Blood Banking and Transfusion Medicine (Second Edition): Basic Principles and Practice

891 Pages·2006·15.98 MB·English

by  Christopher D. Hillyer MD

1600 John F. Kennedy Blvd.
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BLOOD BANKING AND TRANSFUSION MEDICINE, Second Edition ISBN-13: 978-0-443-06981-9
ISBN-10: 0-443-06981-6
Copyright © 2007, 2003 by Churchill Livingstone, an imprint of Elsevier Inc.
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Notice
Knowledge and best practice in this field are constantly changing. As new research and experience broaden
our knowledge, changes in practice, treatment and drug therapy may become necessary or appropriate.
Readers are advised to check the most current information provided (i) on procedures featured or (ii) by the
manufacturer of each product to be administered, to verify the recommended dose or formula, the method
and duration of administration, and contraindications. It is the responsibility of the practitioner, relying on
their own experience and knowledge of the patient, to make diagnoses, to determine dosages and the best
treatment for each individual patient, and to take all appropriate safety precautions. To the fullest extent of
the law, neither the Publisher nor the Editors assume any liability for any injury and/or damage to persons or
property arising out or related to any use of the material contained in this book.
The Publisher
Library of Congress Cataloging-in-Publication Data
Blood banking and transfusion medicine: basic principles & practice /
Christopher D. Hillyer … [et al.].—2nd ed.
p. cm.
Includes bibliographical references and index.
ISBN 0-443-06981-6
1. Blood—Transfusion. 2. Blood banks. I. Hillyer, Christopher D. II. Title.
RM171.B583 2007
615′.39—dc22 2006048955
Acquisitions Editor: Dolores Meloni
Developmental Editor: Kristina Oberle/Kim DePaul
Project Manager: Bryan Hayward
Design Direction: Steven Stave
Printed in United States of America
Last digit is the print number: 9 8 7 6 5 4 3 2 1
FM-F039816.indd iv 9/22/06 8:41:52 AM
About the Editors
Dr. Hillyer is a tenured professor in the Departments of Pathology and Pediatrics, as well as
the Division of Hematology/Oncology, Winship Cancer Institute, Emory University School of
Medicine. He serves as director of the Transfusion Medicine Program at Emory and oversees the
Emory University Hospital Blood Bank, the blood and tissue banks of Children’s Healthcare of
Atlanta, and the Emory Center for the Advancement of International Transfusion Safety. He is
an editor of three textbooks on transfusion medicine and an author of more than 120 articles
and chapters pertaining to transfusion, HIV, cytokines, and herpesviruses (most notably CMV).
Nationally recognized as an expert in hematology and blood transfusion, Dr. Hillyer is President
of AABB (2006–2007) and is a Trustee of the National Blood Foundation (NBF). He has been
awarded research funding from the NIH, CDC, NBF, and other agencies. He currently serves as
principal investigator of a program project grant, several R-series awards, the Emory site of the
NHLBI’s Transfusion Medicine/Hemostasis Clinical Trial Network, and REDS-II. He also is a
co-principal investigator of AABB’s contract with HHS to provide technical assistance to six
developing nations under the President’s Emergency Plan for AIDS Relief (PEPFAR). Dr. Hillyer
is an associate editor of Transfusion and part-time medical director of the American Red Cross
Southern Region. Dr. Hillyer is board certified in Transfusion Medicine, Hematology, Medical
Oncology, and Internal Medicine. He received his BS from Trinity College and his MD from
the University of Rochester School of Medicine, with postgraduate training and fellowships in
hematology-oncology, transfusion medicine, and bone marrow transplantation at Tufts–New
England Medical Center in Boston.
v
Dr. Silberstein is a tenured professor in the Department of Pathology, Harvard Medical School,
and a Senior Investigator at the CBR Institute for Blood Research. He serves as director of the Joint
Program in Transfusion Medicine, with responsibility for the blood and tissue programs at Boston
Children’s Hospital, the Brigham and Women’s Hospitals, and the Dana-Farber Cancer Institute.
