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World Journal of /} O O Official Journal of the Urological Research Society Volume 9, 1991 Editors-in-Chief U. Jonas R. J. Krane Klinik fur Urologie Boston University Medizinische Hochschule University Hospital Konstanty-Gutschow-Strasse 8 Department of Urology W-3000 Hannover 1 75 East Newton Street FRG Boston, MA 02118, USA Assistant to the Editors-in-Chief C. Stief, Hannover, FRG Editors P. H. Abrams, Bristol . Kakizoe, Tokyo R. Ackermann, Dusseldorf . de Klerk, Cape Town O. Alfthan, Helsinki Pp . H. Lange, Minneapolis P. Alken, Mannheim M . Linehan, Bethesda G. Bartsch, Innsbruck L . |. Lipshultz, Houston L. Boccon-Gibod, Paris M . Marberger, Wien W. J. Catalona, St. Louis V . R. Marshall, Adelaide D. S. Coffey, Baltimore K . Okada, Kyoto B. L. R. A. Coolsaet, Antwerp C . A. Olsson, New York F. M. J. Debruyne, Nijmegen D . F. Paulson, Durham M. J. Droller, New York M . Pavone-Macaluso, Palermo W a . Fair, New York M. |. Resnick, Cleveland J. M. Fitzpatrick, Dublin R . Schmidt, San Francisco A. Fritjofsson, Uppsala = . H. Schréder, Rotterdam R. Ghanadian, London C . Schulman, Bruxelles M. A. Ghoneim, Mansoura M . S. Soloway, Memphis D. Griffith, Houston E . D. Vaughan Jr., New York R. Hartung, Munchen R . deVere White, Sacramento R. Hautmann, Ulm H . J. de Voogt, Amsterdam Y. Hirao, Nara A . J. Wein, Philadelphia G. H. Jacobi, Duisburg H . N. Whitfield, London Springer International Copyright Submission of a manuscript implies: that the work described has not been Special regulations for photocopies in the USA: Photocopies may be made published before (except in the form of an abstract or as part of a published for personal or in-house use beyond the limitations stipulated under lecture, review, or thesis); that it is not under consideration for publication Section 107 or 108 of U.S. Copyright Law, provided a fee is paid. 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In these cases, specific written permission must All articles published in this journal are protected by copyright, which covers first be obtained from the publisher. the exclusive rights to reproduce and distribute the article (e. g., as offprints), as well as all translation rights. No material published in this journal may be reproduced photographically or stored on microfilm, in electronic data bases, video disks, etc., without first obtaining written Printers permission from the publisher. Druckerei Parzeller, W-6400 Fulda, FRG The use of general descriptive names, trade names, trademarks, etc., in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations. While the advice and information in this journal is believed to be true and accurate at the date of its going to press, neither the authors, the editors, nor the publisher can accept any legal responsibility for any errors or © Springer-Verlag Berlin Heidelberg 1991 omissions that may be made. The publisher makes no warranty, express Springer-Verlag GmbH & Co. KG, 1000 Berlin 33, FRG or implied, with respect to the material contained herein. Printed in Germany Contents Non-surgical management of BPH H. G. van der Poel, J. A. Schalken, F. M. J. Debruyne Editor: J. M. Fitzpatrick Image analysis and grading of prostate adenocarcinoma M. Vanden Bossche, J. C. Noel, C. C. Schulman T. L. Ratliff, M. A. Hudson, W. J. Catalona Transurethral hyperthermia for benign prostatic hypertrophy Strategy for improving therapy of superficial bladder cancer G. M. Watson, A. P. Perlmutter, T. K. Shah, D. G. Barnes Free papers Heat treatment for severe, symptomatic prostatic outflow J.J. M. Kums, E. M. Delhaas obstruction Intrathecal baclofen infusion in patients with spasticity and neurogenic bladder disease. Preliminary results D. G. Barnes, A. P. Perlmutter, G. M. Watson Transrectal hyperthermia in the benign painful prostate A. Shafik Dilatation and closing urethral reflexes. Description and Z. Leib, A. Lev, C. Servadio clinical significance of new urethral reflexes. Preliminary report Transrectal ultrasound evaluation in local hyperthermia to the benign prostata