University of Pennsylvania News from the C A M B

12 Pages·2008·0.76 MB·English

University of Pennsylvania Spring 2008
News from the
CC AA MM BB

Cell and Molecular Biology Graduate Group

The 2008 CAMB
The CAMB Annual Symposium is
Symposiumwill be a full day (8:30 –6:00) of science

and social interaction for CAMB
Thursday, October 30th.
faculty and students. Talks will be

presented by three faculty and six
at the
students, as well as the keynote
Annenberg Center.
speaker.

The keynote speaker will be
Dr. Susan Lindquist. All thesis level students are

expected to present posters, and all
other CAMB students may
volunteer to do so. A panel of

Dr. Susan Lindquist is a well-known molecular biologist faculty judges will award $100
studying (among other things) the biology of protein folding, prizes to the top posters at the end
heat-shock proteins, and prions. Dr. Lindquist is a Member of the day.
and former Director (2001-2004) of the Whitehead Institute,
a Professor of Biology at MIT, and a Howard Hughes
Medical Institute Investigator.
Previously, she was the Albert D. Lasker Professor of
Medical Sciences from 1999-2001, and a Professor in the

Department of Molecular Biology, University of Chicago, Photos in this issue of the CAMB
since 1978. She received a PhD in Biology from Harvard newsletter include images from the Lea
Elementary School Science Fair, 2007 CBP
University in 1976, and was elected to the American Academy
orientation softball game, 2008
of Arts and Sciences in 1997, the National Academy of
Admissions, and the University of
Sciences in 1997 and the Institute of Medicine in 2006. Pennsylvania Campus in spring.
Lindquist’s honors also include a spot on Discover magazine’s
2002 list of the top 50 women scientists.

Information taken from the website:
http://www.wi.mit.edu/research/faculty/lindquist.html
CAMB News Letter Page 2, Spring 2008
The 2009 admission weekends will be:

January 15-17

February 5-7

February 26-28

Please put these dates on your calendar.
Admission Season 2008
The CAMB office would like to thank everyone involved this season for their hard work, especially the student leaders:

Adam Siebert, Margaret Fleetwood, Elia Tait, Erika Lin Hendel, Matt Cohen,
Bob Simone, Kim Davis, and Sarah Galanti
Please join us in welcoming the 34 CAMB PhD
students who will matriculate in 2008
Alexander Babich Siqing He Stephen Santoro
Temple University Brown University University of Colorado, Boulder

Aaron Black Alyssa Huegel Lauren Smith
University of Washington University of Pennsylvania University of Pittsburgh

Kelsey Breen Cheng Jia Yiwen Song
Syracuse University Tsinghua University University of California, Los Angeles

Jessica Bryant Rachel Kosoff Jonathan Stoltzfus (will defer 1 year)
University of Georgia Pennsylvania State University Messiah College

Amy Campbell Rachel Leskowitz Andria Styborski
Reed College Lehigh University West Chester University

Christopher Campbell Chao Lu Viktoriya Syrovatkina
University of Missouri at Rolla National University of Singapore St. Joseph’s College

Sarah Clark Nancy Maas Kevin Tsai
Colby College Mills College National Taiwan University

Luis Cocka Emily McMillan Maria Vega
University of Maryland, Baltimore University of Maryland, College University of Puerto Rico, Rio Piedras
County Park
Yi Wang

Julie Crudele Melanie Millholland Peking University
Dartmouth College George Washington University
Meredith Wilson

Nicholas Francella Francis Pierciey The College of William and Mary
St. Mary’s College of Maryland Roger Williams University
Kilangsungla Yanger

Erin Graf Thomas Porturas Carleton College
University of Maryland, College Rutgers University
Xiang Zhang
Park
University of Chicago
CAMB News Letter Page 3, Spring 2008
December Graduation

8 CAMB students received PhDs in December 2007.
Natalie Bezman
Advisor: Gary Koretzky
"Regulation of Immunoreceptor and Integrin Signaling by the
Adapter SLP-76"

