2016 Bat SARS-like coronavirus WIV1 encodes an extra accessory protein ORFX involved in modulation of host immune respon

41 Pages·2016·2.17 MB·English

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Bat SARS-like coronavirus WIV1 encodes an extra accessory protein ORFX
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involved in modulation of host immune response
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Lei-Ping Zeng 1, Yu-Tao Gao 1, Xing-Yi Ge 1, Qian Zhang1, Cheng Peng 1, Xing-Lou
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Yang 1, Bing Tan 1, Jing Chen 1, Aleksei A. Chmura 2, Peter Daszak 2, Zheng-Li Shi1*
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1 Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Chinese
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Academy of Sciences, Wuhan, 430071, China;
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2 EcoHealth Alliance, 460 West 34th Street, New York, NY10001, USA
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Running title: SL-CoV ORFX
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Keywords: SARS-like coronavirus, ORFX, reverse genetics, interferon antagonist,
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NF-κB activation
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Word counts: 4823 for main text; 174 for abstract
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* Correspondence: Zheng-Li Shi: