Advances in Swine in Biomedical Research: Volume 2

475 Pages·1996·33.687 MB·English

by  Michael P. Murtaugh PhD, Nancy A. Monteiro-Riviere PhD, Linda Panepinto BS (auth.), Mike E. Tumbleson, Lawrence B. Schook (eds.)

ADVANCES IN SWINE IN
BIOMEDICAL RESEARCH
Volume 2
ADVANCES IN SWINE IN
BIOMEDICAL RESEARCH
Volume 2
Edited by
Mike E. T umbleson
University of Illinois
Urbana, J1Jinois
ond
Lawrence B. Schook
University of Minnesota
SI. Paul, Minnesota
Springer Science+Business Media, LLC
Library of Congress Cataloging in Publication Data
Advances in swine in biomedical research / edited by Mike E. Thmbleson and Lawrence B.
Schook.
p. cm.
"Proceedings of an International Symposium on Swine in Biomedical Research, held De
tober 22-25, 1995, at the University of Maryland, University College Park, Maryland"-T.p.
versa.
Inc\udes bibliographical references and index.
ISBN 978-1-4613-7699-6 ISBN 978-1-4615-5885-9 (eBook)
DOI 10.1007/978-1-4615-5885-9
1. Diseases-Animal models-O>ngresses. 2. Swine as laboratory animals-Congresses. 1.
Thmbleson, M. E. (Mike E.) II. Schook, Lawrence B. III. International Symposium on Swine
in Biomedical Research (1995: University of Maryland)
[DNLM: 1. Disease Models, Animal-congresses. 2. Swine-physiology-congresses. 3.
Genetic Engineering-congresses. QY 6O.S8 A244 1996]
RBl25.A36 1996
619'.9-DC20
DNLM/DLC 96-38650
for Library of Congress CIP
Proceedings of an International Symposium an Swine in Biomedical Research, held October
22-25, 1995, atthe University 01 Maryland, University College Park, Maryland
ISBN 978-1-4613-7699-6
© 1996 Springer Science+Business Media New York
Originally published by Plenum Press, New York in 1996
Softcover reprint of the hardcover 1s t edition 1996
AII rights reserved
10987654321
No part 01 this book may be reproduced, stored in a retrieval system, ar transmitted in any lorm
or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise,
without written permission lrom the Publisher
We wish to give special thanks to
Jenny Malakowsky
and
Treena Schmidt
for their assistance in
preparing this publication
PREFACE
Similarities in structure and function between pigs and human beings include size,
feeding patterns, digestive physiology, dietary habits, kidney structure and function, pulmo
nary vascular bed structure, coronary artery distribution, propensity to obesity, respiratory
rates, tidal volumes and social behaviors. Since the pig is an omnivore, it provides an
adaptable model to evaluate chronic and acute exposures to xenobiotics such as alcohoL
caffeine, tobacco, food additives and environmental pollutants. Swine have been used
successfully as models to evaluate alcoholism, diabetes, absorption, digestion, total paren
teral nutrition, organ transplantation, atherosclerosis, exercise, hypertension. hemorrhagic
hypotension, melanoma, gingivitis, obstructive and reflux nephropathy. osteochondrosis.
dermal healing and septic shock.
A severe and worsening shortage of organs and tissues for transplantation in patients
with severe organ failure has encouraged the consideration of inters pecies or xenotransplan
tation. In developing programs toward this end, the pig generally is viewed as the preferred
donor because of its size, physiology and availability. The pig harbors relatively few diseases
which could be transmitted inadvertently to human patients. The ability to genetically modify
swine to ameliorate the consequences of the human immune response offers a further
significant advantage.
Another important consideration for an animal model is that basic biologic back
ground information be available for investigators to design future prospective studies.
Animal models should accurately and precisely emulate human conditions; survive sufficient
time to be functional; provide for multiple and serial samples; and have a gestation period
adequate for intervention. When considering human fetal research. one must appraise the
ethical implications; therefore. it is paramount that an animal model be developed.
Limitations on the development of animal biotechnologic advances may restrict
opportunities for improving human health. With respect to biologic interactions. interrela
tionships between human health and animal biotechnology are symbiotic as well as syner
gistic. The relationship of bioscience and biotechnology to developing countries is not so
much one of aggressive impact and doubtful benefits, but of indispensability.
