Advanced Biopolymeric Systems for Drug Delivery

390 Pages·2020·10.912 MB·English

by  Amit Kumar Nayak (editor), Md Saquib Hasnain (editor)

Advances in Material Research and Technology
Amit Kumar Nayak
Md Saquib Hasnain Editors
Advanced
Biopolymeric
Systems for
Drug Delivery
Advances in Material Research and Technology
Series Editor
Shadia Jamil Ikhmayies, Physics Department, Isra University, Amman, Jordan
ThisSeriescoverstheadvancesanddevelopmentsinawiderangeofmaterialssuchas
energy materials, optoelectronic materials, minerals, composites, alloys and
compounds, polymers, green materials, semiconductors, polymers, glasses, nano-
materials,magneticmaterials,superconductingmaterials,hightemperaturematerials,
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More information about this series at http://www.springer.com/series/16426
Amit Kumar Nayak Md Saquib Hasnain
(cid:129)
Editors
Advanced Biopolymeric
Systems for Drug Delivery
123
Editors
Amit KumarNayak Md SaquibHasnain
Department ofPharmaceutics Department ofPharmacy
Seemanta Institute of Pharmaceutical Shri Venkateshwara University
Sciences Rajabpur, Gajraula, Uttar Pradesh, India
Jharpokharia, Mayurbhanj, Odisha, India
ISSN 2662-4761 ISSN 2662-477X (electronic)
Advances in MaterialResearch andTechnology
ISBN978-3-030-46922-1 ISBN978-3-030-46923-8 (eBook)
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Preface
At present, drug delivery research and development are recognized as one of the
fieldsofvitalimportanceinbiomedicalandhealthcareapplications.Designingand
development of competent drug delivery systems are now the main focus of drug
delivery researchers and scientists. The innovation in biomaterial sciences and
engineering allows the exploration and exploitation of various advanced biomate-
rials, which possess some important biomaterial characteristics like biodegrad-
ability, biocompatibility, environment responsiveness, etc. For this, biopolymers
are modified or functionalized to make these as advanced materials for improved
drug delivery.
The current book entitled “Advanced Biopolymeric Systems for Drug
Delivery” covers the recent innovations in the developments of various advanced
biopolymeric systems like gels, in situ gels, hydrogels, interpenetrating polymer
networks (IPNs), polyelectrolyte complexes (PECs), graft co-polymers,
stimuli-responsive polymers, polymeric nanoparticles, nanocomposites, polymeric
micelles, dendrimers, liposomes, scaffolds, etc., and their applications in drug
delivery. This volume is a collection of 15 chapters by the academicians and
researchersofvariousfieldsacrosstheworld.Aconciseaccountonthecontentsof
each chapter has been described to provide a glimpse of the book to the readers.
Chapter1entitled“BiopolymersforDrugDelivery”describesawidevarietyof
biopolymers such as cellulose, alginate, chitin, chitosan, pectin, gellan gum, guar
gum, locust bean gum, tamarind gum, sterculia gum, natural starches, gelatine,
collagen, albumin, carrageenans, hyaluronic acid (hyaluronan), and chondroitin
sulfate.Theusesofthesebiopolymersindrugdeliveryhavebeencomprehensively
reviewed.
Chapter 2 entitled “Critical Points in Biopolymeric-Controlled Release Matrix
Systems” deals with different issues of controlled release matrix systems based on
different biopolymers.
Chapter 3 entitled “Biopolymeric Gels in Drug Delivery” presents a review of
biopolymeric gels, their preparation, characterization, and most importantly their
applications in modern drug delivery taking into account the recent innovations.
v
vi Preface
Chapter 4 entitled “In Situ Polymeric Gels for Topical Drug Delivery” sum-
marizes various potential advantages and disadvantages associated with in situ gel
formulations designed for topical applications along with in situ gel formation
mechanisms, factors, preparation methodologies, polymers, characterizations, and
topical drug delivery applications.
Chapter 5 entitled “Stimuli-Responsive Polymeric Systems for Smart Drug
Delivery” presents a general description of smart drug delivery systems based on
the use of stimuli-responsive biopolymers as because these biopolymers comprise
the particularity of responding to small physical or chemical stimuli leading to a
macroscopic alteration in their structure/properties.
Chapter 6 entitled “Smart Polysaccharide Hydrogels in Drug Delivery and
Release”dealswithsustainableissueofsmartpolysaccharidehydrogels,whichare
trending to appear in advanced drug delivery applications. It is worth discussing
this topic to bring forward and unwrap such advanced findings for keen inventors.
Chapter 7 entitled “Polysaccharide-Based Nanoparticles: Nanocarriers for
SustainedDeliveryofDrugs”presentsthelatestdevelopmentsinthelastfiveyears
in the drug delivery field using polysaccharide-based nanoparticles as sustained
drug-releasing nanocarriers.
Chapter 8 entitled “Polysaccharide-Based Nanocarriers for Oral Delivery of
InsulininDiabetes”specificallydescribesthecurrentchallengesfororaldeliveryof
insulin, polysaccharide-based nanocarriers loaded with insulin that can be used for
targeted delivery of insulin with enhanced bioavailability, non-toxicity, and effec-
tivity along with its future prospects.
Chapter 9 entitled “Interpenetrating Polymer Networks in Sustained Drug-
Releasing”presentsadetailedoverviewofthecharacteristicsandrecentsuccessful
applicationsofinterpenetratingpolymernetworks(IPNs)insustaineddrugdelivery
devices.
Chapter 10 entitled “Biopolymeric Nanocomposites in Drug Delivery” offers
the most recent significant researches on various biopolymeric nanocomposites in
drug delivery applications using biomacromolecules including chitosan, car-
boxymethylchitosan,alginate,hyaluronicacid,cellulose,carboxymethylcellulose,
starch, gellan gum, gum acacia/gum arabic, guar gum, gelatin, chondroitin sulfate,
pectin, and collagen.
Chapter 11 entitled “Biopolymeric Micelles” specifically describes about the
background, properties, and characterization of biopolymeric micelles along with
their applications in drug delivery and targeting.
Chapter 12 entitled “Liposomes for Advanced Drug Delivery” summarizes the
recent advances in liposomal drug delivery systems and their applications for
advanced drug delivery.
Chapter 13 entitled “Dendrimers for Advanced Drug Delivery” covers the
recent advances in dendrimer technology, applications of dendrimers in drug
delivery/targeting, and associated cytotoxicity issues.
Chapter 14 entitled “Nanofibers for Filtration Applications” focuses on nano-
fibers by electrospinning method and their applications for filtration. More
specifically, antimicrobial nano-fibrous membranes (as antimicrobial filters, fibers
Preface vii
for oil spill cleanup, and fibers for nanoparticles removal from aqueous solution)
developed from electrospun polymers, and their applications have been discussed.
Chapter 15 entitled “Marine Polysaccharides Systems for Drug Delivery
Applications” discusses about marine polysaccharides like alginate and chitosan
along with their modified derivatives for various drug delivery applications.
Wewouldliketoconveyoursincerethankstoalltheauthorsofthechaptersfor
providing timely and valuable contributions. We thank the publisher—Springer
Nature. We specially thank Dr. Mayra Castro, Dr. Shadia Ikhmayies, and Mr.
Ashok Arumairaj for their invaluable support in the organization of the editing
process right through the beginning to finishing point of this book. We gratefully
acknowledge the permissions to reproduce copyright materials from various sour-
ces. Finally, we would like to thank our family members, all respected teachers,
friends, colleagues, and dear students for their continuous encouragements, inspi-
rations, and moral supports during the preparation of the current book. Together
with our contributing authors and the publishers, we will be extremely pleased if
our endeavor fulfills the needs of academicians, researchers, students, polymer
engineers, biomedical experts, pharmaceutical students, and drug delivery
formulators.
Dr. Amit Kumar Nayak
Seemanta Institute of Pharmaceutical Sciences
Jharpokharia, Mayurbhanj, India
Dr. Md Saquib Hasnain
Shri Venkateshwara University
Rajabpur, Gajraula, India
Contents
Biopolymers for Drug Delivery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Md Saquib Hasnain, Syed Anees Ahmed, Saad Alkahtani,
Milan Milivojevic, Chandi Charan Kandar, Amal Kumar Dhara,
and Amit Kumar Nayak
Critical Points in Biopolymeric-Controlled Release Matrix Systems. . . . 31
Ángela Aguilar-de-Leyva and Isidoro Caraballo
Biopolymeric Gels in Drug Delivery. . . . . . . . . . . . . . . . . . . . . . . . . . . . 57
Moumita Das Kirtania, Nancy Kahali, and Arindam Maity
In Situ Polymeric Gels for Topical Drug Delivery . . . . . . . . . . . . . . . . . 83
Paramita Paul and Gouranga Nandi
Stimuli-Responsive Polymeric Systems for Smart Drug Delivery . . . . . . 115
Dariana Aristizabal Bedoya, Francisco N. Figueroa,
Micaela A. Macchione, and Miriam C. Strumia
Smart Polysaccharide Hydrogels in Drug Delivery and Release. . . . . . . 135
Harshani Iresha and Takaomi Kobayashi
Polysaccharide-Based Nanoparticles: Nanocarriers for Sustained
Delivery of Drugs. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 151
Vandana Singh, Tulika Malviya, Shehala, Surabhi Gupta,
Lalit Mohan Dwivedi, Kirti Baranwal, Mani Prabha, and Aayushee
Polysaccharide-Based Nanocarriers for Oral Delivery of Insulin
in Diabetes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 183
Awanish Kumar, Shraddha Gupta, and Dhakshinamoorthy Vasanth
Interpenetrating Polymer Networks in Sustained Drug-Releasing . . . . . 195
Priyanka Mankotia, Kashma Sharma, Vishal Sharma, and Vijay Kumar
Biopolymeric Nanocomposites in Drug Delivery. . . . . . . . . . . . . . . . . . . 233
Zahra Shariatinia
ix
x Contents
Biopolymeric Micelles. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 291
Smriti Kumari and Kamla Pathak
Liposomes for Advanced Drug Delivery. . . . . . . . . . . . . . . . . . . . . . . . . 317
Amit Verma, Ankita Tiwari, Pritish Kumar Panda, Shivani Saraf,
Ankit Jain, Sarjana Raikwar, Pooja Bidla, and Sanjay K. Jain
Dendrimers for Advanced Drug Delivery. . . . . . . . . . . . . . . . . . . . . . . . 339
Shiv Kumar Prajapati and Aakanchha Jain
Nanofibers for Filtration Applications . . . . . . . . . . . . . . . . . . . . . . . . . . 361
El-Refaie Kenawy and Md Saquib Hasnain
Marine Polysaccharides Systems for Drug Delivery Applications. . . . . . 373
Pandurang Appana Dalavi, Jayachandran Venkatesan, V. Rani,
and Sukumaran Anil