Ventilatory Support and Oxygen Therapy in Elder, Palliative and End-of-Life Care Patients Antonio M. Esquinas Nicola Vargas Editors 123 Ventilatory Support and Oxygen Therapy in Elder, Palliative and End-of-Life Care Patients Antonio M. Esquinas • Nicola Vargas Editors Ventilatory Support and Oxygen Therapy in Elder, Palliative and End-of-Life Care Patients Editors Antonio M. Esquinas Nicola Vargas Intensive Care Unit Geriatric and Intensive Geriatric Care Hospital General Universitario Morales Azienda Ospedaliera S.Giuseppe Moscati Meseguer Avellino Murcia Italy Spain ISBN 978-3-030-26663-9 ISBN 978-3-030-26664-6 (eBook) https://doi.org/10.1007/978-3-030-26664-6 © Springer Nature Switzerland AG 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland Preface Every day in clinical practice, we come across patients requiring care in a palliative context or elderly patients with clinical characteristics or a legal prerogative of do- not-intubate (DNI). Patients with respiratory failure can benefit from palliative use of non-invasive ventilation (NIV)—not only in the sense of comfort care. Efforts have been made in the past to consider this therapeutic approach as an integral part of caring for all patients under invasive mechanical ventilation. Evidence from international guidelines and consensus statements has shown that NIV can be applied in a clinical context even out of the intensive care unit (ICU). This is pos- sible if NIV is applied from a clinical, ethical, physiopathological, organizational, and rehabilitative point of view. This book serves as a platform to elaborate on all these aspects. This is the first time a book assesses NIV in the palliative and elderly context in a very extensive way. Special thanks to all international researchers, physicians, practitioners, and amateurs of NIV who have contributed to this project. Murcia, Spain Antonio M. Esquinas Avellino, Italy Nicola Vargas v Contents Part I P ulmonary Function and Physiology in Elderly 1 Spontaneous Breathing Pattern . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Lorena Olivencia Peña, María Sevilla Martínez, and Alberto Fernández Carmona 2 Gas Exchange and Control of Breathing in Elderly and End-of-Life Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 Annamaria Romano and Rosalba Romano Part II Ventilatory Management Epidemiology and Trends Management 3 Acute and Acute-on-Chronic Respiratory Failure: Impact of Chronic Lung Comorbidities . . . . . . . . . . . . . . . . . . . . . . . . . 23 Filippo Luca Fimognari 4 Chronic Cardiac Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31 Elisa Salsano and Paquale Abete 5 The Infections Causing Acute Respiratory Failure in Elderly Patients . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35 Giampiero Foccillo 6 Neurologic and Psychiatric Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 Florindo D’onofrio Part III Hypercapnic Respiratory Failure 7 Definitions, Criteria and Management of NIV for Very Old Patients with Limitations to Respiratory Care . . . . . . . . . . . . . . . . . . . 57 Gonzalo Segrelles Calvo 8 Ventilatory Support and Oxygen Therapy in the Elderly Palliative and End-of-Life Care Patients . . . . . . . . . . . . . . . . . . . . . . . . 61 Antonello Nicolini, Teresa Diaz de Teran, and Catia Cillòniz vii viii Contents Part IV Acute Hypoxemic Respiratory Failure 9 NIV Applications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 71 Antonino Maffei 10 Oxygen Therapy and Nasal High-Flow Therapy . . . . . . . . . . . . . . . . . . 77 Ipek S. Edipoglu and Yalim Dikmen 11 Medical Conditions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85 Attilio De Blasio 12 Pneumonia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 89 Maurizio Marvisi, Laura Balzarini, Chiara Mancini, and Sara Ramponi 13 Acute Chronic Insufficiency . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 97 María Sevilla Martínez, Lorena Olivencia Peña, and Alberto Fernández Carmona 14 Acute Hypoxemic Respiratory Failure in Immunocompromised Patients: The Role of Non-invasive Ventilation and High-Flow Oxygen Therapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 105 Sammar R. Alsunaid and Ayman O. Soubani 15 Acute Hypoxemic Respiratory Failure: Idiopathic Pulmonary Fibrosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 115 Battistina Farris Part V Surgery and Chronic Stable Conditions 16 NIV After Cardiothoracic Surgery and Thoracic Surgery . . . . . . . . . . 125 Juan Carlos Lopez-Delgado, Gabriel Jesús Moreno-Gonzalez, and Renzo Esteve Avila-Espinoza 17 Nocturnal NIV in COPD Patients with Prolonged Hypercapnia After Ventilatory Support for Acute Respiratory Failure . . . . . . . . . . . 133 Alberto Fernández Carmona, María Sevilla Martínez, and Lorena Olivencia Peña Part VI C omplementary Use of NIV 18 Use of NIV in Non-surgery Procedures in Elderly (Sedation, Bronchoscopy, Gastroscopy) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 143 Raffaele Scala 19 Use of NIV in Surgery Procedures in Elderly (Noninvasive Surgery): Continuous Spinal Anesthesia . . . . . . . . . . . . . 155 Zehra Hatipoglu and Dilek Ozcengiz Contents ix Part VII Invasive Mechanical Ventilation 20 Mechanical Ventilation-Specific Surgery Conditions . . . . . . . . . . . . . . 165 Laura Juez Garcia and Ana Sanchez Fernandez 21 Extubation and Reintubation Conditions . . . . . . . . . . . . . . . . . . . . . . . . 175 Maria Vargas, Giuseppe Servillo, and Aniello Acampora 22 Ventilatory Modes: Pressure Support Ventilation and Other Ventilatory Options . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 181 Pasquale Buonanno, Maria Vargas, and Giuseppe Servillo Part VIII Weaning and Management 23 Weaning Mechanical Ventilation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 193 Pasquale Buonanno, Maria Vargas, and Giuseppe Servillo 24 Rehabilitation in Critical Illness and Palliative Care . . . . . . . . . . . . . . 201 Énio Pestana 25 Sedation and Analgesia in Mechanical Ventilation . . . . . . . . . . . . . . . . 219 Luigi Vivona, Maria Vargas, and Giuseppe Servillo 26 Management of Elderly Patients with Delirium Syndrome . . . . . . . . . 227 Andrea Fabbo and Barbara Manni Part IX D ischarge and Home Mechanical Ventilation 27 Home Discharge: Planning, Policies, and Impact on Hospital Admission and Outcome. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 243 Sven Stieglitz 28 Home Mechanical Ventilation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 247 Sven Stieglitz 29 The Role of Non-invasive Home Mechanical Ventilation in Elderly Patients with Chronic Obstructive Pulmonary Disease . . . . . . . . . . . . 257 Szymon Skoczyński and Patrycja Rzepka-Wrona Part X Ventilatory Management in Outcome 30 Predictors of Outcome of NIV in Elder, Palliative, and End-of-Life Care Patients . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 267 Francesco Panero and Franco Aprà 31 Prognosis Following Acute Exacerbation of COPD Treated with Non-invasive Mechanical Ventilation . . . . . . . . . . . . . . . . . . . . . . . 273 Roberto Bernabeu-Mora x Contents 32 Readmission Elderly Critically Patients . . . . . . . . . . . . . . . . . . . . . . . . . 279 Mohammed AlAhmari Part XI V entilatory Management in End Life Applications 33 End-of-Life Care of Patients with Idiopathic Pulmonary Fibrosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 289 A. Micco, A. Di Sorbo, and M. Del Donno 34 The Hospital Organisation for the Management of Acute Respiratory Failure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 305 Loredana Tibullo, Barbara Bonamassa, and Nicola Vargas 35 Hospital Organisations of ARF in Elderly . . . . . . . . . . . . . . . . . . . . . . . 311 Loredana Tibullo and Fernando Gallucci 36 NIV in Palliative Medicine and End-of- Life Care: The Perspectives of Patients, Families and Clinicians . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 317 Elif Erdogan and Yalim Dikmen 37 Legal Issues (Surrogacy Laws, Informed Consent) . . . . . . . . . . . . . . . . 325 Andrea Fabbo Part XII Ventilatory Management in Palliative Medicine 38 Neuromuscular Patients (Amyotrophic Lateral Sclerosis and Other Conditions) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 339 Giuseppe Fiorentino, Antonio M. Esquinas, and Anna Annunziata 39 Non-neuromuscular Patients (Kyphoscoliosis) . . . . . . . . . . . . . . . . . . . . 349 Aslıhan Gürün Kaya, Aydın Çiledağ, and Akın Kaya 40 Idiopathic Pulmonary Fibrosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 355 M. Del Donno, A. Di Sorbo, and A. Micco 41 Respiratory Failure and Critically Ill Cancer Patients . . . . . . . . . . . . . 371 Stephen Richards and Kwok M. Ho 42 Recommendations for Noninvasive Ventilation on Survival and Quality of Life . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 385 Maria Vargas, Carlo Bussemi, and Carmine Iacovazzo 43 Quality of Life and Complications After Percutaneous Tracheostomy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 397 M. Vargas and G. Servillo 44 The Concept of Quality of Life in Elderly Patients and Advanced Stages . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 403 Barbara Bonamassa, Stella Troiano, and Maria Virginia Scafarto 45 Recommendations: European and Non-European Perspectives About the use of NIV in the Palliative and Elderly Context . . . . . . . . . 409 Nicola Vargas and Antonio Esquinas Part I Pulmonary Function and Physiology in Elderly