ANTICANCER PROPERTIES OF FRUITS AND VEGETABLES A Scientific Review 8823_9789814508889_tp.indd 1 7/11/14 2:44 pm May2,2013 14:6 BC:8831-ProbabilityandStatisticalTheory PST˙ws TThhiiss ppaaggee iinntteennttiioonnaallllyy lleefftt bbllaannkk ANTICANCER PROPERTIES FRUITS VEGETABLES OF AND A Scientific Review Ajaikumar B Kunnumakkara Indian Institute of Technology Guwahati, Assam, India World Scientific NEW JERSEY • LONDON • SINGAPORE • BEIJING • SHANGHAI • HONG KONG • TAIPEI • CHENNAI 8823_9789814508889_tp.indd 2 7/11/14 2:44 pm Published by World Scientific Publishing Co. Pte. Ltd. 5 Toh Tuck Link, Singapore 596224 USA office: 27 Warren Street, Suite 401-402, Hackensack, NJ 07601 UK office: 57 Shelton Street, Covent Garden, London WC2H 9HE Library of Congress Cataloging-in-Publication Data Anticancer properties of fruits and vegetables : a scientific review / [edited] by Ajaikumar B. Kunnumakkara. p. ; cm. Includes bibliographical references and index. ISBN 978-9814508889 (hardcover : alk. paper) I. Kunnumakkara, Ajaikumar B., editor. [DNLM: 1. Neoplasms--prevention & control. 2. Anticarcinogenic Agents. 3. Chemoprevention. 4. Fruit. 5. Phytochemicals. 6. Vegetables. QZ 200] RC268 616.99'405--dc23 2014016544 British Library Cataloguing-in-Publication Data A catalogue record for this book is available from the British Library. Copyright © 2015 by World Scientific Publishing Co. Pte. Ltd. All rights reserved. This book, or parts thereof, may not be reproduced in any form or by any means, electronic or mechanical, including photocopying, recording or any information storage and retrieval system now known or to be invented, without written permission from the publisher. For photocopying of material in this volume, please pay a copying fee through the Copyright Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, USA. In this case permission to photocopy is not required from the publisher. Typeset by Stallion Press Email: [email protected] Printed in Singapore JQuek - Anticancer properties of fruits and.indd 1 12/11/2014 8:52:54 AM b1774 Anticancer Properties of Fruits and Vegetables: A Scientific Review Contents Contributors ix Preface xvii 1 Cancer Preventive and Therapeutic Properties of Fruits and Vegetables: An Overview 1 Chandrasekharan Guruvayoorappan, Kunnathur Murugesan Sakthivel, Ganesan Padmavathi, Vaishali Bakliwal, Javadi Monisha and Ajaikumar B. Kunnumakkara 2 Phytochemicals Safeguard the Genome: Tiny Molecules, Big Role 53 Sanjit Dey, Nilanjan Das, Debdutta Ganguli, Mahuya Sinha, Kunal Sikder, Swaraj Bandhu Kesh, Dipesh Kr Das, Amitava Khan, Ujjal Das, Krishnendu Manna, Sushobhan Biswas, Anirban Pradhan and Rakhi Sharma Dey 3 Phytonutrients from Fruits and Vegetables in Breast Cancer Control 75 Madhumita Roy, Apurba Mukherjee, Sutapa Mukherjee and Jaydip Biswas 4 Anti-Proliferative and Pro-Apoptotic Effects of Bioactive Constituents Derived from Fruits and Vegetables Against Colorectal Cancer 103 Sakshi Sikka and Gautam Sethi v bb11777744__FFMM..iinndddd vv 1111//1144//22001144 99::2255::4466 AAMM b1774 Anticancer Properties of Fruit and Vegetable: A Scientific Review vi Contents 5 Anticancer Activities of Fruits and Vegetables Against Gynecological Cancers 131 Sankar Jagadeeshan, Ajaikumar B. Kunnumakkara, Indu Ramachandran and S. Asha Nair 6 Cancer Chemopreventive and Therapeutic Properties of Fruits and Vegetables Against Head and Neck Malignancies 161 Jesil Mathew Aranjani, Ganesan Padmavathi, Ajaikumar B. Kunnumakkara and Atulya Mathew 7 Anticancer Activities of Fruits and Vegetables Against Liver and Pancreatic Cancers 185 Farid A. Badria, Diaaeldin M. Elimam and Ahmed S. Ibrahim 8 Cancer Preventive and Therapeutic Properties of Fruits and Vegetables Against Lung Cancer 221 Kunnathur Murugesan Sakthivel, Javadi Monisha, Ajaikumar B. Kunnumakkara and Chandrasekharan Guruvayoorappan 9 Prostate Cancer: How Helpful are Natural Agents for Prevention? 251 Manoj K. Pandey, Ajaikumar B. Kunnumakkara and Shantu G. Amin 10 Phytochemicals from Fruits and Vegetables as Potential Anticancer Agents: Special Reference to Skin Cancer 277 Jayesh Antony, Minakshi Saikia and Ruby John Anto 11 Anticancer Effects of Agents Derived from Fruits and Vegetables Against Stomach Cancer 309 Sakshi Sikka and Gautam Sethi bb11777744__FFMM..iinndddd vvii 1111//1144//22001144 99::2255::4466 AAMM b1774 Anticancer Properties of Fruits and Vegetables: A Scientific Review Contents vii 12 Cancer Preventive and Therapeutic Properties of Fruits and Vegetables Against Commonly Occurring Cancers in Humans 337 Javadi Monisha, Ganesan Padmavathi, Vaishali Bakliwal, Naman Katre, Jose Padikkala and Ajaikumar B. Kunnumakkara Index 367 bb11777744__FFMM..iinndddd vviiii 1111//1144//22001144 99::2255::4466 AAMM May2,2013 14:6 BC:8831-ProbabilityandStatisticalTheory PST˙ws TThhiiss ppaaggee iinntteennttiioonnaallllyy lleefftt bbllaannkk b1774 Anticancer Properties of Fruits and Vegetables: A Scientific Review Contributors Ahmed S. Ibrahim Department of Biochemistry Faculty of Pharmacy Mansoura University Mansoura-35516, Egypt Ajaikumar B. Kunnumakkara Department of Biotechnology Indian Institute of Technology Guwahati Assam-781039, India Amitava Khan Department of Physiology University of Calcutta West Bengal-700009, India Anirban Pradhan Department of Physiology University of Calcutta West Bengal-700009, India Apurba Mukherjee Department of Environmental Carcinogenesis & Toxicology Chittranjan National Cancer Institute Kolkata, West Bengal-700 026, India ix bb11777744__FFMM..iinndddd iixx 1111//1144//22001144 99::2255::4466 AAMM