Vascular and Neurological Changes in Early Diabetes. Advances in Metabolic Disorders, Supplement 2

570 Pages·1973·26.038 MB·English

by  Rafael A. Camerini-Dávalos and Harold S. Cole (Eds.)

ADVANCES M
METABOLIC D I M«
Edited by
Rachmiel Levine Rolf Luft
CITY OF HOPE MEDICAL CENTER DEPARTMENT OF ENDOCRINOLOGY
DUARTE, CALIFORNIA AND METABOLISM
KAROLINSKA SJUKHUSET
STOCKHOLM, SWEDEN
Supplement 1
EARLY DIABETES
Edited by RAFAEL A. CAMERINI-DAVALOS AND HAROLD S. COLE
Supplement 2
VASCULAR AND NEUROLOGICAL CHANGES IN
EARLY DIABETES
Edited by RAFAEL A. CAMERINI-DAVALOS AND HAROLD S. COLE
VASCULAR AND NEUROLOGICAL CHANGES IN
EARLY DIABETES
Edited by
Rafael A. CamerinUDavalos and Harold S. Cole
DIABETES CENTER AND DIABETES CENTER AND
DEPARTMENT OF MEDICINE DEPARTMENT OF PEDIATRICS
NEW YORK MEDICAL COLLEGE NEW YORK MEDICAL COLLEGE
NEW YORK, NEW YORK NEW YORK, NEW YORK
1973
ACADEMIC PRESS New York and London
COPYRIGHT © 1973, BY ACADEMIC PRESS, INC.
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PRINTED IN THE UNITED STATES OF AMERICA
List of Contributors
Numbers in parentheses indicate the pages on which the authors' contributions
begin. An asterisk to the left of an author's name indicates an invited speaker who
attended the symposium; daggers indicate the invited discussants.
* R. AGID (575), Institute of Physiology, University P. Sabatier, Toulouse,
France
M. AMHERDT (257, 357), Institut de Biochimie clinique (Department of
Medicine), and Institut d'Histologie et d'Embryologie, and the Depart­
ment of Ophthalmology, University of Geneva, Geneva, Switzerland
P. J. ANDERSON (245), Laboratory for Experimental Pathology, Veterans
Administration Hospital, and Departments of Pathology and Ophthal­
mology, University of Wisconsin Medical School, Madison, Wisconsin
*t PETER H. BENNETT (401, 473), Southwestern Field Studies Section,
Epidemiology and Field Studies Branch, National Institute of Arthritis,
Metabolism, and Digestive Diseases, Phoenix, Arizona
* EDWIN L. BIERMAN (67), Department of Medicine, University of Wash­
ington School of Medicine, and Veterans Administration Hospital,
Seattle, Washington
MAGDOLNA BIHARI-VARGA (103), Third Department of Medicine, Semmel­
weis University Medical School, Budapest, Hungary
J. BIRK (317), Department of Endocrinology and Metabolism, Center of
Internal Medicine and Pediatrics, University of Ulm, Ulm, Germany
* A. BISCHOFF (441), Department of Neurology, University of Zürich
Medical School, Kantonsspital, Zürich, Switzerland
* SÖREN BJÖRKERUD (55), Departments of Histology and Internal Medi­
cine I, University of Göteborg, Göteborg, Sweden
Xll List of Contributors
WALTER D. BLOCK (73), Department of Epidemiology, School of Public
Health, and Department of Biological Chemistry, University of Mi­
chigan Medical School, Ann Arbor, Michigan
* t J. M. B. BLOODWORTH, JR. (245, 373, 471), Laboratory for Experi­
mental Pathology, Veterans Administration Hospital, and Department of
Pathology, University of Wisconsin Medical School, Madison, Wisconsin
MARGARET E. BROSNAN (483), Department of Physiology, Faculty of
Medicine, University of Toronto, Toronto, Canada
* RAFAEL A. CAMERINI-DAVALOS (139, 271, 281, 373), Metabolism Sec­
tion and the Diabetes Center of the Department of Medicine, New
York Medical College, New York, New York
D. P. CAMERON (257), Institut de Biochimie clinique (Department of
Medicine), and Institut d'Histologie et d'Embryologie, and the Depart­
ment of Ophthalmology, University of Geneva, Geneva, Switzerland
* NIELS JUEL CHRISTENSEN (129, 227, 433), The Second Clinic of In­
ternal Medicine, Kommunehospitalet, Aarhus, Denmark
JACOB CHURG (271), Department of Pathology, Division of Renal Path­
ology, Mount Sinai School of Medicine of the City University of New
York, New York, New York
JOSE B. CIBEIRA (451), Fernandez Hospital, Buenos Aires, Argentina
ROY H. CLAUSS (383), Department of Surgery, New York Medical College,
New York, New York
REX S. CLEMENTS, JR. (117), The George S. Cox Medical Research In­
stitute, Department of Medicine, University of Pennsylvania, Philadel­
phia, Pennsylvania
HAROLD S. COLE (373), Diabetes Center and Department of Pediatrics,
New York Medical College, New York, New York
J. W. CONN (19, 215, 393), Department of Internal Medicine (Division
of Endocrinology and Metabolism and the Metabolism Research Unit),
The University of Michigan Medical School, Ann Arbor, Michigan
DEREK CRAWFORD (557), Kaiser-Permanente Medical Center, San Fran­
cisco, California
HAROLD L. CROSSLEY (111), Department of Pharmacology and Toxicology,
University of Rhode Island, Kingston, Rhode Island
List of Contributors xin
* GYTIS DANTA (465), Neurology Department, North Staffordshire Royal
Infirmary, Stoke-on-Trent, United Kingdom
DIETER DEPPERMANN (147), Medical Clinic, University of Heidelberg,
Heidelberg, Germany
WENDEL DESCHNER (147), Medical Clinic, University of Heidelberg,
Heidelberg, Germany
W. E. DULIN (291), Diabetes and Atherosclerosis Research, The Upjohn
Company, Kalamazoo, Michigan
* THEODORE EHRENREICH (271, 281), Metabolism Section and the Dia­
betes Center of the Department of Medicine, and Department of
Pathology, New York Medical College, New York, New York
ROBERT ELASHOFF (557), Instruction and Research Division, Information
Systems, Computer Center, and Department of Biostatistics, University
of California, San Francisco, California
R. S. ELKELES (83), Endocrine Unit, Department of Medicine, and De­
partment of Chemical Pathology, Royal Postgraduate Medical School,
London, England
* MAX ELLENBERG (459 ), The Mount Sinai School of Medicine, The Mount
Sinai Hospital, New York, New York
R. L. ENGERMAN (245), Laboratory for Experimental Pathology, Veterans
Administration Hospital, and Departments of Pathology and Ophthal­
mology, University of Wisconsin Medical School, Madison, Wisconsin
FREDERICK H. EPSTEIN (73), Department of Epidemiology, School of
Public Health, University of Michigan, Ann Arbor, Michigan
TANYA ESPINOZA (281), Metabolism Section and the Diabetes Center of
the Department of Medicine, and Department of Pathology, New York
Medical College, New York, New York
* ISAAC FAERMAN (451), Department of Nutrition, C. Durand Hospital,
Buenos Aires, Argentina
* STEFAN S. FAJANS (19, 215, 393), Department of Internal Medicine
(Division of Endocrinology and Metabolism and the Metabolism Re­
search Unit), The University of Michigan Medical School, Ann Arbor,
Michigan
xiv List of Contributors
J. D. FAULHABER (317), Department of Endocrinology and Metabolism,
Center of Internal Medicine and Pediatrics, University of Ulm, Ulm,
Germany
*ROBERT FELDMAN (557), Kaiser-Permanente Medical Center, Oakland,
California
JOHN C. FLOYD, JR. (19, 215), Department of Internal Medicine (Division
of Endocrinology and Metabolism and the Metabolism Research Unit),
The University of Michigan Medical School, Ann Arbor, Michigan
DORA Fox (451), Department of Nutrition, C. Durand Hospital, Buenos
Aires, Argentina
* RUSSELL FRASER (83), Endocrine Unit, Department of Medicine, and
Department of Chemical Pathology, Royal Postgraduate Medical
School, London, England
ERHARD FUCHS (147), Medical Clinic, University of Heidelberg, Heidel­
berg, Germany
* GEORGE C. FULLER (111), Department of Pharmacology and Toxicol­
ogy, University of Rhode Island, Kingston, Rhode Island
J. H. FULLER (521), Department of Medicine, Guy's Hospital Medical
School, London, England
* KENNETH H. GABBAY (417), Division of Endocrinology, Department of
Medicine, The Children's Hospital Medical Center and Department
of Pediatrics, Harvard Medical School, Boston, Massachusetts
* MARIANO GARCIA (493), National Heart and Lung Institute, Framingham,
Massachusetts
* S. GERO (103), Third Department of Medicine, Semmelweis University
Medical School, Budapest, Hungary
t G. C. GERRITSEN (125, 291), Diabetes and Atherosclerosis Research,
The Upjohn Company, Kalamazoo, Michigan
ALVIN GLASS (557), Kaiser-Permanente Medical Center, San Francisco,
California
LETICIA GLOCER (451), Department of Pathology, Fernandez Hospital,
Buenos Aires, Argentina
ARTHUR L. GORDON (373), Metabolism Section and Diabetes Center, De­
partment of Medicine, New York Medical College, New York, New
York
List of Contributors xv
TA VIA GORDON (493), National Heart and Lung Institute, Bethesda, Mary­
land
t J. J. HOET (333), Université Catholique de Louvain, Louvain, Belguim
I.I.IBRAHIM1 (235), Veterans Administration Hospital, Jefferson Bar­
racks, and Washington University, St. Louis, Missouri
t HISASHI IWATSUKA 2 (139, 305), Metabolism Section and the Diabetes
Center of the Department of Medicine, New York Medical College,
New York, New York
MAURICIO N. JADZINSKY (451), Department of Nutrition, C. Durand Hos­
pital, Buenos Aires, Argentina
R. J. JARRETT (3, 521), Department of Medicine, Guy's Hospital Medical
School, London, England
* KLAUS JOHANSEN (29), Second Clinic of Internal Medicine, Aarhus Uni­
versity School of Medicine, Aarhus, Denmark
WILLIAM B. KANNEL (493), National Heart and Lung Institute, Framing-
ham, Massachusetts
*'t H. KEEN (3, 94, 521 ), Department of Medicine, Guy's Hospital Medical
School, London, England
* NICHOLAS A. KEFALIDES (167), Department of Medicine, University of
Pennsylvania, and Philadelphia General Hospital, Philadelphia, Penn­
sylvania
ANNE KELLOGG (139), Metabolism Section and the Diabetes Center of
the Department of Medicine, New York Medical College, New York,
New York
CHARLES KILO (363, 393), Departments of Pathology and Internal Medi­
cine, Washington University School of Medicine, St. Louis, Missouri
* KENNETH J. KINGSBURY (11), St. Mary's Hospital, London, England
* R. F. KNOPF (215), Department of Internal Medicine (Division of
Endocrinology and Metabolism and the Metabolism Research Unit),
The University of Michigan Medical School, Ann Arbor, Michigan
1 On leave from the Radiobiology Division, Atomic Energy Establishment, Cairo,
Egypt.
2 Present address: Central Research Division, Takeda Chemical Industries, Ltd.,
Osaka, Japan.
xvi List of Contributors
FRANTISEK KUTHAN (383), Departments of Medicine and Surgery, New
York Medical College, New York, New York
DONALD E. LAMPHIEAR (73), Department of Epidemiology, School of
Public Health, University of Michigan, Ann Arbor, Michigan
H. LAUBE (317), Department of Endocrinology and Metabolism, Center
of Internal Medicine ancJ/Pediatrics, University of Ulm, Ulm, Germany
ARNOLD LAZAROW (Guest participant), Department of Anatomy, University
of Minnesota, Minneapolis, Minnesota
P. LEUENBERGER (257), Institut de Biochimie clinique (Department of
Medicine), and Institut d'Histologie et d'Embryologie, and the Depart­
ment of Ophthalmology, University of Geneva, Geneva, Switzerland
B. LEWIS (83), Endocrine Unit, Department of Medicine, and Department
of Chemical Pathology, Royal Postgraduate Medical School, London,
England
BALDUR LIMBURG (373), Metabolism Section and Diabetes Center, De­
partment of Medicine, New York Medical College, New York, New
York
C. LOWY (83), Endocrine Unit, Department of Medicine, and Department
of Chemical Pathology, Royal Postgraduate Medical School, London,
England
* KNUD LUNDBAEK (191), Second University Clinic of Internal Medicine,
Kommunehospitalet, Aarhus, Denmark
t A. S. LUYCKX (334, 582), Hôpital de Bavière, Institut de Médecine,
Liege, Belgium
* DONALD E. MCMILLAN (155), Sansum Clinic Research Foundation,
Santa Barbara, California
PATRICIA MCNAMARA (493), National Heart and Lung Institute, Framing-
ham, Massachusetts
* ROBERT MAHLER (49), Department of Medicine, University Hospital of
Wales, Heath Park, Cardiff, Wales
M. MANCINI (83), Endocrine Unit, Department of Medicine, and De­
partment of Chemical Pathology, Royal Postgraduate Medical School,
London, England
* ALEXANDER MARBLE (539), Joslin Clinic, New England Deaconess Hos­
pital, and Department of Medicine, Harvard Medical School, Boston,
Massachusetts
List of Contributors
xvii
G. MARQUIE (575), Institute of Physiology, University P. Sabatier, Tou­
louse, France
* THOMAS J. MERIMEE (207), Department of Medicine, Boston University
School of Medicine, Boston, Massachusetts
MAX MILLER (401), Department of Medicine, Case Western Reserve Uni­
versity, Cleveland, Ohio
ANTHONY D. MORRISON (117), The George S. Cox Medical Research
Institute, Department of Medicine, University of Pennsylvania, Phila­
delphia, Pennsylvania
t J. M. Moss (582), 1707 Osage Street, Alexandria, Virginia
* WERNER OPPERMANN (139, 271, 281, 373, 383), Metabolism Section
and the Diabetes Center of the Department of Medicine, New York
Medical College, New York, New York
L. ORCI (257), Institut de Biochimie clinique (Department of Medicine),
and Institut d'Histologie et d'Embryologie, and the Department of Oph­
thalmology, University of Geneva, Geneva, Switzerland
* RUTH 0STERBY (323), University Institute of Pathology and the Second
University Clinic of Internal Medicine, Kommunehospitalet, Aarhus,
Denmark
* LEON D. OSTRANDER, JR. (73), Department of Epidemiology, School of
Public Health, and Department of Internal Medicine, University of
Michigan Medical School, Ann Arbor, Michigan
t J. B. O'SULLIVAN (509), Diabetes and Arthritis Research Unit, Depart­
ment of Health, Education and Welfare, Boston, Massachusetts
* J. PAASIKIVI (533), Department of Medicine, Karolinska Institute at
Serafimerlasarettet, Stockholm, Sweden
S. PAL (317), Department of Endocrinology and Metabolism, Center of
Internal Medicine and Pediatrics, University of Ulm, Ulm, Germany
DHANOO PATEL (281), Metabolism Section and the Diabetes Center of the
Department of Medicine, New York Medical College, New York,
New York
SUMER PEK (19, 215), Department of Internal Medicine (Division of
Endocrinology and Metabolism and the Metabolism Research Unit),
The University of Michigan Medical School, Ann Arbor, Michigan
E. F. PFEIFFER (Guest participant), University of Ulm, Ulm, Germany