Biochemistry (Jaypee Gold Standard Mini Atlas Series)

392 Pages·7.138 MB·English

by  Vasudevan D.M., Sreekumari S.

Jaypee Gold Standard Mini Atlas Series
BIOCHEMISTRY
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Jaypee Gold Standard Mini Atlas Series
BIOCHEMISTRY
DM Vasudevan MBBS MD FAMS FRCPath
Professor of Biochemistry and Dean
Faculty of Medicine, Amrita Vishwa Vidyapeetham
(Amrita University), Kochi, Kerala
Principal, College of Medicine, Amrita Institute of
Medical Sciences, Cochin, Kerala
(Formerly, Dean, Sikkim Manipal Institute of Medical Sciences,
Gangtok, Sikkim)
E-mail: [email protected]
[email protected]
Sreekumari S MBBS MD
Professor
Department of Biochemistry
Jubilee Mission Medical College
Thrissur, Kerala
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Jaypee Gold Standard Mini Atlas Series Biochemistry
© 2007, DM Vasudevan, Sreekumari S
All rights reserved. No part of this publication and Photo CD Rom should be reproduced, stored in
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copying, recording, or otherwise, without the prior written permission of the authors and the
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under Delhi jurisdiction only.
Fifth Edition: 2007
ISBN 81-8448-133-0
Typeset at JPBMP typesetting unit
Printed at Ajanta
Preface
This Mini Atlas is a condensed version of the Textbook of
Biochemistry for Medical Students. The original textbook is
now running into 5th edition, and entering the 12th year
of its existence. With humility, we may state that the
medical community of India has warmly received the
original textbook. In retrospect, it gives immense
satisfaction to note that the textbook served the students
and faculty for more than a decade.
There was a consistent demand from the students that
a condensed version would be very useful for revision of
the whole biochemistry; hence, this Atlas. Most of the
figures, charts tables and boxes of the textbook have been
reproduced in this book with minor modifications.
Exhaustive explanations are given, so that the reader will
be able to grasp the important points without any difficulty.
This book will give a quick reference to the essentials of
Biochemistry, and will be very useful to recollect the basic
facts.
The remarkable success of the Textbook of Biochemistry
was due to the active support of the publishers. This is to
record our appreciation for the cooperation extended by
Shri Jitendar P Vij and his associates of M/s Jaypee Brothers
Medical Publishers (P) Ltd, New Delhi.
vi JAYPEE GOLD STANDARD MINI ATLAS SERIES BIOCHEMISTRY
We hope that the students and faculty members will
find this Atlas useful. Now this is in your hands to judge.
End of all knowledge must be building up of character
—Gandhiji
June, 2007
DM Vasudevan
Sreekumari S
Contents
Section 1: Chemical Basis of Life
1. Subcellular Organelles .............................................3
2. Amino Acids and Proteins .....................................11
3. Enzymes.....................................................................22
4. Carbohydrate Chemistry ........................................33
5. Chemistry of Lipids.................................................46
Section 2: Carbohydrate Metabolism
6. Glycolysis..................................................................55
7. Gluconeogenesis......................................................68
8. Glycogenolysis .........................................................72
9. Minor Pathways of Carbohydrates.......................76
10. Insulin and Diabetes Mellitus ..............................86
Section 3: Lipid Metabolism
11. Metabolism of Fatty Acids...................................101
12. Cholesterol Metabolism .......................................123
13. PUFA and Prostaglandins ....................................145
Section 4: Amino Acid Metabolism
14. General Metabolism of Amino Acids................159
15. Glycine Metabolism..............................................176
16. Cysteine and Methionine.....................................181
viii JAYPEE GOLD STANDARD MINI ATLAS SERIES BIOCHEMISTRY
17. Acidic, Basic and Branched Chain
Amino Acids ...........................................................186
18. Metabolism of Aromatic Amino Acids..............195
Section 5: Integration of Metabolism
19: Citric Acid Cycle ....................................................211
20: Electron Transport Chain.....................................220
Section 6: Proteins
21. Plasma Proteins......................................................229
22. Heme and Hemoglobin.........................................241
Section 7: Nutrition
23. Lipid Soluble Vitamins........................................267
24. Water Soluble Vitamins .......................................282
25. Mineral Metabolism..............................................303
26. Energy Metabolism................................................314
Section 8: Molecular Biology
27. Nucleotides .............................................................323
28. DNA Replication....................................................334
29. Transcription and Translation.............................341
30. Recombinant DNA Technology and Other
Molecular Biology Techniques ...........................357
Appendices.................................................................365
Index ..........................................................................373
Section 1
Chemical Basis
of Life