Veterinary Pharmacology and Toxicology PDF
Preview Veterinary Pharmacology and Toxicology
Veterinary Pharmacology and Toxicology A Veterinary Pharmacology and Toxicology Proceedings from the 2nd European Association for Veterinary Pharmacology and Toxicology held at Toulouse, 13th-17th September, 1982 EDITED BY Yves Ruckebusch Ecole Nationale Veterinaire 23, chemin des Capelles 31076 Toulouse Cedex, France Pierre-Louis Toutain Gary D. Koritz Pharmacologie-Toxicologie INRA College of Veterinary Medicine 180. chemin de Tournefeuille University of Illinois 31300 Toulouse, France Urbana, Illinois 61801. USA 1983 M.TP PRESS LIM.ITED ,., a member of the KLUWER ACADEMIC PUBLISHERS GROUP BOSTON I THE HAGUE I DORDRECHT I LANCASTER Published by MTP Press Limited Falcon House Lancaster, England Copyright © 1983 MTP Press Limited Softcover reprint of the hardcover 18t edition 1983 British Library Cataloguing in Publication Data European Association for Veterinary Pharmacology. Conference (2nd: 1982 : Toulouse) Veterinary pharmacology and toxicology. I. Veterinary pharmacology - Europe - Congresses 2. Veterinary toxicology - Europe - Congresses I. Title II. Ruckebusch, Yves III. Toutain, Pierre-Louis IV. Koritz, Gary D. 636.089'5'0944 SF915 ISBN-13: 978-94-009-6606-2 e-ISBN-13: 978-94-009-6604-8 DOl: 10.1007/978-94-009-6604-8 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior permission from the publishers. Typeset by Blackpool Typesetting Services Ltd., Blackpool Contents List of Contributors x Preface and Acknowledgements xviii In Appreciation of A. Yoxall xxi A. S. J. P. A. M. van Miert and P. Lees SECTION I DEVELOPMENTAL PHARMACOLOGY Perinatal pharmacology in ruminant models 3 Y. Ruckebusch 2 Placental transfer of drugs in ruminant animals 23 L. E. Davis and G. D. Koritz 3 Drug disposition in the fetus 39 L.-E. Appelgren 4 Drug disposition in the newborn 49 R. Reiche 5 Postnatal development of renal function in goats 57 C. Friis 6 Developmental patterns of penicillin G excretion 63 C. R. Short 7 Drug effects during development and carcinogenicity 73 G. M. Williams 8 Chemical induced teratogenesis 93 P. Delatour 9 Levamisole as an immunomodulator in the prevention of neonatal disease 99 L. Desplenter 10 Development and prophylaxis of anaemia in calves and lambs 105 P. H. Dilov 11 Oral fluid therapy: some concepts on osmolality, electrolytes and energy 11 5 R. W. Phillips SECTION II RUMINANT PHARMACOLOGY 12 Drug bioavailability in the developing ruminant 133 P. de Backer and M. G. Bogaert v VETERINARY PHARMACOLOGY AND TOXICOLOGY 1 3 Oral antibacterial therapy in pre- and postweaning calves 141 W. L. Jenkins and L. G. Friedlander 14 Influence of ruminant gastrointestinal physiology on the phar- macokinetics of drugs in dosage forms administered orally 151 G. D. Koritz 1 5 Ruminal influences on drug action 1 65 R. H. Dunlop 16 Recent developments in the treatment of metabolic diseases 1 83 W. M. Allen, B. V. Sansom, C. F. Drake and P. R. Moore 1 7 Drug excretion by the mammary gland 193 J. Boisseau and J. P. Moretain 18 Pharmacology of uterine motility and relaxation 203 O. Kern and H. Schill 19 New prostaglandins: present studies and future 213 R. C. Herschler, J. S. Kent and R. V. Tomlinson 20 Worm diseases: economic aspects of anthelmintic treatment 221 H. Van den Bossche 21 Pharmacological basis of the treatment of helminth in cattle 225 A. Dakkak and M. Kessabi 22 Pharmacokinetics of albendazole, fenbendazole and oxfen- dazole 235 A. Bogan and S. E. Marriner 23 Pharmacokinetics of levamisole in goats and pigs 241 P. Nielsen and F. Rasmussen 24 The prophylactic activity of imidocarb against tick-transmitted parasitic infections 247 N. McHardy SECTION III NON-RUMINANT PHARMACOLOGY 25 The distribution and function of histamine receptors 257 P. Eyre and K. B. Mirbahar 26 Serotonin and S:z antagonists 263 L. Ooms, F. Awouters, A. N. Degryse and T. Jageneau 27 Dopaminergic control of gastro-intestinal motility 283 L. Bueno and J. Fioramonti 28 Vomiting and anti-emetics in small animal practice 299 G. R. Hewett 29 Diarrhoea and antidiarrhoeal drugs 