Vitamin C: Current Concepts in Human Physiology PDF
Preview Vitamin C: Current Concepts in Human Physiology
antioxidants Vitamin C Current Concepts in Human Physiology Edited by Ramesh Natarajan and Anitra C. Carr Printed Edition of the Special Issue Published in Antioxidants www.mdpi.com/journal/antioxidants Vitamin C: Current Concepts in Human Physiology Vitamin C: Current Concepts in Human Physiology SpecialIssueEditors RameshNatarajan AnitraC.Carr MDPI•Basel•Beijing•Wuhan•Barcelona•Belgrade Special Issue Editors Ramesh Natarajan Anitra C. Carr Virginia Commonwealth University University of Otago USA New Zealand EditorialOffice MDPI St.Alban-Anlage66 Basel,Switzerland This is a reprint of articles from the Special Issue published online in the open access journal Antioxidants (ISSN 2076-3921) from 2017 to 2018 (available at: https://www.mdpi.com/ journal/antioxidants/specialissues/vitaminC) Forcitationpurposes,citeeacharticleindependentlyasindicatedonthearticlepageonlineandas indicatedbelow: LastName,A.A.; LastName,B.B.; LastName,C.C.ArticleTitle. JournalNameYear,ArticleNumber, PageRange. ISBN978-3-03897-294-5(Pbk) ISBN978-3-03897-295-2(PDF) ArticlesinthisvolumeareOpenAccessanddistributedundertheCreativeCommonsAttribution (CCBY)license,whichallowsuserstodownload,copyandbuilduponpublishedarticlesevenfor commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. The book taken as a whole is (cid:2)c 2018 MDPI, Basel, Switzerland, distributed under the terms and conditions of the Creative CommonslicenseCCBY-NC-ND(http://creativecommons.org/licenses/by-nc-nd/4.0/). Contents AbouttheSpecialIssueEditors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii Prefaceto”VitaminC:CurrentConceptsinHumanPhysiology”. . . . . . . . . . . . . . . . . . ix GinaNauman,JavaughnCoreyGray,RoseParkinson,MarkLevineandChanningJ.Paller SystematicReviewofIntravenousAscorbateinCancerClinicalTrials Reprintedfrom:Antioxidants2018,7,89,doi:10.3390/antiox7070089 . . . . . . . . . . . . . . . . 1 MikeN.Foster,AnitraC.Carr,AlinaAntony,SelenePengandMikeG.Fitzpatrick Intravenous Vitamin C Administration Improved Blood Cell Counts and Health-Related QualityofLifeofPatientwithHistoryofRelapsedAcuteMyeloidLeukaemia Reprintedfrom:Antioxidants2018,7,92,doi:10.3390/antiox7070092 . . . . . . . . . . . . . . . . 23 NicolaBaillie,AnitraC.CarrandSelenePeng The Use of Intravenous Vitamin C as a Supportive Therapy for a Patient with GlioblastomaMultiforme Reprintedfrom:Antioxidants2018,7,115,doi:10.3390/antiox7090115 . . . . . . . . . . . . . . . . 30 MariaLeticiaCastro,GeorgiaM.Carson,MelanieJ.McConnellandPatriesM.Herst HighDoseAscorbateCausesBothGenotoxicandMetabolicStressinGliomaCells Reprintedfrom:Antioxidants2017,6,58,doi:10.3390/antiox6030058 . . . . . . . . . . . . . . . . 36 MelissaPrier,AnitraC.CarrandNicolaBaillie NoReportedRenalStoneswithIntravenousVitaminCAdministration: AProspectiveCase SeriesStudy Reprintedfrom:Antioxidants2018,7,68,doi:10.3390/antiox7050068 . . . . . . . . . . . . . . . . 49 AnitraC.Carr Symposium on Vitamin C, 15th September 2017; Part of the Linus Pauling Institute’s 9th InternationalConferenceonDietandOptimumHealth Reprintedfrom:Antioxidants2017,6,94,doi:10.3390/antiox6040094 . . . . . . . . . . . . . . . . 59 KarelTyml VitaminCandMicrovascularDysfunctioninSystemicInflammation Reprintedfrom:Antioxidants2017,6,49,doi:10.3390/antiox6030049 . . . . . . . . . . . . . . . . 68 Gwendolyn N.Y. van Gorkom, Roel G.J. Klein Wolterink, Catharina H.M.J. Van Elssen, LotteWieten,WilfredT.V.GermeraadandGerardM.J.Bos InfluenceofVitaminConLymphocytes:AnOverview Reprintedfrom:Antioxidants2018,7,41,doi:10.3390/antiox7030041 . . . . . . . . . . . . . . . . 79 Kimberly Sanford, Bernard J. Fisher, Evan Fowler, Alpha A. Fowler III and RameshNatarajan AttenuationofRedBloodCellStorageLesionswithVitaminC Reprintedfrom:Antioxidants2017,6,55,doi:10.3390/antiox6030055 . . . . . . . . . . . . . . . . 93 JulietM.Pullar,SimoneBayerandAnitraC.Carr Appropriate Handling, Processing and Analysis of Blood Samples Is Essential to Avoid OxidationofVitaminCtoDehydroascorbicAcid Reprintedfrom:Antioxidants2018,7,29,doi:10.3390/antiox7020029 . . . . . . . . . . . . . . . . 106 v JulietM.Pullar,AnitraC.Carr,StephanieM.BozonetandMargreetC.M.Vissers HighVitaminCStatusIsAssociatedwithElevatedMoodinMaleTertiaryStudents Reprintedfrom:Antioxidants2018,7,91,doi:10.3390/antiox7070091 . . . . . . . . . . . . . . . . 117 Stine Normann Hansen, Anne Marie V. Schou-Pedersen, Jens Lykkesfeldt and PernilleTveden-Nyborg SpatialMemoryDysfunctionInducedbyVitaminCDeficiencyIsAssociatedwithChangesin MonoaminergicNeurotransmittersandAberrantSynapseFormation Reprintedfrom:Antioxidants2018,7,82,doi:10.3390/antiox7070082 . . . . . . . . . . . . . . . . 126 vi About the Special Issue Editors Ramesh Natarajan, PhD, was Professor of Medicine at Virginia Commonwealth University, Richmond,VA,USA.Dr. Natarajan’sresearchfocusedonpulmonary/criticalcaremedicineandin particular on sepsis, thrombosis and hemostasis, trauma, hemorrhagic shock, resuscitation, brain injury, and vitamin C. He conceived the notion of treating sepsis with parenteral vitamin C and designedanimalmodelsofsepsistotesthishypothesis. HesubsequentlyparticipatedinaPhase IandPhaseIIstudyofintravenousvitaminCinsepsis.Hehaspublished69manuscripts,4textbook chapters,hasgivenover130presentations,andhaspublished140abstracts. Heservesonseveral EditorialBoards,asanadhocreviewerforjournalsandstudysectionsforNIH,CDMRP,andVA.He iscurrentlyworkingonCombatTraumaResearch. AnitraC.Carr, AssociateProfessor, isaSirCharlesHercusHealthResearchFellowandPrincipal InvestigatorattheUniversityofOtago,Christchurch,NewZealand.DrCarrisparticularlyinterested in the role of micronutrients in human health and disease and has spent much of her research careerinvestigatingtheantioxidantandhealtheffectsofvitaminC.In1998–2001, shecarriedout anAmericanHeartAssociationPostdoctoralFellowshipattheLinusPaulingInstitute,OregonState University,Corvallis,USA,underthementorshipofeminentvitaminCresearcher,Prof. BalzFrei. Whilst there, she produced a number of high impact publications on vitamin C in human health anddisease. Recently,DrCarrhasbeencarryingouthumaninterventionstudiesinvestigatingthe bioavailabilityandhealtheffectsofbothoralandintravenousvitaminC,particularlyitsrolesinacute andchronicdiseases,suchascancerandinfection,subjectivemood,andqualityoflife. vii Preface to ”Vitamin C: Current Concepts in Human Physiology” VitaminCissynthesizedbyalmostallanimals. However,forhumans,itisavitaminthatneeds constant replenishment in the diet. While its role as an anti-oxidant and for preventing scurvy have been known for a long time, novel functions and unrecognized associations continue to be identified for this enigmatic molecule. In the past decade, new details have emerged regarding differences in its uptake by oral and intravenous modes. While vitamin C deficiency remains largelyunknownandpoorlyaddressedinmanysegmentsofthepopulation,novelpharmacological rolesforhigh-dose, intravenousvitaminCinmanydiseasestateshavenowbeenpostulated and investigated.Thishasshifteditsroleinhealthanddiseasefromthelong-perceivednotionasmerely avitaminandananti-oxidanttoapleiotropicmoleculewithabroadanti-inflammatory,epigenetic, andanti-cancerprofile. ThisSpecialIssuecomprisesoriginalresearchpapersandreviewsonvitaminCmetabolismand functionthatrelatetothefollowingtopics:understandingitsroleinthemodulationofinflammation andimmunity,therapeuticapplicationsandsafetyofpharmacologicalascorbateindisease,andthe emergingroleofvitaminCasapleiotropicmodulatorofcriticalcareillnessandcancer. RameshNatarajan,AnitraC.Carr SpecialIssueEditors ix
Description:The list of books you might like
