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Virus Mania PDF

316 Pages·2011·18.67 MB·English
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Torsten Engelbrecht ClausK ohnlein ViruMsa nia AvianF lu( HSN1)C,e rvicCaaln ce(rH PV), SARS,B SE,H epatitCi,As I DS,P olio Howt heM edicaIln dustry ContiInnuvaelnltEysp idemics, MakingB illion-Dollar Profits AtO urE xpense Foreworbdys EtiendneeH arveMnD,,P ioneeirnV irology JoachiMmu tteMrD,,E xperotn E nvironmenMteadli cine TorstEenng elbrecht ClauKso hnlein VirusM ania Aboutth Beo ok A dailsyc ant hrougthh en ewspapearnsdT Vn ewsg ivetsh ei mpresstihoantt h ee ntiwroer lids constanitnlvya debdy new andh orrible virus Tehpeil daetmeihscetsa .d linfeesa tutrhee h uman papilloma(vHiPrVua)sl legteodc auscee rviccaanlc earn dt hea viafnl vui ruHsS,N l.T hep ublica lsios continutaelrlryo ribzyre edp oratbso uStA RS,BS E,H epatiCt,iA sI DSE,b olaa,n dP oliHoo.w evetrh,i s virumsa yhemi gnorveesr bya siscc ientfiafcittcsh :ee xistetnhceep ,a thogenaincidtt hyed eadleyf fects oft hesaeg enthsa ven evebre enp roveTnh.e m ediceaslt ablishamnedin ttls o yamle diaac olyctleasi m thatth iesv idenhcaesb eenp roduceBdu.tt hescel aiamrse h ighsluys pebcetc aumsoed ernm edicihnaes pusheddi revcitr upsr oomfe thodass idaen du sedsu bioiunsd irteocotlt os" provteh"ee xisteonfvc ier uses sucahs a ntibotdeys atnsd t hep olymercahsaei rne acti(oPnC R). Thea uthoorfsV iruMsa niaj,o urnalToirsstt eEnn gelbreacnhddt o ctoorfi ntermneadli ciCnlea us Kohnlesihno,wt hatth esael legceodn tagivoiursu saersei ,nf acpta,r ticplreosd ucbeydt hec eltlhse mselves asa consequeonfcc ee rtasitnr efsasc tosrusc ahs d rugTsh.e spea rticalreets h eind entibfyia endt ibody andP CRt esatnsd i nterpraeste epdi demic-causinbgyd ovcitrouwrshseo sh avebe eni noculaftoeordv er 100ye arbsyt het heorthya mti crobaersed eadlayn do nlmyo dermne dicatiaonndvs a ccinweisl l protect usf romv irupsa ndemics. Thec entraailmo ft hibso oki st os teetrh ed iscussbiaoctnko a r easlc ientdiefibca taen dp utm edicine backo nt hep atho fa ni mpartainaall yosfit sh ef actIstw. i lplu tm ediceaxlp erimecnltisn,i tcraila ls, statisatnidgc osv ernmpeonlti cuinedse r mtihcer oscroepvee,a ltihnatgth ep eoplceh argweidt phr otecting ourh ealatnhd s afehtayv dee viatfreodm t hipsa thA.l ontgh ew ayE,n gelbrechKto hannldew iinla ln alyze alplo ssicbalues eofsi llnseuscsah s p harmaceutliicfaelssdt,ry ulgeps e,s ticihdeeasvm,ye talpso,l lution, streasnsd p rocess(eadn ds ometimgeesn eticmaoldliyfi efdo) odAsl.ol f t hescea nh eavidlaym agteh e bodyo fh umanasn da nimaalnsd e venk ill tAhnedmp .r ecistehleysf ea ctotrypsi calplrye vawihle rteh e victiomfsa llegveidr usleisva en dw orkT.o substatnhteisacetl ea imtsh,ea uthocrist deo zenosfh ighly renowned scientistthse,mt haeNm oobnegll a ureaKtaersMy u lliBsa,r baMrcaC lintoWcakl,t eGri lbert, SiFrr anMka cfarlBaunren eatn dm icrobiolaongdPi uslti tPzreirzw ei nneRre neD ubosT.h eb ookp resents approxima1t,e1lp0ye 0r tinsecnite ntriefifce rentcheems a,j oroitfwy h ichha vebe enp ublisrheecde ntly. Thet opiocft hibso oki so fp ivotsailg nificaTnhcepe h.a rmaceutciocmapla niaensdt ops cientriasktes ine normosuusm so fm oneyb ya ttackgienrgm asn dt hem edibao osittsas u dience raantdci inrgcsu lations witsh ensationarleipzoerdt (itnhgce o veraogfet heN ew YorkT imesa ndD erS piegaerle s pecifically analyzeIdn)d.i vidpuaaylt hse h ighepsrti coefa llw,i thoguett tiwnhga tt hedye seravned n eedm ostt o maintain health: enalbioguththt eer nemacelan uts easn dt runee cessiftoirpe rse ventainodnc uroef theiirl lnes"sTehsef. i rsstte ips t og ivuep t hei llusiont hteph raitm apruyr posoefm odermne dical researicst hoi mprove pehoepallemt'ohss te ffectiavnedle yf ficieandtvliys,e"s John AobfHr aarmvsaornd Medical Sc"hTohoepl r.i mapruyr poosfec ommercially-cfluinndirecedas le aricsth om aximize financial retuornn i nvestmneontth ,e alth." ViruMsa niaw ililn forymo uo nh ows ucah ne nvironmteonotrk o ot-ahnodw t oe mpoweyro urself foar h ealthy life. Aboutth Aeu thso r TorstEenng elbrweocrhktas s a freelanjcoeu rnaliinHs atm burgH.e hasw rittaernt icfloers publicatsiuocnhas s M edicaHly pothesBersi,t iMsehd icaJlo urna(lo nlinSei)i,d deutZsecihteu nNge,u e ZurcheZre itunagn,d T heE cologiFsrto.m2 00t0o 2 004h,ew orkeads b usineesdsi toofrt heF inancial TimeDse utschland. ClauKso hnleiisa n m edicaslp eciaolfii sntt erndails easHees c.o mpletheidsr esideinncty h e OncoloDgeyp artmeanttt h eU niversoifKt iye Sli.n c1e9 9h3e,h asw orkeidn h iosw nm edicparla ctice, treatHienpga tiCt ainsdA IDSp atiewnhtosa res keptiocfaa nlt ivmieradli cations. TorsteEnn gelbrecht ClauKso hnlein ViruMsa nia AviaFnl (uH SN1), CerviCcaanlc e(rH PV), SARSB,S E, HepatiCt,Ai IOs S ,P olio How theM edicaIln dustry ContinuaIlnlvye nEtpsi demics, Making Billion-Dollar Profits AtO urE xpense FirEsntg liEsdhi ti2o0n0,7 OriginGaelr maTni deV:i rus-Wahn Publisbhyee dm u-VerlLaagh,n stcin © TorstEenng elbrechtK,i iChlnaluesi n Alrli ghrtess erved TranslatMieogna:nC hapelDaasn,i eElglaen Editing: DanielleC rEogwaen , David Layout: KKorsueglz.e ll CoverH:e ikMeu ller Photo(sc oveGri)i:r sDooyg tsa,G ettIym agemse,d icalpicture Ordetrh ibso ookn liantew ww.trafford.com/06-3226 ore maiolr [email protected] MostT raffortdi daersae l saov ailaabtml aej oorn libnoeo k retailers. ©Copyrig20h0t7 T orstEenng elbraencdhC tl auKsii hnlein. Alrli ghrtess erNvoep da.r otft hipsu blicamtaiybo enr eproduscteodr,ie nad r etrieval systeomrt, r ansmiitnta endy, foorrb mya nym eanesl,e ctrmoencihca,n ipchaolt,oo pcying. recordoirno gt,hw eirsew,i thotuhtwe r ittperni poerr missoifto hnae u thor. Notef oLri brariAa cnast:a logrueicnogfr odtr h ibso oiks a vailafbrloemL ibrary andA rchivCeasn adaatw ww.collectionscanada.ca/amicus/index-e.html PrintienVd i ctorBiCa,C, a nada. ISBN:9 78-1-4251-1467-1 Wea tT raffboerldi tehvaeit ti st hree sponsiofbu isal lilat,syb otihn dividuals andc orporattoim oanksec, h oitcheasat r een vironmeanntdsa olcliysa olluyn d. Youi,nt urn,a rseu pportthiirnseg s poncsoinbdlueec atct hi myeo up urchaa se Traffobrodo ko,rm akeu soef o urp ublissheirnvgi Tcofie nsd.o uhto wy oua re helpipnlge,av siesw iwtw .trafford.com/responsiblepublishing.html Ourm issiiostn oe fficienptrloyv itdhewe o rlfidn'se smto.s cto mprehensive boopku blissheirnvgei ncea,b leivnegar uyt htoore xperiseuncccee ss. Tofi ndo uth owt op ubliysohub ro oky,o uwra ya.n dh avieta vailable worldwivdiesu,is ot n liantwe w w.trafford.com/10510 �TC9f.�9,(q- www .trafford.com NortAhm eric&a i nternational toll-fI8r 8e8e2: 3 24 444( USA& Canada) phon2e5:0 3 836 864+ fax2:5 03 836 804• emaiilnf:o @trafford.com TheU niteKdi ngdo&m Europe phone+:4 4( 0)18762521 13• locraalt 0e8:4 52 309 601 facsim+i4l4e( :0 )18762528 68• emaiiln:f [email protected] 10 9 8 7 6 5 I4 3 2 FoCrh rinsetT,ihe areJsoah,a ,nC naathaarniJdnu al ius For Mariaan,Ed c Kkaarretn Tabloef C ontents ForeworId By Etienndee HarvenM,D . . . . . . . . . . . . . . . . 1.1 . . . . . . . . . . . . . . . . . . . . . . . . . . Foreword II By Joachim Mutter,. M.D .... . . . . . . . . . . . . .1 5. . . . . . . . . . . . . . . . . . . . . . . . . . . Introduction SocietUyn dert heS pelolf a One-DimensioMniaclr obTeh eory 17 Chapte1r MedicinPer esenat sD istortPeidc turofeM icrob.e s.. . . . . . . . 2.9 . . . . . . . . . . . -MicrobBersa:n deadsS capegoa.t s. . . . . . . . . . . . 29. . . . . . . . . . . . . . . . . . . . . -FungAI;i :i nt heF oresSto,i n t heH umanB ody. . . . . . . . . .3 1. . . . . . . . . . . . . . -BacterAitat :h eB eginnionfAg l Lli f.e . . . . . . . . . . . 3.6 . . . . . . . . . . . . . . . . . . . -VirusLeest:h Mail ni-Monst.e r.s ? . . . . . . . . . . . 4.0 . . . . . . . . . . . . . . . . . . . . . . Chapte2r TheM icrobHeu nterSse izPeo wer. . . . . . . . . . . . . .4 9. . . . . . . . . . . . . . . . . . . . . . -Pasteur KaoncdhT: w oo fM anyS cientCihfieca t.s . . . . . . . . 4.9 . . . . . . . . . . . . -ScurvBye,r ibaenrdiP ellagTrhaeM: i crobHeu nterMsa'n yD efeat.s .. . . 5.4 . . -HippocravtoensP ,e ttenkoBfierrc,h er-BeTnhneWe irs:d omo ft heB ody. . .5 5 -ClusterHionwgT :o M akea nE pidemOiuct o fO neI nfectPeadt ie.n t . . .5 8. . . -PoliPoe:s ticSiudcehsa sD DTa nd Heavy MetalSsu sUpnidcei.ro n. . . 6.0 . . . -Gajduse"kS'lso Vwi rus": ILnefienwiatfyeo Erx planantsi..o . . . . . 8.2 . . . . . . . -AfteWro rlWda rI IV:i sibPlreo ooffV iruseWse? D on'Nte edT hat.! . . . 8.3 . . . -TheV iruDsi sastofet rh e 1970sH-IaVna dsS alvatiinot nh e1 980s 88 Chapte3r AIDSF: romS pareT irteo M ultibillionB-uDsoilnleasr.s . . . . . . .9 1. . . . . . . . . . . -AIDSW:h atE xactIlsIy t .? . . . . . . . . . . . . . . 9.2 . . . . . . . . . . . . . . . . . . . . . . . . . -WhereI st heP roooffH IV?. . . . . . . . . . . . . . .9 3. . . . . . . . . . . . . . . . . . . . . . . . . -HIV= AIDS?. . . . . . . . . . . . . . . . . . .9 6. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . -HIVA ntiboTdeys tPsC,R V irLaola dT estsC,D 4C ountA£s :U ninformative asa T ososf a C oi.n . . . . . . . . . . . . . . . . 9.6 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . -DrugsMe,d icinaensdM alnutriLteiaodtn o A IDS. . . . . . . . .1 0.0 . . . . . . . . . . . . -The Ea1r9l8y0 sP:o ppearnsd A IDSD rugs. . . . . . . . . . 