AMIT K. TIWARI, Ph.D.

25 Pages·2017·0.61 MB·English

AMIT K. TIWARI, Ph.D.
HEB-282F, Frederic and Mary Wolfe Center, Department of Pharmacology Experimental
Therapeutics, College of Pharmacy & Pharmaceutical Sciences, Health Science Campus,
The University of Toledo, 3000 Arlington Ave., MS 1015; Toledo, OH 43614
Tel: [phone]; Fax: [phone]; Email: [email protected]

ACADEMIC APPOINTMENTS
2015-Present Principal Investigator, Assistant Professor of Pharmacology
Dept. of Pharmacology & Experimental Therapeutics, College of Pharmacy &
Pharmaceutical Sciences, Health Science Campus, University of Toledo, 3000 Arlington
Ave., Toledo, OH 43614
2013-2015 Assistant Professor of Pharmacology and Toxicology
Dept. of Biomedical Sciences, CVMNAH, Tuskegee University, Tuskegee, AL 36088
2011-2013 PostDoctoral Fellow, (Advisor: James M. Gallo, PhD)
Department of Pharmacology and System Therapeutics, Mount Sinai School of
Medicine, NY, NY 10029
2012-2013 NYAS Fellow,
New York Academy of Sciences Alliance, NY
2010-2011 University Fellow,
College Of Pharmacy And Health Sciences, St. John’s University, Queens, NY 11439
2010 Research Fellow, ZS Chen’s lab, (Summer semester)
College Of Pharmacy And Health Sciences, St. John’s University, Queens, NY 11439
2008-2010 Teaching Fellow,
College Of Pharmacy And Health Sciences, St. John’s University, Queens, NY 11439
2007-2008 Teaching Assistant,
College Of Pharmacy And Health Sciences, St. John’s University, Queens, NY 11439

INDUSTRIAL APPOINTMENTS
2005 – 2006 Nutrition Officer, Nestle Ltd., New Delhi, India.
2004 - 2004 Intern, Zydus Cadilla Healthcare Ltd., Gaziabad, U.P, India.

EDUCATION
2008 – 2011 Ph.D.,
College of Pharmacy and Health Sciences, St. John’s University, Queens, NY
Major: Pharmaceutical Sciences: Pharmacology (GPA - 3.9/4.0)
Advisor: Z.S. Chen, M.D, Ph.D
2006 – 2008 Master of Science,
College of Pharmacy and Health Sciences, St. John’s University, Queens, NY
Major: Pharmaceutical Sciences: Pharmacology (GPA - 3.7/4.0)
Advisor: Z.S. Chen, M.D, Ph.D
2001- 2005 Bachelor of Pharmacy,
Ram-Eesh Institute, G. Noida, U.P.T.U Univ, India
Major: Pharmaceutical Sciences (GPA - 4.0/4.0)
Amit K. Tiwari, Ph.D. C.V. P a g e 2

AWARDS AND ACHIEVEMENTS
2016 Learner Engagement Award, College of Pharmacy, University of Toledo, Ohio
2016 Outstanding Scientist - Excellence in Innovation Research Award, MP, India
2015 ASM-LINK Undergraduate Research Initiative Fellowship Award from NSF/ASM
2015 Travel award, ABRCMS conference, Seattle, Washington
2014 Health Disparity Research Summer Institute, Al, Travel and 2nd Best Poster Award
2014 Travel award, ABRCMS conference, San Antonio, TX
2014 Travel Award, GMaP conference, Johns Hopkins, Bethesda, MD
2013 Top citation Award from FEBS journal 2011-2013
2013 US Permanent residency in EB1A (Aliens with extraordinary ability) category
2012 New York Academy of Science (NYAS) Alliance Fellow
2012 Honored as Pharmacy School Marshal at St. John’s University, NY 2012
commencement event.
2011 The story of my achievements published on the St. John’s University home page
2011 Outstanding performance in Research Award - St. Johns University, NY
2010 University Fellowship, St. Johns University, NY
2010 Ray-Biotech 2010 Biomarker Grant, Co-PI, while being graduate student
2010 Excellence Award for Research in 2009 at Cancer Lab’s, St. John's University, NY
2009 Tiwari et al (2009). Nilotinib (AMN107, Tasigna) reverses multidrug resistance by
inhibiting the activity of the ABCB1/Pgp and ABCG2/BCRP/MXR transporters.
Biochem Pharmacol” was 5th and 4th hottest article in Science Direct from April –
Sept 2009. (http://top25.sciencedirect.com/subject/pharmacology-toxicology-and-
pharmaceutical-science/20/journal/biochemical-pharmacology/00062952/archive/22/)
2009 Top citation award from Elsevier – Tiwari et al. 2009, Biochem Pharmacology
2007 - 2011 Full scholarship with tuition waiver and stipend from St. John's University for
both M.S. and PhD
Amit K. Tiwari, Ph.D. C.V. P a g e 3

