AMIT K. TIWARI, Ph.D. HEB-282F, Frederic and Mary Wolfe Center, Department of Pharmacology Experimental Therapeutics, College of Pharmacy & Pharmaceutical Sciences, Health Science Campus, The University of Toledo, 3000 Arlington Ave., MS 1015; Toledo, OH 43614 Tel: (419) 383-1913; Fax: (419) 383-1909; Email: [email protected] ACADEMIC APPOINTMENTS 2015-Present Principal Investigator, Assistant Professor of Pharmacology Dept. of Pharmacology & Experimental Therapeutics, College of Pharmacy & Pharmaceutical Sciences, Health Science Campus, University of Toledo, 3000 Arlington Ave., Toledo, OH 43614 2013-2015 Assistant Professor of Pharmacology and Toxicology Dept. of Biomedical Sciences, CVMNAH, Tuskegee University, Tuskegee, AL 36088 2011-2013 PostDoctoral Fellow, (Advisor: James M. Gallo, PhD) Department of Pharmacology and System Therapeutics, Mount Sinai School of Medicine, NY, NY 10029 2012-2013 NYAS Fellow, New York Academy of Sciences Alliance, NY 2010-2011 University Fellow, College Of Pharmacy And Health Sciences, St. John’s University, Queens, NY 11439 2010 Research Fellow, ZS Chen’s lab, (Summer semester) College Of Pharmacy And Health Sciences, St. John’s University, Queens, NY 11439 2008-2010 Teaching Fellow, College Of Pharmacy And Health Sciences, St. John’s University, Queens, NY 11439 2007-2008 Teaching Assistant, College Of Pharmacy And Health Sciences, St. John’s University, Queens, NY 11439 INDUSTRIAL APPOINTMENTS 2005 – 2006 Nutrition Officer, Nestle Ltd., New Delhi, India. 2004 - 2004 Intern, Zydus Cadilla Healthcare Ltd., Gaziabad, U.P, India. EDUCATION 2008 – 2011 Ph.D., College of Pharmacy and Health Sciences, St. John’s University, Queens, NY Major: Pharmaceutical Sciences: Pharmacology (GPA - 3.9/4.0) Advisor: Z.S. Chen, M.D, Ph.D 2006 – 2008 Master of Science, College of Pharmacy and Health Sciences, St. John’s University, Queens, NY Major: Pharmaceutical Sciences: Pharmacology (GPA - 3.7/4.0) Advisor: Z.S. Chen, M.D, Ph.D 2001- 2005 Bachelor of Pharmacy, Ram-Eesh Institute, G. Noida, U.P.T.U Univ, India Major: Pharmaceutical Sciences (GPA - 4.0/4.0) Amit K. Tiwari, Ph.D. C.V. P a g e 2 AWARDS AND ACHIEVEMENTS 2016 Learner Engagement Award, College of Pharmacy, University of Toledo, Ohio 2016 Outstanding Scientist - Excellence in Innovation Research Award, MP, India 2015 ASM-LINK Undergraduate Research Initiative Fellowship Award from NSF/ASM 2015 Travel award, ABRCMS conference, Seattle, Washington 2014 Health Disparity Research Summer Institute, Al, Travel and 2nd Best Poster Award 2014 Travel award, ABRCMS conference, San Antonio, TX 2014 Travel Award, GMaP conference, Johns Hopkins, Bethesda, MD 2013 Top citation Award from FEBS journal 2011-2013 2013 US Permanent residency in EB1A (Aliens with extraordinary ability) category 2012 New York Academy of Science (NYAS) Alliance Fellow 2012 Honored as Pharmacy School Marshal at St. John’s University, NY 2012 commencement event. 2011 The story of my achievements published on the St. John’s University home page 2011 Outstanding performance in Research Award - St. Johns University, NY 2010 University Fellowship, St. Johns University, NY 2010 Ray-Biotech 2010 Biomarker Grant, Co-PI, while being graduate student 2010 Excellence Award for Research in 2009 at Cancer Lab’s, St. John's University, NY 2009 Tiwari et al (2009). Nilotinib (AMN107, Tasigna) reverses multidrug resistance by inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters. Biochem Pharmacol” was 5th and 4th hottest article in Science Direct from April – Sept 