A New AUGUST 2021 SCIENTIFICAMERICAN.COM Understanding of Alzheimer’s The Coolest Stars in the Universe The Hype about Hypersonic Weapons W HY ANIMALS PLAY The rules of the game for dogs, apes and elephants © 2021 Scientific American August 2021 VOLUME 325, NUMBER 2 48 ASTRONOMY NEUROSCIENCE 30 Not Quite Stars 56 The Stuttering Mind Brown dwarfs straddle the line Research on the genetic and neuro- between stars and planets, and logical origins of this speech disor- they might help solve mysteries der is pointing to new treatments. about both. By Katelyn Allers By Lydia Denworth NEUROLOGICAL DISEASE SECURITY 38 A New Understanding 64 Overhyped of Alzheimer’s Physics dictates that hypersonic Immune cells called microglia weapons cannot live up to the have become a promising target grand promises made on their for researchers studying the behalf. By David Wright and neurodegenerative disease. Cameron Tracy By Jason Ulrich and EPIDEMIOLOGY David M. Holtzman 72 The Year Flu QUANTUM COMPUTING Disappeared 44 Chemistry’s Public health measures meant Quantum Future to slow the spread of COVID-19 Quantum computers will bring essentially defeated influenza. molecular modeling to a new level By Katie Peek of accuracy, reducing researchers’ mages dependence on serendipity. 74 GTEhNeD WERo SrTlUdD’sI EFSirst AOnNim atl pHlaEy i sC noOt jVusEt Ra l eisurely pursuit. and magesGetty I 48 F BAWryNo hI JliMecyakA niAnLn gnBe thEitmoHe nMAaeVs.l IGspO ahPRryclsiaicayal fitness TIRifn eri Gsta eheanrarmsdc nhaC’ ntwl ybio,n etuheilnced Idbneess tatir tcuoeytnee tdfuo rbry yS oe lxdu a l Tssakuh micollhsue gatahnhse s efy uov nwaf dafilolilln orng wte hpeienrd egp td aoyaro sttuoiucnrcispgc,a esftnoeetrdrsg s,li a nitttog ei s rpa arilnlalisa clonitf iec ce—es and Gallo I and cognition. By Caitlin O’Connell the Nazis. By Brandy Schillace Pcohmotpoegtirnagp fho rb my attoeds—d ign uas staaffes eonnv.ironment. August 2021, ScientificAmerican.com 1 © 2021 scientific American 4 From the Editor 6 Letters 10 Science Agenda Laws that forbid gender-affirming health care for trans people are unscientific. By the Editors 12 Forum Pesticides are killing worms, beetles and other organisms that keep our soils healthy. By Nathan Donley and Tari Gunstone 14 Advances 10 Visualized letters pulled from the brain into text. Hidden history in imperfect diamonds. Grass that can clean a toxic explosive. The key to a potent mosquito repellent. 26 Meter A naturalist marries for science. By Jessy Randall 28 The Science of Health Fewer days on antibiotics may be as good as more. By Claudia Wallis 80 Recommended Why humans cooperate. How animals perceive the world. A novel of love and wolf research. 14 What if a pill could edit human consciousness? By Amy Brady 82 Observatory Why studies that can’t be confirmed often get more citations than studies that can be. By Naomi Oreskes 83 50, 100 & 150 Years Ago By Mark Fischetti 84 Graphic Science Bird counts reveal many rare species and few common ones. By Clara Moskowitz, Jen Christiansen and Liz Wahid 80 Scientific American (ISSN 0036-8733), Volume 325, Number 2, August 2021, published monthly by Scientific American, a division of Springer Nature America, Inc., 1 New York Plaza, Suite 4600, New York, N.Y. 10004-1562. Periodicals postage paid at New York, N.Y., and at additional mailing offices. Canada Post International Publications Mail (Canadian Distribution) Sales Agreement No. 40012504. Canadian BN No. 127387652RT; TVQ1218059275 TQ0001. Publication Mail Agreement #40012504. Return undeliverable mail to Scientific American, P.O. Box 819, Stn Main, Markham, ON L3P 8A2. I ndividual Subscription rates: 1 year $49.99 (USD), Canada $59.99 (USD), International $69.99 (USD). Institutional Subscription rates: Schools and Public Libraries: 1 year $84 (USD), Canada $89 (USD), International $96 (USD). Businesses and Colleges/Universities: 