substitutes such as recombinant hemoglobins, recombinant albumin-Hpidheme complex, modified red blood cells, and perfluorochemicals using material science and molecular engineering. I hope this lineup will go a long way to make this book a successful interdisciplinary landmark toward the beginning of the coming century. The editor wishes to thank all participants for their contributions and oifers gratitude to the members of the Organizing Committee, to the Scientific Program Committee, and especially to Drs. H. Nishide and S. Takeoka, the Conference Secretariat. Finally, it is a pleasure to express indebtedness for the staff of Elsevier for their support for publishing this book and their forbearance and unfaihng courtesy. The Editor Eishun Tsuchida Tokyo, May 1998 Table of Contents Chapter 1 Perspectives of Blood Substitutes 1 E. Tsuchida Chapter 2 The Role of Blood Substitutes in Emerging Healthcare Systems 15 R.M. Winslow Chapter 3 Red Cell Substitutes: Evolution of Approaches for Demonstrating Efficacy 33 J.C. Fratantoni Chapter 4 The Clinical Utility of Human Polymerized Hemoglobins as a Blood Substitute Following Acute Trauma and Urgent Surgery 41 S.A. Gould, E.E. Moore, F.A. Moore, J.B. Haenel, J.M. Burch, H. Sehgal, L. Sehgal, R. DeWoskin, G.S. Moss Chapter 5 Recent Progress in the Development of Recombinant Human Hemoglobin (rHbl.l) as an Oxygen Therapeutic 55 J.W. Freytag, R.F. Caspari, R.J. Gorczynski Chapter 6 Overview of the Effects of Diaspirin Crosslinked Hemoglobin (DCLHb) on Oxygenation, Perfusion of the Microcirculation, and Clinical Studies 75 K.E. Burhop, T.H. Schmitz Chapter 7 Update on Perfluorocarbon-Based Oxygen DeHvery Systems 91 J.G. Riess, P.E. Keipert Chapter 8 Red Cell Substitutes: Past Problems, Current Dilemmas 103 A.G. Greenburg Chapter 9 Round Table Discussion: "The Target and Assessment of Clinical Tests" 111 M. Takaori Chapter 10 Biophysical Criteria for Microcirculatory Efficacy of Blood Substitutes 125 A.G. Tsai, B. Friensenecker, H. Sakai, H. Kerger, M. Intaglietta Chapter 11 Experimental and Mathematical Simulation of Oxygen Transport by Hemoglobin-based Blood Substitute 135 T.C. Page, W.R. Light, J.D. Heliums Chapter 12 Tissue Oxygen Delivery and Tissue Distribution of Liposome Encapsulated Hemoglobin 147 W.T. Phillips, B. Coins, R. Klipper, B.G. Cook, C. Martin, L. Lemen, P.A. Jerabek, S. Khalvati, P.T. Fox, R.O. CliflF, V. Kwasiborski, A.S. Rudolph Chapter 13 Polymeric Biodegradable Hemoglobin Nanocapsule as a New Red Blood Cell Substitute 161 T.M.S. Chang, W.P. Yu Chapter 14 Evaluation of the Oxygen Transporting Capability of Hemoglobin Vesicles 171 S. Takeoka, H. Sakai, K. Kobayashi, E. Tsuchida Chapter 15 Microvascular Responses to Hemodilution with Hb-Vesicles: Importance of Resistance Arteries and Mechanisms of Vasoconstriction 185 H. Sakai, A.G. Tsai, E. Tsuchida, M. Intaglietta Chapter 16 Hemoglobin-based Blood Substitutes and Mechanisms of Toxicity 201 A.I. Alayash Chapter 17 in vivo Oxygenation of Deoxy-Hemolink^^ Following Exchange Transfusions of 50% or 90% the Blood Volume in Rats 211 J. Ning, S.S. Er, L.T. Wong Chapter 18 Safety and Efficacy of Hemoglobin Modified by Cross-linking or Polymerization 225 J.C. Bakker, W.K. Bleeker, H.J.H. Hens, P.T.M. Biessels, M. van Iterson, A. Trouwborst Chapter 19 The Heme Oxygenase System In Liver Microcirculation: A Key Mechanism for Hemoglobin Degradation 241 M. Suematsu, Y. Wakabayashi, N. Goda, S. Takeoka, E. Tsuchida, Y. Ishimura Chapter 20 Vascular Activities of Hemoglobin-Based Oxygen Carriers 251 K. Nakai, I. Sakuma, A. Kitabatake Chapter 21 Zero-Hnk Polymerization: a New Class of Polymeric Hemoglobins 265 A. Razynska, E. Bucci Chapter 22 Recombinant Hemoglobins with Low Oxygen Affinity and High Cooperativity 281 C. Ho, D.P. Sun, T.J. Shen, N.T. Ho, M. Zou, C.K. Hu, Z.Y. Sun, J.A. Lukin Chapter 23 Properties of Poly(ethylene glycol)-conjugated Red Blood Cells 297 T.C. Fisher, J.K. Armstrong, H.J. Meiselman, R.M. Leger, P.A. Arndt, G. Garratty Chapter 24 Oxygen-Transport Albumin: A New Hemoprotein Incorporating Lipidheme as a Red Cell Substitute 315 T. Komatsu, E. Tsuchida, K. Kobayashi Chapter 25 Fluorocarbon Emulsions as Blood Substitutes 327 K.C. Lowe Chapter 26 Heparin-like New Molecules with Blood 339 R. Barbucci Chapter 27 Recent Developments and Future Perspectives for Preserved Platelets and Platelet Substitutes 359 B.M. Alving, C. Krishnamurti Chapter 28 Development and Clinical Implications of Platelet Substitutes 373 Y. Ikeda, M. Murata Chapter 29 Impact on the Appearance of Blood Substitutes Replacing Blood in Transfusion Medicine 383 S. Sekiguchi

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