Yeast Membrane Transport PDF
Preview Yeast Membrane Transport
Advances in Experimental Medicine and Biology 892 José Ramos Hana Sychrová Maik Kschischo E ditors Yeast Membrane Transport Advances in Experimental Medicine and Biology Volume 892 Advances in Experimental Medicine and Biology presents multidisciplinary and dynamic findings in the broad fields of experimental medicine and biology. The wide variety in topics it presents offersreaders multiple perspectiveson a variety of disciplines including neuroscience, microbiology, immunology, biochemistry, biomedical engineering and cancer research. Advances in Experimental Medicine and Biology has been publishing exceptionalworks in the field for over 30 years andisindexedinMedline,Scopus,EMBASE,BIOSIS,BiologicalAbstracts,CSA, BiologicalSciencesandLivingResources(ASFA-1),andBiologicalSciences.The series also providesscientists with up to date informationon emergingtopics and techniques. 2013ImpactFactor:2.012. Moreinformationaboutthisseriesathttp://www.springer.com/series/5584 José Ramos • Hana Sychrová • Maik Kschischo Editors Yeast Membrane Transport 123 Editors JoséRamos HanaSychrová DepartmentofMicrobiology DepartmentofMembraneTransport UniversityofCórdoba InstituteofPhysiology Córdoba,Spain TheCzechAcademyofSciences Prague,CzechRepublic MaikKschischo DepartmentofMathematicsandTechnology UniversityofAppliedSciences Koblenz,Remagen,Germany ISSN0065-2598 ISSN2214-8019 (electronic) AdvancesinExperimentalMedicineandBiology ISBN978-3-319-25302-2 ISBN978-3-319-25304-6 (eBook) DOI10.1007/978-3-319-25304-6 LibraryofCongressControlNumber:2015960745 SpringerChamHeidelbergNewYorkDordrechtLondon ©SpringerInternationalPublishingSwitzerland2016 Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeorpartof thematerialisconcerned,specificallytherightsoftranslation,reprinting,reuseofillustrations,recitation, broadcasting,reproductiononmicrofilmsorinanyotherphysicalway,andtransmissionorinformation storageandretrieval,electronicadaptation,computersoftware,orbysimilarordissimilarmethodology nowknownorhereafterdeveloped. Theuseofgeneraldescriptivenames,registerednames,trademarks,servicemarks,etc.inthispublication doesnotimply,evenintheabsenceofaspecificstatement,thatsuchnamesareexemptfromtherelevant protectivelawsandregulationsandthereforefreeforgeneraluse. Thepublisher,theauthorsandtheeditorsaresafetoassumethattheadviceandinformationinthisbook arebelievedtobetrueandaccurateatthedateofpublication.Neitherthepublishernortheauthorsor theeditorsgiveawarranty,expressorimplied,withrespecttothematerialcontainedhereinorforany errorsoromissionsthatmayhavebeenmade. Printedonacid-freepaper SpringerInternational PublishingAGSwitzerlandispartofSpringerScience+Business Media(www. springer.com) Preface All cells need to communicate with their environment, which means exchange informationandmaterialacrosstheirmembranes.Toensuretheuptakeofnutrients and other necessary compoundsor to extrude toxic metabolites, metabolic waste, orchemicalsignals,cellsusetransportsystemsconsistingofoneormoreproteins embedded in the cell membranes. The significance of transport in organisms and theircellswassummarizedbyDanielC.TostesonwhowroteinhisbookMembrane Transport: People and Ideas (Tosteson 1989): “I conjure a picture of a living organismasanextraordinarilycomplex,self-replicating,self-assembling,dynamic, open, physicochemical system maintained near the steady state by the continual entry and exit of matter and energy.”Thoughthe indispensability and complexity of cell membrane transport have attracted researchers for more than 100 years, researchonmembranetransporthasmadecontinuousprogressinthe last decades andremainsanactivefieldofscientificinvestigation.Yeasts,andmainlythemodel organism Saccharomyces cerevisiae, are among the favorite cells for researchers studying all aspects of transport systems and their mechanisms. However, an importantamountof knowledge has been obtained when employingthe so-called non-conventional and pathogenic yeasts, especially because of their peculiarities and,insomecases,specifictransportsystems.Thetransportersmediatinguptakeof nutrients,fluxesofcationsandanions,ortheextrusionoftoxiccompoundsacross theplasmamembranearediscussedtogetherwiththetransportsystemslocalizedin themembranesofcellorganelles.Eachchaptersummarizesourcurrentknowledge on importanttransportprocessesin yeasts, and as it is based on the experienceof theexpertsworkinginthefieldformanyyears,itprovidesbothageneraloverview ofthemaintransportcharacteristicsforaspecificsubstrateoragroupofsubstrates anduniquedetailsthatonlyanexpertworkinginthefieldisabletotransmittothe reader. Córdoba,Spain JoséRamos Remagen,Germany MaikKschischo Prague,CzechRepublic HanaSychrová v Contents 1 MembraneTransportinYeast,AnIntroduction........................ 