2015 Targeting zoonotic viruses_ Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4_The likely

31 Pages·2015·0.83 MB·English

Accepted Manuscript

Targeting zoonotic viruses: structure-based inhibition of the 3C-like protease
from bat coronavirus HKU4 – the likely reservoir host to the human coronavirus
that causes Middle East Respiratory Syndrome (MERS)

Sarah E. St. John, Sakshi Tomar, Shaun R. Stauffer, Andrew D. Mesecar

PII:
S0968-0896(15)00533-7
DOI:
http://dx.doi.org/10.1016/j.bmc.2015.06.039

Reference:
BMC 12395

To appear in:
Bioorganic & Medicinal Chemistry

Received Date:
16 April 2015
Revised Date:
2 June 2015
Accepted Date:
10 June 2015

Please cite this article as: St. John, S.E., Tomar, S., Stauffer, S.R., Mesecar, A.D., Targeting zoonotic viruses:
structure-based inhibition of the 3C-like protease from bat coronavirus HKU4 – the likely reservoir host to the
human coronavirus that causes Middle East Respiratory Syndrome (MERS), Bioorganic & Medicinal Chemistry
(2015), doi: http://dx.doi.org/10.1016/j.bmc.2015.06.039

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Targeting zoonotic viruses: structure-based inhibition of the 3C-like protease
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from bat coronavirus HKU4 – the likely reservoir host to the human coronavirus
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that causes Middle East Respiratory Syndrome (MERS).
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Sarah E. St. John,

1,2,3 Sakshi Tomar,

1,3 Shaun R. Stauffer,

4 and Andrew D. Mesecar

1,2,3*
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1Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA
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2Department of Chemistry, Purdue University, West Lafayette, Indiana, USA
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3Centers for Cancer Research & Drug Discovery, Purdue University, West Lafayette, Indiana, USA
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4Department of Pharmacology, Department of Chemistry, Vanderbilt University Medical Center,
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Nashville, Tennessee, USA
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*Corresponding Author’s Contact Information:
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Andrew D. Mesecar, Ph.D.
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Professor, Departments of Biological Sciences and Chemistry
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Purdue University
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915 West State Street
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West Lafayette, Indiana 47907
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Ph: 765-494-1924
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Email: