Vascular Pathology And OsteoarthritisPopulation-based studies

89 Pages·2015·5.22 MB·English

by  Theun Antonius Hoeven

Vascular pathology and osteoarthritis
Population-based studies
Theun Hoeven

Vascular Pathology And Osteoarthritis
Population-based studies
Theun hoeven
This thesis is a result of the project: ‘The role of vascular pathology in the development and pro-
gression of osteoarthritis.’ that was supported by the Dutch Arthritis Foundation (nR 10_1_302)

Printing of this thesis was financially supported by:
SBoh, employer of general practitioner trainees, utrecht

The erasmus university Rotterdam

© Theun hoeven, 2015. All rights reserved. no part of this publication may be
reproduced, stored in a retrieval system or transmitted in any form or by means, without prior
written permission of the author.
ISBn: 978-94-6169-585-7
Cover design: Joost Pijnenborg (deBoSSA)
Layout and printed by: optima Grafische Communicatie, Rotterdam, The netherlands
Vascular Pathology And Osteoarthritis
Population-based studies
vasculaire pathologie en artrose
open populatie studies
Proefschrift
ter verkrijging van de graad van doctor aan de
erasmus universiteit Rotterdam
op gezag van de
rector magnificus
Prof.dr. h.A.P. Pols
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
woensdag 1 April 2015 om 09.30uur
door
Theun Antonius Hoeven
geboren te Breda
Promotiecommissie
Promotoren: Prof.dr. S.M.A. Bierma-Zeinstra
Prof.dr. o.h. Franco
Overige leden: Prof.dr. G.J.v.M. van osch
Prof.dr.ir. h. Boersma
Prof.dr. G. Kloppenburg
CONTENTS
Chapter 1 General introduction 1
Chapter 2 Association of atherosclerosis with 13
presence and progression of osteoarthritis:
the Rotterdam Study
Chapter 3 Markers of atherosclerosis in relation 29
to presence and progression of knee
osteoarthritis: a population-based
cohort study
Chapter 4 Carotid atherosclerosis in relation to early 43
signs of knee osteoarthritis: a cross-sectional
study among middle-aged women
Chapter 5 Is type 2 diabetes related to osteoarthritis? 61
A Mendelian randomization study that
investigates glycemic traits and osteoarthritis
Chapter 6 Disability and not osteoarthritis predicts 75
cardiovascular disease: a prospective
population-based cohort study
Chapter 7 General discussion 89
Summary 109
nederlandse samenvatting 113
Dankwoord 117
Curriculum vitae 119
Publications 121
PhD Portfolio 123
01
General introduction
1
General introduction
01
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