RESEARCH FUNDING
Completed
1. Ray-Biotech –Pilot-Biomarker grants - 3-10 to 2-13
Title: Identify biomarkers of resistance or response to anti-EGFR therapy of cancers
Role - Tiwari AK, Co-Principle Investigator
Direct costs: $20,000

2. Morehouse School of Medicine/Tuskegee University/ Univ. Of 3-14 to 2-15
Alabama at Birmingham Comprehensive Cancer Center
Partnership U54 grant – pre-pilot projects -
Title: The role of TTP-Lin28-let-7-axis in the regulation of colorectal cancer treatment
Role - PI (Tiwari AK)
Direct costs: $15,000

3. UAB MHRC- Health Disparities Research Training Program Grant 2014 2-14 to 2-15
Title: Role of ABCC family of transporters and their signaling pathway in the
regulation of chemotherapy responses in pancreatic cancers
Role - PI (Tiwari AK)
Direct costs: $10,000

4. California Grape Commission - 8-14 to 7-15
Title: Effects of Whole Grape Powder on NF-kB driven inflammatory signaling
Role – Co-PI (Tiwari AK); PI (Samuel T)
Direct costs: $30,000

Accepted for funding but withdrawn
1. NIH - U54 grant – pilot project - Accepted 10/14
Title: Targeting mitochondria in triple negative breast cancer
Role - PI (Tiwari AK)
Direct costs: $230,000
*Award Accepted for funding but the PI has to decline due to job change from Tuskegee to Univ of
Toledo; grant was non-transferrable.

Active
1. University of Toledo - Start-up Funds 3-15 to 2-20

Pending/Resubmitting Research Support
1. National Science Foundation – MRI Grant
Role - Tiwari AK, PI
Title: MRI: Acquisition of Multispectral Optoacoustic Tomography Next-GEN Imaging for
Multidisciplinary Life Sciences Research and Training
Amount: $1.06 million; Outcome: Meritorious; Not Funded
Amit K. Tiwari, Ph.D. C.V. P a g e 4

2. NIH – RO-1
Role - Tiwari AK, Co-PI; NK Narayanan, NYU (PI)
Title: Modulation of NK cell-antitumor efficacy against Prostate Cancer by Melinjo Seeds
Amount: $2.5 million; Outcome: Unscored – Revising and resubmitting

3. NIH – 21
Role - Tiwari AK, PI; Singh K, UAB (Co-PI)
Title: Pharmacological assessment of TNBC targeted dynamin related protein-1 antagonists
Amount: $397,450; Outcome: Not Funded

4. NIH – R-15
Role - Tiwari AK, Co-PI; Chauhan H, Creighton Univ (PI)
Title: Prediction of the Hepatotoxicity of Dietary Supplements by Means of Machine-Learning
Amount: $278,000; Outcome: Scored, Not Funded – revising resubmitting

5. NIH – R-15
Role - Tiwari AK, PI
Title: Targeting chemoresistant colon cancer with plant- derived synthetic analogues that inhibit
embryonic signaling pathways
Amount: $450,988; Outcome: Not Funded – revising resubmitting

6. Dominican Republic – MESCyT
Role - Tiwari AK, PI; Terrero D, Colead-PI
Title: Anticancer activities of Fevillea cordifolia and its active constituents
Amount: $195,000; Outcome: Not Funded – revising resubmitting

7. NIH – R-15
Role - Tiwari AK, Co-PI; Chauhan H, Creighton Univ (PI)
Title: Ionically Complexed and Miscible Food Supplements-Delivery Matrices as Safe and Potent
Anticancer Pharmaceuticals
Amount: $278,000; Outcome: Not Funded – revising resubmitting