Carolyn Clark
Advisor: Robert Vonderheide
"The Dynamics of Immunosurveillance in Pancreatic Cancer
from Inception to Invasion and Metastasis”
August Graduation

John Gordan
5 CAMB students received PhDs in August 2007. Advisor: M. Celeste Simon
Theresa J. Alenghat "HIF-1α and HIF-2α have antagonistic effects on c-Myc:
Advisor: Mitchell Lazar implications for normal and transformed cell proliferation”
"Molecular and Physiologic Significance of the Nuclear Re-
Frances High
ceptor Coreceptor-HDAC3 Complex"
Advisor: Jonathan Epstein

Laura K. Conlin "Notch Sgnaling in Cardiac Development”
Advisor: Hillary Nelson
Kristin Ingvarsdottir
“Trehalose is a Positive Regulator of the Heat-Induced Ac-
Advisor: Shelley Berger
tivity of Yeast Heat Shock Transcription Factor”
"Histone Modifications and Histone Modifying Enzymes in

Sheri L. Hanna the Budding Yeast Saccharomyces cerevisiae"
Advisor: Robert Doms
Douglas Lin
"The Contribution of West Nile Virus Envelope Protein N-
Advisor: J. Alan Diehl
Linked Glycosylation on Pathogenesis”
"Interplay between SCF and CDK Complexes in the Control

Jennifer A. Tucker of Cellular Proliferation”
Advisor: Mary Mullins
Stephen Sykes
"Roles of BMP Signaling in Spatiotemporal Coordination
Advisor: Steven McMahon
of Embryonic Axial Patterning "
"Acetylation of Lys120 coordinates the transcription-

Anastasia M. Wyce dependent and –independent functions of p53-mediated apop-
Advisor: Shelley Berger tosis"
"Histone H2B Deubiquitylation and Transcriptional Con-
Jing Wang
trol in the Yeast Saccharomyces cerevisiae ”
Advisor: Mitchell Lazar
"Regulation of Circadian Rythms and Adipogenesis by the

Nuclear Receptor REV-ERBα"
The CAMB SUMMER PICNIC
H Dr. Jane Glick
IN ONOR OF

Will be held
Wednesday, June 11, 2008

at the
James G. Kaskey Memorial
Garden and Biopond

from
3:00-5:00 p.m.
CAMB News Letter Page 4, Spring 2008
May Graduation

11 CAMB students received PhDs in May 2008.
Sara Achenbach Shih-Wen (Wenny) Lin
Advisor: Hillary Nelson Advisor: Hildegund Ertl
"Two Kinases Negatively Regulate the Activity of the Heat "Prime-Boost Vaccine Strategies Using Adeno Virus and
Schock Transcription Factor in Saccharomyces cerevisiae” Adeno-Associated Virus Vectors to Induce CD8+ T Cell
Responses against Human Immunodeficiency Virus Type I”
Lou Altamura

Advisor: Robert Doms
Sarah McCarthy
"Crimean-Congo hemorrhagic fever virus: Identification of an
Advisor: Ronald Harty
NSm protein and oligomerization of the viral glycoproteins”
"A Role for Amino Acids 212KLR214 of Ebola Virus

Justin DiAngelo VP40 in VLP Assembly and Budding“
Advisor: Morris Birnbaum
Sara Sackett
"Allocating Energy Utilization for Growth and Metabolism:
Advisor: Klaus Kaestner
The Interplay Between Insulin and Inflammatory Signaling in
"The Winged Helix Transcription Factor Foxl1 in
Drosophila melanogaster“
Proliferation and Homeostasis of the Gastrointestinal Tract

and Liver“

Earl Stoddard

Advisor: Drew Weissman

"The Interaction of GP340 with HIV and Its Contribution

to Heterosexual Transmission in Females“

Todd Strochlic
Advisor: Christopher Burd
“Regulated Protein Sorting in the Endosomal System”

