White Spot Lesions after Orthodontic Fixed Appliance Treatment The effectiveness of MI Paste Plus

146 Pages·2017·4.58 MB·English

W White Spot Lesions after
h Orthodontic Fixed Appliance Treatment
i
t
e
The effectiveness of MI Paste Plus®
Sp White Spot Lesions after as a remineralising agent
o
t Orthodontic Fixed Appliance Treatment a randomised controlled trial
L
e
s
i 1. MI Paste Plus®, a remineralisation agent,
o
does not show its intended effect in
n The effectiveness of MI Paste Plus®
s patients who have white spot lesions
a (WSL) after orthodontic treatment with
as a remineralising agent
f full fixed appliances.
t
e
r 2. WSL tend to regress over time but do

O not disappear after removal of the
rt a randomised controlled trial appliances.
h
3. After bracket removal the microbial
o
d composition gradually changes towards
o a more healthy composition. This is a
n gradual change that does not occur
t
i immediately after bracket removal.
c

F 4. The ICDAS scoring system on clinical
i
x oral photographs does not have enough
e
discriminatory power to address
d
Moniek Willemien Beerens changes in WSL over time.
A
p 5. Comparing respective clinical oral
p photographs taken over time provides
l
ia discriminatory power in assessing
n changes in WSL severity. This method
c of monitoring WSL over time is useful
e
for clinical decision making in the
T
r management of WSL.
e
a 6. Quantitative light induced fluorescence
tm (QLF) is confirmed as a useful outcome
measure in detecting and monitoring
e
n WSL over time.
t
7. The DGGE-banding pattern software,
Gelcompare-II is susceptible to bias
when used with the provided settings.
8. Denaturing Gradient Gel Electrophoresis
(DGGE) and analysis of microbial
composition does not have a predictive
value for caries risk assessment of the
formation of WSL in orthodontic patients
treated with full fixed appliances.
9. Conventional microbiological plating,
analysing bacteria counts, percentage of
aciduric flora, S. Mutans, Lactobacillus spp.
M and Candida Albicans is not predictive for
o caries risk assessment of the formation
n of WSL in orthodontic patients treated
ie with full fixed appliances.
k
10. This thesis describes the fi rst
W
randomised control trial assessing the
ill eff ectiveness of MI Paste Plus® in vivo for
e
the treatment of WSL after orthodontic
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White Spot Lesions after White Spot Lesions after
Orthodontic Fixed Appliance Treatment Orthodontic Fixed Appliance Treatment
The effectiveness of MI Paste Plus® The effectiveness of MI Paste Plus®
as a remineralising agent as a remineralising agent
a randomised controlled trial a randomised controlled trial
Moniek Willemien Beerens Moniek Willemien Beerens
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COLOFON COLOFON
Lay-out: Nikki Vermeulen - Ridderprint BV Lay-out: Nikki Vermeulen - Ridderprint BV
Printing: Ridderprint BV - www.ridderprint.nl Printing: Ridderprint BV - www.ridderprint.nl
ISBN: 978-94-6299-863-6 ISBN: 978-94-6299-863-6
www.publicatie-online.nl/publicaties/m-beerens/ www.publicatie-online.nl/publicaties/m-beerens/
The research described in this thesis was performed as a research collaboration between the The research described in this thesis was performed as a research collaboration between the
Department of Orthodontics and the Department of Preventive Dentistry of the Academic Department of Orthodontics and the Department of Preventive Dentistry of the Academic
Centre for Dentistry Amsterdam (ACTA), the combined faculty of dentistry of the University Centre for Dentistry Amsterdam (ACTA), the combined faculty of dentistry of the University
of Amsterdam and the VU University Amsterdam, the Netherlands. of Amsterdam and the VU University Amsterdam, the Netherlands.
Copyright © by M.W. Beerens, 2018 Copyright © by M.W. Beerens, 2018
All rights reserved. No parts of this book may be reproduced in any form, by print, photocopy, All rights reserved. No parts of this book may be reproduced in any form, by print, photocopy,
electronic data transfer or any other means, without prior permission of the author. electronic data transfer or any other means, without prior permission of the author.
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White Spot Lesions after White Spot Lesions after
Orthodontic Fixed Appliance Treatment Orthodontic Fixed Appliance Treatment
The effectiveness of MI Paste Plus® The effectiveness of MI Paste Plus®
as a remineralising agent as a remineralising agent
a randomised controlled trial a randomised controlled trial
ACADEMISCH PROEFSCHRIFT ACADEMISCH PROEFSCHRIFT
ter verkrijging van de graad van doctor ter verkrijging van de graad van doctor
aan de Universiteit van Amsterdam aan de Universiteit van Amsterdam
op gezag van Rector Magnificus op gezag van Rector Magnificus
prof. dr. ir. K. I. J. Maex prof. dr. ir. K. I. J. Maex
ten overstaan van een door het College voor Promoties ingestelde commissie, ten overstaan van een door het College voor Promoties ingestelde commissie,
in het openbaar te verdedigen in de Agnietenkapel in het openbaar te verdedigen in de Agnietenkapel
op woensdag 11 april 2018, te 10:00 uur op woensdag 11 april 2018, te 10:00 uur
door door
Moniek Willemien Beerens Moniek Willemien Beerens
geboren te Jakarta, Indonesië geboren te Jakarta, Indonesië
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PROMOTIECOMMISSIE PROMOTIECOMMISSIE
Promotor: Promotor:
Prof. dr. J.M. ten Cate Universiteit van Amsterdam Prof. dr. J.M. ten Cate Universiteit van Amsterdam
Co-promotor: Co-promotor:
Dr. ir. M.H. van der Veen Vrije Universiteit Amsterdam Dr. ir. M.H. van der Veen Vrije Universiteit Amsterdam
Overige leden: Overige leden:
Dr. T.J. Algera Universiteit van Amsterdam Dr. T.J. Algera Universiteit van Amsterdam
Prof. dr. C. van Loveren Universiteit van Amsterdam Prof. dr. C. van Loveren Universiteit van Amsterdam
Prof. dr. B. Prahl- Andersen Vrije Universiteit Amsterdam Prof. dr. B. Prahl- Andersen Vrije Universiteit Amsterdam
Prof. dr. Y. Ren Rijksuniversiteit Groningen Prof. dr. Y. Ren Rijksuniversiteit Groningen
Prof. dr. F.R. Rozema Universiteit van Amsterdam Prof. dr. F.R. Rozema Universiteit van Amsterdam
Faculteit der Tandheelkunde Faculteit der Tandheelkunde
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PARANIMFEN PARANIMFEN
F.C.R. (Fenne) Hoogteijling F.C.R. (Fenne) Hoogteijling
Ir. V. (Viveca) Thörnlund Ir. V. (Viveca) Thörnlund
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Therapeutic reports with controls tend to have no enthusiasm, Therapeutic reports with controls tend to have no enthusiasm,
reports with enthusiasm tend to have no controls. reports with enthusiasm tend to have no controls.
David Lawrence Sackett (1934 – 2015) was an American-Canadian medical doctor and a pioneer David Lawrence Sackett (1934 – 2015) was an American-Canadian medical doctor and a pioneer
in evidence-based medicine. He is known as one of the fathers of Evidence-Based Medicine. in evidence-based medicine. He is known as one of the fathers of Evidence-Based Medicine.
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CONTENTS CONTENTS
CHAPTER 1 General introduction and outline of the thesis 9 CHAPTER 1 General introduction and outline of the thesis 9
CHAPTER 2 White spot lesions after orthodontic treatment with fixed 23 CHAPTER 2 White spot lesions after orthodontic treatment with fixed 23
appliance assessed on clinical photography and appliance assessed on clinical photography and
by quantitative light-induced fluorescence imaging; by quantitative light-induced fluorescence imaging;
a retrospective study a retrospective study
CHAPTER 3 The use of Denaturing Gradient Gel Electrophoreses and 39 CHAPTER 3 The use of Denaturing Gradient Gel Electrophoreses and 39
conventional microbiology as indicator of white spot conventional microbiology as indicator of white spot
lesions in orthodontic patients; a cross-sectional study lesions in orthodontic patients; a cross-sectional study
CHAPTER 4 Remineralising effect of MI Paste Plus® on the regression 55 CHAPTER 4 Remineralising effect of MI Paste Plus® on the regression 55
of early caries after orthodontic fixed appliance of early caries after orthodontic fixed appliance
treatment; a randomized 3-month follow-up clinical trial treatment; a randomized 3-month follow-up clinical trial
CHAPTER 5 Long-term remineralising effect of MI Paste Plus® on 77 CHAPTER 5 Long-term remineralising effect of MI Paste Plus® on 77
the regression of early caries after orthodontic fixed the regression of early caries after orthodontic fixed
appliance treatment; a randomized 12-month follow-up appliance treatment; a randomized 12-month follow-up
clinical trial clinical trial
CHAPTER 6 General discussion 103 CHAPTER 6 General discussion 103
Conclusions 111 Conclusions 111
CHAPTER 7 Summary (ENG) 115 CHAPTER 7 Summary (ENG) 115
Samenvatting (NL) 123 Samenvatting (NL) 123
CHAPTER 8 List of publications 131 CHAPTER 8 List of publications 131
Author contributions 134 Author contributions 134
Dankwoord 139 Dankwoord 139
Curriculum vitae auctoris 143 Curriculum vitae auctoris 143
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