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Biostatistics - The Carter Center PDF

275 Pages·2007·0.84 MB·English
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LECTURE NOTES For Health Science Students Biostatistics Getu Degu Fasil Tessema University of Gondar In collaboration with the Ethiopia Public Health Training Initiative, The Carter Center, the Ethiopia Ministry of Health, and the Ethiopia Ministry of Education January 2005 Funded under USAID Cooperative Agreement No. 663-A-00-00-0358-00. Produced in collaboration with the Ethiopia Public Health Training Initiative, The Carter Center, the Ethiopia Ministry of Health, and the Ethiopia Ministry of Education. Important Guidelines for Printing and Photocopying Limited permission is granted free of charge to print or photocopy all pages of this publication for educational, not-for-profit use by health care workers, students or faculty. All copies must retain all author credits and copyright notices included in the original document. Under no circumstances is it permissible to sell or distribute on a commercial basis, or to claim authorship of, copies of material reproduced from this publication. ©2005 by Getu Degu and Fasil Tessema All rights reserved. Except as expressly provided above, no part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage and retrieval system, without written permission of the author or authors. This material is intended for educational use only by practicing health care workers or students and faculty in a health care field. Biostatistics PREFACE This lecture note is primarily for Health officer and Medical students who need to understand the principles of data collection, presentation, analysis and interpretation. It is also valuable to diploma students of environmental health, nursing and laboratory technology although some of the topics covered are beyond their requirements. The material could also be of paramount importance for an individual who is interested in medical or public health research. It has been a usual practice for a health science student in Ethiopia to spend much of his/her time in search of reference materials on Biostatistics. Unfortunately, there are no textbooks which could appropriately fulfill the requirements of the Biostatistics course at the undergraduate level for Health officer and Medical students. We firmly believe that this lecture note will fill that gap. The first three chapters cover basic concepts of Statistics focusing on the collection, presentation and summarization of data. Chapter four deals with the basic demographic methods and health service statistics giving greater emphasis to indices relating to the hospital. In chapters five and six elementary probability and sampling methods are presented with practical examples. A relatively comprehensive description of statistical inference on means and proportions is given in chapters seven and eight. The last chapter of this lecture note is about linear correlation and regression. i Biostatistics General learning objectives followed by introductory sections which are specific to each chapter are placed at the beginning of each chapter. The lecture note also includes many problems for the student, most of them based on real data, the majority with detailed solutions. A few reference materials are also given at the end of the lecture note for further reading. ii Biostatistics Acknowledgments We would like to thank the Gondar College of Medical Sciences and the Department of Epidemiology and Biostatistics (Jimma University) for allowing us to use the institutions resources while writing this lecture note. We are highly indebted to the Carter Center with out whose uninterrupted follow up and support this material would have not been written. we wish to thank our students whom we have instructed over the past years for their indirect contribution to the writing of this lecture note. iii Biostatistics Table of Contents Preface i Acknowledgements iii Table of contents iv Chapter One : Introduction to Statistics 1.1 Learning Objectives 1 1.2 Introduction 1 1.3 Rationale of studying Statistics 5 1.4 Scales of measurement 7 Chapter Two: Methods of Data collection, Organization and presentation 2.1 Learning Objectives 12 2.2 Introduction 12 2.3 Data collection methods 13 2.4 Choosing a method of data collection 19 2.5 Types of questions 22 2.6 Steps in designing a questionnaire 27 2.7 Methods of data organization and presentation 32 iv Biostatistics Chapter Three : Summarizing data 3.1 Learning Objectives 61 3.2 Introduction 61 3.3 Measures of Central Tendency 63 3.4 Measures of Variation 74 Chapter Four : Demographic Methods and Health Services Statistics 4.1 Learning Objectives 95 4.2 Introduction 95 4.3 Sources of demographic data 97 4.4 Stages in demographic transition 103 4.5 Vital Statistics 107 4.6 Measures of Fertility 109 4.7 Measures of Mortality 114 4.8 Population growth and Projection 117 4.9 Health services statistics 119 Chapter Five : Elementary Probability and probability distribution 5.1 Learning Objectives 126 5.2 Introduction 126 5.3 Mutually exclusive events and the additive law 129 v Biostatistics 5.4 Conditional Probability and the multiplicative law 131 5.5 Random variables and probability distributions 135 Chapter Six : Sampling methods 6.1 Learning Objectives 150 6.2 Introduction 150 6.3 Common terms used in sampling 151 6.4 Sampling methods 153 6.5 Errors in Sampling 160 Chapter seven : Estimation 7.1 Learning Objectives 163 7.2 Introduction 163 7.3 Point estimation. 164 7.4 Sampling distribution of means 165 7.5 Interval estimation (large samples) 169 7.6 Sample size estimation 179 7.7 Exercises 185 Chapter Eight : Hypothesis Testing 8.1 Learning Objectives 186 8.2 Introduction 186 8.3 The Null and Alternative Hypotheses 188 8.4 Level of significance 191 vi Biostatistics 8.5 Tests of significance on means and proportions (large samples) 193 8.6 One tailed tests 204 8.7 Comparing the means of small samples 208 8.8 Confidence interval or P-value? 219 8.9 Test of significance using the Chi-square and Fisher’s exact tests 221 8.10 Exercises 229 Chapter Nine: Correlation and Regression 9.1 Learning Objectives 231 9.2 Introduction 231 9.3 Correlation analysis 232 9.4 Regression analysis 241 Appendix : Statistical tables 255 References 263 vii Biostatistics List of Tables Table 1 overall immunization status of children in adamai Tullu Woreda, Feb 1995 46 Table 2: TT immunization by marital status of the woment of childbearing age, assendabo town jimma Zone, 1996 47 Table 3 Distribution of Health professional by sex and residence 48 Table 4 Area in one tall of the standard normal curve 255 Table 5 Percentage points of the t Distribution 258 Table 6 Percentage points of the Chi-square distribution 260 viii

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