Dr. Silberstein has recently created the Center for Human Cell Therapy at Harvard Medical School.
The goal of this innovative center related to transfusion medicine is to facilitate the translation
of proof-of-principle discoveries to clinical applications. Dr. Silberstein is editor of several texts,
including Hematology and the Handbook of Transfusion Medicine. He is a member of the edito-
rial boards of Blood and Transfusion. Dr. Silberstein is a highly respected physician-scientist well
known for his mentorship; he has trained more than 45 fellows with PhD and MD backgrounds
in transfusion medicine-related research. A leader and expert in transfusion medicine and hema-
tology, Dr. Silberstein’s research has focused on the immunology of B-cells and hematopoiesis,
leading to the publication of more than 75 papers and numerous book chapters and reviews.
Dr. Silberstein is board certified in Transfusion Medicine, Hematology, and Internal Medicine.
He received his Baccalaureate and MD degrees from the University of Leiden, the Netherlands,
and accomplished postgraduate training in Hematology/Oncology and Transfusion Medicine at
Tufts–New England Medical Center in Boston.
FM-F039816.indd v 9/22/06 8:41:53 AM
S Dr. Ness is director of the Transfusion Medicine Division at The Johns Hopkins Hospital and pro-
R
O fessor of Pathology, Medicine, and Oncology at The Johns Hopkins University School of Medicine.
T
DI For many years he also acted as CEO and medical director of the Greater Chesapeake and Potomac
E
E Region of the American Red Cross Blood Services. Dr. Ness has served the AABB for a number
H
T of years and was President in 1999. He served on the editorial board of Transfusion until named
UT Editor in 2003. Dr. Ness has been a member of the American Society of Clinical Pathologists
O
B Board of Registry Blood Bank examination committee, and the FDA Blood Products Advisory
A
Committee, and he consults for many commercial and nonprofit organizations. He is the editor
of several textbooks on transfusion medicine and has published more than 150 articles. Dr. Ness’
research focuses on transfusion-related complications and has been funded by the NIH and
CDC. He was involved in the initial REDS program and now acts as consultant to REDS-II.
He serves as principal investigator for the Johns Hopkins site of the Transfusion Medicine/
Hemostasis Clinical Trial Network, funded by NHLBI. Dr. Ness is co-principal investigator of
a project funded by the REDS-II program to study donor virus epidemiology issues in China.
He has worked extensively in international blood safety initiatives in China, Thailand, Vietnam,
Botswana, and Nigeria. Dr. Ness received his undergraduate education at the Massachusetts
Institute of Technology and his MD degree from the State University of New York at Buffalo. His
postgraduate work includes residency in internal medicine at Johns Hopkins, fellowship train-
ing in hematology-oncology at the University of California, San Francisco, and a transfusion
medicine fellowship at Irwin Memorial Blood Bank in San Francisco.
Dr. Anderson is the Kraft Family Professor of Medicine at Harvard Medical School and serves as
chief of the Division of Hematologic Neoplasia, director of the Jerome Lipper Multiple Myeloma
Center, and vice chair of the Joint Program in Transfusion Medicine at Dana-Farber Cancer
Institute. Currently, Dr. Anderson is chair of the NCCN Multiple Myeloma Clinical Practice
Guidelines Committee, is a Cancer and Leukemia Group B Principal Investigator, and is on the
Board of Scientific Advisors of the International Myeloma Foundation. He has published more
than 300 original articles and 200 book chapters, and has edited multiple textbooks on mul-
tiple myeloma and transfusion medicine. He is a Doris Duke Distinguished Clinical Research
Scientist and has had long-term RO1, PO1, and SPORE funding from the NIH and other agencies.
Dr. Anderson has received numerous awards, including the 2001 Charles C. Lund Award of the
American Red Cross Blood Services, the 2003 Waldenstrom’s award for research in plasma cell
dyscrasias, the 2004 Johnson & Johnson Focused Giving Award for Setting New Directions in
Science and Technology, and the 2005 Robert A. Kyle Lifetime Achievement Award. Dr. Anderson
graduated from Johns Hopkins Medical School, trained in internal medicine at Johns Hopkins
Hospital, and completed hematology, medical oncology, and tumor immunology fellowships at
vi the Dana-Farber Cancer Institute.
Dr. Roback is a tenured associate professor in the Department of Pathology and Laboratory
Medicine at Emory University, associate director of the Emory Transfusion Medicine Program, and
co-director of the Emory University Hospital Blood Bank and Stem Cell Processing Laboratory.
Dr. Roback’s research focuses on human and animal models of CMV infection, emphasizing
approaches to accelerate and improve the antiviral immune response following hematopoietic
stem cell transplantation. He also is inventor or co-inventor of a number of novel devices and
methodologies for rapid pretransfusion blood testing. Dr. Roback’s investigations have been
funded by the NIH, CDC, NBF, and DOD. He is a co-principal investigator of the Emory site for
REDS-II. Dr. Roback has authored 40 peer-reviewed publications and invited reviews, as well as
16 book chapters. He teaches medical, residency, and graduate school courses and was recognized
for excellent clinical pathology teaching with the Golden Apple Award. An active member of a
number of AABB committees, Dr. Roback is editor-in-chief of the 16th edition of the AABB’s
Technical Manual, member of the editorial board for the journal Transfusion, and co-chair
of the NHLBI’s Global Blood Safety and Availability task force on future transfusion medicine
research initiatives. He is a Diplomate of the American Board of Pathology in Clinical Pathology
and Blood Banking and Transfusion Medicine. Dr. Roback received his Baccalaureate degree from
Johns Hopkins University and was awarded a PhD in experimental pathology and an MD from
the University of Chicago. He completed a postdoctoral research fellowship and anatomic pathol-
ogy residency training at Albert Einstein College of Medicine and subsequently completed clinical
pathology and transfusion medicine training at Emory University.
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Contributors
Sharon Adams, MT, CHS (ABHI) Richard J. Benjamin, MS, MBChB, PhD
Supervisor, HLA Laboratory Chief Medical Officer
Department of Transfusion Medicine American Red Cross Biomedical Services
Warren G. Magnuson Clinical Center National Headquarters, Washington, D.C.
National Institutes of Health Assistant Professor of Pathology
Bethesda, Maryland, USA Joint Program in Transfusion Medicine
Harvard Medical School
Boston, Massachusetts, USA
Barbara Alving, MD, MACP
Professor of Medicine
Howard Benn, MD
Uniformed Services University of the Health Sciences
Bethesda, Maryland, USA Chief Fellow, Department of Hematology/
Oncology
Seton Hall University School of Graduate Medical
Education
Kenneth C. Anderson, MD
South Orange, New Jersey, USA
Chief, Division Hematologic Neoplasia
Director, Jerome Lipper Multiple Myeloma Center
Dana-Farber Cancer Institute
Ginine M. Beyer, MD
Kraft Family Professor of Medicine
Harvard Medical School Department of Pathology
Boston, Massachusetts University of Maryland School of Medicine
Baltimore, Maryland, USA vii
James P. AuBuchon, MD
E. Elizabeth French Professor and Chair of Pathology Morris A. Blajchman, MD, FRCP
Dartmouth-Hitchcock Medical Center Professor, Pathology and Molecular Medicine
Lebanon, New Hampshire, USA Head, Transfusion Medicine Services, Hamilton
Regional Laboratory
Medical Director, Canadian Blood Services
Hamilton, Ontario, Canada
Nicholas Bandarenko, MD
Associate Professor of Pathology and Laboratory
Medicine
Transfusion Medicine Service Neil Blumberg, MD
University of North Carolina, Chapel Hill Director, Clinical Laboratories
Chapel Hill, North Carolina, USA Director, Transfusion Medicine
Professor of Pathology and Laboratory Medicine,
University of Rochester School of Medicine
Jon Barrett, MBBCh, FRCOG, MD, Rochester, New York, USA
FRCSC
Associate Professor, Department of Obstetrics and
Mark E. Brecher, MD
Gynecology, University of Toronto
Senior Investigator Maternal and Infant Research Professor, Department of Pathology and
Unit of Center for Research in Women’s Health Laboratory Medicine
Chief of Maternal Fetal Medicine, Sunnybrook and Director, Clinical Pathology
Women’s College Health Sciences Center University of North Carolina
Toronto, Ontario, Canada Chapel Hill, North Carolina, USA
FM-F039816.indd vii 9/22/06 8:41:56 AM
S Hal E. Broxmeyer, PhD Chief Medical Officer and Vice President, Research
R
O and Medical Affairs
T Distinguished Professor, Chairman and Mary
U
B Margaret Walther Professor of Microbiology Cerus Corporation
RI
NT and Immunology Concord, California, USA
O
C Professor of Medicine
Scientific Director of the Walther Oncology Center
Indiana University School of Medicine Robert L. Crookes, MBChB
Indianapolis, Indiana, USA Medical Director
South African National Blood Service
Johannesburg, South Africa
Michael P. Busch, MD, PhD
Vice President, Research, Blood Systems, Inc.,
Scottsdale, Arizona Elizabeth E. Culler, MD
Director, Blood Systems Research Institute, Medical Director
San Francisco, California Blood Assurance, Inc.
Adjunct Professor, Department of Laboratory Chattanooga, Tennessee, USA
Medicine
University of California,
San Francisco, California, USA
Melody J. Cunningham, MD
Assistant Professor of Pediatrics
Harvard Medical School
Jeannie L. Callum, BA, MD, FRCPC
Children’s Hospital Boston
Assistant Professor, Department of Laboratory
Boston, Massachusetts, USA
Medicine and Pathobiology
University of Toronto
Director, Blood and Tissue Banks
Richard J. Davey, MD
Sunnybrook and Women’s College Health
Sciences Center Director, Transfusion Service
Toronto, Ontario, Canada The Methodist Hospital
Houston, Texas, USA
Sally A. Campbell-Lee, MD
Dana V. Devine, PhD
Assistant Professor, Department of Pathology
Associate Medical Director, Division of Transfusion Professor of Pathology and Laboratory Medicine
viii
Medicine Centre for Blood Research
Medical Director, Johns Hopkins Bayview University of British Columbia
Transfusion Medicine Service Executive Director, Research and Development
Baltimore, Maryland, USA Canadian Blood Services
Vancouver, British Columbia, Canada
Jeffrey L. Carson, MD
Roger Y. Dodd, PhD
Richard C. Reynolds Professor of Medicine
Chief, Division of General Internal Medicine Vice President, Research and Development
University of Medicine and Dentistry, New Jersey Director, Holland Laboratory
Robert Wood Johnson Medical School American Red Cross, Biomedical Services
New Brunswick, New Jersey, USA Rockville, Maryland, USA
Kenneth A. Clark, MD, MPH Alexander Duncan, MD
Head, International Blood Safety Assistant Professor, Department of Pathology and
Global AIDS Program Laboratory Medicine
Centers for Disease Control and Prevention Emory University School of Medicine
Atlanta, Georgia, USA Director, Coagulation Laboratories
Atlanta, Georgia, USA
Laurence Corash, MD
Walter H. Dzik, MD
Professor, Laboratory Medicine, University of
California, San Francisco Co-Director, Blood Transfusion Service
Attending Physician, Laboratory Medicine and Massachusetts General Hospital
Medicine-Hematology Division Associate Professor of Pathology
The Medical Center at the University of California, Harvard Medical School
San Francisco Boston, Massachusetts, USA
FM-F039816.indd viii 9/22/06 8:41:56 AM
James R. Eckman, MD Joanna M. Heal, MRCP, MBBS C
O
Director, Georgia Comprehensive Sickle Cell Center Associate Medical Director, American Red Cross NT
R
Grady Health System Blood Services, New York-Penn Region IB
U
Professor of Hematology/Oncology and Medicine Associate Clinical Professor of Medicine, T
O
Winship Cancer Institute Hematology-Oncology Unit R
S
Emory University School of Medicine University of Rochester School of Medicine
Atlanta, Georgia, USA Rochester, New York, USA
A. Bradley Eisenbrey, MD, PhD
Paul C. Hébert, MD, FRCPC,
Chief, Transfusion Medicine Services
MHSc(Epid)
William Beaumont Hospital, Royal Oak,
Michigan Vice-Chair, Department of Medicine
HLA Laboratory Associate Director Professor of Medicine and Epidemiology
Gift of Life of Michigan, Ann Arbor, Michigan Chair in Transfusion and Critical Care Research
Assistant Professor of Pathology Ottawa Health Research Institute and the
Wayne State University School of Medicine University of Ottawa
Detroit, Michigan, USA Ottawa, Ontario, Canada
Eberhard W. Fiebig, MD Nancy Heddle, MSc, FCSMLS(D)
Associate Professor, Department of Laboratory Director, McMaster Transfusion Research Program
Medicine Associate Professor, Department of Medicine
Chief, Divisions of Hematology and Transfusion McMaster University
Medicine Hamilton, Ontario, Canada
University of California
San Francisco, California, USA
John R. Hess, MD, MPH
John M. Fisk, MD Professor of Pathology and Medicine
University of Maryland School of Medicine
Clinical Instructor, Laboratory Medicine
Baltimore, Maryland, USA
SUNY Upstate Medical University College
of Medicine
Assistant Director, Transfusion Medicine
University Hospital of the State University Christopher D. Hillyer, MD
ix
of New York
Director, Transfusion Medicine Program
Syracuse, New York, USA
Professor, Department of Pathology
and Laboratory Medicine and the Division of
Hematology/Oncology, Winship Cancer Institute
Terrence L. Geiger, MD, PhD
Emory University School of Medicine
Assistant Professor, Department of Pathology Atlanta, Georgia, USA
St. Jude Children’s Research Hospital
Memphis, Tennessee, USA
Krista L. Hillyer, MD
Chief Medical Officer, American Red Cross Blood
Mindy Goldman, MD, FRCP(C)
Services, Southern Region
Executive Medical Director Assistant Professor, Department of Pathology
Donor and Transplantation Services and Laboratory Medicine
Canadian Blood Services Emory University School of Medicine
Ottawa, Ontario, Canada Atlanta, Georgia, USA
Shealynn B. Harris, MD Paul V. Holland, MD
Assistant Medical Director Clinical Professor of Medicine and Pathology
American Red Cross Blood Services, UC Davis Medical Center, Sacramento, California
Southern Region Scientific Director, Delta Blood Bank
Atlanta, Georgia, USA Stockton, California, USA
FM-F039816.indd ix 9/22/06 8:41:56 AM
S Kim A. Janatpour, MD Thomas J. Kunicki, PhD
R
O
T Assistant Professor, University of California Associate Professor
U
B Davis School of Medicine, Department of Division of Experimental Hemostasis and
RI
NT Pathology and Laboratory Medicine Thrombosis
O
C Davis Medical Center Department of Molecular and Experimental
Sacramento, California, USA Medicine
The Scripps Research Institute
La Jolla, California, USA
Viviana V. Johnson, MD
Transfusion Medicine Fellow
Department of Pathology Tzong-Hae Lee, MD, PhD
Georgetown University Hospital Director, Molecular Biology
Washington, D.C., USA Blood Systems Research Institute
San Francisco, California, USA
Cassandra D. Josephson, MD
Assistant Professor, Departments of Pathology Karen Shoos Lipton, JD
and Pediatrics
Chief Executive Officer
Emory University School of Medicine
AABB
Assistant Director, Blood Banks and Transfusion
Bethesda, Maryland, USA
Services
Attending Pediatric Hematologist/Oncologist,
Department of Pediatrics
Children’s Healthcare of Atlanta Lennart E. Lögdberg, MD, PhD
Atlanta, Georgia, USA Associate Professor, Department of Pathology
and Laboratory Medicine
Director, Crawford W. Long Hospital Transfusion
Richard M. Kaufman, MD Services
Emory University School of Medicine
Medical Director, Adult Transfusion Service,
Atlanta, Georgia, USA
Brigham and Women’s Hospital
Assistant Professor of Pathology, Harvard Medical
School
Boston, Massachusetts, USA Naomi L. C. Luban, MD
x
Interim Executive Director, Center for Cancer
and Blood Disorders
Thomas S. Kickler, MD Chair, Laboratory Medicine and Pathology
Professor of Medicine and Pathology Director, Transfusion Medicine/The Edward J. Miller
Johns Hopkins University School of Medicine Donor Center
Baltimore, Maryland, USA Vice Chair for Academic Affairs, Department
of Pediatrics
Children’s National Medical Center
Professor, Pediatrics and Pathology
Diane Killion, JD
The George Washington University Medical Center
Staff Counsel Washington, D.C., USA
AABB
Bethesda, Maryland, USA
Catherine S. Manno, MD
Karen E. King, MD Professor and Associate Chair for Clinical Affairs
Department of Pediatrics
Associate Medical Director
Children’s Hospital of Philadelphia
Transfusion Medicine Division
University of Pennsylvania School of Medicine
Johns Hopkins University School of Medicine
Philadelphia, Pennsylvania, USA
Baltimore, Maryland, USA
Steven H. Kleinman, MD Simon Mantha, MD
Kleinman Biomedical Research Department of Laboratory Medicine
Victoria, British Columbia, Canada Yale University School of Medicine
University of British Columbia Yale–New Haven Hospital
Vancouver, British Columbia, Canada New Haven, Connecticut, USA
FM-F039816.indd x 9/22/06 8:41:57 AM
Francesco M. Marincola, MD Patricia T. Pisciotto, MD C
O
Director, HLA and Immunogenetics Research Professor, Laboratory Medicine NT
R
Laboratory University of Connecticut Health Sciences Center IB
U
Department of Transfusion Medicine Director, Blood Bank, John Dempsey Hospital T
O
Warren G. Magnuson Clinical Center Farmington, Connecticut, USA R
S
National Institutes of Health
Bethesda, Maryland, USA
Thomas H. Price, MD
Executive Vice-President, Medical Division
Bruce C. McLeod, MD Medical Director, Puget Sound Blood Center
Professor of Medicine and Pathology Professor of Medicine, University of Washington
Director, Blood Center Seattle, Washington, USA
Rush University Medical Center
Chicago, Illinois, USA
Jayashree Ramasethu, MD
Associate Professor of Clinical Pediatrics
Jay E. Menitove, MD Division of Neonatology
Clinical Professor, Internal Medicine Department of Pediatrics
University of Kansas School of Medicine Georgetown University Hospital
Kansas City, Kansas; Executive Director and Washington, D.C., USA
Medical Director, Community Blood Center
of Greater Kansas City
Kansas City, Missouri, USA Sandra M. Ramirez-Arcos, MSc, PhD
Associate Scientist, Canadian Blood Services
Adjunct Professor, University of Ottawa
Peter A. Millward, MD Research and Development, Infectious Diseases
Assistant Professor, Clinical Pathology Ottawa, Ontario, Canada
Milton S. Hershey Medical Center
Pennsylvania State University
Hershey, Pennsylvania, USA
William Reed, MD
Assistant Medical Director, Research
Edward L. Murphy, MD, MPH Blood Systems Research Institute
Clinical Associate Professor
Professor, Laboratory Medicine and Epidemiology/
Department of Laboratory Medicine xi
Biostatistics
Medical Director, Human Islet and Cellular