1 MaikKschischo,JoséRamos,andHanaSychrová 2 Cell Surface Interference with Plasma Membrane andTransportProcessesinYeasts........................................ 11 JeanMarieFrancois 3 ProtonTransportandpHControlinFungi............................. 33 PatriciaM.Kane 4 Function and Regulation of Fungal Amino Acid Transporters:InsightsfromPredictedStructure....................... 69 ChristosGournas,MartinePrévost,Eva-MariaKrammer, andBrunoAndré 5 WaterTransportinYeasts................................................. 107 FarzanaSabir,CatarinaPrista,AnaMadeira,TeresaMoura, MariaC.Loureiro-Dias,andGraçaSoveral 6 SugarandGlycerolTransportinSaccharomycescerevisiae........... 125 LindaF.Bisson,QingwenFan,andGordonA.Walker 7 TheCRaZyCalciumCycle................................................ 169 EduardoA.Espeso 8 PotassiumandSodiumTransportinYeast .............................. 187 LynneYenush 9 Carboxylic Acids Plasma Membrane Transporters inSaccharomycescerevisiae ............................................... 229 MargaridaCasal,OdíliaQueirós,GabrielTalaia,DavidRibas, andSandraPaiva 10 InorganicPhosphateandSulfateTransportinS.cerevisiae........... 253 D.R.SamynandB.L.Persson vii viii Contents 11 InteractionsBetweenMonovalentCationsandNutrient Homeostasis................................................................. 271 DavidCanadellandJoaquínAriño 12 Mathematical Modelling of Cation Transport andRegulationinYeast.................................................... 291 MatthiaséKahmandMaikKschischo 13 TransportSystemsinHalophilicFungi.................................. 307 Ana Plemenitaš, Tilen Konte, Cene Gostincˇar, andNinaGundeCimerman 14 Antifungals:MechanismofActionandDrugResistance.............. 327 Rajendra Prasad, Abdul Haseeb Shah, andManpreetKaurRawal 15 CandidaEffluxATPasesandAntiportersinClinicalDrug Resistance.................................................................... 351 Rajendra Prasad, Manpreet Kaur Rawal, andAbdulHaseebShah Index............................................................................... 377 Chapter 1 Membrane Transport in Yeast, An Introduction MaikKschischo,JoséRamos,andHanaSychrová Abstract Research on membrane transport has made continuous progress in the last decades and remains an active field of scientific investigation. In the case of yeast, most of the research has been conducted for the model organism Saccha- romycescerevisiae,butalsotheso-callednon-conventionalyeastsarebeingstudied, especially because of their peculiarities and, in some cases, specific transport systems. This book is based on the experience of several experts summarizing thecurrentknowledgeaboutimportantsubstratetransportprocessesinyeast.Each chapterprovidesbothageneraloverviewofthemaintransportcharacteristicsofa specific substrate or groupof substrates andthe uniquedetails thatonlyan expert workinginthefieldisabletotransmittothereader. Keywords Yeast • Membrane • Transport 1.1 Importance ofMembrane TransportProcesses A cell’s existence depends on its membrane. Although membranes were first consideredjustasphysicalboundaries,theirfunctionasapermeabilitybarrierwas quicklyrealized.Lateron,thecrucialsensingfunctionsofmembranestofacilitate information exchange between the external and internal milieu were discovered. In addition to the plasma membrane, eukaryotic cells contain systems of internal M.Kschischo DepartmentofMathematicsandTechnology,UniversityofAppliedSciencesKoblenz, RheinAhrCampus,Remagen,Germany e-mail:[email protected] J.Ramos((cid:2)) DepartmentofMicrobiology,UniversityofCórdoba,Córdoba,Spain e-mail:[email protected] H.Sychrová DepartmentofMembraneTransport,InstituteofPhysiology,TheCzechAcademyofSciences, Prague,CzechRepublic e-mail:[email protected] ©SpringerInternationalPublishingSwitzerland2016 1 J.Ramosetal.(eds.),YeastMembraneTransport,AdvancesinExperimental MedicineandBiology892,DOI10.1007/978-3-319-25304-6_1
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