Catherine Gleason
Advisor: Morris Birnbaum
"Integration of growth factor and nutrient signaling in
the regulation of pancreatic beta-cell growth“

Michele Hickey
Advisor: Celeste Simon
"The role of von Hippel-Lindau mutation in polycythemia and
pulmonary hypertension”

Jennifer Levy
Advisor: Erika Holzbaur
"Roles of Dynein and Dynactin in Cell Migration and
Disease“

2008 Saul Winegrad Awards for Outstanding Dissertation
Congratulations to:
John Gordan Frances High
Advisor: M. Celeste Simon Advisor: Jonathan Epstein
CAMB News Letter Page 5, Spring 2008
CAMB Fall Courses 2008
Class Instructor (s) Day: Time
BIOM 600: Cell Biology and Biochemistry J. Weisel M, W, F: 10:30-12
CAMB 513: Evolution in Cancer C. Maley T, R: 11-1
CAMB 518: Current Topics in Ion Channels C. Deutsch, F. Horrigan M, W, F: 9-10:30
CAMB 530: The Cell Cycle and Cancer A. Diehl, S. McMahon, R. Assoian M: 2-4
CAMB 532: Human Physiology K. Foskett M, W, F: 9-10:30
CAMB 542-401: Topics in Molecular Medicine
R. Wells W: 3-5
(MD/PhD only)
CAMB 542-402: Topics in Molecular Medicine
M. Atchison W: 5-7
(VMD/PhD, PhD)
CAMB 590: Topics in MVP—The Biology of
P. Bates, E. Pearce T, R: 10-11:30
Pathogens
CAMB 597: Developmental Neuroscience M. Granato W, F: 10:45-12:30
C. Krummenacher, P. Lieberman, S. Weiss,
CAMB 601: Advanced Virology Seminar M: 2-3
J. Bergelson
CAMB 605: First Year Seminar D. Epstein T: 1-4
CAMB 608: Regulation of Eukaryotic Gene
T. Kadesch T: 3- 5
Transcription
CAMB 609: Vaccines & Immune Therapeutics D. Weiner, P. Offit, J. Boyer W, R: 3-5
CAMB 610: Molecular Basis of Gene Therapy J. Wilson M,W,F: 9-10
CAMB 615: Topics in Confirmational Disease Y. Argon, H. Ischiropoulos W: 3-5
CAMB 617: Emerging Infectious Diseases H. Shen M, W: 10–11:30
CAMB 620: Molecular Mechanisms of
S. DiNardo T: 10-12
Development
CAMB 630: Topics in Human Genetics N. Spinner, E. Shore, T. Shaikh, S. Grant,
R: 1:30-3:30
and Disease M. Devoto
CAMB 631: Cell Adhesion & the Cytoskeleton D. Boettiger TBD
CAMB 638: Apoptosis Senescence & Autophagy in
X. Yang, W. El-Deiry, B. Keith W: 3-5
Cancer
CAMB 698: Elective tutorials in Cell Biology J. Burkhardt TBD
CAMB students - please remember to discuss your course choices with your program advisor and
communicate with your coordinator so that she can register you properly.
CAMB News Letter Page 6, Spring 2008
Recent Papers from Students
Aggarwal P, Lessie M, Lin DI, Pontano L, Gladden AB, Nuskey B, Goradia A, Wasik MA, Klein-Szanto AJP, Rustgi
AK, Bassing CH, Diehl JA. Nuclear Accumulation of Cyclin D1During S-phase Inhibits Cdt1 Proteolysis and
Triggers p53-dependent DNA Re-replication. Genes & Dev. 21: 2908-2922. 2007.

Agosto LM, Yu JJ, Dai J, Kaletsky R, Monie D, O'Doherty U. HIV-1 integrates into resting CD4+ T cells even at
low inoculums as demonstrated with an improved assay for HIV-1 integration. Virology. 2007 Nov 10;368(1):60-72.
Epub 2007 Jul 13.

