Table Of Content

W TUMOR BOARD REVIEW O R D An Imprint of Springer Publishing E N Evidence-Based Case Reviews and Questions • M IM Third Edition S • C FRANCIS P. WORDEN, MD H E MARTHA P. MIMS, MD, PhD W HELEN K. CHEW, MD Now in its third edition, Tumor Board Review: Evidence-Based Case Reviews and TUMOR Questions is the most comprehensive clinical case review book in the field. With hands-on input from current fellows and oncologists, this new edition has been enhanced and reformatted for greater efficiency and practicality. T The review covers all disease-site areas in oncology and features a wide variety of U BOARD REVIEW board-style questions pivotal in helping fellows and oncologists prepare for both M the American Board of Internal Medicine (ABIM) medical oncology board exam and O maintenance of certification (MOC) assessments. Evidence-based discussions of difficult patient cases offer an in-depth and accurate depiction of what is discussed at R Evidence-Based tumor boards and foster critical thinking essential for clinical practice. Patient cases also B highlight impactful treatment decisions that include newly approved immunotherapies O and targeted therapies. Each chapter contains digestible essentials for each case, including a summary of diagnosis, molecular and genomic testing, treatment options, A Case Reviews and toxicity considerations, follow-up, and survivorship. Each chapter ends with high-yield R multiple-choice questions, corresponding answers, and detailed rationales, ensuring D readers are well-equipped with the knowledge they need to make well-informed, Questions individualized treatment decisions. Tumor Board Review: Evidence-Based Case Reviews R and Questions is an essential case-based reference for anyone working in oncology. E V FRANCIS P. WORDEN Key Features: I E Third Edition n D escribes more than 120 patient cases, including locally advanced and W MARTHA P. MIMS metastatic cases for each major disease site n Contains 300 board-style questions and answers related to case reviews HELEN K. CHEW n I ncludes new advances in diagnosis and therapy, with a greater emphasis on immunotherapies, cancer genomics, and precision-based targeted therapies n P rovides essentials for toxicity considerations, follow-up, and survivorship considerations Third Edition Recommended Shelving: Oncology An Imprint of Springer Publishing 11 W. 42nd Street New York, NY 10036-8002 www.springerpub.com Tumor Board Review Tumor Board Review Evidence-Based Case Reviews and Questions Third Edition Editors Francis P. Worden, MD Professor of Medicine Director of the Hematology/Oncology Fellowship Program University of Michigan Medical School Ann Arbor, Michigan Martha P. Mims, MD, PhD Professor Chief of Hematology-Oncology Baylor College of Medicine Houston, Texas Helen K. Chew, MD Professor of Medicine Director of the Clinical Breast Cancer Program University of California Davis Davis, California Copyright © 2023 Springer Publishing Company, LLC Demos Medical Publishing is an imprint of Springer Publishing Company. All rights reserved. First Springer Publishing edition 2011 (978-1-6170-5046-6); subsequent edition 2015. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior permis- sion of Springer Publishing Company, LLC, or authorization through payment of the appropriate fees to the Copyright Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, 978-750-8400, fax 978-646-8600, [email protected] or on the Web at www.copyright.com. Springer Publishing Company, LLC 11 West 42nd Street, New York, NY 10036 www.springerpub.com connect.springerpub.com/ Acquisitions Editor: David D’Addona Compositor: Exeter Premedia Services Private Limited ISBN: 978-0-8261-4597-0 ebook ISBN: 978-0-8261-4598-7 DOI: 10.1891/9780826145987 22 23 24 25 26 / 5 4 3 2 1 Medicine is an ever-changing science. Research and clinical experience are continually expanding our knowledge, in particular our understanding of proper treatment and drug therapy. The authors, editors, and publisher have made every effort to ensure that all information in this book is in accordance with the state of knowledge at the time of production of the book. Nevertheless, the authors, editors, and publisher are not responsible for any errors or omissions or for any consequence from application of the information in this book and make no warranty, expressed or implied, with respect to the content of this publication. Every reader should examine carefully the package inserts accompanying each drug and should carefully check whether the dosage schedules therein or the contraindications stated by the manufacturer differ from the statements made in this book. Such examination is particularly important with drugs that are either rarely used or have been newly released on the market. Library of Congress Cataloging-in-Publication Data Names: Worden, Francis P., editor. | Mims, Martha Pritchett, editor. | Chew, Helen K., editor. Title: Tumor board review : evidence-based case