2009. (http://top25.sciencedirect.com/subject/pharmacology-toxicology-and- pharmaceutical-science/20/journal/biochemical-pharmacology/00062952/archive/22/) 2009 Top citation award from Elsevier – Tiwari et al. 2009, Biochem Pharmacology 2007 - 2011 Full scholarship with tuition waiver and stipend from St. John's University for both M.S. and PhD Amit K. Tiwari, Ph.D. C.V. P a g e 3 RESEARCH FUNDING Completed 1. Ray-Biotech –Pilot-Biomarker grants - 3-10 to 2-13 Title: Identify biomarkers of resistance or response to anti-EGFR therapy of cancers Role - Tiwari AK, Co-Principle Investigator Direct costs: $20,000 2. Morehouse School of Medicine/Tuskegee University/ Univ. Of 3-14 to 2-15 Alabama at Birmingham Comprehensive Cancer Center Partnership U54 grant – pre-pilot projects - Title: The role of TTP-Lin28-let-7-axis in the regulation of colorectal cancer treatment Role - PI (Tiwari AK) Direct costs: $15,000 3. UAB MHRC- Health Disparities Research Training Program Grant 2014 2-14 to 2-15 Title: Role of ABCC family of transporters and their signaling pathway in the regulation of chemotherapy responses in pancreatic cancers Role - PI (Tiwari AK) Direct costs: $10,000 4. California Grape Commission - 8-14 to 7-15 Title: Effects of Whole Grape Powder on NF-kB driven inflammatory signaling Role – Co-PI (Tiwari AK); PI (Samuel T) Direct costs: $30,000 Accepted for funding but withdrawn 1. NIH - U54 grant – pilot project - Accepted 10/14 Title: Targeting mitochondria in triple negative breast cancer Role - PI (Tiwari AK) Direct costs: $230,000 *Award Accepted for funding but the PI has to decline due to job change from Tuskegee to Univ of Toledo; grant was non-transferrable. Active 1. University of Toledo - Start-up Funds 3-15 to 2-20 Pending/Resubmitting Research Support 1. National Science Foundation – MRI Grant Role - Tiwari AK, PI Title: MRI: Acquisition of Multispectral Optoacoustic Tomography Next-GEN Imaging for Multidisciplinary Life Sciences Research and Training Amount: $1.06 million; Outcome: Meritorious; Not Funded Amit K. Tiwari, Ph.D. C.V. P a g e 4 2. NIH – RO-1 Role - Tiwari AK, Co-PI; NK Narayanan, NYU (PI) Title: Modulation of NK cell-antitumor efficacy against Prostate Cancer by Melinjo Seeds Amount: $2.5 million; Outcome: Unscored – Revising and resubmitting 3. NIH – 21 Role - Tiwari AK, PI; Singh K, UAB (Co-PI) Title: Pharmacological assessment of TNBC targeted dynamin related protein-1 antagonists Amount: $397,450; Outcome: Not Funded 4. NIH – R-15 Role - Tiwari AK, Co-PI; Chauhan H, Creighton Univ (PI) Title: Prediction of the Hepatotoxicity of Dietary Supplements by Means of Machine-Learning Amount: $278,000; Outcome: Scored, Not Funded – revising resubmitting 5. NIH – R-15 Role - Tiwari AK, PI Title: Targeting chemoresistant colon cancer with plant- derived synthetic analogues that inhibit embryonic signaling pathways Amount: $450,988; Outcome: Not Funded – revising resubmitting 6. Dominican Republic – MESCyT Role - Tiwari AK, PI; Terrero D, Colead-PI Title: Anticancer activities of Fevillea cordifolia and its active constituents Amount: $195,000; Outcome: Not Funded – revising resubmitting 7. NIH – R-15 Role - Tiwari AK, Co-PI; Chauhan H, Creighton Univ (PI) Title: Ionically Complexed and Miscible Food Supplements-Delivery Matrices as Safe and Potent Anticancer Pharmaceuticals Amount: $278,000; Outcome: Not Funded – revising resubmitting 8. NIH – R-15 Role - Tiwari AK (PI) Title: Targeting embryogenic signaling pathways in colon cancer Amount: $378,453; Outcome: Not Funded – revising resubmitting 9. NIH – R-03 Role - Tiwari AK (PI) Title: Pharmacological assessment