2013 Evolutionary dynamics of bovine coronaviruses_ natural selection pattern of the spike gene implies adaptive evoluti

43 Pages·2013·3.13 MB·English

1

Evolutionary dynamics of bovine coronaviruses: Natural selection
1

pattern of the spike gene implies adaptive evolution of the strains
2

3

running title: Evolution of Betacoronavirus1
4

5

Contents: Title page (P:1), ABSTRACT (P:2), INTRODUCTION (P:3), RESULTS (P:6),
6

DISCUSSION (P:12), MATERIALS AND METHODS (P:18), ACKNOWLDGEMENTS
7

(P:23), REFERENCES (P:24) and LEGENDS OF FIGURES (P:34)
8

9

Mehdi R M Bidokhti1†, Madeleine Tråvén1, Neel K Krishna2, Muhammad Munir3,4,
10

Sándor Belák3,4, Stefan Alenius1, Martí Cortey5
11

12

1Division of Ruminant Medicine and Veterinary Epidemiology, Department of Clinical Sciences,
13

Swedish University of Agricultural Sciences, Box 7054, SE-750 07 Uppsala, Sweden
14

2Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, 700
15

West Olney Road, Norfolk, Virginia 23507-1696, USA
16

3Department of Virology, Immunobiology and Parasitology, National Veterinary Institute, Box
17

7028, SE-751 89 Uppsala, Sweden
18

4Department of Biomedical Sciences and Veterinary Public Health , Swedish University of
19

Agricultural Sciences, SE-750 07 Uppsala, Sweden
20

5Department of Immunology, The Pirbright Institute, Ash Road, Pirbright GU24 0NF, United
21

Kingdom
22

23

† Corresponding author. E-mail: