University of Groningen Cerebral hemodynamics in stroke and traumatic brain injury Aries, Marinus

201 Pages·2012·5.01 MB·English

University of Groningen

Cerebral hemodynamics in stroke and traumatic brain injury
Aries, Marinus
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Aries, M. (2012). Cerebral hemodynamics in stroke and traumatic brain injury: the interplay between blood
pressure, cerebral perfusion, body position and autoregulation. [S.n.].
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Download date: 17-03-2023
Cerebral Hemodynamics in Stroke
and Traumatic Brain Injury
The interplay between blood pressure, cerebral
perfusion, body position and autoregulation
M.J.H. Aries
Studies described in this thesis were supported by a grant of the Netherlands Organisation
for Health Research and Development (ZonMw) and European Federation of Neurological
Societies (EFNS).
The printing of this thesis was financially supported by Rijksuniversiteit Groningen,
Mundipharma, Boehringer Ingelheim, UCB, Bayer, Baxter and Merck Sharp & Dohme.
© Copyright Marcel Aries 2012
Cover image was adapted from the original article of Warren JV, Sci Am 1974. Chapter
covers were kindly provided by Albert Lemmens (LS collection), Nijmegen.
Lay out: Douwe Oppewal, Groningen.
Printed by: Netzodruk, Groningen.
ISBN: 978-90-367-5974-8
Cerebral Hemodynamics in Stroke and
Traumatic Brain Injury
The interplay between blood pressure, cerebral
perfusion, body position and autoregulation
Proefschrift
ter verkrijging van het doctoraat in de
Medische Wetenschappen
aan de Rijksuniversiteit Groningen
op gezag van de
Rector Magnificus, dr. E. Sterken,
in het openbaar te verdedigen op
maandag 21 januari 2013
om 16.15 uur
door
Marinus Johannes Hermanus Aries
Geboren op 9 maart 1979
te Boxtel
Promotores: Prof. dr. H.P.H. Kremer
Prof. dr. J.H.A. De Keyser
Copromotores: Dr. P.C.A.J. Vroomen
Dr. J.W.J. Elting
Beoordelingscommissie: Prof. dr. A.R. Absalom
Prof. dr. W.H. Mess
Prof. dr. A.F. Bos
Paranimfen: Hanneke Joosten
Myriam McCulloch-Aries

Table of conTenTs
Part 1. Introduction and aims
Chapter 1 Introduction and Outline 9
Part 2. Clinical and methodological background
Chapter 2 Cerebral vasoregulation: clinical perspectives? 15
(Accepted by Ned Tijdschr Geneeskd)
Chapter 3 Cerebral autoregulation in stroke: a review of 29
transcranial Doppler studies (Stroke 2010)
Chapter 4 Reproducibility and variability of dynamic cerebral 47
autoregulation during passive cyclic leg raising (submitted)
Part 3. Blood pressure, cerebral perfusion and vasoregulation in different body
positions in acute stroke and critically ill patients
Chapter 5 Variations of blood pressure in stroke unit patients may result 63
from alternating body positions (J Stroke Cerebrovasc Dis 2012)
Chapter 6 Intra-arterial blood pressure reading in intensive care unit patients 75
in the lateral position (J Clin Nurs 2012)
Chapter 7 Exaggerated postural blood pressure rise is related to a 85
favorable outcome in patients with acute ischemic stroke (Stroke 2012)
Chapter 8 The impact of upright positioning in bed on cerebral blood flow 99
velocity after acute stroke. Implications for safety of
early mobilization after stroke (submitted)
Part 4. Applications in clinical research
Chapter 9 Near-infrared spectroscopy for the detection of desaturations 125
in vulnerable ischemic brain tissue: a pilot study at the
stroke unit bedside (Stroke 2012)
Chapter 10 Continuous monitoring of cerebrovascular reactivity using pulse 131
waveform of intracranial pressure (Neurocrit Care 2012)
Chapter 11 Continuous determination of optimal cerebral perfusion pressure 145
in traumatic brain injury (Crit Care Med 2012)
Chapter 12 Summary and Discussion 161
Chapter 13 Summary in Dutch/ Nederlandse Samenvatting 177
Chapter 14 Acknowledgments/ Dankwoord 187
Chapter 15 Curriculum vitae 193
Chapter 16 Publications/ Publicaties 197
cerebral hemodynamics in stroke and traumatic brain injury 7

chapTer 1
InTroducTIon and ouTlIne