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A PHARMACEUTICO-ANALYTICAL AND EXPERIMENTAL STUDY OF RAJA PRAVARTINI VATI WSR TO ITS ACTION ON UTERUS BY Dr.BHAGYALAKSHMI B R Dissertation Submitted to the RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES, KARNATAKA, BENGALURU In partial fulfillment of the requirements for the degree of AYURVEDA VACHASPATHI (DOCTOR OF MEDICINE) IN RASA SHASTRA UNDER THE GUIDANCE OF Dr. SHOBHA.G.HIREMATH BAMS, MD, P.hD (RS) Professor & H.O.D. Department of P.G. Studies in Rasa Shastra G.A.M.C, Bengaluru - 09 DEPARTMENT OF POST GRADUA TE STUDIES IN RASA SHASTRA GOVERNMENT AYURVEDIC MEDICAL COLLEGE BENGALURU – 560009 2011 – 12 RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES, BANGALORE. DECLARATION BY THE CANDIDATE I hereby declare that this dissertation entitled “A Pharmaceutico- Analytical and Experimental Study of Raja Pravartini Vati WSR to its action on Uterus” is a bonafide and genuine research work carried out by me under the guidance of Dr. SHOBHA G HIREMATH, M.D.(Ayu),PhD(R.S), Professor & HOD Dept. of P.G. Studies, in Rasashastra, G.A.M.C, Bengaluru. Date: Signature of the candidate Place : (DR.BHAGYALAKSHMI B.R) RAJIV GANDHI UNIVERSITY OF HEALTH , , . SCIENCES KARNATAKA BANGALORE CERTIFICATE BY THE GUIDE This is to certify that the dissertation entitled “A Pharmaceutico-Analytical and Experimental Study of Raja Pravartini Vati WSR to its action on Uterus” is a bonafide research work done by Dr. BHAGYALAKSHMI B.R, in partial fulfillment of the requirement for the degree of AYURVEDA VACHASPATI, (DOCTOR OF MEDICINE) IN RASASHASTRA. Signature of the Guide, Date: DR SHOBHA G HIREMATH PROFESSOR AND HOD Place: P.G. Dept. of Rasashastra G.A.M.C, Bengaluru Rajiv Gandhi University of Health Sciences, Karnataka, Bangalore. CERTIFICATE BY THE CO-GUIDE This is to certify that the dissertation entitled “A Pharmaceutico- Analytical and Experimental study of Raja Pravartini Vati WSR to its action on Uterus” is a bonafide research work done by Dr. BHAGYALAKSHMI.B.R in partial fulfillment of the requirement for the degree of AYURVEDA VACHASPATI, (DOCTOR OF MEDICINE) IN RASASHASTRA. Signature of the Co-guide Dr Chandrashekar M Sultanpur Date : Place : Professor Dept. of Pharmacology, Govt College of Pharmacy, Bangalore RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES, BANGALORE. ENDORSEMENT BY THE HOD, PRINCIPAL / HEAD OF THE INSTITUTION This is to certify that the dissertation entitled “A Pharmaceutico-Analytical and Experimental Study of Raja Pravartini Vati WSR to its action on Uterus” is a bonafide research work done by Dr. BHAGYALAKSHMI B.R under the guidance of Dr. SHOBHA G HIREMATH, M.D.(Ayu),PhD(R.S), Professor & HOD Dept. of P.G. Studies, in Rasashastra, G.A.M.C, Bengaluru. Dr. Shobha. G. Hiremath Principal M.D. (AYU) . PhD(R.S) H. O. D G.A.M.C P. G Dept. of Rasashastra Bengaluru. G.A.M.C Bengaluru. Date: Date: Place: Place: RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES, BANGALORE. DECLARATION BY THE CANDIDATE I hereby declare that the Rajiv Gandhi University of Health Science, Karnataka shall have the rights to preserve use and disseminate this dissertation in print or electronic format for academic / research purpose. Date: Signature of the candidate Place: DR BHAGYALAKSHMI B.R Acknowledgment… ACKNOWLEDGMENT First I would like to thank my parents Mr Radhakrishna N S & Mrs Bharati, and all of my family members. My potential has been always appreciated to its best by them in their unique disciplined way. My special love to my husband Dr. Keshava D V for his care and support in my study & research. I express my deepest sense of gratitude, with all humbleness to my guide Dr.Shobha G Hiremath, Professor& HOD, Dept of P.G. studies in Rasa Shastra for her encouragement, noble guidance, and inspiring thoughts throughout my study & research. I would like to express my sincere thanks to my Ex Guide Dr Jagdeesh M.S, Retd Professor, for his guidance in my study. It is my great pleasure to acknowledge my co-guide Dr Chandrashekar M Sulthanpur, Professor Dept of Pharmacology Govt College of Pharmacy for his guidance and support in my