Bezhani S, Winter C, Hershman S, Wagner JD, Kennedy JF, Kwon CS, Pfluger J, Su
Y, Wagner D. (2007) Unique, shared, and redundant roles for the Arabidopsis SWI/SNF chromatin remodeling
ATPases BRAHMA and SPLAYED. Plant Cell. 19(2):403-16.

Buchkovich NJ, Yu Y, Zampieri CA, Alwine JC. The TORrid affairs of viruses: effects of mammalian DNA viruses
on the PI3K-Akt-mTOR signalling pathway. Nat Rev Microbiol. 2008 Apr;6(4):266-75.

Buchkovich, N.J., Maguire, T.G. Yu, Y., Paton, A.W., Paton, J.C. and J.C. Alwine (2008). HCMV specifically con-
trols the levels of the endoplasmic reticulum chaperone BiP/GRP78 which is required for virion assembly. J. Vi-
rol. 82:31-39.

Burkhardt, JK, E. Carrizosa, MH Shaffer. (2008) The actin cytoskeleton in T cell activation. Ann Rev Immunol.
26:233-259.

Cash, T. P., Y. Pan, and M. C. Simon (2007) Reactive oxygen species and cellular oxygen sensing. Free Radical Biol.
Med. 43:1219-1225.

Clark CE, Hingorani SR, Mick R, Combs C, Tuveson DA, and Vonderheide RH. (2007) Dynamics of the immune
reaction to pancreatic cancer from inception to invasion. Can Res, 67: 9518-9527.

Lisa L. Chang and D.S. Kessler. (2007). Formation of the Embryonic Mesoderm. In "Principles of Developmental
Genetics". S.A. Moody, ed. San Diego, Elsevier Inc. pp. 258-294.

M. J. Culyba, N. Minkah, Y. Hwang, O.-M. J. Benhamou, and F. D. Bushman. (2007) DNA branch nuclease
activity of vaccinia A22 resolvase. J. Biol. Chem., 282, 48, 34644-34652.

David A. Hokey, F. Brad Johnson, Jasmine Smith, Joshua L. Weber, Jian Yan, Lauren Hirao, Jean D. Boyer,
Mark G. Lewis, George Makedonas, Michael R. Betts, and David B. Weiner. (2008) Activation drives PD-1 expres-
sion during vaccine-specific proliferation and following lentiviral infection in macaques. European Journal of Immu-
nology.

Diem MD, Chan CC, Younis I, and Dreyfuss G. (2007) PYM binds the cytoplasmic exon-junction complex and ri-
bosomes to enhance translation of spliced mRNAs. Nat Struct Mol Biol. 14:1173-9.
CAMB News Letter Page 7, Spring 2008
Recent Papers from Students cont..
Fournier, A.K., Campbell, L.E., Castagnino, P. Liu, W.F., Chung,
B.M., Weaver, V.M., Chen, C.S., and Assoian, R.K. (2007) Rac-
dependent cyclin D1 gene expression regulated by cadherin- and
integrin-mediated adhesion. J. Cell Science 121: 226-233.

Gillen, C.M., Blair C.R., Heilman, N. R., Somple, M., Stulberg, M.,
Thombre, R., Watson, N., Gillen K. M., Itagaki, H. M. 2006. The
cation-chloride cotransporter, masBSC, is widely expressed in Man-
duca sexta tissues. Journal of Insect Physiology 52, 661-668.

Girgis NM, DeHaven BC, Fan X, Viner KM, Shamim M, Isaacs
SN. Cell surface expression of the vaccinia virus complement control
protein is mediated by interaction with the viral A56 protein and
protects infected cells from complement attack. J Virol. 2008 May;82
(9):4205-14.

Gleason, C. E., Lu, D., Witters, L. A., Newgard, C. B., Birnbaum, M. J. (2007) The role of AMPK and mTOR in nu-
trient sensing in pancreatic b–cells J. Biol. Chem. 282:10341-51.