of TNBC targeted dynamin related protein-1 antagonists Amount: $149,470; Outcome: Not Funded – revising resubmitting 10. AACP Foundation Role - Tiwari AK (PI) Title: Targeting mitochondrial dynamics for novel TNBC therapy Amount: $100,000; Outcome: Not reviewed, resubmitting Amit K. Tiwari, Ph.D. C.V. P a g e 5 PROFESSIONAL SERVICES/ACTIVITIES 2017 Reviewer, INBRE-DRPP Grant 2016-17 Judge and Reviewer, MGRS Conference, Toledo, OH 2016 Thesis Reviewer, MRES Higher education, Macquaire Univ, Australia 2016 Reviewer, Medical Research Council, UK-ASM Newton Grant Panel 2015-16 Reviewer, NSF-GRFP Grant Panel 2015 Judge and Reviewer, Oral and Poster presentation, ABRCMS conference, Seattle, Washington 2015 Judge, Graduate Research Council, University of Toledo 2014 Judge and Reviewer, NSF-GRFP Panel 2014 -15 Judge and Reviewer, Oral & Poster session, ABRCMS, San Antonio, TX 2014 –15 Grant Reviewer, Macquarie University Research Fellowships 2015, Australia 2014 - 15 Chair –CPCE committee, School of Veterinary Medicine, Tuskegee Univ. 2014 –15 Leader – RCMI Translational Research Network (RTRN) Genes, Environment and Toxicology cluster. 2014 Haitian-Tuskegee Training Research Committee; Major Prof - Toxicology 2013 Judge and Reviewer– Abstracts for Annual Biomedical Research Conference for Minority Students (ABRCMS), Nashville, Tennessee, 2013 2013 Judge – Oral session, Phi Zeta Research Day, 14th Biomedical Research Symposium, Tuskegee University, Tuskegee, Sept. 20, 2013 2013 Judge – NanoBio Summit, Center for Nanobiotechnology Research, Alabama State University, Oct. 17-18, 2013, Montgomery, AL 2013 - present Editor: Translational Clin Biol; Cell Signaling; J of Medicinal Chem & Tox 2012 –present Associate Editor-in-Chief - Journal of Post-Doctoral Research (JPR) 2012 –13 NYAS Fellow - volunteered to teach elementary school students in Afterschool STEM Program 2011-12 "Work in Progress" committee and “Pharmacology and Systems Biology Retreat” Organizing Committee in the Dept. of Pharmacology and Systems biology, Mount Sinai School of Medicine, NY (Nov. 2011 – Aug. 2012) 2012 –present Editor - J. of Life Sciences; Editor - Int. J. of Pharmaceutical Res. and Bio- Science (IJPRBS) 2010 -present Senior Scientific committee advisor, Institute of Transgene Life Sciences, India 2010 –present Active Editorial Group Member “Current trends in biotechnology and pharmacy” 2010 - present Elected Editorial Board member of 10 prestigious journals and appointed as journal referee of more than 50 peer-reviewed journals Amit K. Tiwari, Ph.D. C.V. P a g e 6 Committees Serving (University of Toledo): a. University of Toledo: 1. Assessment Committee, CPPS (Feb 2015 – present) 2. Faculty Senate Constitution and Rules Committee, UT (Oct 2015 – present) 3. LGBTQ Committee, UT (Nov 2015 – present) 4. Health Disparity Committee, CPPS (July 2015 – present) b. National and International: 1. AACP Health Disparities and Cultural Competency Nominations Committee (Nov. 2015 – present) 2. AACP Biological section: Chalmers, the Dawson and the Volwiler awards committee 2. Research Innovations Committee, RGVP, Bhopal, India (Jul 2015 – present) 3. External Scientific Committee, Institute of Transgene Life Sciences, India (2010-present) c. Grant reviewer 1. NSF-GRFP 2014-2016 2. Macquarie University Research Fellowships 2015, Australia 3. Medical Research Council, UK – Reviewed - UK-ASM Newton Fund Proposal, 2016 Committees Served a. Tuskegee University: 1. Integrated Biosciences (IBS) PhD Advisory Committee: a. Floyd Davis (PhD – expected 2015) b. Dominique Gales (PhD – expected 