1 year $399 (USD), Canada $405 (USD), International $411 (USD). Postmaster: Send address changes to Scientific American, Box 3187, Harlan, Iowa 51537. R eprints inquiries: [email protected]. To request single copies or back issues, call (800) 333-1199. Subscription inquiries: U.S. and Canada (800) 333-1199; other (515) 248-7684. Send e-mail to [email protected]. Printed in U.S.A. Copyright © 2021 by Scientific American, a division of Springer Nature America, Inc. All rights reserved. Scientific American is part of Springer Nature, which owns or has commercial relations with thousands of scientific publications (many of them can be found at www.springernature.com/us). Scientific American maintains a strict policy of editorial independence in reporting developments in science to our readers. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. 2 Scientific American, August 2021 © 2021 scientific American FROM THE EDITOR Laura Helmuth i s editor in chief of S cientific American. Follow her on Twitter @laurahelmuth Serious Play der there are so many ways it can go wrong. Stuttering is one of the most common neurodevelopmental disorders, as Scientific American c ontributing editor Lydia Denworth writes, starting We hope our cover story t his month brings you as much joy read on page 56. It affects about 5 percent of children and 1 percent ing it as we have had producing it. The author, behavioral ecolo of adults. In the past few years scientists have identified many of gist Caitlin O’Connell, has what sounds like one of the best jobs on the brain regions and some of the genes involved, and they are Earth: observing elephants in the wild and making sense of their rolling out new treatments. behaviors. Some of the silliest behaviors turn out to be surprising It’s refreshing when people who have had a lot of success in ly meaningful. Young elephants play in their water holes much like their careers recognize the importance of luck. Chemist Jeannette human children play in swimming pools during summer break. M. Garcia was mixing ingredients in a lab when a reaction went They have toys and games and battles, with older relatives ready in an unexpected direction and she discovered a new family of to intervene if the play turns dangerous (p age 48) . Many social spe polymers. That’s a surprisingly common origin story for many cies, from meerkats to dogs to great apes, engage in ritualized play scientific advances, but now Garcia ( page 44) wants to reduce the to hone skills they’ll need as adults—and, from everything we can need for serendipity by using quantum computing to predict tell, for the joy of it. the chemically unpredictable. Stars and planets are just different ends of a size spectrum, with In our Science Agenda editorial this month (p age 10) , we show brown dwarfs in between, astronomer Katelyn Allers explains on that antitransgender laws are contrary to science as well as page 30. They can’t quite sustain fusion like a star does, so they’re cruel. The subject is in the news more than ever these days, but harder to see, but they emit enough light from heat that astrono transgender experience is not a fad or an invention. As author mers have recently realized they’re as abundant as stars in the uni Brandy Schillace writes on page 74, the first known transgender verse, and they’re bizarre. Depending on its age and size, a brown health clinic was established in 1919 in Berlin. It thrived until it dwarf might have an atmosphere containing titanium oxide or was destroyed by the Nazis and its library consumed by one of quartz. And Allers has figured out how to measure wind speed on the first Nazi book burnings. a brown dwarf (2,300 kilometers per hour). In our November 2020 issue, we ran a Graphic Science column Many of us have lost loved ones to Alzheimer’s and desperate revealing that the Southern Hemisphere’s flu season