307 J. Fioramonti, C. J. E. Niemegeers and F. Awouters 30 Pharmacology and comparative toxicology of non-steroidal anti-inflammatory agents 321 G. Mazue, P. Richez and J. Berthe 31 Clinical pharmacokinetic studies of digoxin and digitoxin in the dog 333 A. de Rick, F. M. Belpaire, M. G. Bogaert, D. Mattheeuws and S. Chakrabarti vi CONTENTS 32 Influence of anaesthetics and anctllary agents on cardio- vascular and respiratory systems in the horse 341 P. Lees, C. J. Hillidge and L. Serrano 33 Steroidal anti-inflammatory agents in the horse: pharmaco- kinetics and action on the adrenal gland 353 P. L. Toutain and R. A. Brandon 34 Spasmolytic analgesic drugs and small intestinal function in the horse 367 E. L. Gerring and J. V. Davies 35 Physiological, pharmacological and therapeutic aspects of some gastrointestinal disorders in the horse 371 L. P. Phaneuf and Y. Ruckebusch 36 Pharmacological control of reproductive mechanisms in the equine female 381 E. Palmer, B. Bour and F. Chevalier SECTION IV PHARMACOLOGICAL METHODS 37 Clinical utility and limitations of pharmacokinetics 397 J. D. Baggot 38 Pharmacological approach of drugs used in coronary insuf- ficiency and cerebrovascular pathology 41 5 P. Lacroix and P. Linnee 39 Fever, trace metals and disease. The effect of antipyretic agents 421 A. S. J. P. A. M. van Miert, D. Zwart, J. H. M. Verheijden and A. J. H. Schotman 40 Efficacy of penicillin against Streptococcus zooepidemicus. Infection model in the horse 429 K. J. Varma, T. E. Powers, R. C. Garg, S. L. Spurlock and J. D. Powers 41 Receptor binding methods: application to the study of cyclo- pyrrolones, a new family of minor tranquillizers 437 J. C. Blanchard and L. Julou 42 Multiplicity of kappa opiate sites in the central nervous system 451 Y. Audigier, B. Attali, C. Gouarderes, H. Mazarguil and J. Cros 43 Hepatocyte cultures as a research tool in pharmacology and toxicology 465 F. R. Althaus 44 Metabolic radical formation from halothane and enflurane and its modification by enzyme induction and inhibition 479 W. Beuter and A. Schmid 45 Anaesthesia in pharmacological research 485 R. Boivin vii VETERINARY PHARMACOLOGY AND TOXICOLOGY 46 Evaluation of analgesic drug combinations 501 A. J. M. Seegers, L. P. Jager and J. van Noordwijk 47 Enzyme induction and inhibition 523 A. Anad6n 48 Rapid induction of cirrhosis in the liver. A model of hepatic disease 539 A. A. Seawright, J. S. Lee and J. Hrdlicka 49 Behavioural analysis of drug action 553 R. Dantzer 50 Experimental models for respiratory diseases of ruminants and of swine 565 J. Espinasse, J. P. Raynaud, L. Renault and F. Osdoit SECTION V TOXICOLOGY 51 Environmental pollution: the animal as source, indicator and transmitter 595 M. Debackere 52 Residues of drugs and pesticides in milk 609 W. Heeschen and A. Bluthgen 53 Mycotoxin residue problem and human health hazard 625 P. Galtier and J. Le Bars 54 Residues of xenobiotics in animals, milk, and environment in the light of a 1 3 year surveillance 641 T. Juszkiewicz 55 Persistence in milk of active antimicrobial intramammary substances 647 Ph. Archimbault 56 Evaluation of drug residues in animal tissues 659 P. Delatour 57 Photosensitization in ruminants: porphyrins and phylloerythrin 671 B. J. Blaauboer and M. van Graft 58 Fluorosis in the sheep: new data 681 G. Milhaud, B. Enriquez and F. Riviere 59 Chloramphenicol-propylene glycol toxicity following con- stant intravenous infusion in horses 691 S. L. Spurlock, T. E. Powers, K. J. Varma and J. D. Powers 60 Heavy metal intoxications in horses 697 A. A. Seawright, J. Hrdlicka and J. C. Ng 61 Evaluation of subclinical lead poisoning in dairy cattle 715 L. Pinault and G. Milhaud 62 Poisoning of animals in the Los Angeles area with pesticides (1981) 725 K. T. Maddy, S. Edmiston and J. Wellings 63 Toxicological field data in ruminants 733 G. Keck, G. Lorgue and P. Jaussaud viii CONTENTS 64 Adverse drug reactions and interaction (1979-81) 737 Y. Ruckebusch WORKSHOP I MEDICATED FEED 747 Chairmen: M. Lobry and A. S. J. P. A. M. van Miert WORKSHOP II ANIMAL ANAESTHESIA 797 Chairmen: P. Lees, E. L. Gerring, E. P. Steffey Index 825 ix List of Contributors W.M.ALLEN Y. AUOIGIER Agricultural Research Council Laboratoire de Pharmacologie et Institute for Research on Animal Disease de Toxicologie Fondamentales Compton, Newbury, Berks. RG16 ONN CNRS, 205 route de Narbonne England 31400 Toulouse, France F. R. ALTHAUS F.AWOUTERS University of Zurich School Department of Pharmacology of Veterinary Medicine Janssen Pharmaceutica Institute of Pharmacology and B-2340 Beerse, Belgium Biochemistry J. O. BAGGOT Winterthurerstrasse 260 School of Veterinary Medicine 8057 Zurich University of California Switzerland Davis, California 95616, USA A.ANAOON F. M. BELPAIRE Department of Pharmacology J. F. & C. Heymans Institute of and Toxicology Pharmacology Faculty of Veterinary Medicine Faculty of Medicine, State University University of Leon Ghent, Belgium Leon, Spain s.C. BERRY N.A.ANIS Department of Physiology Department of Physiology Royal Veterinary College Royal Veterinary College London NW1 OTU, England London NW1 OTU, England J.BERTHE Service Toxicologie L.-E. APPELGREN C. R. Clin-Midy Department of Pharmacology Rue de Prof. J. Blayac Faculty of Veterinary Medicine 34082 Montpellier Cedex, France The Swedish University of Agricultural Science W. BEUTER Box 573, 75123 Uppsala, Sweden Institute of Pharmacology, Toxicology and Pharmacy, University of Munich Ph. ARCHIMBAULT Veterinarstrasse 13 Virbac, BP 13 D-8000 MGnchen 22, FRG 06201 Nice Cede x, France B. J. BLAAUBOER B. ATTALI Institute of Veterinary Pharmacology, Laboratoire de Pharmacologie et Pharmacy and Toxicology de Toxicologie Fondamentales State University of Utrecht CNRS, 205 route de Narbonne Biltstraat 172 31400 Toulouse, France 3572 BP Utrecht, The Netherlands x LIST OF CONTRIBUTORS J. C. BLANCHARD N.R.BURTON RhOne-Poulenc Recherches Department of Physiology Centre Nicolas Grillet Royal Veterinary College 13, quai Jules-Guesde London NW1 OTU, England 94400 Vitry-sur-Seine, France S. CHAKRABARTI A. BLUTHGEN J. F. & C. Heymans Institute Institute for Hygiene of Pharmacology Federal Dairy Research Centre Faculty of Medicine, State University 0-2300 Kiel, FRG Ghent, Belgium M. G. BOGAERT F. CHEVALIER J. F. & C. Heymans Institute INRA, Physiologie de la Reproduction of Pharmacology 37380 Nouzilly, France Faculty of Medicine, State University Ghent, Belgium J. CROS Laboratoire de Pharmacologie et J.A.BOGAN de Toxicologie Fondamentales Department of Veterinary Pharmacology CNRS, 205 route de Narbonne Veterinary Hospital, Bearsden Road 31400 Toulouse, France Glasgow G61 1 QH, Scotland A.DAKKAK J. BOISSEAU Institut Agronomique et Veterinaire Laboratoire National des Medicaments Hassan II, BP 6202 Veterinaires Rabat-Agdal, Maroc Javene 35300 Fougeres, France R.DANTZER R.BOIVIN Laboratoire de Neurobiologie Laboratoire de Physiologie des Comportements Ecole Nationale Veterinaire de Lyon INRA, Universite de Bordeaux II Marcy L'Etoile 146, rue Leo-Saignat 69260 Charbonnieres-Ies-Bains, France 33076 Bordeaux Cedex, France H. VAN DEN BOSSCHE J. V. DAVIES Department of Comparative Biochemistry Department of Surgery Janssen Pharmaceutica Royal Veterinary College B-2340 Beerse Hawkshead Lane, North Mymms Belgium Hatfield, Herts., England B. BOUR L. E. DAVIS INRA, Physiologie de la Reproduction College of Veterinary Medicine 37380 Nouzilly, France University of Illinois Urbana, Illinois 61801, USA R. A. BRANDON School of Veterinary Medicine P. DEBACKER University of California Veterinary Pharmacology and Toxicology Davis, California 95616, USA Faculty of Veterinary Medicine Casinoplein 24, 9000 Ghent, Belgium G. J. BROUWER University Department of Anaesthesia M.DEBACKERE Royal Liverpool Hospital Veterinary Pharmacology and Toxicology Prescot Street, PO Box 147 Faculty of Veterinary Medicine Liverpool L69 3QX, England Casinoplein 24, 9000 Ghent, Belgium L. BUENO A.N.DEGRYSE Station de Pharmacologie-Toxicologie Department of Veterinary Pharmacology INRA, 180 chemin de Tournefeuille Janssen Pharmaceutica 31300 Toulouse, France B-2340 Beerse, Belgium xi
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