Table Of Content

R Annual Review of Physiology, Volume 63, 2001 CONTENTS PERSPECTIVES, Joseph F Hoffman, Editor Medicine or Physiology: My Personal Mix, Alexander Leaf SPECIAL Topic: INTERMEDIARY METABOLISM, Joseph F Hoffman, Editor '5C NMR of Intermediary Metabolism: Implications for Systemic Physiology, Robert G Shulman and Douglas L Rothman GASTROINTESTINAL PHysIoLoGy, Luis Reuss, Section Editor Gastrin, CCK, Signaling, and Cancer, Enrique Rozengurt and John H Walsh Intracellular Signaling Mechanisms Activated by Cholecystokinin-Regulating Synthesis and Secretion of Digestive Enzymes in Pancreatic Acinar Cells, John A Williams Specific Ca?* Signaling Evoked by Cholecystokinin and Acetylcholine: The Roles of NAADP, cADPR, and IP3, Jose Manuel Cancela The Gastrins: Their Production and Biological Activities, GJ Dockray, A Varro, R Dimaline, and T Wang ENDOCRINOLOGY, Jean D Wilson, Section Editor Control of Growth by the Somatropic Axis: Growth Hormone and the Insulin-Like Growth Factors Have Related and Independent Roles, Andrew A Butler and Derek Le Roith Role of Estrogen Receptor Beta in Estrogen Action, Katarina Pettersson and Jan-Ake Gustafsson StAR Protein and the Regulation of Steroid Hormone Biosynthesis, Douglas M Stocco The Guanylyl Cyclase Family at Y2K, BJ Wedel and DL Garbers CELL PuysioLoGy, Paul De Weer, Section Editor Molecular Diversity of Pacemaker Ion Channels, U Benjamin Kaupp and Reinhard Seifert R Annual Review of Physiology, Volume 63, 2001 CONTENTS PERSPECTIVES, Joseph F Hoffman, Editor Medicine or Physiology: My Personal Mix, Alexander Leaf SPECIAL Topic: INTERMEDIARY METABOLISM, Joseph F Hoffman, Editor '5C NMR of Intermediary Metabolism: Implications for Systemic Physiology, Robert G Shulman and Douglas L Rothman GASTROINTESTINAL PHysIoLoGy, Luis Reuss, Section Editor Gastrin, CCK, Signaling, and Cancer, Enrique Rozengurt and John H Walsh Intracellular Signaling Mechanisms Activated by Cholecystokinin-Regulating Synthesis and Secretion of Digestive Enzymes in Pancreatic Acinar Cells, John A Williams Specific Ca?* Signaling Evoked by Cholecystokinin and Acetylcholine: The Roles of NAADP, cADPR, and IP3, Jose Manuel Cancela The Gastrins: Their Production and Biological Activities, GJ Dockray, A Varro, R Dimaline, and T Wang ENDOCRINOLOGY, Jean D Wilson, Section Editor Control of Growth by the Somatropic Axis: Growth Hormone and the Insulin-Like Growth Factors Have Related and Independent Roles, Andrew A Butler and Derek Le Roith Role of Estrogen Receptor Beta in Estrogen Action, Katarina Pettersson and Jan-Ake Gustafsson StAR Protein and the Regulation of Steroid Hormone Biosynthesis, Douglas M Stocco The Guanylyl Cyclase Family at Y2K, BJ Wedel and DL Garbers CELL PuysioLoGy, Paul De Weer, Section Editor Molecular Diversity of Pacemaker Ion Channels, U Benjamin Kaupp and Reinhard Seifert CONTENTS Cellular Mechanisms of Oxygen Sensing, José Lépez-Barneo, Ricardo Pardal, and Patricia Ortega-Sdenz COMPARATIVE PHYSIOLOGY, George N Somero, Section Editor Evolution and Physiological Roles of Phosphagen Systems, W Ross Ellington Antifreeze and Ice Nucleator Proteins in Terrestrial Arthropods, John G Duman Antifreeze Proteins of Teleost Fishes, Garth L Fletcher, Choy L Hew, and Peter L Davies CARDIOVASCULAR PHysIOLoGy, Jeffrey Robbins, Section Editor Cytoplasmic Signaling Pathways that Regulate Cardiac Hypertrophy, Jeffery D Molkentin and Gerald W Dorn, II Somatic Gene Therapy in the Cardiovascular System, / Baumgartner and JM Isner Genetic Assembly of the Heart: Implications for Congenital Heart Disease, Deepak Srivastava RESPIRATORY PHYSIOLOGY, Carole R Mendelson, Section Editor Molecular Regulation of Lung Development, Wellington V Cardoso The Pulmonary Collectins and Surfactant Metabolism, Samuel Hawgood and Francis R Poulain Surfactant Proteins A and D and Pulmonary Host Defense, Erika Crouch and Jo Rae Wright Function of Surfactant Proteins B and C, Timothy E Weaver and Juliana Johnson Conkright RENAL AND ELECTROLYTE PHYSIOLOGY, Steven C Hebert, Section Editor G Protein—Coupled Prostanoid Receptors and the Kidney, Matthew D Breyer and Richard M Breyer Nephrogenic Diabetes Insipidus, Jean-Pierre Morello and Daniel G Bichet Chloride Channels in the Loop of Henle, W Brian Reeves, Christopher J Winters, and Thomas E Andreoli SPECIAL Topic: CIRCADIAN RHYTHMS, Amita Sehgal, Special Topic Editor Molecular Analysis of Mammalian Circadian Rhythms, Steven M Reppert and David R Weaver Circadian Photoperception, Paul F Devlin and Steve A Kay Endogenous Timekeepers in Photosynthetic Organisms, Carl Hirschie Johnson Viii CONTENTS Molecular Components of the Circadian System in Drosophila, Julie A Williams and Amita Sehgal Genetic and Molecular Analysis of Circadian Rhythms in Neurospora, Jennifer J Loros and Jay C Dunlap ‘NEUROPHYSIOLOGY, Richard W Tsien, Section Editor Dynamic Signaling Between Astrocytes and Neurons, Alfonso Araque, Giorgio Carmignoto, and Philip G Haydon On the Cellular and Network Bases of Epileptic Seizures, David A McCormick and Diego Contreras Maintaining the Stability of Neural Function: A Homeostatic Hypothesis, Graeme W Davis and Ilya Bezprozvanny Resurgence of Sodium Channel Research, Alan L Goldin INDEXES Subject Index Cumulative Index of Contributing Authors, Volumes 59-63 Cumulative Index of Chapter Titles, Volumes 59-63 shiy sue c SUBJECT INDEX A phosphage:n systems and, steroidogenesis, 194-96 Absence seizures 301 \fter-discharges cellular and network bases Action potentials cellular and network bases of epileptic seizures, cellular and network bases of epileptic seizures, 815-38 of epileptic seizures, 822-25 Accelerated 815-38 re-endothelialization Activation circadian rhythms in somatic gene therapy in cholecystokinin-regulating Neurospora and, 783 cardiovascular system synthesis and, 77, 82-83 \lanine and, 436, 440 circadian rhythms in antifreeze proteins of Acetylation Neurospora and, 757-86 teleost fishes and, 369 histone gastrin, CCK, signaling, gastrin, CCK, signaling, estrogen receptor 8 and, and cancer, 56-60, 62, 64 and cancer, 56 172 NAADP, cADPr, and IP3 in surfactant proteins B and Acetylcholine (ACH) Ca** signaling, 99-112 C, 556-57 NAADP, cADPr, and IP3 in pacemaker ion channels \ldosterone Ca** signaling, 99-112 and, 235, 246-48 history of research and, 8 pacemaker ion channels Adenosine triphosphate StAR protein and and, 237 (ATP) steroidogenesis, 194, 197 Acid secretion cell oxygen sensing and Algae gastrin, CCK, signaling, 259, 265, 269 endogenous timekeepers and cancer, 49-66 phosphagen systems and, and, 695-722 gastrins and, 119-32 289-314 Al opregnanolone Acinar cells Adenoviruses StAR protein and pancreatic nephrogenic diabetes stere‘dogenesis, 194 cholecystokinin- insipidus and, 619-20 \llosteric enzymes regulating synthesis somatic gene therapy in °C NMR of intermediary and, 77-91 cardiovascular system metabolism and, 15, NAADP, cADPr, and IP3 and, 433 17-21, 24, 28-32 in Ca?*+ signaling, 99, surfactant proteins A and \lveoli 104 and pulmonary host lung development and, Acquired immunity defense, 537 485-86 surfactant proteins A and D Adenylyl cyclase pulmonary collectins and and pulmonary host guanylyl cyclase family surfactant metabolism, defense, 539-42 and, 215-27 495, 508-9 Actins Adrenals surfactant proteins A and D cholecystokinin-regulating StAR protein and and pulmonary host synthesis and, 77 steroidogenesis, 194-203 defense, 521-42 gastrin, CCK, signaling, Adrenocorticotropic hormone \midation and cancer, 49, (ACTH) gastrin, CCK, signaling, 61-63 StAR protein and and cancer, 53-54, 65 896 SUBJECT INDEX gastrins and, 119, 124-28 convergent evolution, and, 697-99, 701, 706-7, Amphiregulin 380-81 713, 717-19 gastrin, CCK, signaling, gene amplification, guanylyl cyclase family and cancer, 54 382-83 and, 220 Amphiuma spp. ice, 360-70 pacemaker ion channels Cl” channels in loop of introduction, 359-60 and, 241-43 Henle and, 635 irreversible binding, Archaea Amplification 361-66 endogenous timekeepers in gene physiological function, photosynthetic organisms antifreeze proteins of 370-71 and, 721 teleost fishes and, recent evolution, 378-83 Archaeoglobus fulgidus 382-83 regulation of plasma endogenous timekeepers in Androgens AFP production, photosynthetic organisms estrogen receptor 8 and, 372-74 and, 721 165-83 regulation of plasma Arenicola marina Angiogenesis regulation of AFP gene phosphagen systems and, cell oxygen sensing and, expression, 376-78 299 266-67 regulation of plasma arg-13 gene somatic gene therapy in skin AFPs, 374-76 circadian rhythms in cardiovascular system structure-function Neurospora and, 764, 778 and, 427, 429-30, 434-39 relationships, 367 Arginine Animal models thermal hysteresis, 361 pacemaker ion channels somatic gene therapy in type I AFPs, 367-69 and, 241-43 cardiovascular system type III AFPs, 369-70 phosphagen systems and, and, 434-36 Antisecretory drug treatment 313 Antarctica gastrin, CCK, signaling, surfactant proteins B and antifreeze proteins of and cancer, 52-53 Sie teleost fishes and, 359-83 Aortic arch development voltage-gated sodium Antidiuretic hormone (ADH) genetic assembly of heart channels and, 885 history of research and, 7 and, 459-60 Arginine vasopressin Antifreeze proteins (AFPs) Apis mellifera nephrogenic diabetes ice nucleator proteins in phosphagen systems and, insipidus and, 607—22 terrestrial arthropods and 299 Argopecten irradians freeze avoidance, AQP2 mutations phosphagen systems and, nephrogenic diabetes 299 freeze tolerance, insipidus and, 607—22 Aromatase 332-33, 345-47 Aquaporin estrogen receptor 8 and, introduction, 327-28 nephrogenic diabetes 165, 179-81 protein ice nucleators, insipidus and, 607—22 Arterial tone 328-34 Arabidopsis thaliana cell oxygen sensing and, summary, 349-50 antifreeze and ice nucleator 262-63 supercooling, 344-45 proteins in terrestrial Arterioles thermal hysteresis, arthropods, 350 renal 341-43 circadian photoreceptors protein-coupled teleost fishes and and, 678-79, 682-84 prostanoid receptors convergence in parallel, endogenous timekeepers in and the kidney, 579-95 381-82 photosynthetic organisms Arthropods SUBJECT INDEX 897 terrestrial glutamate release from cell oxygen sensing and, antifreeze and ice astrocytes, 803-4 277 nucleator proteins, neuronal activity can \zoxymethane 327-50 induced astrocytic gastrin, CCK, signaling, Aschoff’s rule plasticity, 801 and cancer, 54 circadian photoreceptors physiological roles of and, 679 glutamate-mediated B Ascobolus spp astrocyte-to-neuron Bacteria circadian rhythms in signaling, 807-8 endogenous timekeepers in Neurospora and, 779 proximity of astrocyte photosynthetic organisms Asexual development to neurons, 795, 797 and, 695, 697-99, 701-2, circadian rhythms in target of action of 704, 709, 719-22 Neurospora and, transmitter released surfactant proteins A and D 781-82 from astrocytes, 806 and pulmonary host Asparagine waves of calcium defense, 521, 523-31, gastrin, CCK, signaling, elevation within and 533, 536-37, 539-42 and cancer, 56 between astrocytes, Balloon angioplasty Aspartate 798-99 somatic gene therapy in pacemaker ion channels Astrocytomas cardiovascular system and, 244 gastrin, CCK, signaling, and, 427-41 Aspergillus fumigatus and cancer, 65 band gene surfactant proteins A and D Atherosclerosis circadian rhythms in and pulmonary host somatic gene therapy in Neurospora and, 760-61 defense, 525, 531, 541 cardiovascular system Bartter’s