3D printable Gel-inks for Tissue Engineering: Chemistry, Processing, and Applications PDF
Preview 3D printable Gel-inks for Tissue Engineering: Chemistry, Processing, and Applications
Gels Horizons: From Science to Smart Materials Anuj Kumar Stefan Ioan Voicu Vijay Kumar Thakur Editors 3D printable Gel-inks for Tissue Engineering Chemistry, Processing, and Applications Gels Horizons: From Science to Smart Materials SeriesEditor VijayKumarThakur,SchoolofAerospace,TransportandManufacturing, CranfieldUniversity,Cranfield,Bedfordshire,UK This series aims at providing a comprehensive collection of works on the recent advances and developments in the domain of Gels, particularly as applied to the various research fields of sciences and engineering disciplines. It covers a broad range of topics related to Gels ranging from Polymer Gels, Protein Gels, Self-HealingGels,ColloidalGels,Composites/NanocompositesGels,Organogels, Aerogels,Metallogels&HydrogelstoMicro/Nanogels.Theseriesprovidestimely anddetailedinformationonadvancedsynthesismethods,characterizationandtheir application in a broad range of interrelated fields such as chemistry, physics, polymer science & engineering, biomedical & biochemical engineering, chemical engineering, molecular biology, mechanical engineering and materials science & engineering. This Series accepts both edited and authored works, including textbooks, monographs,referenceworks,andprofessionalbooks.Thebooksinthisserieswill provide a deep insight into the state-of-art of Gels and serve researchers and professionals,practitioners,andstudentsalike. Moreinformationaboutthisseriesathttp://www.springer.com/series/15205 · · Anuj Kumar Stefan Ioan Voicu Vijay Kumar Thakur Editors 3D printable Gel-inks for Tissue Engineering Chemistry, Processing, and Applications Editors AnujKumar StefanIoanVoicu SchoolofChemicalEngineering FacultyofAppliedChemistry YeungnamUniversity andMaterialsScience Gyeongsan,Korea(Republicof) PolytechnicUniversityofBucharest Bucharest,Romania VijayKumarThakur BiorefiningandAdvancedMaterials Scotland’sRuralCollege Dumfries,UK ISSN2367-0061 ISSN2367-007X (electronic) GelsHorizons:FromSciencetoSmartMaterials ISBN978-981-16-4666-9 ISBN978-981-16-4667-6 (eBook) https://doi.org/10.1007/978-981-16-4667-6 ©TheEditor(s)(ifapplicable)andTheAuthor(s),underexclusivelicensetoSpringerNature SingaporePteLtd.2021 Thisworkissubjecttocopyright.AllrightsaresolelyandexclusivelylicensedbythePublisher,whether thewholeorpartofthematerialisconcerned,specificallytherightsoftranslation,reprinting,reuse ofillustrations,recitation,broadcasting,reproductiononmicrofilmsorinanyotherphysicalway,and transmissionorinformationstorageandretrieval,electronicadaptation,computersoftware,orbysimilar ordissimilarmethodologynowknownorhereafterdeveloped. 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The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore Preface Overthepastdecade,additivemanufacturingtechnologieshaveemergedasoneofthe mostwonderfulfabricationmethodsinthefieldoftissueengineeringandregenerative medicineduetotheirprecisecontroland3Dprintingofarchitecturesaspertissue- specificororgan-specificdemandsusingdigitalmodelsbasedonmedicalimaging data. Among them, extrusion-based three-dimensional (3D) printing/bioprinting is a commonly used technique in tissue engineering areas. Various gel-inks or bio- inks have been developed and utilized for 3D printing by including natural and syntheticpolymers,bioceramics,bioactiveglasses,andglass-ceramics.Significant research has been performed in this area, but several challenges are remaining to be overcome in terms of data imaging, additive manufacturing technique, and designofbiomaterial-inks(i.e.gel-inksorbio-inks)withtheirgoodprintabilityand post-printing shape fidelity, 3D printing of curved and complex architectures, etc. Therefore, it is very important to understand the significance of 3D printing tech- niques, especially in tissue engineering applications, where healthcare issues are majorconcernsforhumanbeings.Aconciseunderstandingandanoverviewofthe chemistryandprocessingofbiomaterialsand3Dprintingmethodsforvarioustissue engineeringapplicationsareprovidedinthisbookforthereaders.Valuableknowl- edgeisupdatedandorganizedaccordingtovariouscurrentstudiesworldwideinthe fieldoftissueengineering. This book provides an overview and discusses the chemistry, processing, and tissueengineeringapplicationsofthebiomaterialsthathavebeenusedforsynthe- sizing3D-printablegel-inks.Thisauthoritativebookprovidesthenecessaryfunda- mentals and background for researchers and research professionals who intend to workinthefieldof3Dbioprintingintissueengineering.In3Dbioprinting,thedesign anddevelopmentofthebiomaterial-inks/bio-inksisamajorchallengeinproviding a3Dmicroenvironmentspecificallytotheanatomicalandarchitecturaldemandof nativetissues.Therefore,themainpurposeofthisbookistoprovidethebasicchem- istryofthebiomaterials,theircurrentprocessingdevelopmentsandchallenges,and recentadvancementsintissue-specific3Dprinting/bioprinting.Thetopicscomprise