Working around the Clock

212 Pages·2016·5.17 MB·English

by  Kirsten Van Dycke

Working around the Clock:
Adverse health effects of circadian rhythm disturbance
Werken rond de klok:
Nadelige gezondheidseffecten door verstoring van het circadiane ritme
Kirsten Van Dycke
40036 Dycke, Kirsten.indd 1 11-04-16 11:02
ISBN 978-94-6332-012-2
Design Cover: Lysette Hartman
Design Inside: Ferdinand van Nispen tot Pannerden,
Citroenvlinder DTP&Vormgeving, my-thesis.nl
Printed by: GVO Drukkers en vormgevers, Ede, The Netherlands
Copyright © 2016 Kirsten Van Dycke
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system or
transmitted in any form or by any means without prior permission of the author.
40036 Dycke, Kirsten.indd 2 11-04-16 11:02
Working around the Clock:
Adverse health effects of circadian rhythm disturbance
Werken rond de klok:
Nadelige gezondheidseffecten door verstoring van het circadiane ritme
Proefschrift
ter verkrijging van de graad van doctor aan de
Erasmus Universiteit Rotterdam
op gezag van de rector magnificus
Prof.dr. H.A.P. Pols
en volgens besluit van het College van Promoties.
De openbare verdediging zal plaatsvinden op
dinsdag 7 juni 2016 om 15:30
door
Kirsten Catharina Gabriëlla Van Dycke
geboren te Arnhem
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Promotiecommissie
Promotoren: Prof.dr. G.T.J. van der Horst
Prof.dr. H. van Steeg
Overige leden: Prof.dr. T. Roenneberg
Dr. E.F.C. van Rossum
Dr.ing. R.W.F. de Bruin
Copromotor: Dr. W. Rodenburg
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Contents
Contents 6
Chapter 1 General introduction 9
Chapter 2 Chronically alternating light cycles increase breast 23
cancer risk in mice
Chapter 3 Biomarker discovery using a comparative 39
omics approach in a mouse model developing
heterogeneous mammary cancer subtypes
Chapter 4 Biomarkers for circadian rhythm disturbance 59
independent of time of day
Chapter 5 Diurnal variation of hormonal and lipid biomarkers in 77
a molecular epidemiology-like setting
Chapter 6 Attenuation of circadian rhythmicity in hepatic gene 97
expression upon chronic alternating light cycle
exposure
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Summary and general discussion 113
Nederlandse Samenvatting 129
Curriculum Vitae 134
List of publications 136
PhD portfolio 137
Dankwoord 139
References 142
Appendix 1 A day and night difference in the response of 157
the hepatic transcriptome to cyclophosphamide
treatment
Appendix 2 Supplemental data 181
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