8. NIH – R-15
Role - Tiwari AK (PI)
Title: Targeting embryogenic signaling pathways in colon cancer
Amount: $378,453; Outcome: Not Funded – revising resubmitting

9. NIH – R-03
Role - Tiwari AK (PI)
Title: Pharmacological assessment of TNBC targeted dynamin related protein-1 antagonists
Amount: $149,470; Outcome: Not Funded – revising resubmitting

10. AACP Foundation
Role - Tiwari AK (PI)
Title: Targeting mitochondrial dynamics for novel TNBC therapy
Amount: $100,000; Outcome: Not reviewed, resubmitting
Amit K. Tiwari, Ph.D. C.V. P a g e 5

PROFESSIONAL SERVICES/ACTIVITIES
2017 Reviewer, INBRE-DRPP Grant
2016-17 Judge and Reviewer, MGRS Conference, Toledo, OH
2016 Thesis Reviewer, MRES Higher education, Macquaire Univ, Australia
2016 Reviewer, Medical Research Council, UK-ASM Newton Grant Panel
2015-16 Reviewer, NSF-GRFP Grant Panel
2015 Judge and Reviewer, Oral and Poster presentation, ABRCMS conference,
Seattle, Washington
2015 Judge, Graduate Research Council, University of Toledo
2014 Judge and Reviewer, NSF-GRFP Panel
2014 -15 Judge and Reviewer, Oral & Poster session, ABRCMS, San Antonio, TX
2014 –15 Grant Reviewer, Macquarie University Research Fellowships 2015,
Australia
2014 - 15 Chair –CPCE committee, School of Veterinary Medicine, Tuskegee Univ.
2014 –15 Leader – RCMI Translational Research Network (RTRN) Genes,
Environment and Toxicology cluster.
2014 Haitian-Tuskegee Training Research Committee; Major Prof - Toxicology
2013 Judge and Reviewer– Abstracts for Annual Biomedical Research
Conference for Minority Students (ABRCMS), Nashville, Tennessee, 2013
2013 Judge – Oral session, Phi Zeta Research Day, 14th Biomedical Research
Symposium, Tuskegee University, Tuskegee, Sept. 20, 2013
2013 Judge – NanoBio Summit, Center for Nanobiotechnology Research,
Alabama State University, Oct. 17-18, 2013, Montgomery, AL
2013 - present Editor: Translational Clin Biol; Cell Signaling; J of Medicinal Chem & Tox
2012 –present Associate Editor-in-Chief - Journal of Post-Doctoral Research (JPR)
2012 –13 NYAS Fellow - volunteered to teach elementary school students in
Afterschool STEM Program
2011-12 "Work in Progress" committee and “Pharmacology and Systems Biology
Retreat” Organizing Committee in the Dept. of Pharmacology and Systems
biology, Mount Sinai School of Medicine, NY (Nov. 2011 – Aug. 2012)
2012 –present Editor - J. of Life Sciences; Editor - Int. J. of Pharmaceutical Res. and Bio-
Science (IJPRBS)
2010 -present Senior Scientific committee advisor, Institute of Transgene Life Sciences,
India
2010 –present Active Editorial Group Member “Current trends in biotechnology and
pharmacy”
2010 - present Elected Editorial Board member of 10 prestigious journals and appointed as
journal referee of more than 50 peer-reviewed journals
Amit K. Tiwari, Ph.D. C.V. P a g e 6

Committees Serving (University of Toledo):
a. University of Toledo:
1. Assessment Committee, CPPS (Feb 2015 – present)
2. Faculty Senate Constitution and Rules Committee, UT (Oct 2015 – present)
3. LGBTQ Committee, UT (Nov 2015 – present)
4. Health Disparity Committee, CPPS (July 2015 – present)

b. National and International:
1. AACP Health Disparities and Cultural Competency Nominations Committee (Nov.
2015 – present)
2. AACP Biological section: Chalmers, the Dawson and the Volwiler awards committee
2. Research Innovations Committee, RGVP, Bhopal, India (Jul 2015 – present)
3. External Scientific Committee, Institute of Transgene Life Sciences, India (2010-present)
c. Grant reviewer
1. NSF-GRFP 2014-2016
2. Macquarie University Research Fellowships 2015, Australia
3. Medical Research Council, UK – Reviewed - UK-ASM Newton Fund Proposal, 2016

Committees Served
a. Tuskegee University:
1. Integrated Biosciences (IBS) PhD Advisory Committee:
a. Floyd Davis (PhD – expected 2015)
b. Dominique Gales (PhD – expected 2016)
c. Amina Wafford (PhD – expected 2017)
d. Crystal Lee (PhD – expected 2018)
e. Anusha Angajala (PhD – expected
2. Interdisciplinary Pathobiology PhD Advisory Committee:
a. Roopak Chowdhary (PhD – expected 2016)
b. Mhaer Thalal (PhD – expected 2018)
3. Cultural Organizing Committee – 14th Biomedical Symposium, TU
4. CVNAH, TU Research Committee – AVMA/COE
5. Class of 2016 Faculty Advisor – College of Veterinary Medicine, TU
6. Haitian-Tuskegee Training Research Committee: Served as a Major Professor -
Toxicology to Samuel Raphael (Haitian Trainee) for 8 weeks. (01-15-2014 – 03-15-14)
7. Leader –RTRN, Genes, Environment and Toxicology cluster
8. Tuskegee Biomedical Symposium Committee (07-2013 – 2-2015)
9. Chair –CPCE committee, School of Veterinary Medicine, Tuskegee Univ. (03-2014 – 2-
2015)
10. Phi-Zeta Research Committee (04-2014 to 2-12015)
11. Health and Safety Committee, TU (08-2014 to 2-2015)
Amit K. Tiwari, Ph.D. C.V. P a g e 7

Current Professional Affiliations
2008 – present American Association for Cancer Research (AACR)
2009 – present American Cancer Society (ACS)
2011 – present New York Academy of Sciences (NYAS)
2011 – present American Association for the Advancement of Science (AAAS)
2012 – 2013 American Association of Pharmaceutical Sciences (AAPS)
2015 – present American Association of College of Pharmacy (AACP)
2015 – present American Association of University Professors (AAUP)

Editor and Associate Editor
 Editor - J. of Life Sciences – (http://jexpsciences.com/index.php/jexp/pages/view/editorial_board)
 Editor - Int. J. of Pharmaceutical Res. and Bio-Science (IJPRBS)
(http://www.ijprbs.com/editorialboard.php)
 Editor – Translational Clinical Biology (http://vedicjournals.com/index.php/CS)
 Editor - VRI Cell Signaling (http://vedicjournals.com/index.php/CS)
 Associate Editor: Frontiers in Pharmacology
 Associate Editor: Frontiers in Oncology
 Associate Editor-in-Chief - Journal of Post-Doctoral Research (JPR) (2012 – 2014)
(http:/www.postdocjournal.com/editorial-board.aspx?s=jpr)

Editorial Board Member
 J. of Investigational Biochemistry
 Frontiers in Pharmacology
 Current Clinical Pharmacology
 J. Analytical Oncology;
 Pharmacy and Pharmacology Int. Journal
 Journal of Medicinal Chemistry & Toxicology
 Int. J. of Toxicological and Pharmacological Res. (IJTPR)
 Achieves of Pharmacy Practice
 Annals of Clinical Case Reports
 SM Pharmacology & Therapeutics
 Austin Pharmacology & Pharmaceutics
 Modern Chemotherapy
 Biomedical & Pharmacology Journal
 International Journal of Hospital Pharmacy
 Int. J. of Pharmaceutical and Clinical Research (IJPCR)

Journal Refree
1. Oncogene
2. Clinical Cancer Research
3. Oncotargets
4. Biochemical Pharmacology
5. Cellular Physiology and Biochemistry
6. Drug Discovery Today
7. Molecular Metabolism
Amit K. Tiwari, Ph.D. C.V. P a g e 8