1.0 1. . . . . . . . . . . . . . . . -Howt he" Fast-LLainfee stTyolpei"cG otO uto fS igh.t . . . . . . .1 0.6 . . . . . . . . . . -NewY orkF,e brua2r0y0 5F:r omS uper-DCroungs umetros "Super-AIDS-PVaitriues.n" t .s . . . . . . . . . . . . 1.1 1. . . . . . . . . . . . . . . . . . . . . . . . 7 TabolfCe o ntents -Gall1o9,9 4N:o tH IVB,u tS exD rugLsi kPeo ppeCrasu sAeI DS. . . . . . 1.1 2. . . . -DeSrp ieelOgn: t heP athosfS ensationaJloiusrtniacl i.s .m .. . . . . . . . .1 1.4 . . . -AIDSI sN ota Sexually-TranDsimsietat.se ed. . . . . . . . . . . 1.1 7. . . . . . . . . . . . . -23A pri1l9 84G:a llo's TV AppCeaarvreastn hceVe i rus DoignmS at one. . .1 20 -NeYwo rTki mesCh:i eMfe dicRaelp ortAelrt manC'osz yR elationWsihtihp EpidemAiuct horit.i .e s. . . . . . . . . . . . . . . . . .1 2.2 . . . . . . . . . . . . . . . . . . . . . . . -1987T:o pE xperTtask et heS tagaes C ritoifcA sI DSO rthodo.x.y.. . . . .1 2.3 . . -1994A:I DS-ResearDcahveiHrdo -asC onvincaisna g G irafwfiet h Sunglas.s. e .s . . . . . . . . . . . . . . . . . . . . . 1.2 6. . . . . . . . . . . . . . . . . . . . . . . . . . . . -TheM ediUan detrh eS pelolfC elebrRietsye arch.e r.s . . . . . . . 1.2 .7 . . . . . . . . -AIDSM edicatiTohnesF :a bloefL ifPero-longiEnffge ct.s . . . . . . . .1 2.8 . . . . . . . -PeoplaesG uinePai g.s . . . . . . . . . . . . . . . . . . .1 3.1 . . . . . . . . . . . . . . . . . . . . . . . -AZTS tud1y9 87A: G igantBioct cUhp-. . . . . . . . . . . . . . 1.3 .4 . . . . . . . . . . . . . . . -TheA IDST herapDyi lemma.. . . . . . . . . . . . . . . . .1 3.7 . . . . . . . . . . . . . . . . . . . -Aloln A ZT:T heD eathosfF reddMieer curRyu,d olpNhu reyev and ArthuArs he. . . . . . . . . . . . . . . . . . . . . . . 1.4 1. . . . . . . . . . . . . . . . . . . . . . . . . . . . -BasketbSatla"lrM agiJco"h nson: "ITsNh oe Mraeg iicn A ZT,a ndN o AZTi n' Magic." .' . . . . . . . . . . . . . . . . . . . .1 4.2 . . . . . . . . . . . . . . . . . . . . . . . . . . -HemophiliaancdAs I DS. . . . . . . . . . . . . . . . . . .1 .4 4. . . . . . . . . . . . . . . . . . . . . . -AfricHao:w W ell-KnoDwins easaerseR edefinaesAd I DS. . . . . . . .1 4.7 . . . . . . Chapte4r HepatitCi:Ts o xinSs ucha sA lcohoHle,r oiann,d P rescription DrugsS ufficaes E xplanati.o n.s . . . . . . . . . . . . . . . .1 5.3 . . . . . . . . . . . . . . . . . . . . -HIVM aniaD:e tonatfiooArnn tiviHreapla tiCt Tihse rap.y . . . . . . .1 5.3 . . . . . . -How TCor eatae H epatiCt Viisr u.s . . . . . . . . . . . . . . .1 5.4 . . . . . . . . . . . . . . . . . -HepatiCt Ciasn A lsBoe E xplainWeidht outa Viru.s . . . . . . . . . . . . . . . . . . . 157 -PamelAan dersoTnh:eV iruIsn dustGrrya'nsMd a rshlal.. . . . . . . . 1.5 9. . . . . . . Chapte5r BSE:T heE pidemiTch atN everW as. . . . . . . . . . . . . . . . 1.6 1. . . . . . . . . . . . . . . . . . -BSE:P rophecoifHe osr roarn dW asteosfM oney. . . . . . . . . . .1 6.1 . . . . . . . . . . -TheD ogmao ft heI nfectDiiosuesa BsSeE . . . . . . . . . . . . . 