Vectors. A Survey of Molecular Cloning Vectors and their Uses PDF
Preview Vectors. A Survey of Molecular Cloning Vectors and their Uses
! BIOTECHNOLOGY ! JULIAN Ε. DAVIES, Editor Pasteur Institute Paris, France Editorial Board L. Bogorad Harvard University, Cambridge, USA P. E. Bost Rhône-Poulenc Industries, Vitry-sur-Seine, France P. Broda University of Manchester, Manchester, United Kingdom A. L. Demain Massachusetts Institute of Technology, Cambridge, USA D. H. Gelfand CETUS Corporation, Berkeley, USA D. A. Hopwood John Innes Institute, Norwich, United Kingdom S. Kinoshita Kyowa Hakko Kogyo Co., Tokyo, Japan G. Lancini Gruppo Lepetit, Milan, Italy J.-F. Martin University of Leon, Leon, Spain C. Nash Schering-Plough Corporation, Bloomfield, New Jersey, USA T. Noguchi Suntory, Ltd., Tokyo, Japan J. Nüesch Ciba-Geigy, AG, Basel, Switzerland A. H. Rose University of Bath, Bath, United Kingdom J. A. Shapiro University of Chicago, Chicago, USA D. Wang Massachusetts Institute of Technology, Cambridge, USA BIOTECHNOLOGY SERIES 1. R. Saliwanchik Legal Protection for Microbiological and Genetic Engineering Inventions 2. L. Vining (editor) Biochemistry and Genetic Regulation of Commercially Important Antibiotics 3. K. Herrmann and Amino Acids: Biosynthesis and Genetic Regulation R. Somerville (editors) 4. D. Wise (editor) Organic Chemicals from Biomass 5. A. Laskin (editor) Enzymes and Immobilized Cells in Biotechnology 6. A. Demain and Biology of Industrial Microorganisms N. Solomon (editors) 7. Z. Vanék and Overproduction of Microbial Metabolites: Strain Z. Hostâlek (editors) Improvement and Process Control Strategies 8. W. Reznikoff Maximizing Gene Expression and L. Gold (editors) 9. W. Thilly (editor) Mammalian Cell Technology 10. R. Rodriguez Vectors: A Survey of Molecular Cloning Vectors and and D. Denhardt Their Uses (editors) Other volumes in preparation P. Valenzuela, Genetic Engineering of Yeast for the Production of A. Brake, Foreign Proteins and P. Barr S.-D. Kung and Plant Biotechnology C. Arntzen K. Betteridge Embryo Transfer: Principles and Procedures T. Smith Computer-Aided Analysis of Proteins and Nucleic Acids L. Lasky and Controversies in Viral Vaccination P. Berman (editors) L. Vining, Genetics of Antibiotic Production C. Stuttard, and H. Schrempf Β. Dale Biotechnology Feedstocks D. Fink Analytical Biotechnology C. Ho and Bioreactor Design and Operations D. Wang S. Dagley Biodegradation: The Range and Limitations of Microbial Catabolism S. Narang Genetic Approaches to Protein Engineering V. Sato Monoclonal Antibodies D. Wise Bioelectronic Systems Vectors A Survey of Molecular Cloning Vectors and Their Uses Edited by Raymond L. Rodriguez University of California Davis, California David T. Denhardt University of Western Ontario London, Ontario Butterworths Boston London Durban Singapore Sydney Toronto Wellington Copyright © 1988 by Butterworth Publishers. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission of the publisher. Library of Congress Cataloging-in-Publication Data Vectors : a survey of molecular cloning vectors and their uses. (Biotechnology) Bibliography: p. Includes index. 1. Genetic vectors. 2. Molecular cloning. I. Rodriguez, Raymond L. II. Denhardt, David T. OH442.2.V43 1987 574.87'322 87-786 ISBN 0-409-90042-7 Butterworth Publishers 80 Montvale Avenue Stoneham, MA 02180 10 9 8 7 6 5 4 3 21 Printed in the United States of America CONTRIBUTORS Michael R. Altherr John Collins Department of Genetics Gesellschaft für Biotechnologische University of California Forschung Davis, California Braunschweig, West Germany Paulina Balbas Daniel Cullen Departamento de Biologia Molecular Department of Plant Pathology Centro de Investigacion sobre University of Wisconsin Ingerieria Genetica y Biotecnologia Madison, Wisconsin Universidad Nacional Autonoma de David T. Denhardt Mexico Cancer Research Laboratory Cuernavaca, Morelos University of Western Ontario Mexico London, Ontario Randy M. Berka Canada Genencore, Incorporated South San Francisco, California Gary Ditta Department of Biology Francisco Bolivar University of California at San Diego Departamento de Biologia Molecular La Jolla, California Centro de Investigacion sobre Ingenieria Genetica y Biotecnologia Dylan R. Edwards Universidad Nacional Autonoma de Cancer Research Laboratory Mexico University of Western Ontario Cuernavaca, Morelos London, Ontario Mexico Canada Jürgen Brosius Jeff Errington Department of Genetics and Department of Biochemistry Development University of Oxford Center for Neurobiology and Oxford, United Kingdom Behavior Robert T. Fraley Columbia University Monsanto Company New York, New York St. Louis, Missouri Gianni Cesareni Daniel R. Gallie European Molecular Biology John Innes Institute Laboratory Norwich, England Heidelberg, Germany Philippe Gay Joseph Colasanti CIBA-GEIGY, Limited Department of Microbiology and Agricultural Division Immunology Basel, Switzerland University of Western Ontario London, Ontario Canada vii VÜi Contributors Gregory L. Gray Irene Kuhn Genencore, Incorporated Codon Corporation South San Francisco, California Brisbane, California Donald R. Helinski W. Lindenmaier Department of Biology Gesellschaft für Biotechnologische University of California at San Diego Forschung La Jolla, California Braunschweig, West Germany Barbara Hohn Peter F.R. Little Friedrich Miescher-Institut Institute of Cancer Research Basel, Switzerland Royal Cancer Hospital London, England Paul J. J. Hooykaas Department of Plant Molecular Paul S. Lovett Biology Department of Biological Sciences Leiden University University of Maryland Leiden, The Netherlands Catonsville, Maryland Robert B. Horsch George A. Mackie Monsanto Company Department of Biochemistry St. Louis, Missouri University of Western Ontario London, Ontario Henry V. Huang Canada Department of Microbiology and Immunology David A. Mead Washington University School of Promega Biotec Medicine Madison, Wisconsin St. Louis, Missouri Lois K. Miller Clarence I. Kado Departments of Genetics and Department of Plant Pathology Entomology University of California University of Georgia Davis, California Athens, Georgia Byron Kemper Skorn Mongkolsuk Department of Physiology and Department of Biological Sciences Biophysics University of Maryland University of Illinois Catonsville, Maryland Urbana, Illinois Jean-François Nicolas Harry J. Klee Unité de Génétique Cellulaire Monsanto Company Institut Pasteur St. Louis, Missouri Paris, France Z. Koukolikovâ-Nicola William C. Nierman Friedrich Miescher-Institut Department of Molecular and Plasmid Basel, Switzerland Biology American Type Culture Collection Jacek Kowalski Rockville, Maryland Cancer Research Laboratory University of Western Ontario Nikos Panayotatos London, Ontario Michigan Biotechnology Institute Canada Lansing, Michigan Contributors IX Craig L.J. Parfett Xavier Soberon Cancer Research Laboratory Departamento de Biologia Molecular University of Western Ontario Centro de Investigacion sobre London, Ontario Ingenieria Genetica y Biotecnologia Canada Universidad Nacional Autonoma de Mexico Vincenzo Pirrotta Cuernavaca, Morelos Department of Cell Biology Mexico Baylor College of Medicine Houston, Texas George P. Smith Division of Biological Sciences Anthony A.G. Ridgway University of Missouri Cancer Research Laboratory Columbia, Missouri University of Western Ontario London, Ontario Joseph A. Sorge Canada Stratagene Cloning Systems San Diego, California Raymond L. Rodriguez Department of Genetics Frank H. Stephenson University of California Codon Corporation Davis, California Brisbane, California Stephen G. Rogers Paul Waterhouse Monsanto Company Department of Biochemistry St. Louis, Missouri University of Western Ontario London, Ontario John L.R. Rubenstein Canada Unité de Génétique Cellulaire Institut Pasteur Robert W. West, Jr. Paris, France Department of Biochemistry and Molecular Biology Thomas J. Schmidhauser SUNY Health Science Center Department of Biological Sciences Syracuse, New York Stanford University Stanford, California Brian Seed Department of Molecular Biology Massachusetts General Hospital Boston, Massachusetts PREFACE It has been more than ten years since Stanley Cohen and co-workers first reported the use of bacterial plasmids as molecular cloning vectors. This marked the beginning of a new era in molecular biology and laid the groundwork for what was to become known as the "biotechnology industry." Since that initial report thousands of cloning vectors have been constructed, and their versatility in terms of cloning sites, host-range, and function appears to be limited only by the ingenuity and imagination of the inventor. Whereas insertion of foreign DNA fragments into pSClOl was limited to a single restriction enzyme cleavage site and to E. coli as a host, most vectors currently in use carry multiple restriction-enzyme cleavage sites and have been modified for use with most common laboratory microorganisms. Many vectors now include dual origins of replication that enable them to be shuttled between hosts as dissimilar as E. coli and human cells. Equally impressive is the multitude of purposes for which molecular cloning vectors have been designed. Specialized vectors are now available that enable the investigator to: (1) identify and isolate regulatory DNA sequences such as promoters and terminators; (2) identify open translational reading frames; (3) overproduce useful RNAs and proteins; and (4) determine the nucleotide sequence of genes and segments of DNA. So many gener- alized and specialized cloning vectors now exist that it is sometimes difficult to know which vector is best suited for a particular need. For example, what are the most efficient vectors for constructing cDNA libraries or for moving foreign DNA into plants? xiii XÎV Preface Vectors: A Survey of Molecular Cloning Vectors and Their Uses is a series of chapters contributed by scientists active in the field of molecular and cellular biology that attempts to organize and bring into focus this rapidly changing area of research. The chapters have been broadly grouped according to host organism and function and should provide the reader with a better understanding of the useful properties of molecular cloning vectors, how they were constructed, and how they are used. Each chapter undoubt- edly reflects the unique perspective and expertise of the contributor. How- ever, all of the chapters attempt to address certain common issues such as the relative advantages and disadvantages of the vector, its stability and copy number, and suggestions for future vector constructions. We hope that by assembling in one place a collection of up-to-date critical reviews on molecular cloning vectors, members of our growing community of molecular biologists can stay abreast of recent trends in this field and perhaps anticipate future ones. Also, by focusing on this one aspect of recombinant DNA technology, we hope that this volume will provide a unique vantage point from which to view the exciting new developments now taking place in the fields of molecular biology and biotechnology. We thank Ingrid Krohn and Marisa Sibio of Butterworth Publishers for their encouragement and support and Cheryl Lambing-Ortega, whose or- ganizational and communications skills were invaluable in the early stages of this project. We also thank the 3M Foundation and Great Western Malting Company for their financial support for this project, and, lastly, a special debt of thanks goes to all of the contributors, whose efforts and patience made the volume possible. Raymond L. Rodriguez David T. Denhardt
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