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a tool for predicting loss-to-follow-up among people living with hiv at busia border by denice o ... PDF

101 Pages·2017·4.65 MB·English
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A TOOL FOR PREDICTING LOSS-TO-FOLLOW-UP AMONG PEOPLE LIVING WITH HIV AT BUSIA BORDER BY DENICE O. JUMA MASTER OF SCIENCE IN DATA ANALYTICS KCA UNIVERSITY 2017 A TOOL FOR PREDICTING LOSS-TO-FOLLOW-UP AMONG PEOPLE LIVING WITH HIV AT BUSIA BORDER BY DENICE O. JUMA A DISSERTATION SUBMITTED IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE AWARD OF MASTER OF SCIENCE IN DATA ANALYTICS IN THE FACULTY OF COMMUNICATION AND INFORMATION MANAGEMENT AT KCA UNIVERSITY November, 2017 i DECLARATION I declare that this dissertation is my original work and has not been previously published or submitted elsewhere for award of a degree. I also declare that this contains no material written or published by other people except where due reference is made and author duly acknowledged. Student name: Denice O. Juma Registration number: 15/05987 Sign: ___________________ Date: _________________ I do hereby confirm that I have examined the master's dissertation of Denice O. Juma And have approved it for examination Sign: __________________ Date: ___________________ Dr. Mwangi Henry Dissertation Supervisor Sign: __________________ Date: ___________________ Mrs. Rachael Kibuku Dissertation Supervisor ii ABSTRACT Human Immuno-Deficiency Virus (HIV) and Acquired Immune Deficiency Syndrome (AIDS) are a global emergency. Infection with HIV can lead to poor health, loss of lives, increased number of orphans and reduced national productivity. In Kenya and Uganda, National AIDS & STI Control Programme (NASCOP) and the Uganda AIDS Commission (UAC) respectively are promoting combination of approaches for HIV prevention with the key populations. Studies have revealed that 1.5 million people live with HIV with a 5.9% adult HIV prevalence. There are an estimated 78,000 new HIV infections with 36,000 aids related deaths and 59% adults on antiretroviral treatment (AVERT 2016). Complex socio-cultural, economic, and health-system factors inhibit excellent patient retention. Better tracking, enhanced social support, and regular adherence counselling in addressing stigma, and alternative healing options are needed. Intervention strategies aimed at changing clinic routines and improving patient–provider communication could address many of the identified barriers (Tiruneh et al. 2016). The objective of the study is to develop a tool to predict possible loss-to-follow-up among mobile people living with HIV/AIDS enrolled in care and treatment at the Busia border. Adherence to ARV drugs and retention in care and treatment programs of a sample of PLHIVs in the Northern Transport Corridor of Kenya and Uganda particularly in Busia cross-border site was assessed to determine the factors leading to loss-to-follow-up among them. A design science methodology was adopted in the design, development, testing, implementation and validation of the data mining and analytics tool for predicting possible loss-to-follow-up among people living with HIV. The tool was piloted at two cross-border participating facilities close to the border crossing point. Missing variables speaking to nationality and cross-border and cross- county/district mobility characteristics were collected through a community and facility profile form. Exiting data from daily activity registers were filtered based on main dependent LTFU predictor variables resulting from reviewed literature on factors, used to inform design of the tool and as the training dataset. New PLHIV were enrolled and their data run through the decision tree predictor for results. Metrics were used to assess the differences in tracking and management of PLHIVs before and after implementation of the tool. Model evaluation metrics was used to test the accuracy, efficacy and utility of the tool. Study findings inform future effective interventions on tracing and linking back mobile PLHIVs displaying transnational service access characteristics to adhere and be retained in care and treatment as an effort to achieving the global UNAIDS 90-90-90 targets. Keywords: data mining, loss-to-follow-up, mobility, cross-border referral iii ACKNOWLEDGEMENT I acknowledge the support of my supervisors Dr. Mwangi Henry and Mrs. Rachael Kibuku, colleagues, and other lecturers for their unwavering support and immense contribution and guidance. My family and closest friends whose help and emotional support has seen me through my lowest moments. And above all God, the creator, giver of all that is good for seeing me through this process. iv TABLE OF CONTENTS DECLARATION ............................................................................................................................................... ii ABSTRACT ..................................................................................................................................................... iii ACKNOWLEDGEMENT .................................................................................................................................. iv TABLE OF CONTENTS ..................................................................................................................................... v DEDICATION ................................................................................................................................................ vii LIST OF TABLES ........................................................................................................................................... viii LIST OF FIGURES ........................................................................................................................................... ix ACRONYMS AND ABBREVIATIONS ................................................................................................................ x OPERATIONAL DEFINITION OF TERMS ......................................................................................................... xi CHAPTER ONE ............................................................................................................................................... 1 INTRODUCTION ............................................................................................................................................. 1 1.1 Background of the Study ..................................................................................................................... 1 1.2 Statement of the problem .................................................................................................................. 6 1.3 Purpose of the Study ........................................................................................................................... 9 1.4 Research Objectives .......................................................................................................................... 10 1.5 Research questions ........................................................................................................................... 10 1.6 Study significance .............................................................................................................................. 11 1.7 Motivation ......................................................................................................................................... 12 1.8 Justification of the study ................................................................................................................... 12 1.9 Scope of the Study ............................................................................................................................ 13 CHAPTER TWO ............................................................................................................................................ 15 LITERATURE REVIEW ................................................................................................................................... 15 2.1 Introduction ...................................................................................................................................... 15 2.2 Theoretical Review ............................................................................................................................ 15 2.3 Empirical Review ............................................................................................................................... 16 2.4 Related Work .................................................................................................................................... 18 2.5 Gaps in Literature .............................................................................................................................. 28 2.6 Conceptual Framework ..................................................................................................................... 29 2.7 Operationalization of variables ......................................................................................................... 30 CHAPTER THREE .......................................................................................................................................... 31 RESEARCH METHODOLOGY ........................................................................................................................ 