Ultrasound and photoacoustic methods for anatomic and functional imaging in image guided

137 Pages·2014·3.18 MB·English

Purdue University
Purdue e-Pubs
Open Access Dissertations Theses and Dissertations
8-2016
Ultrasound and photoacoustic methods for
anatomic and functional imaging in image guided
radiation therapy
Justin T. Sick
Purdue University
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Recommended Citation
Sick, Justin T., "Ultrasound and photoacoustic methods for anatomic and functional imaging in image guided radiation therapy"
(2016).Open Access Dissertations. 847.
https://docs.lib.purdue.edu/open_access_dissertations/847
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Graduate School Form
30Updated(cid:20)(cid:21)(cid:18)(cid:21)(cid:25)(cid:18)(cid:21)(cid:19)(cid:20)(cid:24)
PURDUE UNIVERSITY
GRADUATE SCHOOL
Thesis/Dissertation Acceptance
This is to certify that the thesis/dissertation prepared
By JustinTSick
Entitled
UTRASOUNDANDPHOTOACOUSTICMETHODSFORANATOMICANDFUNCTIONALIMAGINGINIMAGE
GUIDEDRADIATIONTHERAPY
DoctorofPhilosophy
For the degree of
Is approved by the final examining committee:
KeithStantz
Chair
JeanniePoulson
DeborahKnapp
ColleenDesRosiers
To the best of my knowledge and as understood by the student in the Thesis/Dissertation
Agreement, Publication Delay, and Certification Disclaimer (Graduate School Form 32),
this thesis/dissertation adheres to the provisions of Purdue University’s“Policy of
Integrity in Research” and the use of copyright material.
KeithStantz
Approved by Major Professor(s):
ShuangLiu
Approved by:
Head of the Departmental Graduate Program Date

i

ULTRASOUND AND PHOTOACOUSTIC METHODS FOR ANATOMIC AND
FUNCTIONAL IMAGING IN IMAGE GUIDED RADIATION THERAPY
A Dissertation
Submitted to the Faculty
of
Purdue University
by
Justin T Sick
In Partial Fulfillment of the
Requirements for the Degree
of
Doctor of Philosophy
August 2016
Purdue University
West Lafayette, Indiana
ii

Dedicated to my parents
iii

ACKNOWLEDGEMENTS
First, I would like to thank Dr. Keith Stantz for his unwavering support, guidance
and expertise that made this work possible. Additionally, I would like to thank my
committee members: Dr. Jeannie Poulson, Dr. Deborah Knapp and Dr. Colleen
DesRosiers for all of their contributions.
So much of this work was made possible by the Purdue University Veterinary
Teaching Hospital, specifically, the department of Radiation Oncology and the
department of Radiology. I am honored to have worked with the brilliant faculty and staff
in such a wonderful hospital.
Finally, the completion of this document would not have been possible without
the love and support from my parents, Thomas and Karen Sick, family, friends and loved
ones. I could not have done it without you.
iv

TABLE OF CONTENTS
Page
LIST OF TABLES ............................................................................................................ vii
LIST OF FIGURES ......................................................................................................... viii
ABSTRACT ........................................................................................................................ x
CHAPTER 1. INTRODUCTION ...................................................................................... 1
1.1 Advantages of the Canine Model ............................................................................ 1
1.2 Radiation Therapy ................................................................................................... 2
1.3 Standard IGRT Imaging Techniques ...................................................................... 3
1.4 Managing Imaging Dose ......................................................................................... 4
1.5 In-vivo Molecular Imaging ..................................................................................... 4
1.6 Therapeutic targets .................................................................................................. 5
1.7 Hypothesis............................................................................................................... 6
CHAPTER 2. SPECIFIC AIMS ........................................................................................ 8
2.1 Specific Aim 1 ........................................................................................................ 8
2.2 Specific Aim 2 ........................................................................................................ 8
2.3 Specific Aim 3 ........................................................................................................ 9
2.4 Innovation and Impact ............................................................................................ 9
CHAPTER 3. QUANTIFY THE RESOLUTION OF 3D US IMAGING
SYSTEMS............................................................................................................. 11
3.1 Introduction ........................................................................................................... 11
3.2 Ultrasound Imaging .............................................................................................. 12
3.2.1 Wave Propagation ........................................................................................ 12
3.2.2 Interactions with Matter ............................................................................... 15
3.2.3 Beam Formation ........................................................................................... 18
3.2.4 Resolution .................................................................................................... 18
v

Page
3.2.5 Artifacts ........................................................................................................ 19
3.3 Methods................................................................................................................. 21
3.3.1 Imaging Protocols ........................................................................................ 21
3.3.2 Phantom Analysis ........................................................................................ 23
3.3.3 Artifact Analysis .......................................................................................... 23
3.4 Results ................................................................................................................... 24
3.4.1 Phantom ....................................................................................................... 24
3.4.2 Artifacts ........................................................................................................ 30
3.5 Discussion ............................................................................................................. 35
3.6 Conclusions ........................................................................................................... 36
CHAPTER 4. CONSTRUCTION OF AN ULTRASOUND GUIDANCE PLATFORM
FOR IMAGE-GUIDED RADIOTHERAPY ........................................................ 38
4.1 Introduction ........................................................................................................... 38
4.2 Materials and Methods .......................................................................................... 39
4.2.1 Construction of a 3D-US Platform .............................................................. 39
4.2.2 Developing an Urological Phantom of the Bladder ..................................... 43
4.2.3 Imaging Protocols ........................................................................................ 49
4.2.4 Image Registration ....................................................................................... 49
4.3 Results ................................................................................................................... 54
4.3.1 Construction of a 3D-US Platform .............................................................. 54
4.3.2 Developing an Urological Phantom of the Bladder ..................................... 57
4.3.3 Image Registration ....................................................................................... 60
4.4 Discussion ............................................................................................................. 67
4.5 Conclusions ........................................................................................................... 70
CHAPTER 5. VALIDATING HEMOGLOBIN SATURATION AND DISSOLVED
OXYGEN IN TUMORS USING PHOTOACOUSTIC SPECTROSCOPIC
IMAGING ............................................................................................................. 72
5.1 Introduction ........................................................................................................... 72
5.2 Materials and Methods .......................................................................................... 74
vi

Page
5.2.1 Phantom Model ........................................................................................... 74
5.2.2 Mouse Model .............................................................................................. 77
5.3 Results .................................................................................................................. 77
5.3.1 Phantom Model ........................................................................................... 77
5.3.2 Mouse Model .............................................................................................. 81
5.4 Discussion ............................................................................................................ 84
5.5 Conclusions .......................................................................................................... 85
CHAPTER 6. DISCUSSION ........................................................................................... 86
CHAPTER 7. CONCLUSIONS AND FUTURE DIRECTIONS ................................... 92
REFERENCES ................................................................................................................. 95
APPENDICES ......................................................................................................................
Appendix A Phantom Artifacts ............................................................................. 100
Appendix B Cytokine Data ................................................................................... 109
VITA ............................................................................................................................... 115
vii

LIST OF TABLES
Table Page
3.1 Phantom Target Characteristics .................................................................................. 22
3.2 Volumes and Voxels Sizes .......................................................................................... 22
4.1 Accuracy of Motions Test ........................................................................................... 56
4.2 Phantom Recipe and Verification ............................................................................... 59
4.3 US-to-CT Transformation Matrices ............................................................................ 63
4.4 Repositioning Transformation Matrices ..................................................................... 65
4.5 Positioning and Coordinate Coincidence Error .......................................................... 69
6.1 Preliminary Cytokine Analysis ................................................................................... 91
B.1 Cytokine Data ........................................................................................................... 110