Staphylococcus aureus Infection and Disease INFECTIOUS AGENTS AND PATHOGENESIS Series Editors: Allen L. Honeyman and Herman Friedman, University of South Florida College of Medicine Mauro Bendinelli, University of Pisa Recent volumes in this series: DNA TUMOR VIRUSES Oncogenic Mechanisms Edited by Giuseppe Barbanti-Brodano, Mauro Bendinelli, and Herman Friedman ENTERIC INFECTIONS AND IMMUNITY Edited by LoisJ.Paradise, Mauro Bendinelli, and Herman Friedman HERPESVIRUSES AND IMMUNITY Edited by Peter G. Medveczky, Herman Friedman, and Mauro Bendinelli HUMAN RETROVIRAL INFECTIONS Immunological and Therapeutic Control Edited by Kenneth E. Ugen, Mauro Bendinelli, and Herman Friedman MICROORGANISMS AND AUTOIMMUNE DISEASES Edited by Herman Friedman, Noel R. Rose, and Mauro Bendinelli OPPORTUNISTIC INTRACELLULAR BACTERIA AND IMMUNITY Edited by Lois J. Paradise, Herman Friedman, and Mauro Bendinelli PSEUDOMONAS AERUGINOSA AS AN OPPORTUNISTIC PATHOGEN Edited by Mario Campa, Mauro Bendinelli, and Herman Friedman PULMONARY INFECTIONS AND IMMUNITY Edited by Herman Chmel, Mauro Bendinelli, and Herman Friedman RAPID DETECTION OF INFECTIOUS AGENTS Edited by Steven Specter, Mauro Bendinelli, and Herman Friedman RICKETTSIAL INFECTION AND IMMUNITY Edited by Burt Anderson, Herman Friedman, and Mauro Bendinelli STAPHYLOCOCCUSAUREUSINFECTION AND DISEASE Edited by Allen L. Honeyman, Herman Friedman, and Mauro Bendinelli A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher. Staphylococcus aureus Infection and Disease Edited by Allen L. Honeyman and Herman Friedman Universityof South FloridaCollegeof Medicine Tampa,Florida and Mauro Bendinelli University of Pisa Pisa, Italy Kluwer Academic Publishers New York, Boston, Dordrecht, London, Moscow eBookISBN: 0-306-46848-4 Print ISBN: 0-306-46591-4 '2002 Kluwer Academic Publishers New York, Boston, Dordrecht, London, Moscow All rights reserved No part of this eBook may be reproduced or transmitted in any form or by any means, electronic, mechanical, recording, or otherwise, without written consent from the Publisher Created in the United States of America Visit Kluwer Online at: http://www.kluweronline.com and Kluwer’s eBookstore at: http://www.ebooks.kluweronline.com Contributors . KENNETH W. BAYLE Department of Microbiology, Molecular Biology and Biochemi.stry, University of Idaho, Moscow, ID 83844-3052 ALISON A. BEHARKA Division of Biology, Kansas State University, and Department of Veterans Affairs, Division of Infectious Disease, University of Iowa, Iowa .City, IA 52246 GREGORY A. BOHACH Department of Microbiology, Molecular Biology and Biochem.istry, University of Idaho, Moscow, ID 83844-3052 STEPHEN K CHAPES Division of Biology, Kansas State University, Manhattan, KS 66506 . AMBROSE L. CHEUNG Department of Microbiology, Dartmouth Medical School, H.anover, NH 03755 PAULM. DUNMAN InfectiousDiseases,WyethA- yerstResearch,Pearl River, NY 10965 . CHRISTOF von EIFF Institute for Medical Microbiology, Westphalian .. Wilhelms Univ.ersity, Munster, Germany LARRY K FOX Department of Veterinary Clinical Medicine and Surgery, Washington.State University, Pullman, WA 99164 YOSHIYUKI KAMIO Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Jap.an JUN KANEKO Departmentof Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan . CHIA Y. LEE Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, KS 66160 v vi CONTRIBUTORS . JEAN C. LEE Department of Medicine, Channing Laboratory, , Brigham and Womens Hospital and Harvard Medical School, Boston, MA02115. GWEN LIU Department of Microbiology and Immunology, UCLA School of Medicine,University ofCalifornia, LosAngeles, LosAngeles, CA 90095 . SARKIS K. MAZMANIAN Department ofMicrobiology and Immunol- ogy, UCLA School ofMedicine, University ofCalifornia, Los Angeles, LosAngeles, CA.90095 CARLL.NELSON Department of Orthopaedic Surgery, Universityof Arkansas