2018 Meeting Program

105 Pages·2017·1.72 MB·English

AANP
AMERICAN ASSOCIATION
OF NEUROPATHOLOGISTS
June 7 - 10, 2018
Hyatt Regency Louisville
Louisville, Kentucky
This activity is provided by the AmericanAssociation of Neuropathologists.
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TABLE OF CONTENTS
President’sWelcome................................................................................................................3
SavetheDate............................................................................................................................4
AANPOrganization....................................................................................................................5
Committees...............................................................................................................................6
CMEInformation.......................................................................................................................7
DisclosureInformation.............................................................................................................9
GeneralInformation...............................................................................................................12
ExhibitorsandSponsors..........................................................................................................14
HyattRegencyFloorPlans......................................................................................................18
MeetingataGlance................................................................................................................19
ThursdaySpecialCourse.........................................................................................................23
BiographiesandPresentationInformation.................................................................24
Overview:ScientificSessions..................................................................................................39
FridayPlatforms1-4(Abstracts1-32).........................................................................40
FridayPosters(Abstracts33-107)...............................................................................42
SaturdayPlatforms5-8(Abstracts108-139)..............................................................46
SaturdayPosters(Abstracts140-218)........................................................................48
EndowedLectureships............................................................................................................52
ParisiLecture...............................................................................................................53
DeArmondLecture......................................................................................................56
SaulR.KoreyLecture...................................................................................................59
MatthewT.MooreLecture.........................................................................................63
AwardforMeritoriousContributionstoNeuropathology.....................................................65
WhatEveryNeuropathologistNeedstoKnow.......................................................................72
DiagnosticSlideSession..........................................................................................................76
SundayPresidentialSymposium.............................................................................................89
BiographiesandPresentationInformation.................................................................90
2017Donations…………………………………………………………………………………………………………………96
AbstractAuthorIndex ………………………………………………………………………………………………………97
Notes.....................................................................................................................................104
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TheAmericanAssociationofNeuropathologists
8156-ES.WadsworthBlvd.,Suite197
Littleton,Colorado80128
Phone:[phone];Fax:[phone]
Email:[email protected]
DearColleagues:
AsthePresidentoftheAmericanAssociationofNeuropathologists(AANP),itgivesmegreat
pleasuretowelcomeyoutoLouisville,KentuckyfortheAANP’s94thAnnualMeeting.
TheAANPhasaproudhistoryofbeingtheonlyassociationexclusivelyfocusedontheclinicaland
scientificpracticeofneuropathologyintheUnitedStates. Sincethe1920s,theAANPhasbeen
workingtoadvancethescience,teachingandtrainingofthediseasesofthenervoussystemandthe
practiceofneuropathology. Mostrecently,wehaveenteredtheeraofgenomicsandprecision
diagnostics. Inanefforttostayrelevantinthisrapidlyevolvingfield,the94thAnnualMeetingserves
toprovidethelatestinsightsintocutting-edgescienceandgroundbreakingresearch.
Thisyear’smeetingincludesaone-daySpecialCourseonThursdaydedicatedtotheNeuropathology
ofAgingandanUpdateonMolecularAnalysisofBrainTumors. Duringthetwodaysofscientific
platformandpostersessions,FridayandSaturday,youhavetheopportunitytomatchyourneeds
andinterestswithavarietyoftopics. SaturdayeveningwillincludetheDiagnosticSlideSession,and
Sundayconcludeswithahalf-dayPresidentialSymposiumfocusingonEmergingTechnologiesin
Neuropathology.
Asacommunitythatgenuinelyenjoystimetogether,youwillhaveampleopportunitytosocialize
witholdfriendsandforgenewneuropathologyconnectionswithcolleaguesfromaroundtheworld.
Ialsowanttothankourexhibitors. Theirattendanceatthismeetingisdeeplyappreciated. Please
visittheexhibitspaceandexploreavarietyofhigh-qualityproductsandservices.
AsIapproachthelastdaysinmytermasPresident,Iwanttothankeachofyouforattendingthe
AANP’s94thAnnualMeetingandforbringingyourexpertise,experience,questionsandcomments
tothisevent. Ihopeyouleavethisconferencewithinnovativeideas,strengthenedconnectionsand
arenewedspirit.
Sincerely,
ElizabethJ.Cochran,MD
President
TheAmericanAssociationofNeuropathologists
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AMERICAN ASSOCIATION OF
NEUROPATHOLOGISTS
AANPOFFICE
8156-ES.WadsworthBlvd.,Suite197,Littleton,CO80128
Phone:[phone];Fax:[phone]
Email:[email protected]
OFFICERS
ElizabethJ.Cochran,MD,MedicalCollegeofWisconsin,President
DanielJ.Brat,MD,PhD,NorthwesternUniversityFeinbergSchoolofMedicine,VicePresident
MatthewFrosch,MD,PhD,HarvardMedicalSchool,PresidentElect
R.RossReichard,MD,MayoClinic,VicePresidentElect
DouglasAnthony,MD,PhD,BrownUniversity,VicePresidentforProfessionalAffairs
CharlesL.WhiteIII,MD,UniversityofTexasSouthwestern,InterimSecretary-Treasurer
EdwardLee,MD,PhD,UniversityofPennsylvania,AssistantSecretary-Treasurer
OTHEREXECUTIVECOUNCILMEMBERS
EileenH.Bigio,MD,NorthwesternUniversityFeinbergSchoolofMedicine
RebeccaD.Folkerth,MD,NewYorkCityOfficeoftheChiefMedicalExaminer
John(Jack)Lee,MD,PhD,NorthShoreUniversityHealthSystem
ThomasJ.Montine,MD,PhD,StanfordUniversitySchoolofMedicine
SuzanneZ.Powell,MD,HoustonMethodistHospital
AriePerry,MD,UniversityofCaliforniaSanFrancisco
ARCHIVIST
MichaelN.Hart,MD,UniversityofWisconsinSchoolofMedicine
OFFICIALJOURNAL
JournalofNeuropathologyandExperimentalNeurology
John(Jack)Lee,MD,PhD,Editor-in-Chief
EileenS.Healy,ManagingEditor
E-mail:[email protected]
Homepage: http://www.jneuropath.com
DIAGNOSTICSLIDESESSION
CaterinaGiannini,MD,PhD,MayoClinic,Moderator
RebeccaD.Folkerth,MD,NewYorkCityOfficeoftheChiefMedicalExaminer,Manager
COUNCILORSTOTHEINTERNATIONALSOCIETYOFNEUROPATHOLOGY
AlexanderJudkins,MD,Children’sHospitalLosAngeles
GeorgePerry,PhD,TheUniversityofTexasatSanAntonio
ArnulfH.Koeppen,MD,AlbanyStrattonVeteransAffairsMedicalCenter
E.TessaHedley-Whyte,MD,MassachusettsGeneralHospital;HarvardMedicalSchool
AdekunleAdesina,MD,PhD,TexasChildren’sHospital
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AANP COMMITTEES
MembershipCommittee
AwardsCommittee PeterPytel,MD(Chair) ProfessionalAffairsCommittee
FaustoRodriquez,MD(Chair) SarahE.Bach,MD DouglasAnthony,MD,PhD(Chair)
MalekAbedalthagafi,MD AnneBuckley,MD,PhD LeomarY.Ballester,MD,PhD*
EwaBorys,MD JohnDeWitt,MD,PhD* MeghanDriscoll,MD*
SonikaDahiya,MD LeslieHamilton,MD StevenDubner,MD
Cheng-YingHo,MD,PhD,FRCPC MelikePekmezci,MD JenniferLibien,MD,PhD
KyleHurth,MD,PhD JoseVelazquezVega,MD* BradleyMiller,MD,PhD
KarraJones,MD,PhD MariaritaSanti-Vicini,MD,PhD
MirnaLechpammer,MD,PhD NominatingCommittee
NormanL.Lehman,MD,PhD AriePerry,MD(Chair) ProgramCommittee
JamesW.Mandell,MD,PhD SuzanneZ.Powell,MD JuliaKofler,MD(Chair)
MariaMartinez-Lage,MD ThomasJ.Montine,MD,PhD AdenkunleAdesina,MD,PhD
CarrieAnnMohila,MD AnthonyT.Yachnis,MD ThomasBeach,MD
DavidNauen,MD,PhD
IvanaDelalle,MD
HilaryNickols,MD,PhD NeuropathologyFellowship SeanFerris,MD,PhD*
EdwardPlowey,MD,PhD ProgramDirectorsCommittee MiguelGuzman,MD
AdityaRaghunathan,MD
(Sub-CommitteeofProfessional KimmoJ.Hatanpaa,MD,PhD
MariaRivera-Zengotita,MD AnneHiniker,MD,PhD
Affairs)
MatijaSnuderl,MD NancyC.Kois,MD,FCAP
SuzanneZ.Powell,MD(Chair)
JoshuaSonnen,MD
MichaelLawlor,MD
MatthewP.Anderson,MD,PhD
GiselleY.Lopez,MD,PhD*
SandraCamelo-Piragua,MD
EducationCommittee HanLee,MD
UmbertoDeGirolami,MD
EdwardB.Lee,MD,PhD(Chair) MichelleMaddenFelicella,MD
KennethFallon,MD
JenniferBaccon,MD,PhD BrentOrr,MD,PhD
MaryFowkes,MD,PhD
RatiChkheidze,MD* RichardPerrin,MD,PhD
MatthewFrosch,MD,PhD
SonikaDahiya,MD CharlesSpecht,MD
MarjorieGrafe,MD,PhD
BrentT.Harris,MD
LeslieHamilton,MD
JesseL.Kresak,MD WebsiteCommittee(AdHocof
RobertHammond,MD
QinwenMao,MD,PhD ProfessionalAffairs)
ChristineM.Hulette,MD
AngelicaOviedo,MD C.DirkKeene,MD,PhD DouglasAnthony,MD,PhD(Chair)
AnatStemmer-Rachamimov,MD MariaBeatrizS.Lopes,MD HenryG.Brown,MD,PhD
RachaelVaubel,MD,PhD* QinwenMao,MD,PhD JohnCrary,MD,PhD
CynthiaT.Welsh,MD
JannaNeltner,MD SonikaDahiya,MD
CharlesL.WhiteIII,MD JosephE.Parisi,MD Kar-MingFung,MD,PhD
QianWu,MD AriePerry,MD MuratGokden,MD
GabrielleA.Yeaney,MD
EdwardStopa,MD LuisF.Gonzalez-Cuyar,MD
JuanC.Troncoso,MD EdwardLee,MD,PhD
ConstitutionCommittee HannesVogel,MD BrianMoore,MD
StevenL.Carroll,MD,PhD(Chair) CindyWelsh,MD HilaryNickols,MD,PhD
KevinBieniek,PhD* CharlesL.WhiteIII,MD J.StephenNix,MD*
AlexanderZ.Feldman,MD* ClaytonWiley,MD,PhD MichaelPunsoni,MD
JamesHackney,MD ThomasWisniewski,MD JingxinQiu,MD,PhD
RyanMiller,MD,PhD AnthonyT.Yachnis,MD CharlesL.White,III,MD
WilliamH.Yong,MD
*JuniorMember
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CME INFORMATION
TARGET AUDIENCE
The educational design of the AANP’s Annual Meeting addresses the needs of physicians and scientists in the
field of neuropathology who are involved in the diagnosis and/or treatment of patients with neurological
disorders.
STATEMENT OF NEED
The purpose of this activity shall be to advance medical and scientific knowledge, understanding, and
competence in the practice of neuropathology. The practice of neuropathology is understood to include
diagnosis of diseases of the nervous system, scientific investigation into their causes, and teaching of
neuropathologyprinciplestocolleaguesandtrainees.
LEARNING OBJECTIVES
Uponcompletionofthisactivity,participantsshouldbeableto:
1. Describenewadvancementsinmechanismsandetiologiesofneurologicdiseases.
2. Discussrecentadvancesinneurologicdiseaseresearch.
3. Evaluatenewmethodologicanddiagnosticknowledgethatcanimprovepatientcareinneuropathology.
DISCLAIMER
Participantshaveanimpliedresponsibilitytousethenewlyacquiredinformationtoenhancepatientoutcomes
andtheir ownprofessional development. Theinformationpresentedinthisactivityisnotmeantto serveasa
guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment
discussedinthisactivityshouldnotbeusedbyclinicianswithoutevaluation ofpatientconditionsandpossible
contraindications on dangers in use, review of any applicable manufacturer’s product information, and
comparisonwithrecommendationsofotherauthorities.
PHYSICIAN ACCREDITATION STATEMENT
The American Association of Neuropathologists is accredited by the Accreditation Council for Continuing
MedicalEducation(ACCME)toprovidecontinuingmedicaleducationforphysicians.