2016) c. Amina Wafford (PhD – expected 2017) d. Crystal Lee (PhD – expected 2018) e. Anusha Angajala (PhD – expected 2. Interdisciplinary Pathobiology PhD Advisory Committee: a. Roopak Chowdhary (PhD – expected 2016) b. Mhaer Thalal (PhD – expected 2018) 3. Cultural Organizing Committee – 14th Biomedical Symposium, TU 4. CVNAH, TU Research Committee – AVMA/COE 5. Class of 2016 Faculty Advisor – College of Veterinary Medicine, TU 6. Haitian-Tuskegee Training Research Committee: Served as a Major Professor - Toxicology to Samuel Raphael (Haitian Trainee) for 8 weeks. (01-15-2014 – 03-15-14) 7. Leader –RTRN, Genes, Environment and Toxicology cluster 8. Tuskegee Biomedical Symposium Committee (07-2013 – 2-2015) 9. Chair –CPCE committee, School of Veterinary Medicine, Tuskegee Univ. (03-2014 – 2- 2015) 10. Phi-Zeta Research Committee (04-2014 to 2-12015) 11. Health and Safety Committee, TU (08-2014 to 2-2015) Amit K. Tiwari, Ph.D. C.V. P a g e 7 Current Professional Affiliations 2008 – present American Association for Cancer Research (AACR) 2009 – present American Cancer Society (ACS) 2011 – present New York Academy of Sciences (NYAS) 2011 – present American Association for the Advancement of Science (AAAS) 2012 – 2013 American Association of Pharmaceutical Sciences (AAPS) 2015 – present American Association of College of Pharmacy (AACP) 2015 – present American Association of University Professors (AAUP) Editor and Associate Editor Editor - J. of Life Sciences – (http://jexpsciences.com/index.php/jexp/pages/view/editorial_board) Editor - Int. J. of Pharmaceutical Res. and Bio-Science (IJPRBS) (http://www.ijprbs.com/editorialboard.php) Editor – Translational Clinical Biology (http://vedicjournals.com/index.php/CS) Editor - VRI Cell Signaling (http://vedicjournals.com/index.php/CS) Associate Editor: Frontiers in Pharmacology Associate Editor: Frontiers in Oncology Associate Editor-in-Chief - Journal of Post-Doctoral Research (JPR) (2012 – 2014) (http:/www.postdocjournal.com/editorial-board.aspx?s=jpr) Editorial Board Member J. of Investigational Biochemistry Frontiers in Pharmacology Current Clinical Pharmacology J. Analytical Oncology; Pharmacy and Pharmacology Int. Journal Journal of Medicinal Chemistry & Toxicology Int. J. of Toxicological and Pharmacological Res. (IJTPR) Achieves of Pharmacy Practice Annals of Clinical Case Reports SM Pharmacology & Therapeutics Austin Pharmacology & Pharmaceutics Modern Chemotherapy Biomedical & Pharmacology Journal International Journal of Hospital Pharmacy Int. J. of Pharmaceutical and Clinical Research (IJPCR) Journal Refree 1. Oncogene 2. Clinical Cancer Research 3. Oncotargets 4. Biochemical Pharmacology 5. Cellular Physiology and Biochemistry 6. Drug Discovery Today 7. Molecular Metabolism Amit K. Tiwari, Ph.D. C.V. P a g e 8 8. J of Cellular and Molecular Medicine 9. J. Cancer Therapy (JCT) – Review Editor 10. J. Experimental Pharmacology (JEP) 11. Current Clinical Pharmacology (CCP) 12. Clinical Pharmacology: Adv. and Applic (CPAA) 13. J. Cancer Research Updates (JCRU) 14. J. of Animal Production Advances (JAPA) 15. J. Of Exp. Therap. & Integrat Med. (JETIM) 16. J. Of Pharmacy and Nutrition (JPN) 17. J. Of Pharmacy and Bioallied Sci. (JPBS) 18. The J. of Medicinal Plant Research (JMPR) 19. Therap. and Clinical Risk Management (TCLRM) 20. Cancer Management and Research (CMR) 21. Current Neuropharmacology (CN) 22. Oncotargets and Therapy 23. American J. Of Mol. Biol – Review Editor 24. Pharmacogenomics and Personalized Medicine 25. Bioinorganic Chemistry and Application 26. Stem Cells And Cloning: Advances & Applications 27. Molecular Medicine Reports 28. Expert Review of Anticancer Therapy 29. Cancers 30. BMC Cancer 31. Cellular Biochemistry 32. Antibiotics 33. Molecules 34. American J of Cancer Research 35. Chinese Journal Of Cancer (CJC) 36. Leukemia Research (LR) 37. Marine Drugs 38. Cancer Chemotherapy & Pharmacology 39. Medicinal Chemistry Communications 40. Pharmaceutica Analytica Acta 41. Metal Based Drugs (MBD) 42. J. Microbiology and Infectious Disease 43. Frontiers in Pharmacology 44. J. Of Analytical Oncology (JAO) 45. PLoS One 46. Nutrition and Cancer 47. J. of Investigational Biochemistry (JIB) 48. Molecular Cancer Biology 49. J. Of Microbiology And Infectious Diseases 50. J. Of Cellular and Molecular Medicine 51. Onco-Reviews 52. J. Of Bacteriology Research (JBR) 53. African J. Of Microbiology Res. (AJMR) 54. Expert Opinion On Therapeutic Patents 55. Drug Discoveries & Therapeutics (DDT) 56. Pharmacology and Pharmacy International (PPI) 57. VRI Cell Signaling 58. Expert Opinion In Metabolism And Toxicology 59. Drug, Design, Development & Therapy 60. J. of Animal Science Advances (JASA) 61. Cell Signaling (VRI publications) 62. Toxicology & Applied Pharmacology Amit K. Tiwari, Ph.D. C.V. P a g e 9 63. Chemical Research in Toxicology 64. Medical Science Monitor 65. Cancer Therapy & Biology 66. Scientific Reports – Nature Press 67. Indian J of Pharmaceutical Sciences 68. Springer Plus 69. Journal of Natural Products 70. Pharmacology & Pharmacy International 71. Gene reports 72. Nutrients 73. MDPI cancer 74. Aging 75. BMC Complimentary & Alternative Medicine TEACHING EXPERIENCE ST. JOHN’S UNIVERSITY Teaching Fellow, 08/2008 – 07/2010 Taught molecular biology laboratory courses including Pharmacology, Biochemistry, Oncology, Cardiovascular, Immunology, Endocrinology and Compounding laboratory courses to graduate pharmacy students (2nd – 5th year) from (2008 – 2010; including summer sessions) Managed class and lab of 85 students/term, while supervising a team of 4 assistants Teaching Assistant, 08/2007 – 08/2008 Experience in assisting undergraduate pharmacy labs Pharmaceutical compounding; Parenteral preparations; Pharmacogenetics TUSKEGEE UNIVERSITY – ASSISTANT PROFESSOR TERM COURSE SUBJECTS SPECIFIC STUDENT NUMBER S Fall PHSI.0442.0 Pharmacology PK/PD, Immunosuppressant’s, Biologic 2014 1.13FA: modifiers, Cardiovascular, GI, Respiratory 75 Fall NURS 0314; Pharmacology Pharmacology basics, ANS, CNS, Onco- 2014 Pharmacolo pharmacology, Respiratory, gy Cardiovascular, Pharmacogenetics 25 Spring PHSI.0543.0 Pharmacology Antimicrobial agents, Anticancer 2014 1.14SP: therapeutics, Neuropharmacology 76 Spring PHSI.0546.0 Toxicology Toxicokinetics,Metal toxicity, 2014 1.14SP: Mycotoxins, Zootoxins, Herbicides 74 Fall PHSI.0442.0 Pharmacology Pharmacometrics, Pharmacogenetics, 2013 1.13FA: PK/PD, Cardiovascular, GI, Endocrinology, Corticoids, Respiratory drugs, 76 Amit K. Tiwari, Ph.D. C.V. P a g e 10 UNIVERSITY OF TOLEDO– ASSISTANT PROFESSOR I joined the Pharmacology Department in the late spring of 2015. I have spent majority of my time in summer laboratory instructions, setting the assays/Labs, preparing and disseminating lectures for PHCL 4140/5140; PHCL-5100/7100; PHCL-4700; PHCL3730/5720; PHPR 5770; PHCL6600; PHCL- 5500/7500. Course evaluations by students are extremely encouraging and productive. Course no. Title Credits Term Students Lecture/Hrs PHCL-4140/5140a Interpretation of Pharm Data 3 Su, 15 12 1 (3h) PHCL-5100/7100b Experimental Therapeutics I 3 Fall,15 8 1 (1.5h) PHCL-6600c Seminars in Pharmacology 1 Fall,15 5 