Electrical Engineering Li Wu B Biosensors Based on Nanomaterials i o and Nanodevices s e n Biosensors Based on Nanomaterials and Nanodevices links s interdisciplinary research from leading experts to provide graduate o students, academics, researchers, and industry professionals alike r s with a comprehensive source for key advancements and future trends in nanostructured biosensor development. It describes the concepts, B principles, materials, device fabrications, functions, system integra- a tions, and applications of various types of biosensors based on signal s e transduction mechanisms, including fluorescence, photonic crystal, d surface-enhanced Raman scattering, electrochemistry, electro- luminescence, field-effect transistor, and magnetic effect. The book: o n • Explains how to utilize the unique properties of nanomaterials N to construct nanostructured biosensors to achieve enhanced a performance n • Features examples of biosensors based on both typical and o emerging nanomaterials, such as gold nanoparticles, quantum m dots, graphene, graphene oxides, magnetic nanoparticles, carbon a nanotubes, inorganic nanowires/nanorods, plasmonic nanostruc- t tures, and photonic crystals e • Demonstrates the broad applications of nanostructured biosensors r i in environmental monitoring, food safety, industrial quality assur- a ance, and in vitro and in vivo health diagnosis l s • Inspires new ideas for tackling multiscale and multidisciplinary issues in developing high-performance biosensors for complex a practical biomedical problems n d Biosensors Based Focusing on the connection between nanomaterials research and N biosensor development, Biosensors Based on Nanomaterials and a Nanodevices illustrates the exciting possibilities and critical chal- n lenges of biosensors based on nanomaterials and nanodevices for o Nanomaterials on future health monitoring, disease diagnosis, therapeutic treatments, d and beyond. e v Nanodevices i and c e s K15174 Edited by Jun Li • Nianqiang Wu Biosensors Based Nanomaterials on Nanodevices and Nanomaterials and Their Applications Series Editor: M. Meyyappan Nanorobotics: An Introduction Lixin Dong and Bradley J. Nelson Biosensors Based on Nanomaterials and Nanodevices Jun Li and Nianqiang Wu, Editors Plasma Processing of Nanomaterials R. Mohan Sankaran, Editor Graphene: Synthesis and Applications Wonbong Choi and Jo-won Lee, Editors Inorganic Nanoparticles: Synthesis, Applications, and Perspectives Claudia Altavilla, Enrico Ciliberto, Editors Carbon Nanotubes: Reinforced Metal Matrix Composites Arvind Agarwal, Srinivasa Rao Bakshi, and Debrupa Lahiri Inorganic Nanowires: Applications, Properties, and Characterization M. Meyyappan and Mahendra Sunkara Biosensors Based Nanomaterials on Nanodevices and Edited by Jun Li • Nianqiang Wu Boca Raton London New York CRC Press is an imprint of the Taylor & Francis Group, an informa business CRC Press Taylor & Francis Group 6000 Broken Sound Parkway NW, Suite 300 Boca Raton, FL 33487-2742 © 2014 by Taylor & Francis Group, LLC CRC Press is an imprint of Taylor & Francis Group, an Informa business No claim to original U.S. Government works Version Date: 20130725 International Standard Book Number-13: 978-1-4665-5152-7 (eBook - PDF) This book contains information obtained from authentic and highly regarded sources. Reasonable efforts have been made to publish reliable data and information, but the author and publisher cannot assume responsibility for the valid- ity of all materials or the consequences of their use. The authors and publishers have attempted to trace the copyright holders of all material reproduced in this publication and apologize to copyright holders if permission to publish in this form has not been obtained. If any copyright material has not been acknowledged please write and let us know so we may rectify in any future reprint. Except as permitted under U.S. Copyright Law, no part of this book may be reprinted, reproduced, transmitted, or uti- lized in any form by any electronic, mechanical, or other means, now known or hereafter invented, including photocopy- ing, microfilming, and recording, or in any information storage or retrieval system, without written permission from the publishers. For permission to photocopy or use material electronically from this work, please access www.copyright.com (http:// www.copyright.com/) or contact the Copyright Clearance Center, Inc. (CCC), 222 Rosewood Drive, Danvers, MA 01923, 978-750-8400. CCC is a not-for-profit organization that provides licenses and registration for a variety of users. For organizations that have been granted a photocopy license by the CCC, a separate system of payment has been arranged. Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used only for identification and explanation without intent to infringe. Visit the Taylor & Francis Web site at http://www.taylorandfrancis.com and the CRC Press Web site at http://www.crcpress.com Contents Editors ............................................................................................................................................vii Contributors ....................................................................................................................................ix 1. Opportunities and Challenges of Biosensors Based on Nanomaterials and Nanodevices ...................................................................................1 Jun Li and Nianqiang (Nick) Wu Section I Optical Biosensors 2. Synthesis and Characterization of Quantum Dots .......................................................11 Haiguang Zhao and Dongling Ma 3. Quantum Dots for Bioimaging ..........................................................................................41 Zoraida P. Aguilar 4. Fluorescent Sensors Based on Energy Transfer and Charge Transfer.......................71 Ming Li and Nianqiang (Nick) Wu 5 Graphene-Based Optical Biosensors and Imaging ........................................................93 Zhiwen Tang, Shijiang He, Hao Pei, Dan Du, Chunhai Fan, and Yuehe Lin 6. Biosensing Based on Surface-Enhanced Raman Spectroscopy ................................111 Gang Logan Liu, Wenwei Zheng, Pingping Zhang, and Fanqing (Frank) Chen 7. In Vivo Biodetection Using Surface-Enhanced Raman Spectroscopy .....................157 Seunghyun Lee, Ulhas S. Kadam, Ana Paula Craig, and Joseph Irudayaraj 8. Photonic Crystal Biosensors .............................................................................................179 Bashar Hamza, Maurya Srungarapu, Anand Kadiyala, Jeremy Dawson, and Lawrence Hornak 9. Nanomaterial-Based Electrochemiluminescence Biosensors ...................................209 Rongfu Huang and Liang-Hong Guo Section II Electrical Biosensors 10. Nanocrystalline Diamond Biosensors ...........................................................................243 Prabhu U. Arumugam, Shabnam Siddiqui, Hongjun Zeng, and John A. Carlisle 11. Carbon Nanotube–Based Electrochemical Biosensors ...............................................273 Feng Du, Lin Zhu, and Liming Dai v vi Contents 12. Vertically Aligned Carbon Nanofibers for Biointerfacing ........................................295 Ryan Pearce, Timothy E. McKnight, and Anatoli Melechko 13. Graphene-Based Electrochemical Biosensors ...............................................................317 Chun Xian Guo, Shu Rui Ng, and Chang Ming Li 14. Bioelectronics on Graphene ..............................................................................................351 Vikas Berry 15. Nanowire Field-Effect Transistor Biosensors ...............................................................369 Fumiaki Ishikawa, Xiaoli Wang, Noppadol Aroonyadet, and Chongwu Zhou Section III Magnetic Nanoparticles for Biosensing and Cancer Treatment 16. Biosensing and Cancer Treatment with Magnetic Nanoparticles ............................397 Stefan Bossmann, Viktor Chikan, and Raj Kumar Dani Section IV Biosensors Based on Thermal Properties 17. Solid–Liquid Phase Change Nanoparticles as Thermally Addressable Biosensors.....................................................................................................433 Chaoming Wang, Yan Hong, Liyuan Ma, and Ming Su 18. Microfluidic and Lab-on-Chip Technologies for Biosensors ....................................443 Yuxin Liu and Xiang Li Editors Jun Li earned a PhD in chemistry at Princeton University in 1995. He then served as a postdoctoral research associate at Cornell University from 1994 to 1997. He currently serves as a professor in the Department of Chemistry, Kansas State University, Manhattan, Kansas. Dr. Li has been engaged in research on nanosciences and nanotechnology through his career with Molecular Imaging Co. (1997–1998), the Institute of Materials Research and Engineering (Singapore, 1998–2000), NASA Ames Research Center (2000–2007), and Kansas State University (2007–present). He has published 120 peer-reviewed papers/book chapters and is a coinventor of 15 patent applications. His research work in nanotechnology has been highlighted in over 40 public news reports. He received the first annual Nano50 Award from NASA Tech Briefs in the Innovator category in 2005. He has also been serving as an associate editor for IEEE Transactions on Nanotechnology since 2007. Dr. Li’s research interests include integrating nanomaterials, particularly carbon nano- tubes and semiconductor nanowires, into functional devices including on-chip inter- connects, thermal interface materials, solar cells, supercapacitors, lithium–ion batteries, nanoelectrode array–based ultrasensitive biosensors, electrical neural interface, and nano- dielectrophoretic chips for capture and detection of bacterial or viral particles. Nianqiang (Nick) Wu currently serves as an associate professor in the Department of Mechanical and Aerospace Engineering at West Virginia University, Morgantown, West Virginia. He earned a PhD in materials science and engineering at Zhejiang University, China, in 1997, and was a postdoctoral fellow at the University of Pittsburgh from 1999 to 2001. Afterward he directed the Keck Surface Science Center at Northwestern University, Evanston, Illinois. He then joined WVNano Initiative and the Department of Mechanical and Aerospace Engineering at West Virginia University in 2005. He currently serves as the secretary of the sensor division in the Electrochemical Society and on the advisory board of Interface, the home journal of the Electrochemical Society. He has organized several symposia on biosensors and solar fuels, holds four patents/disclosures, and has published 3 book chapters and more than 110 journal papers. Dr. Wu’s research interests include low-dimension nanomaterials, chemical sensors and biosensors, photocatalysts and photoelectrochemical cells, and electrochemical devices for energy conversion and storage. He strives to develop nanostructures for sensor applica- tions, to study the charge transfer, energy transfer, and mass transport at the nanoscale in sensing materials and devices, and to develop lab-on-chip devices for point-of-care diagnosis. vii Contributors Zoraida P. Aguilar Ana Paula Craig Zystein, LLC Department of Agricultural and Biological Fayetteville, Arkansas Engineering Purdue University West Lafayette, Indiana Noppadol Aroonyadet Department of Electrical and Engineering—Electrophysics Federal University of Minas Gerais University of Southern California Belo Horizonte, Brazil Los Angeles, California Liming Dai Department of Macromolecular Science Prabhu U. Arumugam and Engineering Department of Mechanical Engineering Case Western Reserve University Louisiana Tech University Cleveland, Ohio Ruston, Louisiana Raj Kumar Dani Vikas Berry Department of Chemistry Department of Chemical Engineering Kansas State University Kansas State University Manhattan, Kansas Manhattan, Kansas Jeremy Dawson Lane Department of Computer Science and Stefan Bossmann Electrical Engineering Department of Chemistry West Virginia University Kansas State University Morgantown, West Virginia Manhattan, Kansas Dan Du School of Mechanical and Materials John A. Carlisle Engineering Advanced Diamond Technologies, Inc. Washington State University Romeoville, Illinois Pullman, Washington Feng Du Fanqing (Frank) Chen Department of Macromolecular Science Division of Life Sciences and Engineering Lawrence Berkeley National Laboratory Case Western Reserve University Berkeley, California Cleveland, Ohio Viktor Chikan Chunhai Fan Department of Chemistry Shanghai Institute of Applied Physics Kansas State University Chinese Academy of Sciences Manhattan, Kansas Shanghai, People’s Republic of China ix