Mike Tumbleson, University of Illinois
Larry Schook, University of Minnesota
vii
ACKNOWLEDGMENTS
The coeditors wish to extend appreciation to members ofthe organizing and scientific
committees. They provided assistance in developing the sound technical program, as well
as aiding in peer review of the submitted papers. Participating individuals were:
• Craig Beattie, USDA/ARS/MARC
• Richard Binns, The Babraham Institute
• David Brown, University of Minnesota
• Harold Gonyou, Prairie Swine Centre
• Eric Johnson, University of Minnesota
• Charles Louis, University of Minnesota
• Arthur Matas, University of Minnesota
• James Mickelson, University of Minnesota
• Thomas Molitor, University of Minnesota
• Nancy Monteiro-Riviere, North Carolina State University
• Michael Murtaugh, University of Minnesota
• Jack Odie, North Carolina State University
• Reinhard Pabst, Hannover Medical School
• Linda Panepinto. Panepinto & Associates
• Victor Perman, University of Minnesota
• Jeffrey Platt, Duke University
• Peter Reeds, USDAI ARS/CNRC
• Mark Rutherford, University of Minnesota
• Gail Scherba, University of Illinois
• Steve Squinto, Alexion Pharmaceutical
• Bert Stromberg, University of Minnesota
• James Terris, Uniformed Services University
• Matthew Wheeler, University of Illinois
• Federico Zuckermann, University of Illinois
ix
CONTENTS
Volume 2
Methods and Techniques
37. Swine Research Breeds, Methods, and Biomedical Models .................. 423
Michael P. Murtaugh, Nancy A. Monteiro-Riviere, and Linda Panepinto
38. The Pig as a Model for Cutaneous Pharmacology and Toxicology Research .... 425
Nancy A. Monteiro-Riviere and Jim Riviere
39. An in vitro Pig Skin Model for Predicting Human Skin Penetration and
Irritation Potential .............................................. 459
William G. Reifenrath, Barbara W. Kemppainen, and Winifred G. Palmer
40. Swine Liver Usage in Extracorporeal Detoxification ....................... 475
Vyacheslav E. Ryabinin
41. Pig Behavior and Biomedical Research: Suitable Subjects and Experimental
Models ............................................' ........... 485
Harold W. Gonyou
42. Current Status of in vitro Production of Porcine Embryos ................... 491
Hiroaki Funahashi and Billy N. Day
43. Reproductive Physiology in Chinese Meishan Pigs: A University of Illinois
Perspective .................................................... 503
Brett R. White, JoElla Barnes, and Matthew B. Wheeler
44. Selection for Extremes in Serum FSH Concentrations Results in Reduced
Testis Size and Fertility in Meishan and White Composite Boars ......... 523
Donald D. Lunstra, J. Joe Ford, and Thomas H. Wise
45. Reproductive Characteristics in Sinclair Miniature Swine ................... 533
Guy F. Bouchard, Ronald M. McLaughlin, Mark R. Ellersieck,
Gary F. Krause, Craig Franklin, and Chada S. Reddy
xi
xii Contents
46. A Comparison of Physiological and Biochemical Parameters in Fully
Conscious Hormel-Hanford and Yucatan Strains of Miniature Pig ........ 543
George 1. Ikeda, Theodore C. Michel, Dennis W. Gaines, Vira L. Olivito,
Philip P. Sapienza, Leonard Friedman, Curtis N. Barton, and
Michael W. O'Donnell
47. Biochemical Indices of Stress Associated with Short-Term Restraint in Hormel
and Yucatan Miniature Swine ..................................... 557
Leonard Friedman, Linda Panepinto, Dennis W. Gaines, Ruey Chi,
Robert C. Braunberg, and James Terris
48. The Minipig as a Model for the Study of Aging in Humans: Selective
Responses of Hormones Involved in Carbohydrate and Lipid Metabolism
in Different Sexes .............................................. 571
Sam 1. Bhathena, Elliott Berlin, and Wesley A. Johnson
49. Aging and Miniature Swine Heart and Liver Plasma Membranes ............. 581
Elliott Berlin, Melanie A. Banks, Sam 1. Bhathena, Renee C. Peters, and
Wesley A. Johnson
50. Comparing Porcine Models of Coronary Restenosis ....................... 595
Robert N. Willette, Hong Zhang, Calvert Louden and Robert K. Jackson
51. Sinclair Miniature Swine Melanoma as a Model for Evaluating Novel
Lymphography Contrast Agents ................................... 607
David K. Johnson, Erik R. Wisner, Stephen M. Griffey, Adele R. Vessey,
and Patrick J. Haley
52. The Yucatan Miniature Pig Model of Ventricular Septal Defect ............... 613
M. Michael Swindle, Robert P. Thompson, Alison C. Smith,
George B. Keech, Blase A. Carabello, Wolfgang Radtke, Derek Fyfe and