31 v 3.1 Introduction ...................................................................................................................................... 31 3.2 Research Design ................................................................................................................................ 31 3.3 Target Population.............................................................................................................................. 38 3.4 Sampling and Sampling procedure ................................................................................................... 39 3.5 Available PLHIV Data ......................................................................................................................... 41 3.6 Data Mining Process ......................................................................................................................... 49 CHAPTER FOUR ........................................................................................................................................... 58 RESEARCH FINDINGS AND DISCUSSIONS .................................................................................................... 58 4.1 Introduction ...................................................................................................................................... 58 4.2 Results and findings .......................................................................................................................... 58 4.3 Discussion of Results ......................................................................................................................... 69 CHAPTER FIVE ............................................................................................................................................. 80 SUMMARY, CONCLUSIONS AND RECOMMENDATIONS ............................................................................. 80 5.1 Introduction ...................................................................................................................................... 80 5.2 Summary ........................................................................................................................................... 80 5.3 Conclusions ....................................................................................................................................... 81 5.4 Recommendations ............................................................................................................................ 81 5.5 Contribution to knowledge ......................................................................................................... 82 REFERENCES ................................................................................................................................................ 83 APPENDICIES ............................................................................................................................................... 86 APPENDIX I: FIGURE A1 - Uganda Daily Activity Register (DAR) ............................................................. 86 APPENDIX II: FIGURE B1 - Kenya Daily Activity Register (DAR) ............................................................... 87 APPENDIX III: FIGURE C1 - Harmonized inter-facility referral form ........................................................ 88 vi DEDICATION This dissertation work is dedicated to my future wife Patience Wakesho, who has been a constant source of support and encouragement during the challenges of school and life. I am truly thankful for having you in my life. This work is also dedicated to my parents, Pamella Juma and John Juma, who have always loved me unconditionally and whose good examples have taught me to work hard for the things that I aspire to achieve. vii LIST OF TABLES TABLE 1 Demographics comparison for Kenya and Uganda ...................................................................... 3 TABLE 2 Design Science Principles and Guidelines ................................................................................. 33 TABLE 3 Target Population ....................................................................................................................... 38 TABLE 4 Sample Size ................................................................................................................................ 41 TABLE 7 Selected Factors Motivating PLHIVs to Default ARV Drugs ................................................... 59 TABLE 8 Data Mining and data Analytics tool selection comparison matrix ........................................... 53 viii LIST OF FIGURES FIGURE 1 Data mining models and tasks .................................................................................................... 5 FIGURE 2 Proximity to referral facility and across-borders ........................................................................ 8 FIGURE 3 Land cross-border learning site ................................................................................................ 14 FIGURE 4 Design Science Process ............................................................................................................ 32 FIGURE 5 Three cycles of Design Science ................................................................................................ 34 FIGURE 6 User interface design cycle ....................................................................................................... 36 FIGURE 7 Berry and Linnof’s Data Mining Methodology ........................................................................ 37 FIGURE 8 Measure Evaluation Data on cross-border sites (July, 2017) ................................................... 40 FIGURE 9 Facility Client Profile Form ...................................................................................................... 61 FIGURE 10 Kenya - Mobilization, Testing, Enrolment, Care, and Treatment and follow up ................... 44 FIGURE 11 Uganda - Mobilization, Testing, Enrolment, Care, and Treatment and follow up ................. 45 FIGURE 12 Proposed Tool for predicting LTFUs ..................................................................................... 46 FIGURE 13 Current HIV Algorithm (Kenya/Uganda) ............................................................................... 47 FIGURE 14 Loss-To-Follow-Up Prototype Design ................................................................................... 48 FIGURE 15 User Interface Development ................................................................................................... 66 FIGURE 16 Master Facility List and Facility Profile form ........................................................................ 67 FIGURE 17 Daily Activity Register ........................................................................................................... 68 FIGURE 18 Findings of the Integrated Health Service Outreach by CB-HIPP ......................................... 42 FIGURE 19 Highlights from the IHSO ...................................................................................................... 43 FIGURE 20 Busia County Referral Hospital Dataset - Kenya ................................................................... 50 FIGURE 21 Busia Health Centre IV Dataset - Uganda .............................................................................. 50 FIGURE 22 Fixing problems with the data ................................................................................................ 51 FIGURE 23 Data Transformation ............................................................................................................... 52 FIGURE 24 LTFU Learner and Predictor designed and developed ........................................................... 54 FIGURE 25 Color Manager Node demonstration LTFU categorization .................................................... 57 FIGURE 26 Classified data (Decision Tree Predictor - apply decision) .................................................... 69 FIGURE 27 Decision Tree .......................................................................................................................... 70 FIGURE 28 Decision Trees Evaluation Results ......................................................................................... 74 FIGURE 29 PART Rule Evaluation Results .............................................................................................. 75 FIGURE 30 Naive Bayes Evaluation Results ............................................................................................. 76 FIGURE 31 Scatter Plot of P (LTFU=yes) vs Viral load ........................................................................... 78 FIGURE 32 Scatter Plot of P (LTFU=yes) vs CD4 Count ......................................................................... 78 FIGURE 33 Scatter Plot of P (LTFU=yes) vs Window Period .................................................................. 78 FIGURE 34 Scatter Plot of P (LTFU=yes) vs Age in years ....................................................................... 78 FIGURE 35 Data captured for walk-in PLHIVs at Kenya and Uganda facilities ....................................... 65 FIGURE 36 ROC Curve - Area Under ROC ............................................................................................. 79 ix

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