Advanced Trauma and Surgery PDF
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Advanced Trauma and Surgery Xiaobing Fu Liangming Liu Editors 123 Advanced Trauma and Surgery Xiaobing Fu Liangming Liu (cid:129) Editors Advanced Trauma and Surgery 123 Editors XiaobingFu LiangmingLiu Key Laboratoryof WoundRepair State Key Laboratoryof Trauma, andRegenerativeMedicine of PLA BurnsandCombinedInjury, TheFirstAffiliatedHospitalofPLAGeneral DapingHospital, Research Institute Hospital ofSurgery Beijing ThirdMilitary Medical University China Chongqing China ISBN978-981-10-2424-5 ISBN978-981-10-2425-2 (eBook) DOI 10.1007/978-981-10-2425-2 LibraryofCongressControlNumber:2016948248 ©SpringerNatureSingaporePteLtd.2017 Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeorpart of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission orinformationstorageandretrieval,electronicadaptation,computersoftware,orbysimilarordissimilar methodologynowknownorhereafterdeveloped. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publicationdoesnotimply,evenintheabsenceofaspecificstatement,thatsuchnamesareexemptfrom therelevantprotectivelawsandregulationsandthereforefreeforgeneraluse. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authorsortheeditorsgiveawarranty,expressorimplied,withrespecttothematerialcontainedhereinor foranyerrorsoromissionsthatmayhavebeenmade. Printedonacid-freepaper ThisSpringerimprintispublishedbySpringerNature TheregisteredcompanyisSpringerNatureSingaporePteLtd. Theregisteredcompanyaddressis:152BeachRoad,#22-06/08GatewayEast,Singapore189721,Singapore Preface As we know that trauma and accident injury are one among the main causes of death in human, and they are the first cause of death in youth below 45 years. Effective and precise prevention and management of serve damage in tissues and organs will benefit not only in reducing the early mortality, but also in improving the quality of life after survival in later. Advances in basic research and clinical management in trauma and surgery have confirmed these conceptions. In this monograph titled Advanced Trauma and Surgery, recently advanced knowledgeandskillsinearlywoundcare,traumaticorburnshock,pathogenesisin sepsis and tissue repair and regenerative medicine are offered. The authors pay much attention to the cellular, molecular, and gene research and their relationship with the pathogenesis in trauma and injury. Also, how to translate application of these advanced theories and skills in management of trauma patients is highlighted. Wewouldliketosaythatthisbookisnotservedasthesophisticatedinstruction manualtoguidethosewhohavelessexperiencethroughdifficultexperiencesinthe management of trauma and surgery. It is our hope that this book can be served as the advanced textbook tohelp the young scientists and clinicians to know thenew knowledgeandtechnologyinthesefields,whichwillbenefittheirworkinresearch and clinic through multidisciplinary collaboration. We would like to express our gratitude to all authors who contribute his knowledge and time for this book. We thank Prof. Zengang Wang and Prof. Zhiyong Sheng in particular, for their continued support and guide in the fields of trauma and burn. Both of them are very famous experts in trauma, burn, field surgery, and traffic medicine. Their professional contribution is not only in China, butalsointheworld.Theirideashavebeenresponsibleforinfluencingtheideasin young generation, and we appreciate them very much for the great contribution. Beijing, China Xiaobing Fu Chongqing, China Liangming Liu v Contents Damage Control Theory in Treatment of Multiple Injuries.. ..... .... 1 Xiangjun Bai Open Abdomen Treatment for Severe Trauma ... .... .... ..... .... 13 Lianyang Zhang Advances in the Management of Thoracic Trauma .... .... ..... .... 23 Dingyuan Du The Normalization and Promotion of Large Craniotomy Treatment for Severe Traumatic Brain Injury.... .... .... ..... .... 47 Baiyun Liu and Xiang Mao Current Developments on Traffic Medicine .. .... .... .... ..... .... 59 Jihong Zhou and Jun Qiu The Features of Explosive Fragments Induced Injury and Management... .... .... ..... .... .... .... .... .... ..... .... 79 Jianmin Wang Advances in Early Treatment of Combat and Traumatic Shock... .... 