PHYSICIAN CREDIT DESIGNATION
TheAmericanAssociationofNeuropathologistsdesignatesthisliveeducationalactivityforamaximumof25.25
AMAPRACategory1CreditsTM. Physiciansshouldclaimonlythecreditcommensuratewiththeextentoftheir
participationintheactivity.
MAINTENANCE OF CERTIFICATION
The94thAnnualMeetingoftheAmericanAssociationofNeuropathologistswillofferbothContinuingMedical
Education(CME)andAmericanBoardofPathology(ABPath)ContinuousCertification,formerlyMaintenance
ofCertification(MOC),PartII:LifelongLearningandSelf-Assessment.Participationintheliveactivityand
successfulcompletionofthecorrespondingevaluationcomponentforeacheligiblesessionenables
participantstoearnuptoamaximumof16.25SAMcredits.
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CME INFORMATION (Continued)
CME AND SAM CREDIT
InstructionstoReceiveCMECredit
In order to receive credit for this activity, the participant must complete the CME evaluations and credit
applications for sessions attended, which are made available through the AANP Meeting App or by using the
followinglinkhttp://eventmobi.com/aanp2018.
InstructionstoReceiveSAMCredit
Shortlyafterthe94thAnnualMeeting,theevaluationcomponentforSAMcreditwilllaunchat
www.neuropath-education.org.ParticipantswillneedtousetheirDayspringwebsitelog-intogainaccessto
eachevaluationcomponentandmusthaveattendedthelivesessionheldatthe2018AnnualMeetingin
Louisville,KY.EachSAMcosts$25.00unlessyoupreviouslypurchasedtheSAMsbundle.
To purchase the SAMs bundle visit this link: www.neuropath.org/sams-bundle. Please note there is a one to
two-weekdelayinunlimitedaccessbeingsetuponyourDayspringaccount.
ThechartbelowoutlineswhichsessionsareofferedforCMEcreditandthemaximumnumberofcredithours
aphysiciancanearnforeacheducationalactivitybeingaccreditedforAMAPRACategory1CreditTMatthis
year’sAnnualMeeting.ThechartalsooutlinestheSAMcreditavailableforeachsession.
Activity CMECreditHours SAMCreditHours
SpecialCourse 6.75 6.75
ScientificSessions 8.0 0
KoreyLecture 1.0 1.0
DeArmondLecture 1.0 1.0
ParisiLecture 1.0 1.0
MooreLecture 0.75 0.75
WhatEveryNeuropathologistNeedsto
1.0 0
Know
DiagnosticSlideSession 3.0 3.0
PresidentialSymposium 2.75 2.75
Total 25.25 16.25
CONTACT INFORMATION
For any questions regarding the accreditation of this meeting, please contact AANP’s CME Coordinator, Sarah
Porter,viae-mailat:[email protected],orviaphoneat:303-557-0859x84.
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DISCLOSURE INFORMATION
DisclosureofCommercialSupport:
Thisactivityissupportedbyaneducational,in-kinddonationofmicroscopes,providedbyNikonInstruments,Inc.
DisclosureofR13Grant:
Fundingforthisconferencewasmadepossible,inpartby1R13AG059336-01fromNationalInstituteonAging.Theviews
expressedinwrittenconferencematerialsorpublicationsandbyspeakersandmoderatorsdonotnecessarilyreflectthe
officialpoliciesoftheDepartmentofHealthandHumanServices;nordoesmentionbytradenames,commercialpractices,
ororganizationsimplyendorsementbytheU.S.Government.
DisclosureofUnlabeledUse:
Thiseducationalactivitymaycontaindiscussionofpublishedand/orinvestigationalusesofagentsthatarenotindicated
by the FDA. The American Association of Neuropathologists does not recommend the use of any agent outside of the
labeledindications.
Theopinionsexpressedinthiseducationalactivityarethoseofthefacultyanddonotnecessarilyrepresenttheviewsof
any organization associated with this activity. Please refer to the official prescribing information for each product for
discussionofapprovedindications,contraindicationsandwarnings.
DisclosureofConflictofInterest:
TheAmericanAssociationofNeuropathologistsrequiresinstructors,planners,managersandotherindividualswhoarein
apositionto controlthe contentofthisactivitytodisclose allrelevant financialrelationshipswithcommercialinterests
theymayhaveasrelatedtothecontentofthisactivity. AllidentifiedconflictsofinterestarethoroughlyvettedbyAANP
for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and
appropriatenessofpatientcarerecommendations.