syndrome Aspergillus niger and, 433 Cl~ channels in loop of circadian rhythms in Autocrine function Henle and, 631, 639-40 Neurospora and, 759-60 growth control by Bi-allelic disruptive mutation \strocyte-neuron interactions somatotropic axis and, estrogen receptor 8 and, dynamic signaling and 141-56 165-83 astrocytes integrate Autonomous clocks Bicuculline neuronal inputs, circadian system in cellular and network bases 799-800 Drosophila and, 729 of epileptic seizures, 831 astrocytes possess a Autosomal dominant Bidirectional signaling form of excitability inheritance dynamic signaling between based on variations of nephrogenic diabetes astrocytes and neurons, intracellular calcium, insipidus and, 607—22 795-808 797 Autosomal recessive Biochemistry bi-directional inheritance '5C NMR of intermediary glutamate-mediated nephrogenic diabetes metabolism and, 15-16, signaling, 801-3 insipidus and, 607—22 31-32, 43 glutamate released from AVP gene Biological clock astrocytes modulates mammalian circadian circadian rhythms in synaptic transmisssion rhythms and, 662 Neurospora and, 757-86 and neuronal AVPR2 mutations circadian system in excitability, 804-7 nephrogenic diabetes Drosophila and, 729, introduction, 795 insipidus and, 607—22 732-45 mechanisms of Azide endogenous timekeepers in 898 SUBJECT INDEX photosynthetic organisms 13C NMR of intermediary Bufo marinus and, 695-722 metabolism and, 43 history of research and, 8 mammalian circadian Brain Burst-generating neurons rhythms and, 647-68 cellular and network bases cellular and network bases Biopsy of epileptic seizures, of epileptic seizures, '3C NMR of intermediary 815-38 815-38 metabolism and, 21, 25 circadian photoreceptors Busycon contrarium bli-3 gene and, 688 phosphagen systems and, circadian rhythms in '3C NMR of intermediary 299 Neurospora and, 783 metabolism and, 15, 18, Blood 33, 35-36, 41-43 C antifreeze proteins of dynamic signaling between Clq receptors teleost fishes and, 359, astrocytes and neurons, surfactant proteins A and D 372-74 795-808 and pulmonary host Blood pressure estrogen receptor 8 and, defense, 533 protein-coupled prostanoid 165-83 Ca*+ receptors and the kidney, growth control by antifreeze proteins of 579-95 somatotropic axis and, teleost fishes and, 381-82 Bmall gene 143 cell oxygen sensing and, circadian rhythms in mammalian circadian 262-65, 268-72, 274, Neurospora and, 757, rhythms and, 647-68 276-78 771-72 pacemaker ior channels cholecystokinin-regulating mammalian circadian and, 237-38, 245, 248 synthesis and, 77-91 rhythms and, 650-53, Brain clock dynamic signaling between 660-62, 667 circadian system in astrocytes and neurons, BNP gene Drosophila and, 729-48 795-808 guanylyl cyclase family Brain tumors gastrin, CCK, signaling, and, 222 gastrin, CCK, signaling, and cancer, 56-57 Body fluid freezing and cancer, 65 guanylyl cyclase family antifreeze and ice nucleator Branching morphogenesis and, 227 proteins in terrestrial lung development and, history of research and, arthropods, 327-50 471-87 11-12 Body fluids Branchiostoma florida homeostatic neural history of research and, 6-8 phosphagen systems and, function control and, Bolitophagus reticulatus 299 847-65 antifreeze and ice nucleator Breast cancer pacemaker ion channels proteins in terrestrial estrogen receptor 8 and, and, 247 arthropods, 334 182 protein-coupled prostanoid Bone morphogenetic Breasts receptors and the kidney, protein-4 (BMP-4) estrogen receptor 8 and, 579-95 lung development and, 165, 181-82 voltage-gated sodium 479-80, 482 Budding channels and, 871 Boreogadus saida lung development and, Ca** signaling antifreeze proteins of 474-76 evoked by cholecystokinin teleost fishes and, 366, Buffering and acetylcholine 380 phosphagen systems and, acetylcholine, 109-10 Bottom-up analysis 289, 304-5 cADPr, 103-5