Gordan, J. D., C. B. Thompson, and M. C. Simon (2007) HIF and c-Myc: sibling rivals for control of cancer cell me-
tabolism and proliferation. Cancer Cell 12:108-113.

Gordan, JD and Simon MC. 2007. Hypoxia inducible factors: central regulators of the tumor phenotype. Curr. Opin.
In Genes & Dev. 17:71-77.

Gordan, JD, JA Bertout, C.-J. Hu, JA Diehl, and MC Simon. 2007. HIF-2a promotes hypoxic cell poliveration by
enhancing c-Myc transcriptional activity. Cancer Cell 11:335-347. *previewed in Nature Reviews Cancer

Hannah BP, Heldwein EE, Bender FC, Cohen GH and Eisenberg RJ. 2007. Mutational evidence of internal fusion
loops in HSV glycoprotein B . J. Virol. 81:4858-4865.

Hershman, SG, Chen, Q, Lee, JY, Kozak, ML, Yue, P, Wang, L, and Johnson, FB. (2008) Genomic distribution and
functional analyses of potential G-quadruplex-forming sequences in Saccharomyces cerevisiae. Nucleic Acids Research
36: 144-156.

Hickey, M. M., W. K. Rathmell, J. C. Lam, N. A. Bezman, and M. C. Simon (2007) von Hippel-Lindau mutation in
mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2a signaling and splenic erythropoiesis. J. Clin.
Invest. 117:3879-3889.

High, F, Epstein, JA. Signaling pathways regulating cardiac neural crest migration and differentiation. Novartis
Found. Symp. 283:152-161; discussion 161-164, 238-241, 2007.

High, FA, Epstein, JA The multifaceted role of Notch in cardiac development and disease. Nat. Rev. Genet. 9(1):49-
61, 2008.

High, FA, Lu, MM, Pear, WS, Loomes, KM, Kaestner, KH and Epstein. JA. Endothelial expression of the Notch
ligand Jagged1 is required for vascular smooth muscle development. PNAS, 105(6):1955-1959, 2008.

High, FA, Zhang, M, Proweller, A, Tu, L, Parmacek, MS, Pear, WS, Epstein, JA. An essential role for Notch in
neural crest during cardiovascular development and smooth muscle differentiation. J. Clin. Invest. 117:353-363, 2007.
* with commentary in same issue

Hokey DA, F. Brad Johnson, Jasmine Smith, Joshua L. Weber, Jian Yan, Lauren Hirao, Jean D. Boyer, Mark G.
Lewis, George Makedonas, Michael R. Betts, and David B. Weiner. (2008) Activation drives PD-1 expression during
vaccine-specific proliferation and following lentiviral infection in macaques. European Journal of Immunology.

Hsiao, A, K. Toscano, and J. Zhu. 2008. Post-transcriptional cross-talk between pro- and anti-colonization pili bio-
synthesis systems in V. cholerae. Mol. Microbiol. 67: 849–860.
CAMB News Letter Page 8, Spring 2008
Recent Papers from Students cont..
Hu H, Fernando K, Ni H, Weissman D. HIV Envelope Suppresses CD4+ T Cell Activation Independent of T
Regulatory Cells. J Immunol. 2008 Apr 15;180(8):5593-600.

Javvadi P, Segan AT, Tuttle SW, Koumenis C. 2008. The chemopreventive agent curcumin is a potent radiosensi-
tizer of human cervical tumor cells via increased reactive oxygen species production and overactivation of the mitogen-
activated protein kinase pathway. Mol Pharmacol.

Jingxuan Liu, Anand Sitaram, Christopher G. Burd (2007) Regulation of Copper-Dependent Endocytosis and
Vacuolar Degradation of the Yeast Copper Transporter, Ctr1p, by the Rsp5 Ubiquitin Ligase. Traffic 8 (10) , 1375–
1384

Johnson, JE, Smith, SJ, Kozak, ML, Johnson, FB. (2008) In vivo veritas: using yeast to probe the biological
functions of G-quadruplexes. Biochimie.