Paul C. Gillette
53. An External Thoracic Duct Venous Shunt to Allow for Long Term Collection
of Lymph and Blood in the Conscious Pig ........................... 621
H. Vince Mendenhall, Christopher Horvath, Marek Piechowiak,
Lisa Johnson, and Kim Bayer
54. Pregnant Yucatan Miniature Swine as a Model for Investigating Fetal Drug
Therapy ...................................................... 629
Donald B. Wiest, M. Michael Swindle, Sandra S. Gamer, Alison C. Smith,
Paul C. Gillette
55. A Swine Model for Determining the Bioavailability of Lead From
Contaminated Media ............................................ 637
Stan W. Casteel, Ross P. Cowart, Christopher P. Weis,
Gerry M. Henningsen, Eva Hoffman, William J. Brattin,
Matthew F. Starost, John T. Payne, Steven L. Stockham,
Stephen V. Becker, and James R. Turk
Contents xiii
56. Evaluation of Sinclair Miniature Swine as an Osteopenia Model ............. 647
Guy F. Bouchard, Rogely W. Boyce, Carol L. Paddock, Edward Durham,
and Chada S. Reddy
57. Neovascularization of the Ischemic Myocardium by Cardiomyoplasty: Its
Study Using the Casting Method and Selective Acute Myocardial
Infarction in Swine ............................................. 653
Jose M. Borrego, Antonio Ordonez, Ana Hernandez, and Jose Perez
58. Vaccination Study with the Sinclair Miniature Swine-Effect of Vaccine Dose
and Litter ..................................................... 663
Guy Bouchard, Edward Durham, Boh Chang Lin, Susan Turnquist, and
Chada Reddy
59. Early Characterization of Panepinto Micro/Miniature Swine for Use as
Transgenic Animal Models ....................................... 671
Victoria Hampshire, John Bacher, Melvin Dennis, Axel Wolff, and
Melissa Yarko
60. Miniature Swine Breeds Used Worldwide in Research ...................... 681
Linda M. Panepinto
61. The Siberian Miniature Pig, Its Development, Genetics, and Use in Biomedical
Research ...................................................... 693
Vilen Tikhonov
Nutrition
62. Pigs as Models for Nutrient Functional Interaction ........................ 709
Peter Reeds and Jack Odie
63. A Piglet Model for Neonatal Amino Acid Metabolism during Total Parenteral
Nutrition ...................................................... 713
Ronald O. Ball, James D. House, Linda 1. Wykes, and Paul B. Pencharz
64. The Neonatal Piglet as a Model to Study Insulin Like Growth Factor Mediated
Intestinal Growth and Function ................................... 733
Sharon M. Donovan, Vicki M. Houle, Marcia H. Monaco,
Elizabeth A. Schroeder, Yookyoung Park, and Jack OdIe
65. The Perinatal Pig in Pediatric Gastroenterology ........................... 745
Per. T. Sangild, Marian Silver, Mette Schmidt, and Abigail L. Fowden
66. Prenatal and Perinatal Development ofIntestinal Transport and Brush Border
Hydrolases in Pigs .............................................. 757
Randal K. Buddington, Christiane Malo, and Hongzheng Zhang
xiv Contents
67. Changes in Pig Intestinal Structure and Functions and Resident Microbiota
Induced by Acute Secretory Diarrhea ............................... 769
Gayatri Chandra, Monika Oli, Bryon W. Petschow, and
Randal K. Buddington
68. Helicobacter Pylori Infection in Gnotobiotic Piglets: A Model of Human
Gastric Bacterial Disease ........................................ 779
Steven Krakowka and Kathryn A. Eaton
69. An Experimental Rotaviral Enteritis Model with Neonatal Pigs .............. 811
Guillermo G. Gomez, Edward 1. Rozhon, Richard A. Goforth, and
Oulayvanh Thirakoune
70. Influence of Dietary Protein and Fat Sources on the Levels of Blood
Homocysteine in a Pig Model: Preliminary Observations ............... 821
Ghulam Sarwar, Nimal Ratnayake, Robert W. Peace, and Herbert G. Botting
71. Lung Eicosanoid Production in Neonatal Pigs Fed Formula Supplemented with
N-3 and N-6 Fatty Acids ......................................... 829
Margaret C. Craig-Schmidt and Meng-Chuan Huang
72. Genetically Diverse Pig Models in Nutrition Research Related to Lipoprotein
and Cholesterol Metabolism ...................................... 843
Wilson G. Pond and Harry 1. Mersmann
73. Glucose and Fatty Acid Metabolism in the Newborn Pig .................... 865
Pierre-Henri Duee, Jean-Paul Pegorier, Beatrice Darcy-Vrillon, and
Jean Girard2
Author Index ........................................................... 885
Subject Index ........................................................... 889