Bipolar II Disorder: Recognition, Understanding, and Treatment

324 Pages·2019·4.588 MB·English

by  Holly A. Swartz (editor), Trisha Suppes (editor)

Recognition, Understanding, and
Treatment
Edited by
Holly A. Swartz, M.D.
Trisha Suppes, M.D., Ph.D.
BIPOLAR II DISORDER
RECOGNITION, UNDERSTANDING,
AND TREATMENT

BIPOLAR II DISORDER
RECOGNITION, UNDERSTANDING,
AND TREATMENT
Edited by
Holly A. Swartz, M.D.
Trisha Suppes, M.D., Ph.D.
Note: The authors have worked to ensure that all information in this book is accu­
rate at the time of publication and consistent with general psychiatric and medical

standards, and that information concerning drug dosages, schedules, and routes of

administration is accurate at the time of publication and consistent with standards set

by the U.S. Food and Drug Administration and the general medical community. As

medical research and practice continue to advance, however, therapeutic standards

may change. Moreover, specific situations may require a specific therapeutic response

not included in this book. For these reasons and because human and mechanical er­
rors sometimes occur, we recommend that readers follow the advice of physicians di­
rectly involved in their care or the care of a member of their family.

Books published by American Psychiatric Association Publishing represent the find­
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Library of Congress Cataloguing-in-Publication Data
Names: Swartz, Holly A., editor. | Suppes, Trisha, editor. | American Psychiatric
Association Publishing, issuing body.
Title: Bipolar II disorder : recognition, understanding, and treatment / edited by
Holly A. Swartz, Trisha Suppes.
Other titles: Bipolar II disorder (Swartz)
Description: First edition. | Washington, D.C. : American Psychiatric Association
Publishing, [2019] | Includes bibliographical references and index. |
Identifiers: LCCN 2019011723 (print) | LCCN 2019012924 (ebook) | ISBN
9781615372591 () | ISBN 9781615371785 (pbk. : alk. paper)
Subjects: | MESH: Bipolar Disorder—diagnosis | Bipolar Disorder—therapy
Classification: LCC RC516 (ebook) | LCC RC516 (print) | NLM WM 171.7 |
DDC 616.89/5—dc23
LC record available at https://lccn.loc.gov/2019011723
British Library Cataloguing in Publication Data
A CIP record is available from the British Library.
To Steven, Sophie, and Eli—each special, for different reasons.
H.A.S.
To my sisters and brothers Deborah, John, Alexandra, and Michael
with great appreciation you are in my life.
T.S.
To our patients and colleagues who taught us about bipolar II
disorder; you made this book possible.

Contents
Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix

Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .xv

Holly A. Swartz, M.D., and Trisha Suppes, M.D., Ph.D.
Part I

Recognition
1
A Neglected Condition. . . . . . . . . . . . . . . . . . . . . .3

Holly A. Swartz, M.D., and Trisha Suppes, M.D., Ph.D.
2
Diagnosing Bipolar II Disorder. . . . . . . . . . . . . . .17

Nicole Kramer, M.A., M.S., and Trisha Suppes, M.D., Ph.D.
3
Interface Between Borderline Personality

Disorder and Bipolar II Disorder . . . . . . . . . . . . .51

Mark Zimmerman, M.D., and Theresa A. Morgan, Ph.D.
4
Psychiatric and Medical Comorbidities

With Bipolar II Disorder . . . . . . . . . . . . . . . . . . . .71

Joshua D. Rosenblat, M.D., Michael J. Ostacher, M.D., M.P.H., M.M.Sc.,
and Roger S. McIntyre, M.D., F.R.C.P.C.
5
Suicide and Bipolar II Disorder. . . . . . . . . . . . . .99

Ayal Schaffer, M.D., F.R.C.P.C., and

Mark Sinyor, M.Sc., M.D., F.R.C.P.C.

Part II

Understanding
6
Genetics of Bipolar II Disorder . . . . . . . . . . . . .121

Melvin McInnis, M.D.
7
Functional Brain Imaging and

Neural Determinants in Bipolar II Disorder . . .139

Anna Manelis, Ph.D., Adriane M. Soehner, Ph.D., and
Mary L. Phillips, M.D., M.D.(Cantab.)
Part III

Treatment
8
Mood Stabilizers and Antipsychotic

Medications in Bipolar II Disorder. . . . . . . . . . .165

Eva Solé, M.D., Marina Garriga, M.D., and
Eduard Vieta, M.D., Ph.D.
9
Antidepressant Medications in

Bipolar II Disorder . . . . . . . . . . . . . . . . . . . . . . .183

Susan L. McElroy, M.D., and Alex Israel, M.D.
10
Psychosocial Interventions in

Bipolar II Disorder . . . . . . . . . . . . . . . . . . . . . . .203

Danielle M. Novick, Ph.D., and Holly A. Swartz, M.D.
Part IV

Special Populations
11
Bipolar II Disorder in Childhood and

Adolescence. . . . . . . . . . . . . . . . . . . . . . . . . . . .241

Manivel Rengasamy, M.D., and Boris Birmaher, M.D.
12
Reproductive-Age Women With

Bipolar II Disorder . . . . . . . . . . . . . . . . . . . . . . .263

Eydie L. Moses-Kolko, M.D., Crystal T. Clark, M.D., M.Sc.,
Sarah DeBrunner, M.D., and Katherine L. Wisner, M.D., M.S.
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .287
Contributors
Boris Birmaher, M.D.
Professor of Psychiatry and Endowed Chair in Early Bipolar Disorder, Di­
rector of the Child and Adolescent Bipolar Services Program, Co-Director
of Psychiatry Research Pathway Program, Department of Psychiatry, Uni­
versity of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
Crystal T. Clark, M.D., M.Sc.
Assistant Professor of Psychiatry and Behavioral Sciences and Obstetrics
and Gynecology, Asher Center for the Study and Treatment of Depressive
Disorders, Northwestern Feinberg School of Medicine, Chicago, Illinois
Sarah DeBrunner, M.D.
Clinical Assistant Professor, University of Pittsburgh School of Medicine,
Department of Psychiatry, University of Pittsburgh Medical Center, Pitts­
burgh, Pennsylvania
Marina Garriga, M.D.
Psychiatrist, Department of Psychiatry and Psychology, Institute of Neuro­
science, University of Barcelona, Hospital Clinic, IDIBAPS, CIBERSAM,
Barcelona, Catalonia, Spain
Alex Israel, M.D.
Graduate Medical Resident in Psychiatry, Western Psychiatric Institute
and Clinic, Pittsburgh, Pennsylvania
Nicole Kramer, M.A., M.S.
Doctoral Candidate and Research Assistant, Prevention and Intervention
Laboratory, Stanford University School of Medicine, Stanford, California
ix