mainly(1)biomaterialtypes,theirsynthesisand/ormodifications,andprocessingfor theparticular3Dprintingmethod,(2)characterizationmethodsbeforeprintingand v vi Preface post-printingaswellasinvitroandinvivoanalyses,and(3)theirapplicationsand usesinvarioustissueengineeringapplications.Thisbookservesasago-toreference on bioprinting and is ideal for students, researchers, and professionals, including thoseinacademia,government,themedicalindustry,andhealthcare. Chapter 1 provides the introduction to 3D printing technology for biomedical applications, describing the progress and development of printing technology to create organs or tissues including limitations. Chapter 2 presents the characteriza- tionofbio-inksfor3Dprintingapplicationsbyexplainingnumerouscharacterization methods.Chapter3discussesthe3Dprintingofhydrogelconstructstowardtargeted development in tissue engineering. Chapter 4 presents and discusses 3D-printable self-healingscaffoldsfortissueengineeringapplications.Chapter5focusesongel- inks for 3D printing in corneal tissue engineering applications. Chapter 6 intro- ducesthecurrentstateof3D-printablegel-inksutilizedforskinwoundtreatments, whereasChap.7presentsbiofunctionalinksfor3Dprintinginskintissueengineering applications. Chapter 8 explores the possibilities of using starch gels combined with different bioceramics for additive manufacturing and alternative fabrication methods for developing biomimetic implants for filling large bone defects, while Chap.9focusesonadditivemanufacturingofbioceramicscaffoldsforbonetissue engineeringapplicationsbyemphasizingstereolithographicprocessing.Chapter10 is concerned with 3D-printable gel-inks for microbes and microbial structures to study microbes and microbe-host interactions, biofilm formation, antibiotic resis- tance,andmicrobiomethrough3Dmodelingofmicrobesandinfectionsforunder- standingdiseasesinabroadersense.Chapter11describesthemethodsofpolysaccha- ridecrosslinking,specificallyfuturecrosslinkingmethodsofalginatehydrogelsfor 3Dprintingforbiomedicalapplications,includingtissueengineeringareas.Lastly, Chap. 12 discusses the future perspectives for gel-inks for 3D printing in tissue engineeringbyconsideringprecursorsandotherspecificchallenges. Atlast,butmostimportantly,wewouldliketothankandacknowledgetheauthors who contributed to this book. In addition, we thank all reviewers for giving their valuabletimetoprovidetheirreviewstimelytoimprovethequalityofthisbook. Gyeongsan,SouthKorea AnujKumar Bucharest,Romania StefanIoanVoicu Dumfries,UK VijayKumarThakur About This Book 1. Provides the background for 3D printing and tissue engineering and their challenges. 2. Providesthechemistry,functionalization,andprocessingofbiomaterials. 3. Describes the pre-printing and post-printing processes for biomaterials accordingtoparticular3Dprintingmethods. 4. Discussestheefficacyofgel-inksforvarioustissueengineeringapplications. 5. Discusses the futuristic perspective in terms of 3D, 4D, and 5D printing/bioprintingtechnology. vii Contents 1 Introduction to 3D Printing Technology for Biomedical Applications .................................................. 1 SatishKumar,RamarajuBendi,andVipinKumar 2 CharacterizationofBioinksfor3DBioprinting .................. 27 SayandeepSahaandPallabDatta 3 3D Printing of Hydrogel Constructs Toward Targeted DevelopmentinTissueEngineering ............................. 79 AlexandraI.Cernencu 4 Three-Dimensional Self-healing Scaffolds for Tissue EngineeringApplications ...................................... 129 DurgalakshmiDhinasekaran,MohanrajJagannathan,andAnujKumar 5 Gel-Inksfor3DPrintinginCornealTissueEngineering .......... 161 SongulUlag,SumeyyeCesur,EcemDogan,MustafaSengor, NazmiEkren,CemBulentUstundag,andOguzhanGunduz 6 ThreeDimensional(3D)PrintableGel-InksforSkinTissue Regeneration ................................................. 191 SiminNazarnezhad, SaraHooshmand, FrancescoBaino, andSaeidKargozar 7 BiofunctionalInksfor3DPrintinginSkinTissueEngineering ..... 229 ElifIlhan, EsmaAhlatciogluOzerol, SaadetAlpdagtas, MustafaSengor,CemBulentUstundag,andOguzhanGunduz 8 Bioceramic-StarchPasteDesignforAdditiveManufacturing andAlternativeFabricationMethodsAppliedforDeveloping BiomedicalScaffolds .......................................... 261 AndreeaMaidaniucandFlorinMiculescu ix x Contents 9 AdditiveManufacturingofBioceramicScaffoldsforBone TissueRegenerationwithEmphasisonStereolithographic Processing .................................................... 297 FrancescoBaino,ElisaFiume,GiuliaMagnaterra,andEnricaVerné 10 3DPrintableGel-InksforMicrobesandMicrobialStructures ..... 333 EcemSaygiliandMohamedS.Draz 11 MethodsofPolysaccharidesCrosslinking:Future-Promising Crosslinking Techniques of Alginate Hydrogels for 3D PrintinginBiomedicalApplications ............................. 355 RefatM.Hassan(El-Moushy) 12 FuturePerspectivesforGel-Inksfor3DPrintinginTissue Engineering .................................................. 383 AnujKumar,VijayKumarThakur,andStefanIoanVoicu
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