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mebooksfree.com mebooksfree.com Wintrobe’s CLINICAL HEMATOLOGY FOURTEENTH EDITION Editors: John P. Greer, MD Professor Departments of Medicine and Pediatrics Divisions of Hematology and Oncology Vanderbilt University Medical Center Nashville, Tennessee George M. Rodgers, MD, PhD Professor of Medicine and Pathology University of Utah School of Medicine Health Sciences Center Medical Director, Coagulation Laboratory ARUP Laboratories Salt Lake City, Utah Bertil Glader, MD, PhD Professor Departments of Pediatrics and Pathology Stanford University Medical Center Stanford, California Lucile Packard Children’s Hospital Palo Alto, California mebooksfree.com Daniel A. Arber, MD Professor and Chair Department of Pathology University of Chicago Chicago, Illinois Robert T. Means, Jr., MD Professor of Internal Medicine James H. Quillen College of Medicine East Tennessee State University Johnson City, Tennessee Alan F. List, MD Senior Member Department of Malignant Hematology President and CEO Moffitt Cancer Center Tampa, Florida Frederick R. Appelbaum, MD Deputy Director Fred Hutchinson Cancer Research Center Professor University of Washington School of Medicine Seattle, Washington Angela Dispenzieri, MD Professor Division of Hematology and Division of Clinical Chemistry Departments of Internal Medicine and Laboratory Medicine Mayo Clinic Rochester, Minnesota Todd A. Fehniger, MD, PhD Associate Professor Division of Oncology Department of Medicine mebooksfree.com Washington University School of Medicine Saint Louis, Missouri mebooksfree.com Acquisitions Editor: Ryan Shaw Editorial Coordinator: Annette Ferran Editorial Assistant: Kate Sherrer Marketing Manager: Julie Sikora Production Project Manager: David Saltzberg Design Coordinator: Holly McLaughlin Manufacturing Coordinator: Beth Welsh Prepress Vendor: S4Carlisle Publishing Services Fourteenth edition Copyright © 2019 Wolters Kluwer. Copyright © 1942, 1946, 1951, 1956, 1961, 1967, 1971, 1974, 1981 Lea & Febiger; Copyright © 1993, Williams & Wilkins; Copyright © 1999, 2004, 2009 Lippincott Williams & Wilkins; Copyright © 2014, Lippincott Williams & Wilkins, a Wolters Kluwer business. All rights reserved. This book is protected by copyright. No part of this book may be reproduced or transmitted in any form or by any means, including as photocopies or scanned-in or other electronic copies, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above- mentioned copyright. To request permission, please contact Wolters Kluwer at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103, via email at [email protected], or via our website at lww.com (products and services). 9 8 7 6 5 4 3 2 1 Printed in China Library of Congress Cataloging-in-Publication Data Names: Greer, John P., editor. Title: Wintrobe’s clinical hematology / editors, John P. Greer [and 8 others]. mebooksfree.com Other titles: Clinical hematology Description: Fourteenth edition. | Philadelphia, PA: Wolters Kluwer, [2019] | Includes bibliographical references and index. Identifiers: LCCN 2018042668 | ISBN 9781496347428 (hardback) Subjects: | MESH: Hematologic Diseases | Blood | Hematology—methods Classification: LCC RB145 | NLM WH 120 | DDC 616.1/5—dc23 LC record available at https://lccn.loc.gov/2018042668 This work is provided “as is,” and the publisher disclaims any and all warranties, express or implied, including any warranties as to accuracy, comprehensiveness, or currency of the content of this work. This work is no substitute for individual patient assessment based on healthcare professionals’ examination of each patient and consideration of, among other things, age, weight, gender, current or prior medical conditions, medication history, laboratory data, and other factors unique to the patient. The publisher does not provide medical advice or guidance, and this work is merely a reference tool. Healthcare professionals, and not the publisher, are solely responsible for the use of this work, including all medical judgments, and for any resulting diagnosis and treatments. Given continuous, rapid advances in medical science and health information, independent professional verification of medical diagnoses, indications, appropriate pharmaceutical selections and dosages, and treatment options should be made, and healthcare professionals should consult a variety of sources. When prescribing medication, healthcare professionals are advised to consult the product information sheet (the manufacturer’s package insert) accompanying each drug to verify, among other things, conditions of use, warnings, and side effects and identify any changes in dosage schedule or contraindications, particularly if the medication to be administered is new, infrequently used, or has a narrow therapeutic range. To the maximum extent permitted under applicable law, no responsibility is assumed by the publisher for any injury and/or damage to persons or property, as a matter of products liability, negligence law or otherwise, or from any reference to or use by any person of this work. shop.lww.com mebooksfree.com DR. MAXWELL M. WINTROBE mebooksfree.com mebooksfree.com Contributors Archana M. Agarwal Associate Professor Department of Pathology University of Utah Health Salt Lake City, Utah Claudio Anasetti, MD Professor Oncologic Sciences University of South Florida Senior Member, Department Chair Department of Blood and Marrow Transplantation H. Lee Moffitt Cancer Center Tampa, Florida Jennifer Andrews, MD, MSc Assistant Professor Departments of Pathology, Microbiology and Immunology, and Pediatrics Vanderbilt University Medical Center Nashville, Tennessee Stephen M. Ansell, MD, PhD Professor of Medicine Department of Medicine Consultant, Division of Hematology mebooksfree.com Mayo Clinic Rochester, Minnesota Frederick R. Appelbaum, MD Deputy Director Fred Hutchinson Cancer Research Center Professor University of Washington School of Medicine Seattle, Washington Daniel A. Arber, MD Professor and Chair Department of Pathology University of Chicago Chicago, Illinois Maria R. Baer, MD Professor of Medicine University of Maryland School of Medicine Director, Hematologic Malignancies Greenebaum Cancer Center University of Maryland Baltimore, Maryland Charles D. Bangs, BS Cytogenetic Laboratory Supervisor Department of Pathology Stanford Health Care Palo Alto, California James C. Barton, MD Clinical Professor of Medicine