experimental studies. With a humble respect I acknowledge Dr.Dattatri, Professor, Dept of PG Studies in Rasa Shastra for his encouragement and help in my study & research. It is my privilege and pleasure to express my heartfelt gratitude towards Dr. M Ramesh, HOD Dept of Prasooti Tantra and Stri Roga for inspiration and guidance throughout my work. I express my gratification to Dr Ramachandra Shetty, HOD, Dept of Pharmacology and Principle Dr Shashidhar, Govt College of Pharmacy for their inspirational support & and providing an opportunity to carry out my experimental work in their institution. I would like to thank Dr Mangalgi, Joint Director, Dept of AYUSH, and Principal Dr H T Srinivas for their support and providing facility in my studies. I am immensely grateful to Dr. Revathi, Bangalore Test House (BTH) for their kind co-operation for carrying out my Analytical Study. I would like to express my sincere thanks to all my seniors Dr Ambujakshi, Dr Jyoyhi Varatti, Dr Sadguna, Dr Sudharshan Achar, Dr Indrani and Dr Naveen for their guidance and support throughout my study. Acknowledgment… My sincere thanks to all my PG Colleagues Dr Pratibha M Patil, Dr Amol, Dr Sangamesh, Dr Sacchidanad,and Dr Ali for their kind support and co-operation throughout my PG currier. My special thanks to all my Juniors, friends of other departments for their help and co-operation in my research work. It is my pleasure to acknowledge PG Scholars of Pharmacy College specially Choudary, Sandeep, Vishal, Santhosh, Deepika, Sindu for their sincere help in carrying out my Experimental Study. I would like to thank Dr Vamsheedhar and Mr Prakash for helping in carrying out my Histopathological studies. I am thankful to Dr Niranjan and Dr Jyothi, of ALN Rao Ayurvedic Medical College, Koppa, and Dr Ashok, Dept of Pharmacology, IPGT&R, Jamnagar, for their guidance in carrying out my research work. I am thankful to all the faculty, staff and students of the institute for the assistance at various steps. I am grateful to all the teachers came in my life who taught me ‘the science of life’. This acknowledgement would remain incomplete if I do not mention my sincere regards to all subjects included in this study and also to those who helped me directly or indirectly to complete the task. Dr Bhagyalakshmi B.R Place - Bengaluru Date - Abstract… ABSTRACT Title – “A Pharmaceutico-Analytical and Experimental study of Raja Pravartini Vati WSR to its action on Uterus” Back ground Diseases pertaining to reproductive system of females are increasing due to modern ways of lifestyle. Ammenorrhoea, Dysmenorrhoea is very common among working women who are exposed to mental stress due to hormonal disturbances. “Raja Pravartini vati” is the prescribed formulation for Ammenorrhoea, and Dysmenorrhoea mentioned in Bhaishajya Ratnavali under stree roga adhikara. It contains Shuddha Tankana, Shuddha Hingu, Shuddha Kaseesa, and Kumarisara. So the present study was done evaluate the effect of Raja Pravartini vati Pharmaceutically, Analytically and Experimentally. Objectives To prepare “Raja Pravartini vati” according to Bhaishajya Ratnavali reference. To conduct physicochemical analysis of final product “Raja Pravartini Vati” To undertake the Estrogenic, Histopathological and Contractile activity of “Raja Pravartini Vati” on the uterus of experimental animals Pharmaceutical Study – Raja pravartni vati is a Khalveeya Rasa yoga. The ingredients of RPV viz Tankana, Kaseesa, Hingu, and Kanyasara were taken from a certified company. Processing of these raw materials was done. Tankana shodhana was done by Bharjana method, Kaseesa was processed by Bhavana with Nimbuka swarasa, and Hingu were processed by Bharjana with Goghrita. These processed ingredients were taken in Khalva yantra and properly mixed and Kumari swarasa bhavana was given. After proper trituration Vatis of 375 mg were made. Analytical Study – Analytical study of final product was done organoleptically, physico chemically for total ash, Acid insoluble ash, loss on drying, disintegration time and chemically for assay for iron and borax.
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