20th Anniversary Meeting Society for research on Biological rhythms Program and Abstracts

272 Pages·2008·1.47 MB·English

20th Anniversary Meeting
Society for research on Biological rhythms
Program and Abstracts
SrBr
May 17–21, 2008
Sandestin Golf and Beach Resort
Destin, Florida
Society for reSearch on Biological rhythmS i
executive committee animal issues committee trainee professional
development day
Martha Gillette, Ph.D., President Larry Morin, Ph.D., Chair
organizing committee
University of Illinois at Stony Brook University
Urbana-Champaign Eric Bittman, Ph.D. Kenneth P. Wright Jr.,
Joseph Takahashi, Ph.D., President-elect University of Massachusetts Ph.D., Chair
Northwestern University University of Colorado at Boulder
Lance Kriegsfeld, Ph.D.
Amita Sehgal, Ph.D., Treasurer University of California–Berkeley Nicolas Cermakian, Ph.D.
University of Pennsylvania McGill University
Laura Smale, Ph.D.
David Weaver, Ph.D., Secretary Michigan State University Marian Comas
University of Massachusetts Medical University of Groningen
chronohistory committee
School Stephanie Crowley
members-at-large Anna Wirz-Justice, Ph.D., Chair Brown University
University of Basel Elizabeth B. Klerman, M.D., Ph.D.
Charlotte Helfrich-Foerster, Ph.D. Josephine Arendt, Ph.D. Harvard Medical School
University of Regensburg
University of Surrey Luciano Marpegan, Ph.D.
Martha Merrow, Ph.D. Eric Bittman, Ph.D. Washington University
University of Groningen
University of Massachusetts Michael J. Muskus
Ignacio Provencio, Ph.D. Serge Daan, Ph.D. University of Missouri–
University of Virginia University of Groningen Kansas City
ex-officio members Patricia DeCoursey, Ph.D. Ozgur Tataroglu
University of South Carolina Heidelberg University
Lawrence Morin, Ph.D., Comptroller
Stony Brook University Jeffrey Hall, Ph.D. David Weaver, Ph.D.
Brandeis University University of Massachusetts Medical
William J. Schwartz, M.D., School
Past President J. Woodland Hastings, Ph.D.
University of Massachusetts Medical Harvard University trainee research awards
School Elizabeth Klerman, M.D., Ph.D. committee
Martin Zatz, Ph.D., M.D., Editor Brigham & Women’s Hospital Kenneth Wright Jr.,
Journal of Biological Rhythms and Harvard Medical School Ph.D., Chair
program committee Michael Menaker, Ph.D. University of Colorado at Boulder
University of Virginia
Michael Antle, Ph.D.
Ravi Allada, M.D., Marty Zatz, M.D., Ph.D. University of Calgary
Program Chair Editor, Journal of Biological Rhythms
Justin Blau, Ph.D.
Northwestern University
communications committee New York University
Russel Van Gelder, M.D., Ph.D.
Nicolas Cermakian, Ph.D.
University of Washington Frank AJL Scheer, Ph.D.,
McGill University
Carla Green, Ph.D. Program Chair
University of Virginia Brigham and Women's Hospital, Deborah Bell-Pedersen, Ph.D.
Harvard Medical School Texas A&M University
Charalambos Kyriacou, Ph.D.
University of Leicester Janis Anderson, Ph.D. Susan Doyle, Ph.D.
Brigham and Women's Hospital, University of Virginia
Michael Nitabach, J.D., Ph.D.
Harvard Medical School Samer Hattar, Ph.D.
Yale University
Ralph Mistlberger, Ph.D. Johns Hopkins University
Shantha Rajaratnam, Ph.D.
Simon Fraser University David Welsh, Ph.D.
Monash University
Shelley A. Tischkau, Ph.D. University of California–
Fred Turek, Ph.D. Southern Illinois University School of San Diego
Northwestern University
Medicine Erik Herzog, Ph.D.
Hiroki Ueda, M.D., Ph.D. Washington University
nominating committee
RIKEN
Ralph Mistlberger, Ph.D.
Phyllis Zee, M.D., Ph.D. Rae Silver, Ph.D., Chair Simon Fraser University
Northwestern University Barnard College and
Shelley Tischkau, Ph.D.
Columbia University
facilities chair Southern Illinois University School of
Justin Blau, Ph.D. Medicine
Shelley Tischkau, Ph.D. New York University
Elizabeth Klerman, M.D., Ph.D.