University of California, San Francisco
Therapy Laboratory
San Francisco, California, USA
University of California
San Francisco, California, USA
Paul M. Ness, MD
Director, Transfusion Medicine Division
Marion E. Reid, PhD
Johns Hopkins Medical Institutions
Professor, Pathology, Medicine, and Oncology Director, Immunohematology
Johns Hopkins University School of Medicine New York Blood Center
Baltimore, Maryland, USA New York, New York, USA
Diane J. Nugent, MD
John D. Roback, MD, PhD
Assistant Professor
Co-Director, Transfusion Medicine Program
David Geffen School of Medicine at UCLA
Associate Professor, Department of Pathology
University of California, Los Angeles
and Laboratory Medicine
Director, Division of Hematology
Emory University School of Medicine
Children’s Hospital of Orange County
Atlanta, Georgia, USA
General Pediatrics, Irvine Medical Center
Los Angeles, California, USA
Scott D. Rowley, MD, FACP
Peter L. Perrotta, MD Chief, Adult Blood and Marrow Transplantation
Associate Professor of Pathology Program
West Virginia University Hackensack University Medical Center
Morgantown, West Virginia, USA Hackensack, New Jersey, USA
FM-F039816.indd xi 9/22/06 8:41:57 AM
S S. Gerald Sandler, MD Leslie E. Silberstein, MD
R
O
T Professor of Medicine and Pathology Director, Joint Program in Transfusion Medicine
U
B Georgetown University School of Medicine Children’s Hospital Boston, Dana-Farber Cancer
RI
NT Director, Transfusion Medicine Institute, Brigham and Women’s Hospital
O
C Department of Laboratory Medicine Professor of Pathology, Harvard Medical School
Georgetown University Hospital Boston, Massachusetts, USA
Washington, D.C., USA
Steven R. Sloan, MD, PhD
Audrey N. Schuetz, MD Assistant Professor of Pathology Pediatrics
Department of Pathology and Laboratory Medicine Joint Program in Transfusion Medicine
Emory University School of Medicine Harvard Medical School
Atlanta, Georgia, USA Boston, Massachusetts, USA
Eileen Selogie, MT(ASCP)SBB Edward L. Snyder, MD
Consultant Compliance Officer Professor, Laboratory Medicine
Department of Pathology, Blood Donor Services Yale University School of Medicine
Presbyterian Intercommunity Hospital Director, Blood Bank, Yale–New Haven Hospital
Whittier, California, USA New Haven, Connecticut, USA
Beth Shaz, MD Ronald G. Strauss, MD
Assistant Professor, Emory University School Professor of Pathology and Pediatrics
of Medicine University of Iowa College of Medicine
Department of Pathology and Laboratory Medicine Iowa City, Iowa, USA
Director, Grady Memorial Hospital Blood Bank
Atlanta, Georgia, USA
David F. Stroncek, MD
Chief, Laboratory Services Section
R. Sue Shirey, MD, MT(ASCP) SBB Department of Transfusion Medicine
Technical Specialist, Transfusion Medicine Division, Warren G. Magnuson Clinical Center
Johns Hopkins Hospital National Institutes of Health
xii
Baltimore, Maryland, USA Bethesda, Maryland, USA
Ira A. Shulman, MD D. Michael Strong, PhD, BCLD(ABB)
Director of Transfusion Medicine Executive Vice President, COO
Professor and Vice Chair of Pathology Puget Sound Blood Center
Keck School of Medicine of the University Research Professor
of Southern California Department of Orthopaedics and Sports Medicine
Director of Laboratories and Pathology, LAC + USC Department of Surgery
Medical Center University of Washington School of Medicine
Los Angeles, California, USA Seattle, Washington, USA
Suzanne Shusterman, MD Leon L. Su, MD
Instructor, Harvard Medical School Associate Medical Director
Department of Pediatric Oncology Blood Systems, Inc.
Dana-Farber Cancer Institute Assistant Medical Director
Children’s Hospital Boston United Blood Services, Arizona
Boston, Massachusetts, USA Scottsdale, Arizona, USA
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