1.6 2. . . . . . . . . . . . . . -ActiviFsemi gnfeodSr a fet.y . . . . . . . . . . . . . . . . .1 6.4 . . . . . . . . . . . . . . . . . . . . -TheI nfectHiyopno theIssFi osu ndeodn D ubiouEsx perime.n. t s. . . . .1 6.6 . . . -BSE:A GenetDiecf eDcut eT oI nbreed.i n.g . . . . . . . . . . . 1.6 8. . . . . . . . . . . . . . -BSEa sa nE ffeocfCt h emicPaoli son.i. n g. . . . . . . . . . . . .1 7.0 . . . . . . . . . . . . . . -BSEI sN ota nI nfectDiiosuesa s. e. . . . . . . . . . . . . . . 1.7 3. . . . . . . . . . . . . . . . . . Chapte6r SARS:H ysteroina t heH eelosf A IDSa ndB SE . . . . . . . . . . . 1.7 5. . . . . . . . . . . . . -Fir9s/t1 1N,e xtt heW ari nI raq-atnhde SnA RS.? .. . . . . . . . . .1 7.5 . . . . . . . . . -CritiTchaolu ghotnsS ARSE pidemiolHoogwyD :i dC arlUor banRiea llDyi e? 178 -AntiviTrhaelr apMyo:r eP aitnh aGna in. . . . . . . . . . . . . .1 8.1 . . . . . . . . . . . . . . -SARSV:i ruEsn emyN otF ound. . . . . . . . . . . . . . . .1 .8 2. . . . . . . . . . . . . . . . . . . 8 TabolfCe o ntents -CortisaonndeO theSrt eroiQduse:s tionaEbflfee c.t s. . . . . . .1 8.5 . . . . . . . . . . . -TheT herapeuDtiilce mmoaf O urT ime. . . . . . . . . . . . 1.8 6. . . . . . . . . . . . . . . . . -GuangdonTgh:eH igh-TeRcehv olutiDoinr'tSsye cre.t . . . . . . 1.8 7. . . . . . . . . . Chapte7r H5N1A:v ianF lua ndN ota Glimmeorf P roof 191 -TheM ediaB:i gP harmaM'esg aphon.e . . . . . . . . . . .1 9.1 . . . . . . . . . . . . . . . . . . -H5N1:N o EvidenocfVe i ruEsx isteanncdeP athgoeniEcf fe.c t . . . . 1.9 3. . . . . . -(NoOtn lyF)a ctoFrayr minMga kesB irdSsi ck. . . . . . . . . 1.9 6. . . . . . . . . . . . . . -GuesswoornkR ugen. . . . . . . . . . . . . . . .2 0.3 . . . . . . . . . . . . . . . . . . . . . . . . . . . -TheD utcBhi rFdl uP ani2c0,0 3C:a ughitnV iruTsun neVli sio.n . . . .2 0.4 . . . . -RatP oisoCnasr royf Bfi rd.s .. . .... .. .. .. .. . . . . . . 2.0 6. . . . . . . . . . . . . . . . . . -On theD utyT o AvoSiede inWgh at'Rsi ghUtn deOru rN oses. . . . . 2.0 6. . . . . . -Moret ha1n5 0D eadP eople-WRheaatl Clayu seTdh eiDre aths.? . . . 2.0 8. . . . -No Reasofno rPa ndemPiacn ic. . . . . . . . . . . . . .2 0.9 . . . . . . . . . . . . . . . . . . . . . -TamifluF:r omS helf-WartmoBe irgS ellerD-etaot Bhr inge.r ?. . . . 2.1 2. . . . . . -TamiflSut udiaensd t heP robleomfI ndependence . . . . . .2 1.6 . . . . . . . . . . . . . -DonalRdu msfeMladk esG ianPtr ofit.s . . . . . . . . . . . 2.1 7. . . . . . . . . . . . . . . . . . -Pandemi19c1 8R:e suolfta Viruosr t heF irWsotr lWda r?. . . . . . 2.2 0. . . . . . . . -TheP andemoifc1 918M:y steriSopurse a.d . . . . . . . . . .2 2.2 . . . . . . . . . . . . . . . -FailIendf ection At.t e.m p.t s. . . . . . . . . . . . 2.2 6. . . . . . . . . . . . . . . . . . . . . . . . . -Pandem1i9c1 8O:v ermedicaatnidMo an ssV accination Ca.m pa.i g.n s.2 2.8 . . -DoctoRress pontdot heC atastroWpihtehO verwhelmSiinlge n.c e. . . 2.3 3. . . . Chapte8r CervicCaaln cearn dO therV accinatiPoonlsi:c vys .E videnc.e . . . . .2 3.5 . . . . . . -FluV accinDeosT :h eyM akeS ense.? . . . . . . . . . . . 2.3 5. . . . . . . . . . . . . . . . . . . -DeadlIym munitbyyR, o bertK eFn.n edJyr .. . . . . . . . . . 23.7 . . . . . . . . . . . . . . . -FrauWda,s teB,r ibery-Corriunpt thieHo ena ltShe rvi.c e. . . . . ..2 4 7. . . . . . . . . -HPVV accinatAigoani nCsetr viCcaanlc eNro:t P roveSna faen dE ffect.i v.e 2 .5 5 -HPVV accinAe P:o ssiDbilsea sftoetrr h eN extG enerat.i o.n . . . . 2.6 0. . . . . . . . Epilogue SideE ffect-Free AltetronM aetdiivceast ioanndsV accinations 263 Literat.u re. . . . . . . . . . . . . . . . . . . 2.6 7. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Index. .........:. . . . . . . . . . . .... . . . .. .. .. .. .. .3 .1 .1 . .. .. . .. .. .. .. .. . .. . 9 ForeworId TheC ontenotf T hisB ookH asT oB e Read, Quicklayn dW orldwide The boVoikr Muasn ibayT orstEenng elbraencdCh lta uKso hnlepirne sean ts tragmiecs satghea t hwoiplelf,u clolnyt,re it botu htree -inseorfet tihoivnca allu iens thec onduocfvt i rruess eaprucbhl,hi eca lptohl icmieedsic,ao mmunicaatnido ns, activitthipeeh sa romfa ceuctoimcpaaln Oibevsi.o ueslleym,e nettahriyc alh arvuel es beento, vae rdya ngereoxutse nnetg,l ecitnme adn yo ft hefseiel dfso arn a larming numbeorfy ears. WhenA mericjaonu rnaCleilsiFtaa rbceoru ragye opuusbllisihneH da,rp esr ' Magazi(nMera ch2 006t)h ea rti"cOlueot f c ont-rAoIDlSa ndt hec orrupotfi on medicsacli enscoem,re"e adperrosb aabtltye mpttoe dr eatshseumrsee tlhvaettsh is "corrupwtaiso nia"sn o lactaesTdeh .i sv eirfsya frro m tthreu atshd ocumenstoe d well thiinbs o obky E ngelbraencdKh oth enlinI.ti so nltyh e otfit ph ei ceberg. Corrupotfir oens eairsacw hi desprpehaendo mecnuornr efnoutnldyi nm anym ajor, supposceodnltya ghieoaulspt rho blermasn,g ifrnogm A IDtSo H epatCi,tB iosv ine sponogrimfe ncephatlhoy(p BaSoEr " madc owd isea,sS eA"R)SA,v ainf laun d currveanct cinaptriaocnt( ihcuemsa n papilolroH mPaVvv aicrcuisnn a).t io Inr eseaornca hlo lft hessiedx i stincth epaulcbtolhni cce srcnise nrteisfieca rch onv irus(eopsrr ioinnst hec asoef B SEs)l ipponetdto h ew rontgr afcolkl owing basictahlesl aym esy stematic pathway. Thiinsc lpusadetevhswe kareyay l always stepisn:v enttihrneig s okfa d israosutesp idemiincc,ri minaetulisnigpv aeat nh ogen, ignorailntge rntaotxicivaceu semsa,n ipulaetpiindge miowliotnghoy n -verifiable numbetroms a ximitzhfeeal spee rcepotfai noi nm minceantta straonpdph reo,m ising salvawtiitovhna cicneTsh.ig su aranltaerefgsie n anrceitaulrB nusht.o wi sip to ssible toa chieavloelf t hiSsi?m pblyyr elyoinnt gh em ospto werafcult ivoafth ourm an decismiaokni npgr oceis.sFe,E. A R! Wea re wniottn esvsiirneagpl i demicasr;we i wten esespiindge moiffc easr A.n d botthh mee diaan dt hpeh armaceuitnidcuasclta rrymr oys otf t hree sponsifobri lity ampliinfygf earsf,ea rst hahta ppeinn,c idael,nlt tyoa lwayisg niftanet astically profitbaubslien Reessse.a hrycpho thecsoeevsr itnhge asre eoasfv irruess eaarrceh practinceavleslrcy i entyiv fiecrailfwliietadhp proprcioanttser. Io nlst,et ahdeayr e establbiys" hceodnn sseusT.h"ii sst herna pirdelsyh aipnetdao d ogmae,f ficiently 11

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