Southern Illinois University
Elizabeth Klerman, M.D., Ph.D. Harvard Medical School
School of Medicine
Brigham & Women’s Hospital
and Harvard Medical School
ii SrBr 2008 program and aBStractS
Horacio de la Iglesia, Ph.D. Advisory Board Laura Smale
University of Washington Michigan State University
Timothy J. Bartness
Naomi Rogers, Ph.D. Georgia State University Joseph S. Takahashi
University of Sydney Northwestern University
Domien G.M. Beersma
David Weaver, Ph.D. University of Groningen David K. Welsh
University of Massachusetts Medical University of California–
Eric Bittman
School San Diego
University of Massachusetts–Amherst
Phyllis Zee, M.D., Ph.D. Russell N. Van Gelder
Vincent M. Cassone
Northwestern University University of Washington
Texas A&M University
School of Medicine
David R. Weaver
Horacio O. de la Iglesia
projectionists University of Washington University of Massachusetts Medical
School
Norman Atkins, Jr Marie Dumont
University of Illinois at Urbana- University of Montreal conference arrangements
Champaign Charmane Eastman
Ethan Buhr Rush Medical Center
Northwestern University Isaac Edery
Erin Evans Rutgers University
Brigham and Women's Hospital/ Russell Foster 302 East John St., Suite 202
University of Surrey University of Oxford Champaign, IL 61820
Phone: [phone]
Rhiannon Mear Jaga Giebultowicz E-mail: [email protected]
Simon Fraser University Oregon State University www.srbr.org
Roxanne Sterniczuk Martha Gillette
University of Calgary University of Illinois at
Ian Webb Urbana-Champaign
University of Western Ontario Michael Gorman
University of California–San Diego
Journal of Biological
rhythms Carla Green
University of Virginia
Martin Zatz, Ph.D., M.D., Editor
Erik Herzog
Associate Editors Washington University
Josephine Arendt John Hogenesch
University of Surrey University of Pennsylvania
School of Medicine
Paul Hardin
Texas A&M Helena Illnerova
Czech Academy of Sciences
Michael Hastings
MRC, Cambridge Carl Hirschie Johnson
Vanderbilt University
Sato Honma
Hokkaido University David Kennaway
School of Medicine University of Adelaide Medical School
William J. Schwartz Charalambos P. Kyriacou
University Massachesetts Medical University of Leicester
School Jennifer Loros
Dartmouth Medical School
Editorial Board
Ralph E. Mistlberger
Serge Daan
Simon Fraser University
University of Groningen
Larry Morin
Bruce Goldman
Stony Brook University
University of Connecticut
Hitoshi Okamura
Terry Page
Kyoto University
Vanderbilt University
Till Roenneberg
Ueli Schibler
Ludwig Maximilian University
University of Geneva
Rae Silver
Michael Terman
Columbia University
Columbia University
Society for reSearch on Biological rhythmS iii
Society for research on Biological rhythms
gratefully thanks our Sponsors
Supported in part by a grant from
iv SrBr 2008 program and aBStractS
table of contents
General Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .2
Headquarters
SRBR Information Desk and Message Center
Messages
Hotel Check-in
Posters
The Village of Baytowne Wharf
Special Events
Meeting at a Glance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .4
Trainee Professional Development Day . . . . . . . . . . . . . . . . . . . . . . . . . . . .6
Aaron Lerner Memorial Symposium . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .8
Program Overview . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .9
Poster Titles . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .20
Symposium Abstracts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .42
Slide Session Abstracts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .62
Poster Abstracts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .98
Index of Authors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .245
Participants . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .247
Notes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .261
Maps . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .267
Society for reSearch on Biological rhythmS 1
President’s Welcome our standing committees on Animal Issues, chaired
by Larry Morin; on ChronoHistory, chaired by Anna
The Society for Research on Biological Rhythms
Wirz-Justice; and on Communications, chaired by
first convened in May 1986 at Wild Dunes, South
Frank Scheer; as well as the Editorial Board of the
Carolina. After 20 years, we continue to fulfill
Journal of Biological Rhythms, chaired by Marty
founding President Fred Turek's vision of a vibrant
Zatz. Results of the election of the new SRBR board,
society and a long series of successful meetings. Our
coordinated by Rae Silver, chair of the Nominations
goal remains to bring together researchers and their
Committee, will be announced at the Business
research on all aspects of biological rhythms. We
Meeting on Wednesday. If you have ideas on ways
encourage the exchange of information and ideas
to enhance the activities of these arms of the society,
during the scheduled scientific sessions, as well as the
take the opportunity during the meeting to talk to
enlightenment that comes from discussions exposed
any member of these groups, which are listed in the
to the sun, sand, and sea breeze.
Program Book.
Welcome to the 11th Biennial Meeting! We are
Special thanks are due Michelle Chappell, Karen
the beneficiaries of months of planning and work
Nichols and Amy Hubbard at Conference &
by many people. Program Chair Ravi Allada and
Institutes of the University of Illinois, for their skill
his committee have put together an outstanding set
in organizing this event, coordinating with Sandestin
of scientific sessions, diverse in form and content.
and anticipating our needs, and ensuring that it all
Facilities Chair Shelley Tischkau choreographed the
holds together while it runs. We are deeply grateful
complex shifts of space through time. Ken Wright,
to our corporate and government sponsors for their
Jr. and his committee have organized and established
generous support. Their names are listed at the front
the first full SRBR Trainee Professional Development
of this book, and posted throughout Sandestin
Day and overseen trainee awards for research
Conference Center. Please take time to personally
accomplishment.
thank their representatives for their investment in the
Various sub-groups will meet while we are here. We SRBR.
have two satellite symposia, one honoring Aaron
Last, but by no means least, I extend my thanks to
Lerner’s discovery of melatonin, organized by Jo
each of you, the speakers, presenters, and participants.
Arendt and Al Lewy, and the other focused on
Your passion, originality, and engagement will ensure
the Systems Biology of Clocks, organized by John
success. Best wishes for a fulfilling meeting!
Hogenesch. The SRBR Biennial Meeting is an
Martha U. Gillette
opportunity for convening the Board of Directors,
President, SRBR, 2006–2008
general information
Headquarters is at the Baytowne Conference Center, where all scientific activities will be held. The
Conference Center is conveniently located within walking distance of all hotel rooms.
SRBR Information Desk and Message Center is in the Foyer of the Baytowne Conference
Center main level.
The desk hours are as follows:
Morning Afternoon
Friday, May 16 2:00–6:00 pm
Saturday, May 17 7:30–11:00 am 1:00–7:00 pm
Sunday, May 18 7:00–11:00 am 3:00–7:00 pm
Monday, May 19 7:30–11:00 am 3:00–6:00 pm
Tuesday, May 20 7:30–11:00 am 3:00–6:00 pm
Wednesday, May 21 7:30–10:00 am
2 SrBr 2008 program and aBStractS
Messages can be left on the SRBR message board next to the registration desk. Meeting participants are
asked to check the message board routinely for mail, notes, and telephone messages. The telephone number
for onsite information is 217-714-9479.
Hotel check-in will be at the individual properties.
Posters will be available for viewing in the Magnolia ABC rooms.
Poster numbers 1–100 Sunday, May 18, 10:00 am–10:30 pm
Poster numbers 101–200 Monday, May 19, 10:00 am–10:30 pm
Poster number 201–301 Tuesday, May 20, 10:00 am–10:30 pm
All posters must be removed by 10:00 am on Wednesday, May 21.
The Village of Baytowne Wharf—Indulge your senses at Sandestin’s charming Village of
Baytowne Wharf, a picturesque pedestrian village overlooking the Choctawatchee Bay. Discover a unique
collection of more than 40 specialty merchants ranging from quaint boutiques and intimate eateries to
lively nightclubs—all set up against a backdrop of vibrant special events.
Special Events
Saturday, may 17
Trainee Professional Development Symposium • 9:00 am–4:00 pm
Aaron Lerner Memorial Symposium • 2:00–5:00 pm
Welcome Reception • 7:00–9:00 pm • Grand Lawn
In case of inclement weather, the reception will be held in the Azalea Room.
monday, may 19
Executive Committee Meeting • 12:30–2:30 pm • Magnolia E
ChronoHistory Committee Meeting • 2:30–3:30 pm • Magnolia E
Presidential Symposium • 4:30–6:00 pm • Azalea Ballroom
tuesday, may 20
JBR Editors' Meeting • 2:00–4:00 pm • Magnolia D
Wednesday, may 21
Business Meeting • 4:00–5:00 pm • Azalea Ballroom
All attendees are invited to attend.
Pittendrigh/Aschoff Lecture: Ueli Schibler, University of Geneva • 5:30–6:30 pm • Azalea Ballroom
Closing Banquet • 8:00 pm • Magnolia ABC
All guests need to purchase a banquet ticket in advance at the registration desk.
Society for reSearch on Biological rhythmS 3
meeting at a glance
All events will take place in the Baytowne Conference Center.
Saturday, may 17-
9:00 am–4:00 pm Trainee Professional Development Symposium
2:00–5:00 pm Aaron Lerner Memorial Symposium
7:00–9:00 pm Welcome Reception • Grand Lawn
Sunday, may 18-
8:00–10:00 am Poster Setup • Magnolia ABC
8:30–10:30 am Symposium 1: Molecular Clocks 1• Azalea Ballroom
Symposium 2: Circadian Neural Networks • Camellia I & II
10:30–11:00 am Refreshment Break
11:00 am–12:30 pm Slide Sessions A–C
A) Molecular Clocks I • Azalea I & II
B) Feeding and Metabolism • Camellia I & II
C) Sleep • Azalea III
12:30–4:30 pm Free Time
4:30 pm–6:30 pm Symposium 3: Technological Advances in Circadian Biology • Azalea III
Symposium 4: Comparative Clocks • Azalea I & II
Symposium 5: Circadian and Homeostatic Regulation of Human Sleep • Camellia I
& II
8:00–10:30 pm Poster Session I • Magnolia ABC
monday, may 19-
8:30–10:30 am Symposium 6: Interplay between Circadian Clocks and Metabolism • Azalea
Ballroom
Symposium 7: Disordered Human Circadian Clocks • Camellia I & II
10:30–11:00 am Refreshment Break
11:00 am–12:30 pm Slide Session D–F
D) Light Signaling • Azalea III
E) Neuronal Networks • Azalea I & II
F) Peripheral Clocks I • Camellia I & II
12:30–2:30 pm Executive Committee Meeting • Magnolia E
2:30–3:30 pm ChronoHistory Committee Meeting • Magnolia E
4 SrBr 2008 program and aBStractS
12:30–4:30 pm Free Time
4:30–6:00 pm Presidential Symposium: Is It Time for a New View of Circadian Clocks? • Azalea
Ballroom
8:00 pm–10:30 pm Poster Session II • Magnolia ABC
tuesday, may 20-
8:30–10:30 am Symposium 8: Post-translational Regulation of Circadian Clocks • Azalea Ballroom
Symposium 9: Circadian Clocks and Sleep • Camellia I & II
10:30–11:00 am Refreshment Break
11:00 am–12:30 pm Slide Session G-I
G) Molecular Clocks II • Azalea I & II
H) Peripheral Clocks II • Camellia I & II
I) Human Clocks • Azalea III
12:30–4:30 pm Free Time
2:00–4:00 pm JBR Editors' Meeting • Magnolia D
4:30–6:30 pm Symposium 10: Non–image Forming Photoreception • Camellia I & II
Symposium 11: Systems Biology and Modeling of Circadian Rhythms • Azalea I & II
Symposium 12: Seasonal and Circannual Rhythms • Azalea III
8:00–10:30 pm Poster Session III • Magnolia ABC
Wednesday, may 21-
8:30–10:30 am Symposium 13: Interplay between Circadian and Social Behavior • Azalea I & II
Symposium 14: Clocks, Cell Cycle and Cancer • Azalea III
Symposium 15: Clocks, Brain Function, and Dysfunction • Camellia I & II
10:30–11:00 am Refreshment Break
11:00 am–12:30 pm Slide Session J–L
J) Systems Biology and Modeling • Azalea I & II
K) Entrainment and Photoreception • Azalea III
L) Neural Clocks and Output • Camellia I & II
12:30–4:00 pm Free Time
4:00–5:00 pm Business Meeting • Azalea Ballroom
5:30–6:30 pm Pittendrigh/Aschoff Lecture: Ueli Schibler, University of Geneva, The Mammalian
Circadian Timing System: From Gene Expression to Metabolism • Azalea Ballroom
8:00–11:00 pm Closing Banquet • Magnolia ABC
Society for reSearch on Biological rhythmS 5
trainee professional development day
Saturday, may 17-
9:00–9:15 am Welcome and Orientation • Magnolia A
9:30–10:30 am Keynote Address • Martha Merrow, University of Groningen
10:40–11:30 am Session 1
The Peer Review Process and How To Get Published • Magnolia B
Marty Zatz, Editor, Journal of Biological Rhythms
Grantsmanship USA—NIH • Magnolia C
Gary Pickard, Colorado State University, and Michael Selmanoff, National Institutes
of Health
Choosing Where To Post Doc(S): How This Affects Your Search for a Faculty
Position • Jasmine
Martha Gillette, University of Illinois at Urbana-Champaign, and Erik Herzog,
Washington University, St. Louis
Circadian Techniques—Hormone Assays • Camellia I
Josephine Arendt, University of Surrey
Circadian Techniques—Basics of Mathematical Modeling • Camellia II
Elizabeth Klerman, Harvard Medical School
11:40 am–12:30 pm Session 2
Grantsmanship USA—NSF • Magnolia B
Erik Herzog, Washington University
Grantsmanship—Europe • Magnolia C
Marie Currie Grant, Welcome Trust and Howard Cooper, University of Lyon
Developing and Maintaining Records of Research/Academic Performance and
Interview Skills and Giving a Job Talk • Jasmine
David Weaver, University of Massachusetts Medical Center, and Ken Wright,
University of Colorado at Boulder
Working Internationally Non-USA to USA • Camellia I
Horacio de la Iglesia, University of Washington and Naomi Rogers, University of
Sydney
Career Paths––Industry • Camellia II
Lauren Shearman, Merck Research Laboratories
12:30–1:45 pm Lunch • Magnolia A
6 SrBr 2008 program and aBStractS