Katrina M. Nolan, Andrea P.O. Jordan, and James A. Hoxie. 2008. Effects of Partial Deletions within the Human
Immunodeficiency Virus Type 1 V3 Loop on Coreceptor Tropism and Sensitivity to Entry Inhibitors. J. Virol. 82:
664-673.

Khan SN, Witsch EJ, Goodman NG, Panigrahi AK, Chen C, Jiang Y, Cline AM, Erikson J, Weigert M, Prak ET,
Radic M. (2008). Editing and escape from editing in anti-DNA B cells. Proc Natl Acad Sci U S A.: 105(10):3861-6.

Kudchodkar, S.B., Del Prete, G.Q., Maguire, T.G. and J.C. Alwine (2007). AMPK-Mediated Inhibition of
mTOR Kinase is Circumvented during Immediate Early Times of HCMV Infection. J. Virol. 81:3649-3651.

Laakso M, Lee F.H., Haggarty B, Agrawal C, Nolan K, Biscone M, Romano J, Jordan A.P.O., Leslie G, Meissner
E.G., Su L, Hoxie J, and Doms R.W. (2007) V3 Loop Truncations in HIV-1 Envelope Impart Resistance to Coreceptor
Inhibitors and Enhanced Sensitivity to Neutralizing Antibodies. PLoS Pathogens 3(8): 1118-1128.

Lasaro MO, Tatsis N, Hensley SE, Whitbeck JC, Lin SW, Rux JJ, Wherry EJ, Cohen GH, Eisenberg RJ, Ertl HC1.
Targeting of antigen to the herpesvirus entry mediator augments primary adaptive immune responses. Nat Med. 2008
Feb;14(2):205-12.

Lazear, E , Carfi A, Whitbeck JC, Cairns TM, Krummenacher C,
Cohen GH and Eisenberg RJ. 2007. Engineered disulfide bonds in
herpes simplex virus type 1 gD separate receptor binding from fusion
initiation and viral entry. J. Virol. 82(2):700-709.

Li H, Murphy S, Giles-Davis W, Edmonson S, Xiang Z, Li Y,
Lasaro MO, High KA, Ertl HCJ. Pre-existing AAV capsid-specific
CD8+ T cells are unable to eliminate AAV-transduced hepatocytes,
Mol Ther 15:792-800, 2007 [Epub 2007 Jan 23].

Lin DI, Aggarwal P and Diehl JA. Phosphorylation of MCM3 on
Ser112 Regulates its Incorporation into the MCM2-7 Helicase. In
press PNAS 2008.

Lin DI, Lessie, MD, Gladden AB, Bassing CH, Wagner K-U, Diehl JA. Disruption of cyclin D1nuclear export and
proteolysis accelerates mammary carcinogenesis. Oncogene. 27:1231-1242. 2008.

Lin J., Zhi Y., Mays L.E., Wilson, J.M. (2007). Vaccines based on novel adeno-associated viruses elicit aberrant CD8+
T cell responses in mice. J. Virol. Nov; 81(21):11840-9.

Lin SW, Hensley SE, Tatsis N, Lasaro M, Ertl HC. Recombinant AAV vectors induce transgene product-specific
CD8+ T cells that are functionally impaired. J Clin Invest. 2007 Dec;117(12):3958-70.

Liu J, Sitaram A and Burd CG (2007). Regulation of copper-dependent endocytosis and vacuolar degradation of the
yeast copper transporter, Ctr1p, by the Rsp5 ubiquitin ligase. Traffic 8: 1375-1384.
CAMB News Letter Page 9, Spring 2008
Recent Papers from Students cont..

Liu+, J., +Schmitz, K.R., Li, S., Setty, T.G., Wood, C.S., ^Ferguson, K.M., and ^Burd, C.G., 2008. Golgi localization of
glycosyltransferases requires a Vps74 oligomer. Dev. Cell., 14:523-534.
+denotes equal contributions ^ denotes co-corresponding authors

Liu, Z., T. Miyashiro, A. Tsou, A. Hsiao., M. Goulian, and J. Zhu. Mucosal Penetration Primes Vibrio cholerae for
Host Colonization by Repressing Quorum Sensing. Proc. Natl. Acad. Sci. USA. In press.

Luallen R.J., Lin J, Fu H, Cai K.K., Agrawal C, Mboudjeka I, Lee F.H., Montefiori D, Smith D.F., Doms R.W., Geng
Y. (2008) An engineered Saccharomyces cerevisiae strain binds the brodly neutralizing HIV-1 antibody 2G12 and elicits
mannose-specific, gp120 binding antibodies. Journal of Virology, in press.

Lum, J. J., T. Bui, M. Gruber, J. D. Gordan, R. J. DeBerardinis, K. L. Covello, M. C. Simon and C. B. Thompson
(2007) The transcription factor HIF-1a plays a critical role in the growth factor-dependent regulation of both aerobic
and anaerobic glycolysis. Genes and Dev. 21:1037-1049. Previewed in Nature Reviews Cancer.

Marshall HM, Ronen K, Berry C, Llano M, Sutherland H, Saenz D, Bickmore W, Poeschla E, Bushman FD. Role
of PSIP1/LEDGF/p75 in Lentiviral Infectivity and Integration Targeting. PLoS ONE. 2007 Dec 19;2(12):e1340.

Mays L.E., Chen Y.H. (2007). Maintaining Immunological Tolerance with Foxp3. Cell Research Nov;17(11):904-18.

Mellert H., S.M. Sykes, M.E. Murphy and S.B. McMahon. 2007. The ARF/oncogene pathway activates p53 acety-
lation within the DNA binding domain. Cell Cycle 6:1304-1306.

Murphy SL, Li H*, Zhou S, Schlachterman A, High KA. Prolonged susceptibility to antibody-mediated neutraliza-
tion for adeno-associated vectors targeted to the liver. Mol Ther 16:138-145, 2008 [Epub 2007 Oct 23].

Pan, Y., K. D. Mansfield, C. Bertozzi, V. Rudenko, D. A. Chan, A. J. Giaccia, and M. C. Simon (2007) Multiple factors
affecting cellular redox status and energy metabolism modulate HIF prolyl hydroxylase activities in vivo and in vi-
tro. Mol. Cell. Biol. 27:912-925.

Patel J.H. and S.B. McMahon. 2007. BCL2 Is a Downstream Effector of MIZ-1 Essential for Blocking c-MYC-
induced Apoptosis. J. Biol. Chem. 282: 5-15. •Editor’s Choice. 2007. Science 315:303.

Patel, S. A. and M. C. Simon (2008) Biology of hypoxia-inducible factor-2a in development and disease. Cell Death
Diff. 15:628-634.

Rankin, E. B., M. P. Biju, Q. Liu, T. L. Unger, J. Rha, R. S. Johnson, M. C. Simon, B. Keith, and V. H. Haase (2007)
Hypoxia-inducible factor-2 (HIF)-2 regulates hepatic erythropoietin in vivo. J. Clin. Invest. 117:1068-1077.

Rivera, R.M., Stein, P., Weaver, J.R., Mager, J., Schultz, R.M. and M.S. Bartolomei. (2008). Manipulations of mouse
embryos prior to implantation result in aberrant expression of imprinted genes on day 9.5 of development. Human Mo-
lecular Genetics, 17:1-14.

Schoenly KA & Weiner DB. Human immunodeficiency virus type 1 vaccine development: recent advances in the
cytotoxic T-lymphocyte platform "spotty business". 2008. J Viorl. Apr: 82(7): 3166-80.

Shineman, D.W., Zhang,B., Leight, S., Pratico, D., Lee,V.M.-Y. 2008. Isoprostane increases Abeta levels and pro-
motes Alzheimer’s disease pathology through thromboxane receptor activation. JNeurosci. In press.

Stiles, KM, Milne, RSB, Cohen GH, Eisenberg RJ and Krummenacher C. 2008. The herpes simplex virus receptor
nectin-1 is down-regulated after trans-interaction with glycoprotein D. Virology. 373:98-111.

Swaminathan G, Varghese B, Fuchs SY. 2008. Regulation of prolactin receptor levels and activity in breast cancer.
Journal of Mammary Gland Biology and Neoplasia. 13(1):81-91.

Swaminathan G, Varghese B, Thangavel C, Carbone CJ, Plotnikov A, Suresh Kumar KG, Jablonski EM, Clevenger
CV, Goffin V, Deng L, Frank SJ, and Fuchs SY (2008) Prolactin stimulates ubiquitination, initial internalization and
degradation of its receptor via catalytic activation of Janus kinase 2, J Endocrinol, 196:R1-R7.
CAMB News Letter Page 10, Spring 2008
Recent Papers from Students cont..
Viner KM, Girgis N, Kwak H, Isaacs SN. B5-deficient vaccinia virus as a vaccine vector for the expression of a foreign
antigen in vaccinia immune animals. Virology. 2007 May 10;361(2):356-63.

Wan, L-B. and M.S. Bartolomei. (2008). Regulation of imprinting in clusters: noncoding RNAs versus insulators. In
Advances in Genetics. (eds. R.E. Hill and V. van Heyningen) Academic Press, 61:207-223.

G. Wang, A. Garrigue, A. Ciuffi, K. Ronen, J. Leipzig, C. C. Berry, C. Legrasle-Peyrou, F. Benjelloun, S. Hacein-Bey-
Abina, A. Fischer, M. Cavazzana-Calvo, and F. D. Bushman. Genotoxicity of integrating gene transfer vectors: char-
acterization by DNA bar coding and pyrosequencing. Nuc. Acids Res. (in press).

Wiedmer A, Wang P, Zhou J, Rennekamp AJ, Tiranti V, Zaviani M, Lieberman PM. Epstein-Barr virus immediate
early protein Zta co-opts mitochondrial single stranded DNA binding protein to promote viral and inhibit mitochon-
drial DNA replication. J Virol. 2008 May;82(9):4647-55.

Xu R-H, Cohen M, Tang Y, Lazear E, Whitbeck JC, Eisenberg RJ, Cohen GH, and Sigal LJ. 2008. The orthopox-
virus type I IFN binding protein is essential for virulence and an effective target for vaccination. J. Exp. Med . 205:
981-992.

Xu, J., Pope, S.D., Jazirehi, A.R., Attema, J.L., Papathanasiou, P., Watts, J., Zaret, K.S., Weissman, I.L., and Smale,
S.T. (2007) Pioneer factor interactions and unmethylated CpG dinucleotides mark silent tissue-specific enhancers in
embryonic stem cells. Proceedings of the National Academy of Sciences, USA 104, 12377-12382.

Bu Yin, Velibor Savic, Craig H. Bassing. ATM Prevents Unattended DNA Double Strand Breaks on Site and in
Generations to Come. Cancer Biol Ther. 2007 Nov 21;6(12).

Yu X, Kong Y, Dore LC, Abdulmalik O, Katein AM, Zhou S, Choi JK, Gell D, Mackay JP, Gow AJ, Weiss MJ. An
erythroid chaperone that facilitates folding of alpha-globin subunits for hemoglobin synthesis. J Clin Invest. 2007
Jul;117(7):1856-65.

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Announcing the arrivals of :

Isabelle Marie Bertout Crooks
born on April 17th, 2008 to
Jessica Bertout and her
husband Steven Crooks

Adiv Noam born on Sunday,
May 11, 2008 to Abigail
Druck-Shudofsky and her
husband Aryeh.