Quality Assurance SPM8 Susan Whitfield-Gabrieli MIT Topics in fMRI What makes for a successful fMRI experiment? • Basic cognitive neuroscience Experimental design Analysis • Comparative cognitive neuroscience (development, aging, diseases) Experimental design, Analysis + Normalization, variability in the hrf… • Quality Assurance (QA) in fMRI QA in fMRI Before Quality Assurance QA in fMRI Before QA After QA QA: Outline • EEG – fMRI QA Analogy • fMRI quality assurance protocol • QA (bottom up) • QA (top down) Guidelines for ERP Studies Quality Assurance in EEG/ERP • Data inspection essential • Artifact detection / rejection essential: artifacts can be orders of magnitude larger than signal EEG (eye blinks) EEG/fMRI (ballistocardiogram) • Apparent small differences in data processing may yield large differences in results EEG Artifact Detection: odd = left even = right z = midline Muscle Blinks EEG Data Inspection Epoch Eye correction Baseline
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