Table Of Content

Arsenic Arsenic exposure sources, Health risks, and Mechanisms of Toxicity Edited by J. cHrisTopHer sTATes University of Louisville Louisville, Ky, Usa Copyright © 2016 by John Wiley & sons, Inc. all rights reserved. Published by John Wiley & sons, Inc., Hoboken, New Jersey Published simultaneously in Canada No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, scanning, or otherwise, except as permitted under section 107 or 108 of the 1976 United states Copyright act, without either the prior written permission of the Publisher, or authorization through payment of the appropriate per‐copy fee to the Copyright Clearance Center, Inc., 222 Rosewood Drive, Danvers, Ma 01923, (978) 750‐8400, fax (978) 750‐4470, or on the web at www.copyright.com. 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Ra1231.a7a7683 2015 615.9′25715–dc23 2015018789 set in 10/12pt Times by sPi Global, Pondicherry, India Printed in the United states of america 10 9 8 7 6 5 4 3 2 1 1 2016 Contents Contributors ix Preface xiii Part I Fundamentals oF arsenIC exPosure and metabolIsm 1 1 History of arsenic as a Poison and a medicinal agent 3 Michael F. Hughes 2 Geogenic and anthropogenic arsenic Hazard in Groundwaters and soils: distribution, nature, origin, and Human exposure routes 23 David A. Polya and Michael Lawson 3 remediation of arsenic in drinking Water 61 Cathleen J. Webb and Arden D. Davis 4 the Chemistry and metabolism of arsenic 81 David J. Thomas vi Contents Part II ePIdemIoloGy and dIsease manIFestatIons oF arsenIC exPosure 111 5 Human Population studies and nutritional Intervention 113 Yu Chen and Fen Wu 6 skin manifestations of Chronic arsenicosis 127 Nilendu Sarma 7 lung Cancer and other Pulmonary diseases 137 Cara L. Sherwood and R. Clark Lantz 8 bladder Cancer and arsenic 163 Matthew K. Medeiros and A. Jay Gandolfi 9 neurological effects of arsenic exposure 193 Dominic B. Fee 10 diabetes mellitus 221 Miroslav Stýblo and Christelle Douillet 11 Hepatotoxicity 249 Gavin E. Arteel 12 Genetic epidemiology of susceptibility to arsenic‐Induced diseases 267 Mayukh Banerjee and Ashok K. Giri Part III meCHanIsms oF toxICIty 289 13 arsenic Interaction with Zinc Finger motifs 291 Laurie G. Hudson, Karen L. Cooper, Susan R. Atlas, Brenee S. King and Ke Jian Liu 14 role in Chemotherapy 315 Koren K. Mann and Maryse Lemaire 15 Genotoxicity 347 Ana María Salazar and Patricia Ostrosky‐Wegman 16 arsenic and signal transduction 369 Ingrid L. Druwe and Richard R. Vaillancourt Contents vii 17 stem Cell targeting and alteration by arsenic 397 Yuanyuan Xu, Erik J. Tokar and Michael P. Waalkes 18 epigenetics and arsenic toxicity 421 Somnath Paul and Pritha Bhattacharjee Part IV models For arsenIC toxIColoGy and rIsk assessment 439 19 Cancer Induced by exposure to arsenicals in animals 441 Erik J. Tokar, Yuanyuan Xu and Michael P. Waalkes 20 arsenic‐Induced Cardiovascular disease 453 Aaron Barchowsky and J. Christopher States 21 Invertebrate models in arsenic research: Past, Present, and Future 469 Iain L. Cartwright 22 toxicokinetics and Pharmacokinetic modeling of arsenic 495 Elaina M. Kenyon and Harvey J. Clewell, III 23 Considerations for a biologically based risk assessment for arsenic 511 Harvey J. Clewell, III, P. Robinan Gentry and Janice W. Yager 24 translating experimental data to Human Populations 535 J. Christopher States Index 549