105 Tao Li and Liangming Liu Calcium Desensitization Mechanism and Treatment for Vascular Hyporesponsiveness After Shock .... .... .... ..... .... 119 Liangming Liu, Tao Li, Guangming Yang and Chenyang Duan Acute Coagulopathy of Trauma-Shock .. .... .... .... .... ..... .... 137 Baiqiang Li and Haichen Sun Research Progress in Trauma Metabolism and Nutrition ... ..... .... 145 Weiqin Li and Xiao Shen Metabolic Changes and Nutrition Therapy in Burn Patients. ..... .... 155 Xi Peng vii viii Contents Early Prediction and Prevention of Trauma-Related Infection/Sepsis .... .... .... ..... .... .... .... .... .... ..... .... 167 Xiaoyuan Ma, Lixing Tian and Huaping Liang Genetic Polymorphisms and Trauma Precision Medicine ... ..... .... 189 Wei Gu and Jianxin Jiang Novel Inflammatory and Immunomodulatory Mediators in Sepsis. .... 211 Cindy Cen, Monowar Aziz and Ping Wang Research Advances in Biomarker for Sepsis.. .... .... .... ..... .... 235 Daizhi Peng and Xiao Liu Trauma, Regulated Cell Death, and Inflammation. .... .... ..... .... 253 Jie Fan and Liyan Fan To Explore Sepsis, We Need New Thought... .... .... .... ..... .... 283 Lei Li, Guie Liu and Qing Ouyang Regenerative Medicine in China: The Capacity, Capability and Reliability. .... .... .... ..... .... .... .... .... .... ..... .... 291 Biao Cheng, Shuliang Lu, Xiaosong Gu and Xiaobing Fu The Differences of Cell Biology in the Repair Process of Wound and Refractory Wound Surface... .... .... .... ..... .... 323 Chun Qing, JiaoYun Dong and Ming Tian Stem Cell Based Biotherapy for Radiation Related Injury .. ..... .... 357 Tingyu Dai, Liao Wu, Zelin Chen and Chunmeng Shi Spinal Cord Injury and Regenerative Repair. .... .... .... ..... .... 387 Chaozhi Liu and Yamin Wu Cells Transplantation for the Repair of Peripheral Nerve Injuries. .... 409 Bingcang Li Sweat Gland Regeneration: Basic Scientific Problems and Possible Technical Approaches. .... .... .... .... .... ..... .... 437 Sha Huang, Sa Cai, Xiaoyan Sun, Cuiping Zhang, Zhiyong Sheng and Xiaobing Fu Index .... .... .... .... .... ..... .... .... .... .... .... ..... .... 451 Editors and Contributors About the Editors Prof. Xiaobing Fu, M.D., Ph.D., He is an academi- cian (Chinese Academy of Engineering, Division of Health and Medicine); president of the College of Life Science, the General Hospital of PLA; director of the Key LaboratoryofWoundRepairand Regenerationof PLA,TraumaCenterofPostgraduateMedicalCollege. He has made great contributions on trauma, espe- ciallyintissuerepairandregeneration.Hisworkswere supported in part by the National Basic Science and Development Program (973 Program), National High-Technique Program (863 Program), Grant for National Distinguished Young Scientists, and Grant forNationalNaturalScienceFoundationofChina.Hehaspublishedmorethan500 scientific papers, including papers published in the Lancet (1998, 2001), and 20 books as the editor in chief, and won the 25 international and national prizes of Sci-Tech Progress from 1989 to 2015. He was the member of the Scientific Committee of the Third Joint Meeting of the European Tissue Repair Society and the Wound Healing Society held in Boudreaux in1999; he was also a member of the Scientific Committee, advisor or memberoftheInternationalFacultyfromtheFirstWorldUnionofWoundHealing Societies (WUWHS) Congress to 5th WUWHS Congress, held in Melbourne in 2000, Toronto in Canada in 2008, Yokohama in Japan in 2012, and Florence in Italy in 2016. He was the vice chairman of Trauma and Burn Section of the International Conference on Life Science and Clinical Medicine in 2000. Now,heisthechairmanoftheAsianWoundHealingAssociation(AWHA),the president of the Chinese Tissue Repair Society (CTRS), the president of the ix x EditorsandContributors Chinese Tissue Repair and Regeneration Society (CTRRS), and the member of National Natural Science Foundation of China. Professor Fu was awarded the International Lifetime Achievement Award in Wound Repair and Regeneration in 2008. He was selected as the academician (Chinese Academy of Engineering, Division of Health and Medicine) in 2009. Liangming Liu, M.D., He is a research professor, doctoral supervisor, director of Shock Research Lab, Research Institute of Surgery, Third Military Medical University. He is also a shock research specialist; a distinguished young scholar of national science foun- dation of China; the committee member of InternationalFederationofShockSocietyandChinese Trauma Society; the vice chairman of Shock Society of China and War Wound and Trauma Committee of PLA; the standing member of Cardiovascular Committee of Chinese Pharmacology Society; the editorial board member of Annals of Cardiology and CardiovascularDiseases, Frontier of Medicine, ChinJ Traumatology, andMilitary Medical Research; the invited reviewer of Intl J Cardiology, Cell Biol Intl, J Endocrinology, Exp and Ther Med, Pharmacol Reports, and so on; and the eval- uation expert of National Natural Science Foundation of China and Yangtse River Scholars of Education Ministry in China. He has long been undertaking the studies of pathogenesis, prevention, and care of traumatic shock. His main grants comprise the state and military key and major projectssuchasthekeyprojectofthenationalnaturalsciencefoundationofChina, the national major new drug development plan, and the national major research program of basic science (973 plan). In the flied of shock research, he raised the calcium desensitization mechanism of vascular hyporeactivity in critical illness such as severe trauma and shock and raised the effective prevention and treatment measures;heraisedthenewconceptthatpermissivehypotensiveresuscitationisall needed for uncontrolled hemorrhagic shock before and after bleeding controlled; and he developed a series of emergent care devices for war wound and trauma, which play important roles in combat casualty care, disaster rescue, and military training. These studies published over 350 papers including in Ann Surg, Cardiovasc Res, Crit Care Med, Crit Care, and Anesthesiology and Shock and obtained 12 national and provisional science and technology progress awards. Contributors MonowarAziz CenterforImmunologyandInflammation,TheFeinsteinInstitute for Medical Research, Manhasset, NY, USA Xiangjun Bai Department of Trauma Surgery, Tongji Hospital, Hua Zhong University of Science and Technology, Wuhan, People’s Republic of China EditorsandContributors xi Sa Cai The First Affiliated Hospital, Chinese PLA General Hospital, Beijing, People’s Republic of China Cindy Cen Department of Surgery, Hofstra Northwell School of Medicine, Manhasset, NY, USA Zelin Chen State Key Laboratory of Trauma, Burns and Combined Injury, ChongqingEngineeringResearchCenterforNanomedicine,InstituteofCombined Injury, College of Preventive Medicine, Third Military Medical University, Chongqing, China Biao Cheng The General Hospital of PLA, College of Life Sciences, Medical College of PLA, Beijing, People’s Republic of China; The Key Laboratory of Trauma Treatment & Tissue Repair of Tropical Area, PLA, Guangzhou, People’s Republic of China Tingyu Dai State Key Laboratory of Trauma, Burns and Combined Injury, ChongqingEngineeringResearchCenterforNanomedicine,InstituteofCombined Injury, College of Preventive Medicine, Third Military Medical University, Chongqing, China JiaoYunDong MedicalSchool,RuiJinHospital,ShanghaiJiaoTongUniversity, Shanghai, People’s Republic of China Dingyuan Du Chongqing Institute of Accident and Emergency Medicine, Chongqing Emergency Medical Center, Chongqing, People’s Republic of China Chenyang Duan State Key Laboratory of Trauma, Burns and Combined Injury, Second Department of Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing, People’s Republic of China Jie Fan School of Medicine and Veterans Affairs Pittsburgh Healthcare System, University of Pittsburgh, Pittsburgh, PA, USA LiyanFan SchoolofMedicine,CaseWesternReserveUniversity,Cleveland,OH, USA Xiaobing Fu The College of Life Sciences, Chinese PLA General Hospital, Chinese PLA Medical College, Beijing, People’s Republic of China; The First Affiliated Hospital, Chinese PLA General Hospital, Beijing, People’s Republic of China Wei Gu State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Research Institute of Surgery, Third Military Medical University, Chongqing, People’s Republic of China Xiaosong Gu Nantong University, Nantong, Jiangsu, People’s Republic of China Sha Huang The College of Life Sciences, Chinese PLA General Hospital, Chinese PLA Medical College, Beijing, People’s Republic of China
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