AI-First Healthcare AI Applications in the Business and Clinical Management of Health Kerrie L. Holley & Siupo Becker, M.D. AI-First Healthcare AI Applications in the Business and Clinical Management of Health Kerrie L. Holley and Siupo Becker, M.D. BBeeiijjiinngg BBoossttoonn FFaarrnnhhaamm SSeebbaassttooppooll TTookkyyoo AI-First Healthcare by Kerrie L. Holley and Siupo Becker, M.D. Copyright © 2021 Kerrie L. Holley and Siupo Becker. All rights reserved. Printed in the United States of America. Published by O’Reilly Media, Inc., 1005 Gravenstein Highway North, Sebastopol, CA 95472. O’Reilly books may be purchased for educational, business, or sales promotional use. Online editions are also available for most titles (http://oreilly.com). For more information, contact our corporate/institutional sales department: 800-998-9938 or [email protected]. Acquisitions Editor: Michelle Smith Indexer: WordCo Indexing Services, Inc. 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If any code samples or other technology this work contains or describes is subject to open source licenses or the intellectual property rights of others, it is your responsibility to ensure that your use thereof complies with such licenses and/or rights. 978-1-492-06315-5 [LSI] Table of Contents Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi 1. Myths and Realities of AI. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 AI Origins and Definition 2 AI and Machine Learning 4 AI Transitions 11 AI—A General Purpose Technology 15 AI Healthcare Myths 17 Myth: AI Will Cure Disease 21 Myth: AI Will Replace Doctors 25 Myth: AI Will Fix the “Healthcare Problem” 27 Myth: AI Will Decrease Healthcare Costs 29 AI Myths 33 Myth: AI Is an Existential Threat 34 Myth: AI Is Just Machine Learning 35 Myth: AI Overpromises and Underdelivers 36 Myth: True Conversational AI Already Exists 37 Myth: AI as Overlord 38 AI Technology Myths 39 Myth: AI Algorithms Are Biased 40 Myth: AI Sees, Hears, and Thinks 40 Myth: AI Diagnoses Diseases Better Than Doctors 41 Myth: AI Systems Learn from Data 43 Myth: AI Is a Black Box 43 Myth: AI Is Modeled After the Brain 45 AI-First Healthcare 45 iii 2. Human-Centered AI. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 Toward Human-Centered AI 49 AI Centaur Health 50 Human-Centered AI 53 Intersection of AI and Humans 54 AI and Human Sociocultural Values 58 AI Understanding Humans 61 Humans Understanding AI 64 Human Ethics and AI 66 Human-Centric Approach 67 Making Human-Centered AI Work 69 Summary 71 3. Monitoring + AI = Rx for Personal Health. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73 Prescription (Rx) for Personal Health 76 Three Realms Influencing Healthcare 78 Ambient Computing and Healthcare 81 Continuous Monitoring Using AI 83 Continuous Monitoring 84 Beeps, Chimes, Dings, and Dongs 85 Health Continuum 86 Application of IoT and AI to Medical Care 88 IoT and AI 88 Health Determinants and Big Data 92 Summary 93 4. Digital Transformation and AI. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 95 Digital Transformation of Healthcare 97 Path A: Creating Digital Operations and Processes 99 Path B: Building New Capabilities 100 Path C: Transforming Business Processes 101 Paths to the Digital Transformation of Healthcare 102 Digital Healthcare 102 AI Applied to Digital Healthcare 104 AI, Digitization, and Big Tech 105 Preventive and Chronic Disease Management 106 AI and Prevention 107 AI and Chronic Disease 108 AI and Mental Health 110 AI and Telemedicine 111 Medication Management and AI 113 Medication Adherence 114 iv | Table of Contents Digital Medication 115 AI and Digitization Applied to Administrative Tasks 117 Summary 119 5. An Uncomfortable Truth. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 121 Healthcare Waste 122 Healthcare Spend and AI 123 Treatment Decisions and AI 126 Administrative Costs 131 Administrative Processes and Waste 133 Job Security and AI 135 Clinician Time 136 Ambient Clinical Intelligence 137 AI Use in Diagnostic Imaging and Analysis 137 Summary 142 6. Emerging Applications in Healthcare Using AI. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 145 Improving Human Health 146 Improving Human Lives 147 Making Technology Work for Healthcare 148 Ambient Intelligence 148 From a Patient’s Perspective 151 From a Doctor’s Perspective 153 From a Hospital System’s Perspective 156 From an Insurer’s Perspective 160 Emerging Applications and Services 162 Coordination of Care Platform 163 Disease State Management Platform 164 Human to Machine Experience Services 165 Customer Journey Platform 166 Clinician Decision Support Tools 167 Ambient Intelligence Environments 167 Digital Twin Platform 168 Real-Time Healthcare 169 Internet of Behaviors 170 Summary 171 7. AI at Scale for Healthcare Organizations. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173 Achieving AI at Scale 173 Transforming Healthcare 178 The Chasm 182 Invisible Engines—Healthcare Platforms 183 Table of Contents | v The Road to a Healthcare Platform 186 Ecosystems 190 Application Programming Interfaces (APIs) 191 Summary 191 Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 195 vi | Table of Contents Preface The number of books describing artificial intelligence (AI), machine learning, deep learning, natural language processing, and the full constellation of AI technologies could fill a library. Coupled with the ever-growing list of articles, videos, and blogs, there is no lack of content. Clinicians, computer scientists, technologists, physicians, philosophers, and journalists each tackle different AI issues and challenges. However, we couldn’t find a book that discussed AI from a medical doctor and a tech‐ nologist’s paired perspectives. This is a book that tracks the journey of a physician and a technologist working together, discussing AI’s opportunity while explaining AI for the consumption of a clinician, an IT worker, a user, an executive, or a business stakeholder. Our goal is for you to understand the possibilities for improvements in healthcare supercharged by artificial intelligence. While discussing this vast potential, we strove to maintain the awe of AI while grounding the reader in the reality of AI today. We hope that Chapter 1 will provide you with confidence that you understand the myth versus the reality. More impor‐ tantly, this first chapter seeks to familiarize you with the language of AI—what is a model, an algorithm, a neural network, and more—without your needing to brush up on linear algebra or computer science. Chapter 2 integrates human-centered design, with providers and technologists work‐ ing together to build smart systems to ensure that AI is used to do good. Chapter 3 helps the reader see how combining AI with sensing and monitoring, given the growth of intelligent objects, affords unparalleled opportunity for accelerating per‐ sonalized medicine. Chapter 4 describes digital transformation and AI, and the utility of AI for digital transformation. Several opportunities exist for using AI to reduce the amount of waste in healthcare and to reduce medical errors, as addressed in Chapter 5. Chapter 6 describes several AI solutions that, when realized, materially affect the quadruple aim of healthcare. Last, Chapter 7 provides a road map for how organizations realize AI’s benefits not just for a single instance but at scale. vii The state of healthcare is top of mind because it touches most aspects of our lives. The COVID-19 pandemic exposes the slow train wreck of dumb systems frustrating doctors, provider systems, and patients. There is no “silver bullet,” no quick fix, no one-size-fits-all solution, but the potential to transform healthcare with AI is now possible. We hope this book provides a blueprint for organizations in their journey to leverage AI to make healthcare better for everyone. Conventions Used in This Book The following typographical conventions are used in this book: Italic Indicates new terms, URLs, email addresses, filenames, and file extensions. O’Reilly Online Learning For more than 40 years, O’Reilly Media has provided technol‐ ogy and business training, knowledge, and insight to help companies succeed. Our unique network of experts and innovators share their knowledge and expertise through books, articles, and our online learning platform. 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