for Medical Scie.nces, Little Rock, AR 72205 VIJAYKUMAR PANCHOLI Bacterial Pathogenesis and Immunology, The Rockefeller.University, NewYork, NY10021 GEORG PETERS Institute for Medical Microbiology, Westphalian .. Wilhelms University, Mu.nster, Germany RICHARD A. PROCTOR Departments of Medicine and Medical Microbiology/Immunology, University of Wisconsin, Madison, WI 53706 . STEVEN J. PROJAN Antibacterial Research, WyethA-yerst Research, Pearl River, NY10965 . PATRICK M. SCHLIEVERT Department of Microbiology, University of Minnesota Medica.l School, Minneapolis, MN 55455 OLAF SCHNEEWIND Department ofMicrobiology and Immunology, UCLA School ofMedicine, University of California, Los Angeles, Los Angeles, CA 90095 . MARK S. SMELTZER Department of Microbiology and Immunology and Department of Orthopaedic Surgery, University of Arkansas for Medical Sciences, Little.Rock, AR 72205 GEORGE C. STEWART Department of Diagnostic Medicine/Patho- biology, College ofVeterinary Medicine, Kansas State University, Man- hattan, KS 66506. TOSHIO TOMITA Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, Sendai 981-8555, Japan . HUNG TON-THAT Department of Microbiology and Immunology, CONTRIBUTORS vii UCLA School ofMedicine, University ofCalifornia, LosAngeles, Los Angeles,CA90095 . ALBION D. WRIGHT Division of Biology, Kansas State University, Manhattan, KS 66506 . JEREMY M. YARWOOD Department of Microbiology, University of Minnesota Medica.l School, Minneapolis, MN 55455 SHUPING ZHANG Department of Diagnostic Medicine/Pathobiol- ogy, College ofVeterinaryMedicine, Kansas State University, Manhat- tan, KS 66506 This page intentionally left blank. Preface to the Series The mechanisms of disease production by infectious agents are presently the focus of an unprecedented flowering of studies. The field has undoubt- edly received impetus from the considerable advances recently made in the understanding of the structure, biochemistry, and biology of viruses, bacteria, fungi, and other parasites. Another contributing factor is our improved knowledge of immune responses and other adaptive or con- stitutive mechanisms by which hosts react to infection. Furthermore, recombinant DNA technology, monoclonal antibodies, and other newer methodologies have provided the technical tools for examining questions previously considered too complex to be successfully tackled. The most important incentive of all is probably the regenerated idea that infection might be the initiating event in many clinical entities presently classified as idiopathic or of uncertain origin. Infectious pathogenesis research holds great promise. As more infor- mation is uncovered, it is becoming increasingly apparent that our present knowledge of the pathogenic potential of infectious agents is often limited to the most noticeable effects, which sometimes represent only the tip of the iceberg. For example, it is now well appreciated that pathologic processes caused by infectious agents may emerge clinically after an incu- bation of decades and may result from genetic, immunologic, and other indirect routes more than from the infecting agent in itself. Thus, there is a general expectation that continued investigation will lead to the isolation of new agents of infection, the identification of hitherto unsuspected etio- logic correlations, and, eventually, more effective approaches to prevention and therapy. Studies on the mechanisms of disease caused by infectious agents demand a breadth of understanding across many specialized areas, as well as much cooperation between clinicians and experimentalists. The series InfectiousAgents andPathogenesis is intended not only to document the state of the art in this fascinating and challenging field but also to help lay bridges among diverse areas and people. M. Bendinelli H. Friedman ix
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