. Jason A. Burdick l Robert L. Mauck Editors Biomaterials for Tissue Engineering Applications A Review of the Past and Future Trends SpringerWienNewYork Prof. Dr. Jason A. Burdick Prof. Dr. Robert L. Mauck University of Pennsylvania University of Pennsylvania Dept. of Bioengineering Dept. of Orthopaedic Surgery 210 S. 33rd Street, 240 Skirkanich Hall McKay Orthopaedic Research Laboratory 19104-6321 Philadelphia 36th Street and Hamilton Walk Pennsylvania 19104 Philadelphia Pennsylvania USA USA Contents 1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Jason A. Burdick and Robert L. Mauck Biomaterials Technologies for Tissue Engineering 2 Hydrogels in Tissue Engineering . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Sarah E. Grieshaber, Amit K. Jha, Alexandra J. E. Farran, and Xinqiao Jia 3 Fibrous Scaffolds for Tissue Engineering . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 Wan-Ju Li and James A. Cooper Jr. 4 Bioelastomers in Tissue Engineering . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 75 Zhengwei You and Yadong Wang 5 Microscale Biomaterials for Tissue Engineering . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 119 Ian Wheeldon, Javier Fernandez, Hojae Bae, Hirokazu Kaji, and Ali Khademhosseini 6 Micro and Nanotechnologies for Tissue Engineering . . . . . . . . . . . . . . . . . . . . . . . . . 139 Nadeen O. Chahine and Pen-hsiu Grace Chao 7 Bioceramics in Tissue Engineering . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 179 Yunzhi Yang, Yunqing Kang, Milan Sen, and Sangwon Park 8 Natural Materials in Tissue Engineering Applications . . . . . . . . . . . . . . . . . . . . . . . 209 Elyssa L. Monzack, Karien J. Rodriguez, Chloe M. McCoy, Xiaoxiao Gu, and Kristyn S. Masters 9 Engineered Polypeptides for Tissue Engineering . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 243 Wei Shen v vi Contents Specific Applications in Tissue Engineering 10 Cartilage Engineering: Current Status and Future Trends . . . . . . . . . . . . . . . . . 279 Emily E. Coates and John P. Fisher 11 Biomaterials for Regeneration of Tendons and Ligaments . . . . . . . . . . . . . . . . . 307 Taymour M. Hammoudi and Johnna S. Temenoff 12 Materials for Bone Graft Substitutes and Osseous Tissue Regeneration . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 343 Steven B. Nicoll 13 Fibrocartilage Tissue Engineering . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 363 Christopher J. Hunter 14 Liver Tissue Engineering . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 389 Sihong Wang and Deepak Nagrath 15 Cardiac Tissue Engineering . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 421 Devang Odedra, Loraine Chiu, Lewis Reis, Fiona Rask, Katherine Chiang, and Milica Radisic 16 Biomaterials Approaches in Vascular Engineering: a Review of Past and Future Trends . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 457 Donny Hanjaya-Putra, Maureen Wanjare, and Sharon Gerecht 17 Neural Tissue Engineering . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 489 Erin Lavik 18 Controlling Stem Cells with Biomaterials . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 511 Nivedita Sangaj and Shyni Varghese Concepts in Biomaterial Translation and Product Development 19 Translation of New Tissue Engineering Materials to Clinical Application 541 Benjamin A. Byers and Dolores Baksh About the Editors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 563 Contributors Hojae Bae Department of Medicine, Center for Biomedical Engineering, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA Dolores Baksh Research & Development, Organogenesis Inc., 150 Dan Road, Canton, MA 02021, USA, viii Contributors Alexandra J. E. Farran Department of Materials Science and Engineering, Delaware Biotechnology Institute, University of Delaware, Newark, DE 19716, USA Javier Fernandez Department of Medicine, Center for Biomedical Engineering, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA John P. Fisher Fischell Department of Bioengineering, University of Maryland, 3238 Jeong H. Kim Building, College Park, MD 20742, USA, jpfi Contributors ix Yunqing Kang Houston Biomaterials Research Center, Department of Restorative Dentistry and Biomaterials, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA Ali Khademhosseini Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Harvard Medical School/Brigham and Women’s Hospital, 65 Landsdowne Street, Rm. 265, Cambridge, MA 02139, USA, x Contributors Lewis Reis Department of Chemical Engineering and Applied Chemistry, Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada Karien J. Rodriguez Department of Biomedical Engineering, University of Wisconsin, Madison, WI, 53706, USA Nivedita Sangaj Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA,