Urinary tract PDF
Preview Urinary tract
Handbook of Experimental Pharmacology Volume 202 Editor-in-Chief FranzB.Hofmann EditorialBoard JosephA.Beavo DetlevGanten Jan-AndersKarlsson MartinC.Michel CliveP.Page WalterRosenthal Forfurthervolumes: http://www.springer.com/series/164 . Karl-Erik Andersson Martin C. Michel l Editors Urinary Tract Editors Dr.Karl-ErikAndersson Prof.Dr.MartinC.Michel WakeForestUniversity UniversityofAmsterdam MedicalCenterBlvd. AcademicMedicalCenter 27157-1088Winston-Salem Dept.Pharmacology& NorthCarolina Pharmacotherapy USA Meibergdreef15 [email protected] 1105AZAmsterdam Netherlands [email protected] ISSN0171-2004 e-ISSN1865-0325 ISBN978-3-642-16498-9 e-ISBN978-3-642-16499-6 DOI10.1007/978-3-642-16499-6 SpringerHeidelbergDordrechtLondonNewYork LibraryofCongressControlNumber:2011921350 #Springer-VerlagBerlinHeidelberg2011 Thisworkissubjecttocopyright.Allrightsarereserved,whetherthewholeorpartofthematerialis concerned,specificallytherightsoftranslation,reprinting,reuseofillustrations,recitation,broadcasting, reproductiononmicrofilmorinanyotherway,andstorageindatabanks.Duplicationofthispublication orpartsthereofispermittedonlyundertheprovisionsoftheGermanCopyrightLawofSeptember9, 1965,initscurrentversion,andpermissionforusemustalwaysbeobtainedfromSpringer.Violations areliabletoprosecutionundertheGermanCopyrightLaw. Theuseofgeneraldescriptivenames,registerednames,trademarks,etc.inthispublicationdoesnot imply,evenintheabsenceofaspecificstatement,thatsuchnamesareexemptfromtherelevantprotec- tivelawsandregulationsandthereforefreeforgeneraluse. Coverdesign:deblik,Berlin Printedonacid-freepaper SpringerispartofSpringerScience+BusinessMedia(www.springer.com) ThisbookisdedicatedtothememoryofthelateProf.AlisonBradingwho passedawaywhilethisbookwasbeingproduced. . Preface Functionaldisordersoftheurinarytractarecommonandinmanycaseshavemajor adverse effects on the quality of life of the afflicted patients. These include disorders of the ureters, the bladder, the urethra, the prostate and the pelvic floor. For a long time, only surgical approaches and conservative treatment could be offeredforsuchdisorders.Thelasttwodecadeshaveseenanamazingproliferation ofknowledgeinthefieldofanatomy,physiologyandpharmacologyoftheurinary tract. Several major new treatments have emerged from such research and are benefitting millions of patients. However, therapeutic needs remain and only a profoundknowledgeontheunderlyingtissue,cellandmolecularprocessesislikely to provide novel treatments addressing such needs. Therefore, we are very happy that internationally leading experts have contributed to the writing of this book and we thank all of them for their efforts. Their combined insight provides a comprehensive overview of the state of knowledge regarding the pharmacology oftheurinarytract.Therefore,wetrustthatthisbookwillbecomeavaluablesource of information for basic and clinical researchers alike in a dynamically growing field. Winston-Salem,NC,USA Karl-ErikAndersson Amsterdam,TheNetherlands MartinC.Michel September2010 vii . Contents OverviewontheLowerUrinaryTract ....................................... 1 ChristopherChapple AnimalModelsinOveractiveBladderResearch ........................... 15 BrianA.ParsonsandMarcusJ.Drake AnimalModelsofStressUrinaryIncontinence ............................. 45 Hai-HongJiangandMargotS.Damaser AnimalModelsforBenignProstaticHyperplasia .......................... 69 J.PaulHieble UseofFunctionalImagingtoMonitorCentralControlofVoiding inHumans ..................................................................... 81 DerekJ.Griffiths NeuroanatomyoftheLowerUrinaryTract ................................ 99 JonathanM.BeckelandGertHolstege AnatomyandHistologyoftheLowerUrinaryTract ..................... 117 WisuitPradidarcheep,ChristianWallner,NoshirF.Dabhoiwala, andWouterH.Lamers NeurophysiologyoftheLowerUrinaryTract ............................. 149 JonathanM.BeckelandGertHolstege AfferentMechanismintheUrinaryTract ................................. 171 AnthonyJ.Kanai UrothelialSignaling .......................................................... 207 LoriA.Birder ix
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