was the mild ly hope for a meaningful treatment. Recent research on immune est ever recorded, an early sign that the 2020–2021 flu season in the cells called microglia in the brain is leading to some new ap North might not be so bad. On page 72, datavisualization design proaches. Neurologists Jason Ulrich and David M. Holtzman er and S cientific American c ontributing artist Katie Peek follows ( page 38) describe how genetics, mouse models and patient stud up with a remarkable series of graphics depicting how flu basical ies point to a twophase progression of the disease. The story goes ly disappeared around the world during the C OVID pandemic. The into great detail to show exactly where this research stands, with coronavirus is more elusive than flu, in part because it can be spread hope but without hype. by those who have no symptoms and don’t know they’re infected. As neuroscientist SooEun Chang points out, “speech is one But if people wash their hands, wear masks in crowded indoor of the most complex motor behaviors we perform.” It’s no won areas and stay home if they’re sick, that can stop the flu cold. BOARD OF ADVISERS Robin E. Bell Jonathan Foley John Maeda Research Professor, Lamont-Doherty Earth Observatory, Executive Director, Project Drawdown Global Head, Computational Design + Inclusion, Automattic, Inc. Columbia University Jennifer A. Francis Satyajit Mayor Emery N. Brown Senior Scientist, Woods Hole Research Center Senior Professor, National Center for Biological Sciences, Edward Hood Taplin Professor of Medical Engineering Carlos Gershenson Tata Institute of Fundamental Research and of Computational Neuro science, M.I.T., Research Professor, National Autonomous University of Mexico John P. Moore and Warren M. Zapol Prof essor of Anesthesia, Harvard Medical School Professor of Microbiology and Immunology, Alison Gopnik Weill Medical College of Cornell University Vinton G. Cerf Professor of Psychology and Affiliate Professor Priyamvada Natarajan Chief Internet Evangelist, Google of Philosophy, University of California, Berkeley Professor of Astronomy and Physics, Yale University Emmanuelle Charpentier Lene Vestergaard Hau Donna J. Nelson Scientific Director, Max Planck Institute for Infection Biology, Mallinckrodt Professor of Physics and of Applied Physics, Professor of Chemistry, University of Oklahoma and Founding and Acting Director, Max Planck Unit for the Harvard University Lisa Randall Science of Pathogens Hopi E. Hoekstra Professor of Physics, Harvard University Rita Colwell Alexander Agassiz Professor of Zoology, Harvard University Martin Rees Distinguished University Professor, University of Maryland College Park Astronomer Royal and Professor of Cosmology and Astrophysics, and Johns Hopkins Bloomberg School of Public Health Ayana Elizabeth Johnson Institute of Astronomy, University of Cambridge Kate Crawford Founder and CEO, Ocean Collectiv Daniela Rus Director of Research and Co-founder, AI Now Institute, Christof Koch Andrew (1956) and Erna Viterbi Professor of Electrical Engineering and Distinguished Research Professor, New York University, Chief Scientist, MindScope Program, Allen Institute for Brain Science and Computer Science and Director, CSAIL, M.I.T. and Principal Researcher, Microsoft Research New York City Meg Lowman Meg Urry Nita A. Farahany Director and Founder, TREE Foundation, Rachel Carson Fellow, Israel Munson Professor of Physics and Astronomy, Yale University Professor of Law and Philosophy, Director, Ludwig Maximilian University Munich, and Research Professor, Amie Wilkinson Duke Initiative for Science & Society, Duke University University of Science Malaysia Professor of Mathematics, University of Chicago 4 Scientific American, August 2021 Illustration by Nick Higgins © 2021 Scientific American LETTERS [email protected] “ I haven’t lost my love of the sciences and