Electrical stimulation-modulation Z. Leib, A. Lev, E. Goren, C. Servadio Observations on the influence of cyproterone acetate on the Editors: R. A. Schmidt, E. A. Tanagho sonographic image of the benign prostate in patients treated R. A. Schmidt, E. A. Tanagho with local hyperthermia Editorial C. J. Parker, B. R. P. Birch, A. Connelly, T. Briggs, C. A. Gleason K. Anson, R. A. Miller Electrophysiological fundamentals of neurostimulation The Porges Urospiral: a reversible endoprostatic prosthetic stent R. A. Schmidt, E. A. Tanagho G. Williams Neuromicturition Early experience of the use of permanently implanted prostatic stents for the treatment of bladder outflow obstruction H. Madersbacher Intradural spinal stimulation approach to selection/follow-up L. A. Klein Balloon dilatation of the prostate as compared with P. E. V. Van Kerrebroeck, E. Koldewijn, H. Wijkstra, transurethral resection of the prostate for treatment of benign F. M. J. Debruyne prostatic hypertrophy Intradural sacral rhizotomies and implantation of an anterior sacral root stimulator in the treatment of neurogenic bladder G. Williams dysfunction after spinal cord injury Balloon dilatation of the prostatic urethram should it have a place in the urologist’s armamentarium? W. F. Thon, L. S. Baskin, U. Jonas, E. A. Tanagho, R. A. Schmidt T. J. Christmas, R. S. Kirby Surgical principles of sacral foramen electrode implantation Alpha-adrenoceptor blockers in the treatment of benign prostatic hyperplasia W. F. Thon, L. S. Baskin, U. Jonas, E. A. Tanagho, R. A. Schmidt R. S. Kirby, T. Christmas Neuromodulation of voiding dysfunction and pelvic pain The potential value of 5-alpha-reductase inhibition in the treatment of bladder outflow obstruction due to benign J. M. Vapnek, R. A. Schmidt prostatic hyperplasia Restoration of voiding in chronic urinary retention using the neuroprosthesis Free papers J. W. Moul, R. K. Dodge, J. E. Robertson, D. F. Paulson, M. M. Hassouna, M. M. Elhilali P. J. Walther Role of the sacral root stimulator in voiding dysfunction The impact of the ,,cisplatin era“ of treatment on survival in testicular cancer R. A. Schmidt Round table G. Janetschek, G. Griessmair, G. Mikuz, G. Bartsch Experimental testicular torsion: time course of the effect J.J. M. Kums, E. M. Delhaas on the contralateral testicular histology Intrathecal baclofen infusion in patients with spasticity and neurogenic bladder disease Basic research in uro-oncology: clinical consequences Free papers A. Belldegrun, R. Figlin, G. Haas, J. deKernion Editor: F. M. J. Debruyne Immunotherapy for metastatic renal-cell carcinoma F. M. J. Debruyne, J. A. Schalken T. Hald, K. Steven Editorial Restoration of voiding function M. J. G. Bussemakers, J. T. Isaacs, F. M. J. Debruyne, I. Hahn, J. Nauclér, S. Sommar, M. Fall W. J. M. Van de Ven, J. A. Schalken Urodynamic assessment of pelvic floor training Oncogene expression in prostate cancer H. Schulze Biochemical profiles and hormone receptors in prostate cancer Renal cell carcinoma Editor: E. P. Allhoff S. P. Lerner, Y. C. Tsai, P. A. Jones Genetic aspects of bladder cancer progression E. P. Allhoff Editorial D. K. Chopin, J.-C. Laurent Monoclonal antibodies in bladder cancer cytology A. S. Abi-Aad, A. Belldegrune, J. B. deKernion Renal cell carcinoma: physiology, diagnosis, and therapy W. de Riese, E. Allhoff, M. Werner, J. Atzpodien, H. Kirchner, C. G. Stief, M. Djamilian, R. Schlick, U. Jonas G. D. Steinberg, B. A. Reitz, F. F. Marshall Proliferate behaviour and cytogenetic changes in human Surgical treatment of renal cell carcinoma with extension renal-cell carcinoma into the vena cava F. Steinbach, M. Stéckle, J. W. Thiirow, S. Stérkel, H. Kirchner, W. de Riese, E. Allhoff, H. Poliwoda, S. Melchior, S. C. Miiller, R. Stein, R. Hohenfellner J. Atzpodien Parenchyma-sparing surgery for renal tumors: experiences Immunotherapy of advanced renal cell cancer using in over 120 patients subcutaneous recombinant interleukin-2 and interferon-alpha W. de Riese, E. Allhoff, H. Kirchner, C. G. Stief, S. Pomer, R. Thiele, V. Daniel, R. Weimer, H. Léhrke, J. Atzpodien, H.-J. Maschek, U. Jonas V. Schirrmacher, G. Staehler Complete spontaneous regression in metastatic renal cell Sequential treatment of patients with advanced renal cell carcinoma carcinoma with autologous tumor vaccine and subcutaneous administration of recombinant interleukin-2 and R. J. A. van Moorselaar, J. A. Schalken, interferon-alpha, G. O. N. Oosterhof, F. M. J. Debruyne Use of animal models in diagnosis and treatment of renal E. P. Allhoff, S. Liedke, H. Kirchner, J. Atzpodien, cell carcinoma W. de Riese, C. G. Stief, U. Jonas Current clinical relevance of immunotherapy in metastatic B. J. Schmitz-Dréger, T. Ebert, K. Decken renal cell cancer Monoclonal antibodies and renal cell carcinoma — current possibilities and future options M. Goepel, H. Riibben Adjuvant therapy in renal cancer R. Heicappell, R. Ackermann Current strategies for immunotherapy of renal cell carcinoma Free papers S. D. Fossa, A. E. Stenwig, H. H. Lien C. G. Stief, F. Holmquist, E. P. Allhoff, K. E. Andersson, Long-term results in patients with metastatic renal cell U. Jonas carcinoma treated with interferon with or without vinblastine 210 Preliminary report on the effect of the nitric oxide donor L. Bergmann, E. Weidmann, H. M. Enzinger, K. Fenchel, SIN-1 on human cavernous tissue in vivo D. Jonas, P. S. Mitrou A. Stav, L. Ovadia, M. Landau, N. Weksler, A. Sternberg Interleukin-2 and interferon-alpha, as a daily alternating Cancer of prostate with osseous metastases schedule in advanced renal cell cancer Author Index Abi-Aad, A. S., 168 Fossa, S. D., 210 Miller, R. A., Tanagho, E. A., 109, 114, Figlin, R., 157 Ackermann, R., 204 Mitrou, P. S., 133, 138 Allhotf, E. P., 79, 167, Gleason, C. A., 110 Miiller, S. C., Thiele; R., 223 Griessmair, G., 51 184, 219, 228 Goepel, M., 232 Thon, W. F., 133, 138 Anson, T., 22 Noel, J. C., 2 Thiirow, J. W., 178 Haas, G., 157 Atzpodien, J., 79, 184, Hassouna, M. M., 145 Tsai, YC: 6 Hahn, I., 162 219, 228 Heicappell, R., 204 Oosterhof, G. O. N., 192 Hald, T., 160 Hohenfellner, R., 178 Van de Ven, W. J. M., 58 Holmquist, F., 237 Barnes, D. G., 7, 12 Hudson, M. A., 95 van der Poel, H. G., 86 Parker, C. J., 22 Baskin, L. S., 133, 138 Perlmutter, A. P., 7, 12 Van Kerrebroeck, P. E. Janetschek, G., 51 Belldegrune, A., 168 Isaacs, J. T., 58 Poliwoda, H., 219 V., 126 Jonas, U., 237 Bergmann, L., 215 Pomer, S., 223 van Moorselaar, R. J. A., Bossche, M. Vanden, 2 Jonas, D., 215 192 Kums, J. J. M., 99 Briggs, T., 22 Jonas, U., 79, 133, 138, Vapnek, J. M., 142 Bussemakers, M. J. G., 184, 228 Ratliff, T. L., 95 Landau, M., 240 58 Jones, P. A., 69 Reitz, B. A., 173 Watson, G. M., 7, 12 Riibben, H., 232 Weidemann, E., 215 Mikuz, G., 51 Catalona, W. J., 95 Kirby, R. S., 36, 41 Weimer, R. 223 Moul, J. W., 45 Chopin, D. K., 75 Kirchner, H., 79, 184, Schalken, J. A., 57,58, 86 Werner, M., 79 Christmas, T. J., 36, 41 219, 228 Schirrmacher, V., 223 Wijkstra, H., 126 Nauclér, J., 162 Klein, L. A., 29 Schlick, R., 79 Willams, G., 26, 32 Daniel, V., 223 Koldewijn, E., 126 Schmidt, R. A., 109, 114, Ovadia, L., 240 de Riese, W., 79, 184, Kums, J. J. M., 153 133, 138, 142, 149 219, 228 Schmitz-Drager, B. J., Paulson, D. F., 45 Debruyne, F. M. J., 57, Laurent, J.-C., 75 198 Free papers 58, 86, 126, 192 Leib, Z..,.45,:19 Schulman, C. C., 2 Allhoff, E. P., 237 Robertson, J. E., 45 Decken, K., 198 Lerner, S. P., 69 Schulze, H., 64 Andersson, K. E., 237 deKernion, J. B., 168 Lev, A., 15, 19 Servadio, C., 15, 19 Shafik, A., 105 Delhaas, E. M., 153 Liedke, S., 22 Shak. TK, 7 Bartsch, G., 51 Sommar, S., 162 Djamilian, M., 79 Lien, H. H., 210 Staehler, G., 223 Belldegrun, A., 157 Stav, A., 240 Lohrke, H., 223 Stein, R., 178 Sternberg, A., 240 Ebert, T., 198 Steinbach, F., 178 deKernion, J., 157 Steven, K., 160 Elhilali, M. M., 145 Madersbacher, H., 122 Steinberg, G. D., 173 Delhaas, E. M., 99 Stief, C.G., 237 Enzinger, H. M., 215 Marshall, F. F., 173 Stief, C. G., 79, 184, 228 Dodge, R. K., 45 Maschek, H.-J., 184 Stéckle, M., 178 Walther, P. J., 45 Fenchel, K., 215 Melchior, S., 178 Stérkel, S., 178 Fall, M., 162 Weksler, N., 240