Biomedical Defense Principles to Counter DNA Deep Hacking

384 Pages·2022·14.413 MB·English

by  Rocky Termanini

Biomedical Defense Principles to Counter DNA
Deep Hacking
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Biomedical Defense Principles
to Counter DNA Deep
Hacking
Rocky Termanini
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Dedication
The Success Chariot Victory Lap
I dedicate this book to my three fixtures of my life. First, my
wife who is a formidable powerhouse with sparkling energy all
day all the time. She is a driving force in writing and completing
this wonderful subject of DNA Hacking. Second, my daughter
Nadia Hinedi, the high-spirited attorney who shines with
dynamic maturity, intellectual eloquence, and judgmental
brilliance. Third, my son Dr. Sami Termanini MD for his
audacity to climb the mountain of life, the tenacity of a
marathon runner to overcome all unknown barriers, and his
courage to believe he is tougher than life. God gives his hardest
battles to his strongest soldiers.
Despite the pandemic that has still its arms around us, few
people deserve a standing ovation and a medal of Honor: My
Senior Acquisitions Editor Chris Katsaropoulos, Ana Claudia
Garcia, my Senior Project Editor Ms. Emily Thompson,
my Content Manager Sajana Devasi PK, and Mr. Mohanraj
Rajendran Copyrights Coordinator.
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Contents
About the Author xv The emergence of DNA bio-hacking 16
Acknowledgment xvii Hall of fame of DNA bio-hackers 16
Advanced DNA bio-hacking
technologies 18
1. The miraculous architecture of
The cloud of malware of DNA bio-
the gene pyramid
hacking 19
My name is DNA 1 Eysenck’s theory 20
Initial thoughts 1 Profiling, Dr. Edward Jones, our actor 20
Anatomyof DNA 1 Our hypothetical DNA lab 21
Watson and crick story 2 A change of belief 21
DNA double helix 2 Dr. Edward’s DNA-hacking rationale 21
What is a gene? 3 Data guardian turned into hacker 22
What is the chromosome? 3 The “toxic stress” syndrome 23
Chromosomes in forensics 3 DNA-hacker fingerprinting 23
The central dogma 3 The crime databases 24
Proteins 4 The combined DNA index system
Amino acid 5 (CODIS) 24
RNA structure 5 The national crime information center DB
Transcription (phase-1of central dogma) 5 (NCIC) 25
The transcription process 5 How does ransomware work? 25
Translation (phase-2 of central dogma) The storyof the recent North Korean
process 5 WannaCry ransomware attack 25
Anatomyof CRISPR machine 6 What’s the next step for Dr. Edward? 26
CRISPR structure 7 Appendices 26
Drawbacks and unethical issues 8 Appendix-AGlossary: Courtesyof The
Bio-hacking CRISPR, cracking the National Academies of Sciences,
biological atom 8 Engineering, and Medicine 26
CRISPR cyber hacking 9 Notes: Hans Eysenck 29
Appendix 9 Recommended sources 29
Appendix-A: Glossary of DNA (courtesy
E. coli
MERIT CyberSecurity technical 3. The story as the carrier of
library) 9 DNA malware code
Appendix-B: Landmine Nobel sweet
What is Escherichia coli (E. coli)? 31
irony 12
Defense by offense 32
Appendix-C: CRISPER pioneers 13
The CRISPR-Cas immunity projects 33
Recommended sources 13
CODIS data bank structures 33
The malicious code injection method 33
2. History of bio-hackers, psychological
Dr. Edward’s bio-attack plan 34
profiling, and fingerprinting of the
Strategic attack timeline 34
bio-hacker
Anatomyof spyware 35
Spyware’s spying process 36
The chemistryof DNA bio-hacking 15
Hackers wear four colorful hats 16 Digital malware data destruction
process 36
vii
viii Contents
DNA sequence malware setup 36 Appendix-B: CRISPR glossary from MERIT
DNA fingerprinting 36 cybersecurityarchive library 58
Design of the DNA sequence Recommended sources 61
malware 37
The drone flight for malware delivery 37 5. The genome vandalism. “When ISIS
DNA genome browser 37 meets CRISPR”
Genome browser users 38
A precious thought 63
Appendices 39
The next generation of bio-hacking 63
Appendix-A SQL storage on DNA 39
ISIS, the army from hell 64
Appendix-B SQL command converted to
ISIS was born 65
DNA code 40
The bitcoin story 65
Appendix-C DNA profiling (fingerprinting)
Bio-hacking is a money-making
technology 40
service 66
Appendix-D how to convert gene sequence
ISIS meets CRISPR 66
into protein 41
CRISPR 101 66
Appendix-E the BLAST browser 42
DNA 101 67
Appendix-F glossary of genome technology
DNA physical and sequence data
extracted from MERIT cybersecurity
banking 70
library 42
DNA ecosystem 70
Recommended sources 43
Anatomyof DNA synthesizers 70
Anatomyof DNA sequencers 71
4. CRISPR the magical knife, the
Anatomyof CRISPR 71
good, the bad, and the ugly
Miraculous power of CRISPR 72
Awarmup thought 45 Autonomyof the human genome
Crystal balling the future with blurry (NHG) 72
vision 45 Mapping of the genome 73
Game-changing discovery, an eureka Hard copyof the genome 74
moment 46 Bio vandalism and geneticallyengineered
Doudna and Charpentier get nobel 46 bioweaponrydthe new paradigm
Historical CRISPRovation 46 shift 74
CRISPR the new sunrise of gene Bio-hacking strategies and tools 75
editing 47 Hacking the prison computer systems,
The grim side of CRISPR 47 it really happened 76
The partners who are racing for CRISPR the unethical sawing machine,
bio-genetics fame 49 gene-editing babies 76
Jennifer A. Doudna 49 SARS-CoV-2 omicron variant 76
Emmanuelle Charpentier 50 The virus started in Wuhan, China 77
Feng Zhang 51 Generating malicious DNA sequence 77
Embryo concerns 51 DNA forensics, going back in time with
A crack in the creation 52 reverse bio-hacking 78
Doudna meets Charpentier 52 Genome vandalism 78
Nobel 2020 winners in chemistry 52 Hacking the human genome databases 79
CRISPR timeline 53 What are the databases 79
The impossible became possible 53 Bio-hacking DNA ecosystem 80
The Frankenstein unfortunate legacy 54 Bio-hacking DNA data storage 80
Genetic manipulation gone awry 55 The Trojan horse saga 80
He Jiankui, China’s Dr. Frankenstein 55 The Trojan horse malware 80
Who is He Jiankui? 55 The ransom formula 81
Lulu and Nana 56 The Dillinger ransome 81
Appendices 56 DNA bio-hacking with website-powered
Appendix-A: the human genome 56 ransom attack 82
The Human Genome Project (HGP) 57 DNA bio-hacking with SQL injection
(SQLI) attack 82
Contents ix
DNA bio-hacking with microchip 83 AFIS (automated fingerprint identification
Aword on RFID 83 system) record layout; hacking IAFIS
DNA bio-hacking with external buffer system 106
overflow payload 84 The million stolen fingerprints 107
DNA bio-hacking with internal DNA profiling 107
sequenced malicious binary 84 Mitochondrial DNA 107
Appendices 85 The two bio-hacking scenarios 108
Appendix-A: Strategic terms used in DNA Scenario-1: hacking the combined DNA
cyber hacking 85 index system (CODIS) 109
Appendix-B: The national center for Introduction 109
biotechnology information (BCBI) 85 Architecture of the almighty CODIS 109
Appendix-C: Immune-system arms NDIS the smart DNA indexing engine of
race 86 CODIS 111
Appendix-D: DNA data format 87 CODIS technologyand DNA
Recommended sources 87 analysis 112
Biohacking-as-a-service (BhaaS)
E. Coli
6. The plasmids and organizations 112
COVID-19 saga, loaded directly The strategy of attack on CODIS 113
into DNA CODIS vulnerabilities 113
REDIS: remote dictionary server
DNA the new beast 91
(Redis) 114
Anatomyof coronavirus 91
CODIS management 114
Bio-hacking DNAwith COVID-19 93
CODIS storage stats 114
The CORONA attack (Act-1) 93
Hacking CODIS execution 115
The CORONA attack (Act-2) 93
Hacking the combined DNA index
Neuro-invasion of COVID-19 in the
system (CODIS) 116
human brain 94
Scenario-1 hacking CODIS DNA
E. Coli physical transport (spyware
criminal database 117
delivery) 95
Hacker’s zero day 119
Pathogens transported into DNA lab 96
Scenario-2 hacking genome
Lab definitions 96
databanks 120
DNA bio-hacking with FASTQ method 97
Goals for the human genome project
Appendices 100
(HGP) 121
Glossary of COVID-19dfrom MERIT
Medical implications 122
CyberSecurity consulting 100 First step in hacking HGP: knowing the
References 101
CODIS system as a geneticist and
system guru 123
7. DNA fingerprinting, biohacking-
Blast search engine 123
as-a service to alter criminal Important database tools 123
records from DNA national The cancer moonshot project 124
Banks Hacking prerequisites 124
Hacking biometrics technologies 126
God created the fingers, we created
A snapshot of history 126
the DNA fingerprinting 103
The medical examiner system 126
DNA is the Holy Grail 104
CODIS 126
DNA profiling is the enemyof
The onion router (TOR) and the dark
privacy 104
web 127
Bio-medical engineering and
The dark web 128
bio-informatics 104
Appendix 129
Definition of forensic science 104
Appendix-A REDIS technology 129
In the beginning we had fingerprints 105
Appendix-B Glossaryof CODIS 129
Definition of human fingerprinting 105
Biological sibling 131
IAFISdthe integrated automated
Appendix-C glossary of the dark
fingerprint identification system 105
web 150