mathematics. Your magazine provides me with the joy I used to feel but without the heartache.” tracie s. johnson v ia e-mail HOUSTON-EDWARDS REPLIES: In re- ical feedstocks, shipping and aviation. sponse to Rosenblatt: In percolation theory, Keeping warming within the 1.5 de- a “dial” controls the local connectivity of a grees Celsius limit necessary to avoid cat- network. When its needle lands on a critical astrophic climate destabilization requires point, a phase transition occurs, and the us to reach net-zero emissions, meaning global connectivity of the network changes we must leave the majority of the world’s dramatically. To apply the theory to LQG, existing gas reserves unburned. And one needs to describe how and why this dial whether methane is synthetic, biogenic or April 2021 moves to the critical point. But as theoreti- fracked, if it’s pumped through the exist- cal physicist Lee Smolin explained in an e- ing distribution network, it will face leak- mail to S cientific American, n ature exhib- age, adding to atmospheric warming. PERCOLATION INSPIRATION its several instances of “self-organized crit- Perhaps the most important omission It was an absolute delight to read about ical phenomena,” in which the dial tunes is that decarbonizing gas does not solve percolation theory in “The Math of Making itself toward the critical threshold. Smolin the health impacts of combustion. With Connections,” by Kelsey Houston-Edwards. hypothesizes that such a self-organized low-carbon gases, we only get more ex- Please feature more articles by this author phase transition might explain “the emer- pensive ways of polluting our homes. and about mathematics as applied to sci- gence of classical spacetime in a quantum Sasan Saadat ence. I’m not a mathematician, yet I enjoy theory of gravity,” including loop quantum Research and policy analyst, Earthjustice learning about theory and application. I gravity. He and physicist Mohammad An- love the expanse of disciplines you cover. sari explored these ideas in the 2008 paper WEBBER REPLIES: I t seems that we agree I am an African-American woman with “Self-Organized Criticality in Quantum that addressing climate change is the most a biology degree. I used to work as a re- Gravity.” It is unclear how extensively a urgent and important challenge of the 21st search assistant in cancer research. That “self-tuning” version of percolation could be century. That realization led me to the con- was until the racism that I consistently en- used for understanding a self-organized clusion that we need every solution possi- countered wore me down, and I just phase transition in the case of LQG. ble to get us to carbon neutrality (and car- didn’t want to ever work with scientists bon negativity!) as quickly, safely and again. Although I am in another line of CLIMATE PRIORITY affordably as possible. As I write in the ar- work, I haven’t lost my love of the sciences I was troubled by “What to Do about Nat- ticle, I think the first two priorities for de- and mathematics. Your magazine pro- ural Gas,” Michael E. Webber’s article carbonizing the economy are (1) conserva- vides me with the joy I used to feel but about ways to decarbonize the natural gas tion and efficiency and (2) electrification. without the heartache. system. Pointing out that the primary al- Because low-carbon fuels play an impor- Tracie S. Johnson via e-mail ternative, electrification, will be challeng- tant role for sectors that are difficult to elec- ing is fair enough. But electrification does trify, we need to make progress on decar- One approach to developing a theory of not have barriers that are greater than, or bonizing gases as the third step. quantum gravity is called loop quantum even equal to, a zero-carbon gas system, As someone who invented sensors to gravity (LQG). It treats space as a discrete which faces structural limitations. To