8. J of Cellular and Molecular Medicine
9. J. Cancer Therapy (JCT) – Review Editor
10. J. Experimental Pharmacology (JEP)
11. Current Clinical Pharmacology (CCP)
12. Clinical Pharmacology: Adv. and Applic (CPAA)
13. J. Cancer Research Updates (JCRU)
14. J. of Animal Production Advances (JAPA)
15. J. Of Exp. Therap. & Integrat Med. (JETIM)
16. J. Of Pharmacy and Nutrition (JPN)
17. J. Of Pharmacy and Bioallied Sci. (JPBS)
18. The J. of Medicinal Plant Research (JMPR)
19. Therap. and Clinical Risk Management (TCLRM)
20. Cancer Management and Research (CMR)
21. Current Neuropharmacology (CN)
22. Oncotargets and Therapy
23. American J. Of Mol. Biol – Review Editor
24. Pharmacogenomics and Personalized Medicine
25. Bioinorganic Chemistry and Application
26. Stem Cells And Cloning: Advances & Applications
27. Molecular Medicine Reports
28. Expert Review of Anticancer Therapy
29. Cancers
30. BMC Cancer
31. Cellular Biochemistry
32. Antibiotics
33. Molecules
34. American J of Cancer Research
35. Chinese Journal Of Cancer (CJC)
36. Leukemia Research (LR)
37. Marine Drugs
38. Cancer Chemotherapy & Pharmacology
39. Medicinal Chemistry Communications
40. Pharmaceutica Analytica Acta
41. Metal Based Drugs (MBD)
42. J. Microbiology and Infectious Disease
43. Frontiers in Pharmacology
44. J. Of Analytical Oncology (JAO)
45. PLoS One
46. Nutrition and Cancer
47. J. of Investigational Biochemistry (JIB)
48. Molecular Cancer Biology
49. J. Of Microbiology And Infectious Diseases
50. J. Of Cellular and Molecular Medicine
51. Onco-Reviews
52. J. Of Bacteriology Research (JBR)
53. African J. Of Microbiology Res. (AJMR)
54. Expert Opinion On Therapeutic Patents
55. Drug Discoveries & Therapeutics (DDT)
56. Pharmacology and Pharmacy International (PPI)
57. VRI Cell Signaling
58. Expert Opinion In Metabolism And Toxicology
59. Drug, Design, Development & Therapy
60. J. of Animal Science Advances (JASA)
61. Cell Signaling (VRI publications)
62. Toxicology & Applied Pharmacology
Amit K. Tiwari, Ph.D. C.V. P a g e 9

63. Chemical Research in Toxicology
64. Medical Science Monitor
65. Cancer Therapy & Biology
66. Scientific Reports – Nature Press
67. Indian J of Pharmaceutical Sciences
68. Springer Plus
69. Journal of Natural Products
70. Pharmacology & Pharmacy International
71. Gene reports
72. Nutrients
73. MDPI cancer
74. Aging
75. BMC Complimentary & Alternative Medicine
TEACHING EXPERIENCE
ST. JOHN’S UNIVERSITY
Teaching Fellow, 08/2008 – 07/2010
Taught molecular biology laboratory courses including Pharmacology, Biochemistry,
Oncology, Cardiovascular, Immunology, Endocrinology and Compounding laboratory courses
to graduate pharmacy students (2nd – 5th year) from (2008 – 2010; including summer sessions)
 Managed class and lab of 85 students/term, while supervising a team of 4
assistants

Teaching Assistant, 08/2007 – 08/2008
 Experience in assisting undergraduate pharmacy labs
 Pharmaceutical compounding; Parenteral preparations; Pharmacogenetics
TUSKEGEE UNIVERSITY – ASSISTANT PROFESSOR
TERM COURSE SUBJECTS SPECIFIC STUDENT
NUMBER S
Fall PHSI.0442.0 Pharmacology PK/PD, Immunosuppressant’s, Biologic
2014 1.13FA: modifiers, Cardiovascular, GI,
Respiratory 75
Fall NURS 0314; Pharmacology Pharmacology basics, ANS, CNS, Onco-
2014 Pharmacolo pharmacology, Respiratory,
gy Cardiovascular, Pharmacogenetics 25
Spring PHSI.0543.0 Pharmacology Antimicrobial agents, Anticancer
2014 1.14SP: therapeutics, Neuropharmacology 76
Spring PHSI.0546.0 Toxicology Toxicokinetics,Metal toxicity,
2014 1.14SP: Mycotoxins, Zootoxins, Herbicides 74
Fall PHSI.0442.0 Pharmacology Pharmacometrics, Pharmacogenetics,
2013 1.13FA: PK/PD, Cardiovascular, GI,
Endocrinology, Corticoids, Respiratory
drugs, 76
Amit K. Tiwari, Ph.D. C.V. P a g e 10