1 (1h) Pharmacol II: CNS Endocrine PHCL3730/5720e 3 Spr, 15 105 10 (1h) and Pharmacology Advanced Drug Delivery PHPR 5770f 3 Spr, 15 24 1 (2h) Systems-I Pharmacol II: CNS Endocrine PHCL3730/5720e 3 Fall, 16 103 12 (1h) and Pharmacology PHCL-6600c Seminars in Pharmacology 1 Fall, 16 3 1 (1h) PHCL-5100/7100b Experimental Therapeutics I 3 Fall,16 5 1 (1.5h) PHCL-5500/7500c From Experimental to Appl Therap 4 Fall,16 5 1 (2h) a. Co-taught with Jeff Sarver, Scott Hall and Caren Steinmiller; b. Co-taught with Scott Hall; c. Co-taught with Ezdihar Hassoun; d. Co-taught with Ana Oyarce, Wissam Aboualaiwi; e. Co-taught with Yousef Sari, Jeff Sarver; f. Co-taught with Sai Boddu; I now serve as a course coordinator for PHCL-4700 with majority of the course responsibility and am currently working to develop new assessment and lectures for the course. Classroom teaching assessment: Some examples of student assessment in different student populations: PharmD - PHCL4700: Pharmacol II: CNS Endocrine and Pharmacology (Fall 2016) “Slide content and quality is good, and the online google forms help to solidify where I stand on knowledge based material. Also, it helps to get an idea of how you ask questions on exams and in what style they are written.” “Dr. Tiwari, you are awesome! Your lectures are so clear and easy to follow.” “I like how you are passionate about teaching this topic, it keeps us engaged.” “I like the style. Having sample questions to access what we know is very helpful.” “feel engaged during lecture material. enjoy the diagrams and repetitive content presented in different ways to ensure that we understand concepts” “The lecture quality has been very good! I feel like it is important to spend a lot of time going through the details of each slide and that has been sufficient thus far. Also I think feedback questions like this that test your knowledge of the material is helpful as well.” MS and PhD – PHCL5100/7100; PHCL5500/7500 (Fall 2016) “I love colors, but sometimes the contrast makes it hard to read. I think the blue background needed to be much darker or lighter and darker lettering. As for the actual lecture, it was great! I feel like I understand the concepts and it is very interesting. The explanations are very relatable and clear.” “The graphs were helpful in understanding the lecture” “It was very neatly put together. Well delivered. You explained well the complex ideas” “Honestly, best lecturer in this class to date. It was new material presented in a useful and thought provoking manner. The slides were clear and discussing one thing helped to clarify the points.” BSPS – PHCL3700: (Spr 2015) “This was my first time ever having Dr. Tiwari as a professor and I was thoroughly impressed! He seemed so passionate about what he was teaching (although later I found he didn't care for the material he taught). He was phenomenal at teaching us at 8am and not making students fall asleep. He really pushed for student interaction too. I think the reason why I remember so much from his course is because of how he presented it. I would love to see Dr. Tiwari teach more courses, he did a fantastic job!” “Dr. Tiwari was a great instructor his use of examples and graphs was very pivotal to my learnering experience” “Much of Dr. Tiwari's material was introducing new topics to us, but relied on the pharmacokinetic and pharmacodynamic properties taught to us last semester in PHCL 3700. Dr. Tiwari did a good job of introducing these topics in a way that related back to what we had previously learned.”
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