his measure the emissions from combustion, substance composed of individual spatial credit, Webber names some of these limi- I’m well aware of its pollution. And as atoms, or nodes, at the Planck distance tations. But his presentation of them someone who quantitatively analyzes dif- scale of 10−35 meter. They are connected to as solvable with some tweaks is disingenu- ferent forms of energy, I’m also aware of one another in a way that would seem to ous. Even by the gas industry’s own esti- the significant ecosystem impacts of some lend itself very well to percolation theory, mates, two decades of scaling up all low- utility-scale renewables. The energy sys- which is precisely geared toward modeling carbon gases would displace only about 13 tem is all about trade-offs, and there is no the connections among discrete nodes. Has percent of the U.S.’s existing gas demand. one fuel or technology option that is pure- percolation been applied to advancing LQG Also, it would squander any genuinely sus- ly villainous or virtuous. Rather we must and quantum gravity? tainable gases that could be used where we design a suite of solutions that meets soci- Edward Rosenblatt v ia e-mail might actually need them, such as chem - ety’s complex needs. 6 Scientific American, August 2021 © 2021 Scientific American ESTABLISHED 1845 EDITOR IN CHIEF Laura Helmuth PREDICTIONS AND MANAGING EDITOR Curtis Brainard COPY DIRECTOR Maria-Christina Keller CREATIVE DIRECTOR Michael Mrak EDITORIAL MEMORY LOSS CHIEF FEATURES EDITOR Seth Fletcher CHIEF NEWS EDITOR Dean Visser CHIEF OPINION EDITOR Michael D. Lemonick In “Prediction Predicament” [Advances], FEATURES Hannah Seo notes that making predictions SENIOR EDITOR, SUSTAINABILITY Mark Fischetti SENIOR EDITOR, SCIENCE AND SOCIETY Madhusree Mukerjee SENIOR EDITOR, MEDICINE / SCIENCE POLICY Josh Fischman SENIOR EDITOR, TECHNOLOGY / MIND Jen Schwartz impairs people’s ability to remember pre- SENIOR EDITOR, SPACE / PHYSICS Clara Moskowitz SENIOR EDITOR, EVOLUTION / ECOLOGY Kate Wong dictive events. I see this a lot in the mar- NEWS SENIOR EDITOR, MIND / BRAIN Gary Stix ASSOCIATE EDITOR, TECHNOLOGY Sophie Bushwick tial arts. Often when an instructor demon- SENIOR EDITOR, SPACE / PHYSICS Lee Billings ASSOCIATE EDITOR, SUSTAINABILITY Andrea Thompson SENIOR EDITOR, HEALTH AND MEDICINE Tanya Lewis ASSISTANT NEWS EDITOR Sarah Lewin Frasier strates a technique, the students will be MULTIMEDIA busy imagining what comes next and how SENIOR EDITOR, MULTIMEDIA Jeffery DelViscio SENIOR EDITOR, AUDIENCE ENGAGEMENT Sunya Bhutta SENIOR EDITOR, COLLECTIONS Andrea Gawrylewski they think the technique should be per- ART formed while failing to see the variation ART DIRECTOR Jason Mischka SENIOR GRAPHICS EDITOR Jen Christiansen PHOTOGRAPHY EDITOR Monica Bradley ART DIRECTOR, ONLINE Ryan Reid that the instructor is demonstrating. It’s ASSOCIATE GRAPHICS EDITOR Amanda Montañez ASSOCIATE PHOTO EDITOR Liz Tormes like the students are watching to confirm COPY AND PRODUCTION their predictions instead of observing to SENIOR COPY EDITORS Angelique Rondeau, Aaron Shattuck MANAGING PRODUCTION EDITOR Richard Hunt PREPRESS AND QUALITY MANAGER Silvia De Santis learn something new. CONTRIBUTORS Ian McIntyre v ia e-mail EDITORS EMERITI Mariette DiChristina, John Rennie EDITORIAL Gareth Cook, Katherine Harmon Courage, Lydia Denworth, Ferris Jabr, Anna Kuchment, Robin Lloyd, Steve Mirsky, RECOVERING FROM ADDICTION Melinda Wenner Moyer, George Musser, Ricki L. Rusting, Dava Sobel, Claudia Wallis “Hope for Meth Addiction,” by Claudia ART Edward Bell, Zoë Christie, Lawrence R. Gendron, Nick Higgins, Katie Peek, Beatrix Mahd Soltani Wallis [Science of Health], encouragingly EDITORIAL ADMINISTRATOR Ericka Skirpan EXECUTIVE ASSISTANT SUPERVISOR Maya Harty describes the growing evidence base for contingency management as an effective SCIENTIFIC AMERICAN