PlannersandManagers
Thefollowingplannersandmanagershavenothingtodisclose:
AdekunleAdesina,DouglasAnthony,JenniferBaccon,EileenBigio,DanielBrat,RatiChkheidze,ElizabethCochran,Sonika
Dahiya, IvanaDelalle, SeanFerris,RebeccaFolkerth,Matthew Frosch,CaterinaGiannini,MiguelGuzman,BrentHarris,
Kimmo Hatanpaa, Anne Hiniker, Julie Kofler, Nancy Kois, Jesse Kresak, Edward Lee, Giselle Lopez, Michelle Madden
Felicella,QinwenMao, Thomas Montine, Brent Orr,AngelicaOviedo, RichardPerrin, Arie Perry, SarahPorter, Suzanne
Powell, R. Ross Reichard, Charles Specht, Anat Stemmer-Rachamimov, Rachel Vaubel, Cynthia (Cindy) Welsh, Charles
White,QianWu,GabrielleYeaney
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DISCLOSURE INFORMATION (Continued)
The following planners/managers reported the following financial relationships or relationships to products or devices
theyortheirspouse/partnerhavewithcommercialinterestsrelatedtothecontentofthisCMEActivity.
ThomasBeach Consultant/IndependentContractor:GlaxoSmithKline,Prothena,Roche,
Ventana,AvidRadiopharmaceuticals,NavideaBiopharmaceuticals
Grant/ResearchSupport:AvidRadiopharmaceuticals,Navidea
Biopharmaceuticals
MikeLawlor Consultant/IndependentContractor:WaveLifeSciences,Dynacure,
AdvisoryBoard-AudentesTherapeutics,SolidBiosciences,Ichorion
Therapuetics
Grant/ResearchSupport:AudentesTherapeutics,SolidBiosciences,
IchorionTherapeutics
HanLee StockShareholder(Spouse/Partner):Gilead
Employee(Spouse/Partner):Theravance
John(Jack)Lee Consultant/IndependentContractor:Holdsjointpatentsonadrugfor
treatmentofAlzheimer'sdisease/seniledementiaandanxietydisorders
withothersandCornelliConsulting,Milan,Italy(Noroyaltiesassociated–
patenttiedtoresearchinearlystages)
Faculty,Authors,ContentDevelopers
Thefollowingfaculty,authors,andcontentdevelopershavenothingtodisclose:
Kenneth Aldape, Leomar Ballester, Laurent Benayoun, Mercia Bezerra Gondim, Kevin Bieniek, Melissa M. Blessing,
ChristopherBorck,DanielBrat,SandraCamelo-Piragua,Cheng-Hsuan(Jason)Chiang,P.J.Cimino,ElizabethCochran,Kyle
Conway, Shannon Coy, John Crary, Travis Danielsen, Philip De Jager, Suzanne de la Monte, Ivana Delalle, Phedias
Diamandis, Dennis Dickson, Brittany Dugger, Rebecca Folkerth, Andrew Gao, Bernardino Ghetti, Jason Gregory, Peng
ChengHan,FadiHannaAl-Shaikh,BrianHarding,CynthiaHawkins,Lili-NazHazrati,BertrandHuber,CristianeIda,Bryan
Iorgulescu,VanyaJaitly,KarraJones,MissiaKohler,OlgaKrasnozhen-Ratush,EdwardLee,JulieannLee,NormanLehman,
BenjaminLiechty,Hsiang-ChihLu,Jian-QiangLu,QinwenMao,MariaMartinez-Lage,PhillipMcMullen,II,RupalMehta,
DavidMeredith,StevenA.Moore,ElizabethMormino,E.KellyMrachek,DavidNauen,PeterNelson,JannaNeltner,Aivi
Nguyen,BrentOrr,JoseOtero,DoreenPalsgrove,MeganParilla,MelikePekmezci,RichardPerrin,JoannaPhillips,R.Ross
Reichard, Fausto Rodriguez, Matthew Rose, Shahram Saberi, Julie Schneider, Nima Sharifai, Anne Shepler, Shu-Hsien
Sheu, Matija Snuderl, Raymond Sobel, David Solomon, Isaac Solomon, ThorStein, Mario Suva, DianaThomas, Rachael
Vaubel,Angela Viaene,MariaAdelitaVizcainoVillalobos,JamieWalker,ChristopherWilliam
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