Process development of propionic acid production by fermentation PDF
Preview Process development of propionic acid production by fermentation
Iowa State University Capstones, Theses and Retrospective Theses and Dissertations Dissertations 1997 Process development of propionic acid production by fermentation Zhong Gu Iowa State University Follow this and additional works at:https://lib.dr.iastate.edu/rtd Part of theChemical Engineering Commons Recommended Citation Gu, Zhong, "Process development of propionic acid production by fermentation " (1997).Retrospective Theses and Dissertations. 11799. https://lib.dr.iastate.edu/rtd/11799 This Dissertation is brought to you for free and open access by the Iowa State University Capstones, Theses and Dissertations at Iowa State University Digital Repository. It has been accepted for inclusion in Retrospective Theses and Dissertations by an authorized administrator of Iowa State University Digital Repository. For more information, please [email protected]. INFORMATION TO USERS This manuscript has been reproduced fiom the microfihn master. UMI films the text directly from the original or copy submitted. Thus, some thesis and dissertation copies are in typewriter &ce, while others may be fi'om zny type of computer printer. The quality of this reproduction is dependent upon the quality of the copy submitted. Broken or indistinct print, colored or poor quality illustrations and photographs, print bleedthrough, substandard margins, and improper alignment can adversely affect reproduction. In the unlikely event that the author did not send UMI a complete manuscript and there are missing pages, these will be noted. Also, if unauthorized copyright material had to be removed, a note will indicate the deletion. Oversize materials (e.g., maps, drawings, charts) are reproduced by sectioning the original, beginning at the upper left-hand comer and continuing from left to right in equal sections with small overlaps. Each original is also photographed in one exposure and is included in reduced form at the back of the book. Photographs included in the original manuscript have been reproduced xerographically in this copy. Higher quality 6" x 9" black and white photographic prints are available for any photogr^hs or illustrations appearing in this copy for an additional charge. Contact UMI directly to order. UMI A Bell & Howell Informadon ConqsaiQ^ 300 North Zed) Road, Ann Aibor MI 48106-1346 USA 313/761-4700 800/521-0600 Process development of propionic acid production by fermentation by Zhong Gu A dissertation submitted to the graduate faculty in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY Major: Chemical Engineering Major Professor: Charles E. Glatz Iowa State University Ames, Iowa 1997 DMI Number: 9737713 UMI Microform 9737713 Copyright 1997, by UMI Company. All rights reserved. This microform edition is protected against unauthorized copying under Title 17, United States Code. UMI 300 North Zeeb Road Ann Arbor, MI 48103 ii Graduate College Iowa State University This is to certify that the Doctoral dissertation of Zhong Gu has met the dissertation requirements of Iowa State University Signature was redacted for privacy. Major Professor Signature was redacted for privacy. For the Major Program Signature was redacted for privacy. oixme Graduate College iii I dedicate this work to my late father Yongkang. iv TABLE OF CONTENTS ABSTRACT viii INTRODUCTION I Dissertation Organization 1 Literature Review 1 Propionic acid fermentation 1 Acid recovery from fermentation 3 Liquid-liquid extraction with amine 6 The solvent system 6 Extraction chemistry 7 Factors affecting amine extraction 10 Effect of pH 10 Effect of identity of acid 11 Effect of amine concentration 11 Effect of temperature 11 Acid regeneration 12 Solvent toxicity 13 Propionic acid downstream processes 16 PROPIONIC ACID PRODUCTION BY EXTRACTIVE FERMENTATION: PART 1. SOLVENT CONSIDERATIONS 18 Summary 18 Introduction 18 V Materials and Methods 22 Materials 22 Organic chemicals 22 Microorganism and media 22 Methods 23 Partitioning 23 Solvent toxicity 24 Strain screening 24 Single-component solvents 25 Reducing solvent toxicity 26 Distillation 26 Results 27 Partitioning 27 Solvent toxicity 30 Strain screening 30 Smgle-component solvent 33 Reducing solvent toxicity 33 Distillation 39 Discussion 39 Partitioning 39 Solvent toxicity 41 vi Distillation 42 Conclusions 43 Acknowledgments 44 References 44 PROPIONIC ACID PRODUCTION BY EXTRACTIVE FERMENTATION: PART 2. FERMENTATION STUDIES AND ECONOMIC EVALUATION 49 Summary 49 Introduction 50 Materials and Methods 53 Materials 53 Methods 53 Fermentation 53 Economic evaluation 56 Results 62 Fermentation 62 Economic evaluation 67 Discussion 72 Fermentation 72 Economic evaluation 78 Conclusions 79 Acknowledgments 80 References 80
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