CUSTOM MEDIA treatment for stimulant use disorder, par- MANAGING EDITOR Cliff Ransom CREATIVE DIRECTOR Wojtek Urbanek MULTIMEDIA EDITOR Kris Fatsy MULTIMEDIA EDITOR Ben Gershman ticularly in conjunction with bupropion ENGAGEMENT EDITOR Dharmesh Patel ACCOUNT MANAGER Samantha Lubey and naltrexone. It notes that one trial of ACTING PRESIDENT the two drugs found that they helped a sig- Stephen Pincock nificant number of treated users test meth- EXECUTIVE VICE PRESIDENT Michael Florek VICE PRESIDENT, COMMERCIAL Andrew Douglas amphetamine-free “at least three quarters PUBLISHER AND VICE PRESIDENT Jeremy A. Abbate of the time.” CLIENT MARKETING SOLUTIONS MARKETING DIRECTOR, INSTITUTIONAL PARTNERSHIPS AND CUSTOMER DEVELOPMENT Jessica Cole Wallis’s piece is to be applauded for its PROGRAMMATIC PRODUCT MANAGER Zoya Lysak DIRECTOR, INTEGRATED MEDIA Matt Bondlow apparent recognition that complete absti- BUSINESS DEVELOPMENT Stan Schmidt nence is not the only recovery pathway. HEAD, PUBLISHING STRATEGY Suzanne Fromm Harm reduction is effective, and reoccur- CONSUMER MARKETING & PRODUCT DEVELOPMENT TEAM LEAD Raja Abdulhaq rence of substance use is not unusual for SENIOR MARKETING MANAGER Christopher Monello PRODUCT MANAGERS Ian Kelly, John Murren most people as they seek recovery. While SENIOR WEB PRODUCER Jessica Ramirez abstinence-based approaches may be SENIOR COMMERCIAL OPERATIONS COORDINATOR Christine Kaelin MARKETING & CUSTOMER SERVICE ASSISTANT Justin Camera ideal for some, they don’t work for every- ANCILLARY PRODUCTS one. Contingency management and harm ASSOCIATE VICE PRESIDENT, BUSINESS DEVELOPMENT Diane McGarvey CUSTOM PUBLISHING EDITOR Lisa Pallatroni reduction are both important strategies CORPORATE that can lead to improved health and well- HEAD, COMMUNICATIONS, USA Rachel Scheer ness for those who are still struggling with PRESS MANAGER Sarah Hausman harmful substance use. PRINT PRODUCTION PRODUCTION CONTROLLER Madelyn Keyes-Milch ADVERTISING PRODUCTION CONTROLLER Dan Chen Ann Herbst I nterim CEO, Young People in Recovery LETTERS TO THE EDITOR Scientific American, 1 New York Plaza, Suite 4600, New York, NY 10004-1562 or [email protected] ERRATA Letters may be edited for length and clarity. We regret that we cannot answer each one. In “The Math of Making Connections,” by Join the conversation online—visit Scientific American on Facebook and Twitter. Kelsey Houston-Edwards, the bottom il- HOW TO CONTACT US Subscriptions Reprints Permissions lustration in the box “Square Lattice” For new subscriptions, renewals, gifts, To order bulk reprints of articles (minimum For permission to copy or reuse material: should have depicted the white pipe at the payments, and changes of address: of 1,000 copies): [email protected]. Permissions Department, Scientific U.S. and Canada, 800-333-1199; American, 1 New York Plaza, Suite 4600, top left of the lattice filling with water. outside North America, 515-248-7684 or Reprint Department, New York, NY 10004-1562; [email protected]; Scientific American, In “Scientists: Admit You Have Values,” [email protected] www.ScientificAmerican.com/permissions. 1 New York Plaza, Please allow six to eight weeks for processing. by Naomi Oreskes [Observatory], the end Submissions Suite 4600, To submit article proposals, follow the Advertising of the quote attributed to Francis Bacon guidelines at www.ScientificAmerican.com. New York, NY www.ScientificAmerican.com has electronic should have read: “... man prefers to be- Click on “Contact Us.” 10004-1562; contact information for sales representatives We cannot return and are not responsible 212-451-8415. of Scientific American in all regions of lieve what he wants to be true.” for materials delivered to our office. For single copies of back issues: 800-333-1199. the U.S. and in other countries. August 2021, ScientificAmerican.com 7 © 2021 Scientific American