Table Of Content

Larsen: Williams Textbook of Endocrinology, 10th ed., Copyright © 2003 Elsevier Section 1 - Hormones and Hormone Action 1 - Principles of Endocrinology 2 - The Endocrine Patient 3 - Genetic Control of Peptide Hormone Formation 4 - Mechanism of Action of Hormones That Act on Nuclear Receptors 5 - Mechanism of Action of Hormones That Act at the Cell Surface 6 - Laboratory Techniques for Recognition of Endocrine Disorders Section 2 - Hypothalamus and Pituitary 7 - Neuroendocrinology 8 - Anterior Pituitary 9 - Posterior Pituitary Gland Section 3 - Thyroid 10 - Thyroid Physiology and Diagnostic Evaluation of Patients with Thyroid Disorders 11 - Thyrotoxicosis 12 - Hypothyroidism and Thyroiditis 13 - Nontoxic Goiter and Thyroid Neoplasia Section 4 - Adrenal Cortex and Endocrine Hypertension 14 - The Adrenal Cortex 15 - Endocrine Hypertension Section 5 - Reproduction 16 - The Physiology and Pathology of the Female Reproductive Axis 17 - Fertility Control: Current Approaches and Global Aspects 18 - Disorders of the Testes and the Male Reproductive Tract 19 - Sexual Dysfunction in Men and Women Section 6 - Endocrinology and the Life Span 20 - Endocrine Changes in Pregnancy 21 - Endocrinology of Fetal Development 22 - Disorders of Sex Differentiation 23 - Normal and Aberrant Growth 24 - Puberty: Ontogeny, Neuroendocrinology, Physiology, and Disorders 25 - Endocrinology and Aging Section 7 - Mineral Metabolism 26 - Hormones and Disorders of Mineral Metabolism 27 - Metabolic Bone Disease 28 - Kidney Stones Section 8 - Disorders of Carbohydrate and Lipid Metabolism 29 - Type 2 Diabetes Mellitus 30 - Type 1 Diabetes Mellitus 31 - Complications of Diabetes Mellitus 32 - Glucose Homeostasis and Hypoglycemia 33 - Obesity 34 - Disorders of Lipid Metabolism Section 9 - Polyendocrine Disorders 35 - Pathogenesis of Endocrine Tumors 36 - Multiple Endocrine Neoplasia 37 - The Immunoendocrinopathy Syndromes Section 10 - Paraendocrine and Neoplastic Syndromes 38 - Gastrointestinal Hormones and Gut Endocrine Tumors 39 - Endocrine-Responsive Cancer 40 - Humoral Manifestations of Malignancy 41 - Carcinoid Tumors, Carcinoid Syndrome, and Related Disorders Appendix: Reference Values Larsen: Williams Textbook of Endocrinology, 10th ed. , Copyright © 2003 Elsevier I Williams Textbook of Endocrinology T E ENTH DITION P. Reed Larsen MD, FACP, FRCP Professor of Medicine Harvard Medical School Chief, Division of Endocrinology, Diabetes and Hypertension Brigham and Women's Hospital Boston, Massachusetts Henry M. Kronenberg MD Professor of Medicine Harvard Medical School Chief, Endocrine Unit Massachusetts General Hospital Boston, Massachusetts Shlomo Melmed MD Senior Vice President, Academic Affairs Cedars Sinai Research Institute Professor of Medicine and Associate Dean University of California, Los Angeles, School of Medicine Los Angeles, California Kenneth S. Polonsky MD Adolphus Busch Professor and Chairman Department of Medicine Professor, Department of Cell Biology and Physiology Washington University School of Medicine St. Louis, Missouri SAUNDERS An Imprint of Elsevier Science Bookmark URL: 1.html/top Larsen: Williams Textbook of Endocrinology, 10th ed. , Copyright © 2003 Elsevier II SAUNDERS An Imprint of Elsevier Science The Curtis Center Independence Square West Philadelphia, Pennsylvania 19106 WILLIAMS TEXTBOOK OF ENDOCRINOLOGY ISBN 0-7216-9184-6 Copyright © 2003, 1998, 1992, 1985, 1981, 1974, 1968, 1962, 1955 by Elsevier Science (USA). Copyright 1950 by W.B. Saunders Company Copyright renewed 1990 by A.B. Williams, R.I. Williams Copyright renewed 1983 by William H. Daughaday Copyright renewed 1978 by Robert H. Williams All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission in writing from the publisher. Notice Medicine is an ever-changing field. Standard safety precautions must be followed, but as new research and clinical experience broaden our knowledge, changes in treatment and drug therapy may become necessary or appropriate. Readers are advised to check the most current product information provided by the manufacturer of each drug to be administered to verify the recommended dose, the method and duration of administration, and contraindications. It is the responsibility of the treating physician, relying on experience and knowledge of the patient, to determine dosages and the best treatment for each individual patient. Neither the publisher nor the editor assumes any liability for any injury and/or damage to persons or property arising from this publication. T P HE UBLISHER Library of Congress Cataloging-in-Publication Data Williams textbook of endocrinology/P. Reed Larsen ... [et al.].10th ed. p.; cm. ISBN 0-7216-9184-6 1. Endocrinology. 2. Endocrine glandsDiseases. I. Williams, Robert Hardin. II. Larsen, P. Reed. RC648 .T48 2002 616.4dc21 DNLM/DLC 2002019193 Acquisitions Editor: Catherine Carroll Senior Developmental Editor: Faith Voit Project Manager: Norman Stellander Designer: Steven Stave PIT/MVB Printed in the United States of America. Last digit is the print number: 9 8 7 6 5 4 3 2 1 Bookmark URL: 2.html/top Larsen: Williams Textbook of Endocrinology, 10th ed. , Copyright © 2003 Elsevier III Contributors Eli Y. Adashi Presidential Professor of Obstetrics and Gynecology and John A. Dixon Professor and Chair, Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah The Physiology and Pathology of the Female Reproductive Axis; Fertility Control: Current Approaches and Global Aspects Lloyd P. Aiello Associate Professor of Ophthalmology, Harvard Medical School; Assistant Director, Beetham Eye Institute; Investigator and Head, Section of Eye Research, Joslin Diabetes Center, Boston, Massachusetts Complications of Diabetes Mellitus Andrew Arnold Murray-Heilig Chair in Molecular Medicine and Professor of Medicine and Genetics, University of Connecticut School of Medicine; Director, Center for Molecular Medicine, and Chief, Division of Endocrinology and Metabolism, University of Connecticut, Farmington, Connecticut Pathogenesis of Endocrine Tumors Jennifer Berman Assistant Professor, Department of Urology, David Geffen School of Medicine at University of California, Los Angeles; Attending Surgeon, UCLA Medical Center; Co-Director, Female Sexual Medicine Center at UCLA, Los Angeles, California Sexual Dysfunction in Men and Women IV Laura Berman Assistant Professor, Department of Urology, David Geffen School of Medicine at University of California, Los Angeles; Co-Director, Female Sexual Medicine Center at UCLA, Los Angeles, California Sexual Dysfunction in Men and Women Shalender Bhasin Professor of Medicine, University of California, Los Angeles, School of Medicine; Chief, Division of Endocrinology, Metabolism, and Molecular Medicine, Charles Drew University and King-Drew Medical Center, Los Angeles, California Sexual Dysfunction in Men and Women Andrew J. M. Boulton Professor of Medicine, University of Manchester; Consultant Physician, Manchester Royal Infirmary, Manchester, United Kingdom Complications of Diabetes Mellitus Robin P. Boushey General Surgery Resident, Department of Surgery, University of Toronto, Toronto, Ontario, Canada Gastrointestinal Hormones and Gut Endocrine Tumors Glenn D. Braunstein Professor of Medicine, University of California, Los Angeles, School of Medicine; Chairman, Department of Medicine, The James R. Klinenberg, MD, Chair in Medicine, Cedars-Sinai Medical Center, Los Angeles, California Endocrine Changes in Pregnancy F. Richard Bringhurst Associate Professor of Medicine, Harvard Medical School; Physician, Massachusetts General Hospital, Boston, Massachusetts Hormones and Disorders of Mineral Metabolism V Michael Brownlee Anita and Jack Saltz Professor of Diabetes Research and Professor of Medicine and Pathology, Albert Einstein College of Medicine, Bronx, New York Complications of Diabetes Mellitus Serdar E. Bulun Associate Professor of Obstetrics-Gynecology and Molecular Genetics; Director, Division of Reproductive Endocrinology and Infertility, University of Illinois, Chicago, Illinois The Physiology and Pathology of the Female Reproductive Axis Charles F. Burant Associate Professor, Department of Internal Medicine, University of Michigan; Attending Physician, University of Michigan Hospitals, Ann Arbor, Michigan Type 2 Diabetes Mellitus John B. Buse Associate Professor of Medicine; Chief, Division of General Medicine and Clinical Epidemiology; Director, Diabetes Care Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina Type 2 Diabetes Mellitus; Type 1 Diabetes Mellitus David A. Bushinsky Professor of Medicine and of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry; Chief, Nephrology Unit, Strong Memorial Hospital, Rochester, New York Kidney Stones Judy L. Cameron Associate Professor, Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania; Associate Scientist, Oregon National Primate Research Center, Oregon Health and Science University, Portland, Oregon Neuroendocrinology VI Christin Carter-Su Professor of Physiology; Associate Director, Michigan Diabetes Research and Training Center, University of Michigan Medical School, Ann Arbor, Michigan Mechanism of Action of Hormones That Act at the Cell Surface Roger D. Cone Senior Scientist, Vollum Institute; Associate Professor, Department of Cell and Developmental Biology, Oregon Health and Science University, Portland, Oregon Neuroendocrinology Felix A. Conte Professor of Pediatrics, Department of Pediatrics, University of California, San Francisco, School of Medicine, San Francisco, California Disorders of Sex Differentiation Philip E. Cryer Irene E. and Michael M. Karl Professor of Endocrinology and Metabolism in Medicine, Washington University School of Medicine; Chief of Endocrinology, Diabetes, and Metabolism, Barnes-Jewish Hospital, St. Louis, Missouri Glucose Homeostasis and Hypoglycemia Terry F. Davies Professor of Medicine and Director, Division of Endocrinology, Diabetes and Bone Diseases, Mount Sinai School of Medicine; Attending Physician, Mount Sinai Hospital, New York, New York Thyroid Physiology and Diagnostic Evaluation of Patients with Thyroid Disorders; Thyrotoxicosis; Hypothyroidism and Thyroiditis Marie B. Demay Associate Professor of Medicine, Harvard Medical School; Associate Physician, Massachusetts General Hospital, Boston, Massachusetts Hormones and Disorders of Mineral Metabolism VII Robert G. Dluhy Professor of Medicine, Harvard Medical School; Clinical Chief, Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, Massachusetts Endocrine Hypertension Daniel J. Drucker