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Biochemistry PDF

1568 Pages·2013·32.77 MB·English
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Biochemistry FOURTH EDITION U. Satyanarayana, M.Sc., Ph.D., F.I.C., F.A.C.B., Professor of Biochemistry & Director (Research) Dr. Pinnamaneni Siddhartha Institute of Medical Sciences (Dr. NTR University of Health Sciences) Chinaoutpalli, Gannavaram (Mdl) Krishna (Dist), A.P., India U. Chakrapani, M.B.B.S., M.S., D.N.B, Table of Contents Cover image Title page Copyright Preface to the Fourth Edition Preface to the First Edition Acknowledgements Scope of Biochemistry Section One: Chemical Constituents of Life Chapter 1: Biomolecules and the Cell Summary The cell Eukaryotic cell Chapter 2: Carbohydrates Summary Monosaccharides—structural aspects Structure of glucose Disaccharides Polysaccharides Homopolysaccharides Heteropolysaccharides Agar and pectins Glycoproteins Self-assessment excercises Chapter 3: Lipids Summary Fatty acids Essential fatty acids Triacylglycerols Phospholipids Glycolipids Lipoproteins Steroids Amphipathic lipids Soaps and detergents Self-Assessment excercises Chapter 4: Proteins and Amino Acids Summary Amino acids Structure of proteins Self-assessment excercises Chapter 5: Nucleic Acids and Nucleotides Summary Nucleotides Structure of DNA Organization of DNA in the cell Structure of RNA Self-assessment excercises Chapter 6: Enzymes Summary Historical background Nomenclature and classification Chemical nature and properties of enzymes Factors affecting enzyme activity Active site Enzyme inhibition Enzyme specificity Coenzymes Mechanism of enzyme action Regulation of enzyme activity in the living system Units of enzyme activity Non-protein enzymes Applications of enzymes Diagnostic importance of enzymes Isoenzymes Enzyme pattern in diseases Diagnostic importance of enzymes in other body fluids and tissues Self-assessment excercises Chapter 7: Vitamins Summary Individual vitamins Vitamin A Vitamin D Vitamin E Vitamin K Vitamin C (Ascorbic acid) Thiamine (Vitamin B1) Riboflavin (Vitamin B2) Niacin Pyridoxine (Vitamin B6) Biotin Pantothenic acid Folic acid Cobalamin (Vitamin B12) Vitamin like compounds Choline Inositol Lipoic acid Para aminobenzoic acid Bioflavonoids Antivitamins Self-Assessment Exercises Section Two: Physiological Biochemistry Chapter 8: Digestion and Absorption Summary Carbohydrates Proteins Lipids Nucleic acids Abnormalities related to digestion and absorption Self-assessment exercises Chapter 9: Plasma Proteins Summary Albumin Globulins Immunoglobulins Blood clotting Self-assessment exercises Chapter 10: Hemoglobin and Porphyrins Summary Hemoglobin Hemoglobin derivatives Abnormal hemoglobins Sickle-cell anemia or sickle-cell hemoglobin Thalassemias Porphyrins Biosynthesis of heme Porphyrias Degradation of heme to bile pigments Jaundice Self-assessment exercises Chapter 11: Biological Oxidation Summary Bioenergetics High-energy compounds Biological oxidation Electron transport chain Oxidative phosphorylation Self-assessment exercises Section Three: Metabolisms Chapter 12: Introduction to Metabolism Summary Chapter 13: Metabolism of Carbohydrates Summary Glycolysis Citric acid cycle Gluconeogenesis Glycogen metabolism Futile cycles Glycogen storage diseases Hexose monophosphate shunt Uronic acid pathway Metabolism of galactose Metabolism of fructose Metabolism of amino sugars Glyoxylate cycle Self-assessment Exercises Chapter 14: Metabolism of Lipids Summary Fatty acid oxidation Ketone bodies Biosynthesis of fatty acids Synthesis of triacylglycerols Metabolism of phospholipids Metabolism of glycolipids Metabolism of cholesterol Lipoproteins Metabolism of HDL Disorders of plasma lipoproteins Fatty liver Lipotropic factors

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