Voltage-Gated Ion Channels as Drug Targets PDF
488 Pages·2004·4.842 MB·English
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Content: Introduction : on ion channels / Murali Gopalakrishnan, David Rampe, David Triggle, Wei Zheng -- The voltage-gated ion channel superfamily / William A. Catterall -- State-dependent drug interactions with ion channels / Stefan I. McDonough, Bruce P. Bean -- Assay technologies : techniques available for quantifying drug-channel interactions / Derek Leishman, Gareth Waldron -- Overview of voltage-gated calcium channels / Clinton Doering, Gerald Zamponi -- Drugs active at T-type Ca²⁺ channels / Thomas M. Connolly, James C. Barrow -- L-type calcium channels / David J. Triggle -- N-type calcium channels -- Molecular, biophysical and functional properties of voltage-gated sodium channels / Douglas S. Krafte, Mark Chapman, Ken McCormack -- Small molecule blockers of voltage-gated sodium channels / Jesús E. González, Andreas P. Termin, Dean M. Wilson -- Potassium channels : overview of molecular, biophysical and pharmacological properties / Murali Gopalakrishnan, Char-Chang Shieh, Jun Chen -- Kv1.3 potassium channel : physiology, pharmacology and therapeutic indications / K. George Chandy, Heike Wulff, Christine Beeton, Peter A. Calabresi, George A. Gutman, Michael Pennington -- Drugs active at kv1.5 potassium channels / Stefan Peukert, Heinz Gögelein -- Medicinal chemistry of Ca²⁺-activated K⁺ channel modulators / Sean C. Turner, Char-Chang Shieh -- Drugs active at ATP-sensitive K⁺ channels / William A. Carroll -- Compounds that activate KCNQ(2-5) family of potassium ion channels / Grant McNaughton-Smith, Alan D. Wickenden -- Inherited disorders of ion channels / Kate Bracey, Dennis Wray -- Structural and ligand-based models for HERG and their application in medicinal chemistry / Yi Li, Giovanni Cianchetta, Roy J. Vaz -- Ion channel safety issues in drug development / Armando A. Lagrutta, Joseph J. Salata
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