UNIVERSITY OF TOLEDO– ASSISTANT PROFESSOR
I joined the Pharmacology Department in the late spring of 2015. I have spent majority of my time in
summer laboratory instructions, setting the assays/Labs, preparing and disseminating lectures for PHCL
4140/5140; PHCL-5100/7100; PHCL-4700; PHCL3730/5720; PHPR 5770; PHCL6600; PHCL-
5500/7500. Course evaluations by students are extremely encouraging and productive.
Course no. Title Credits Term Students Lecture/Hrs
PHCL-4140/5140a Interpretation of Pharm Data 3 Su, 15 12 1 (3h)
PHCL-5100/7100b Experimental Therapeutics I 3 Fall,15 8 1 (1.5h)
PHCL-6600c Seminars in Pharmacology 1 Fall,15 5 1 (1h)
Pharmacol II: CNS Endocrine
PHCL3730/5720e 3 Spr, 15 105 10 (1h)
and Pharmacology
Advanced Drug Delivery
PHPR 5770f 3 Spr, 15 24 1 (2h)
Systems-I
Pharmacol II: CNS Endocrine
PHCL3730/5720e 3 Fall, 16 103 12 (1h)
and Pharmacology
PHCL-6600c Seminars in Pharmacology 1 Fall, 16 3 1 (1h)
PHCL-5100/7100b Experimental Therapeutics I 3 Fall,16 5 1 (1.5h)
PHCL-5500/7500c From Experimental to Appl Therap 4 Fall,16 5 1 (2h)
a. Co-taught with Jeff Sarver, Scott Hall and Caren Steinmiller; b. Co-taught with Scott Hall; c. Co-taught with Ezdihar Hassoun; d. Co-taught
with Ana Oyarce, Wissam Aboualaiwi; e. Co-taught with Yousef Sari, Jeff Sarver; f. Co-taught with Sai Boddu; I now serve as a course
coordinator for PHCL-4700 with majority of the course responsibility and am currently working to develop new assessment and lectures for the
course.
Classroom teaching assessment:
Some examples of student assessment in different student populations:
PharmD - PHCL4700: Pharmacol II: CNS Endocrine and Pharmacology (Fall 2016)
“Slide content and quality is good, and the online google forms help to solidify where I stand on knowledge based
material. Also, it helps to get an idea of how you ask questions on exams and in what style they are written.”
“Dr. Tiwari, you are awesome! Your lectures are so clear and easy to follow.”
“I like how you are passionate about teaching this topic, it keeps us engaged.”
“I like the style. Having sample questions to access what we know is very helpful.”
“feel engaged during lecture material. enjoy the diagrams and repetitive content presented in different ways to
ensure that we understand concepts”
“The lecture quality has been very good! I feel like it is important to spend a lot of time going through the details of
each slide and that has been sufficient thus far. Also I think feedback questions like this that test your knowledge of
the material is helpful as well.”

MS and PhD – PHCL5100/7100; PHCL5500/7500 (Fall 2016)
“I love colors, but sometimes the contrast makes it hard to read. I think the blue background needed to be much
darker or lighter and darker lettering. As for the actual lecture, it was great! I feel like I understand the concepts and
it is very interesting. The explanations are very relatable and clear.”
“The graphs were helpful in understanding the lecture”
“It was very neatly put together. Well delivered. You explained well the complex ideas”
“Honestly, best lecturer in this class to date. It was new material presented in a useful and thought provoking
manner. The slides were clear and discussing one thing helped to clarify the points.”

BSPS – PHCL3700: (Spr 2015)
“This was my first time ever having Dr. Tiwari as a professor and I was thoroughly impressed! He seemed so
passionate about what he was teaching (although later I found he didn't care for the material he taught). He was
phenomenal at teaching us at 8am and not making students fall asleep. He really pushed for student interaction
too. I think the reason why I remember so much from his course is because of how he presented it. I would love to
see Dr. Tiwari teach more courses, he did a fantastic job!”
“Dr. Tiwari was a great instructor his use of examples and graphs was very pivotal to my learnering experience”
“Much of Dr. Tiwari's material was introducing new topics to us, but relied on the pharmacokinetic and
pharmacodynamic properties taught to us last semester in PHCL 3700. Dr. Tiwari did a good job of introducing
these topics in a way that related back to what we had previously learned.”