reviews and questions / editors, Francis P. Worden, Martha Pritchett Mims, Helen K. Chew. Description: Third edition. | New York, NY : Springer Publishing Company, [2023] | Includes bibliographical references and index. Identifiers: LCCN 2022019636 (print) | LCCN 2022019637 (ebook) | ISBN 9780826145970 (paperback) | ISBN 9780826145987 (ebook) Subjects: MESH: Neoplasms | Evidence-Based Medicine | Practice Guideline | Case Reports Classification: LCC RC254 (print) | LCC RC254 (ebook) | NLM QZ 200 | DDC 616.99/4--dc23/eng/20220624 LC record available at https://lccn.loc.gov/2022019636 LC ebook record available at https://lccn.loc.gov/2022019637 Publisher’s Note: New and used products purchased from third-party sellers are not guaranteed for q uality, authenticity, or access to any included digital components. Printed in the United States of America. Contents Contributors xv Preface xxi 1. Head and Neck Cancer 1 Irene Tsung, Samuel B. Reynolds, and Paul L. Swiecicki Introduction 1 Case Summaries 1 Case 1.1: Locally Advanced Cancer of the Oropharynx 1 Case 1.2: Locally Advanced Nasopharyngeal Cancer 4 Case 1.3: Metastatic Adenoid Cystic Carcinoma 7 Case 1.4: Metastatic Squamous Cell Carcinoma 9 Review Questions 12 Answers and Rationales 15 References 16 2. Thyroid Cancer 19 Kamya Sankar and Francis P. Worden Introduction 19 Case Summaries 21 Case 2.1: Locally Advanced Anaplastic Thyroid Cancer 21 Case 2.2: Metastatic Medullary Thyroid Cancer 22 Case 2.3: Metastatic Radioactive Iodine Refractory Differentiated Thyroid Cancer 24 Review Questions 29 Answers and Rationales 31 References 32 3. Non-Small Cell Lung Cancer 35 Natalie Chen, Cyrus A. Iqbal, Omayra Gonzalez-Pagan, Meera Patel, Daniel Wang, and Quillan Huang Introduction 35 Case Summaries 36 Case 3.1: Early-Stage Resectable Lung Cancer 36 Case 3.2: Locally Advanced Unresectable Lung Cancer 38 Case 3.3: Metastatic Lung Can cer Without Driver Mutations 40 Case 3.4: Metastatic Lung Adenocarcinoma With a Targetable Driver Mutation 43 Case 3.5: Metastatic Non-Small Cell Lung Cancer in the Second Line 45 Review Questions 47 Answers and Rationales 49 References 50 v vi Contents 4. Small Cell Lung Cancer 53 Ebaa Al-Obeidi and Karen Kelly Introduction 53 Case Summaries 53 Case 4.1: Newly Diagnosed Extensive-Stage Small Cell Lung Cancer 53 Case 4.2: Relapsed Small Cell Lung Cancer 56 Case 4.3: Limited-Stage Small Cell Lung Cancer and the Role of Prophylactic Cranial Irradiation Versus MRI Brain Surveillance 57 Review Questions 61 Answers and Rationales 64 References 65 5. Hormone Receptor-Positive Breast Cancer 67 Katherine Sanchez, Jennifer Collins, Sudha Yarlagadda, Jingxin Sun, Sarah Premji, Maryam Nemati Shafaee, and Julie Nangia Introduction 67 Case Summaries 67 Case 5.1 : Early-Stage Breast Cancer 67 Case 5.2 : Early-Stage Hormone-Positive Breast Cancer 71 Case 5.3 : Locally Advanced Breast Cancer 73 Case 5.4 : Stage IV Breast Cancer 75 Case 5.5 : Recurrent Stage IV Breast Cancer 78 Review Questions 81 Answers and Rationales 83 References 84 6. Triple-Negative Breast Cancer 87 Richard Benjamin Young and Helen K. Chew Introduction 87 Case Summaries 87 Case 6.1: Localized Triple-Negative Breast Cancer 87 Case 6.2: Locally Advanced Triple-Negative Breast Cancer 89 Case 6.3: Metastatic Triple-Negative Breast Cancer 92 Review Questions 96 Answers and Rationales 98 References 98 7. Esophageal Cancer 101 Kamya Sankar, Charles B. Nguyen, and Bryan J. Schneider Introduction 101 Case Summaries 103 Case 7.1: Locally Advanced, Resectable Esophageal Adenocarcinoma 103 Case 7.2: Locally Advanced Esophageal Squamous Cell Carcinoma 106 Case 7.3: Locally Advanced Cervical Esophageal Squamous Cell Carcinoma 106 Case 7.4: Metastatic Esophageal Adenocarcinoma 107 Case 7.5: Human Epidermal Growth Factor Receptor 2-Positive Metastatic Esophageal Cancer 110 Review Questions 112 Answers and Rationales 115 References 116 Contents vii 8. Gastric Cancer 119 Karen Riggins and Huili Zhu Introduction 119 Case Summaries 119 Case 8.1: Resectable Gastric Cancer 119 Case 8.2: Unresectable Locally Advanced Gastric Cancer 123 Case 8.3: Metastatic Gastric Adenocarcinoma 125 Review Questions 131 Answers and Rationales 134 References 135 9. Pancreatic Cancer 139 Huili Zhu, Zachary Phillip Yeung, Benjamin Musher, and Shalini Makawita Introduction 139 Case Summaries 139 Case 9.1: Resectable Pancreatic Cancer 139 Case 9.2: Borderline Resectable Pancreatic Cancer 143 Case 9.3: Locally Advanced Pancreatic Cancer 145 Case 9.4: Metastatic Pancreatic Cancer 146 Review Questions 149 Answers and Rationales 151 References 152 10. Neuroendocrine Cancer 155 Tannaz Armaghany and Zachary Phillip Yeung Introduction 155 Case Summaries 156 Case 10.1: Gastric Neuroendocrine Neoplasm 156 Case 10.2: Pancreatic Neuroendocrine Neoplasm 159 Case 10.3: Midgut Neuroendocrine Tumor and Carcinoid Syndrome 165 Case 10.4: Poorly Differentiated Neuroendocrine Carcinoma 170 Review Questions 173 Answers and Rationales 176 References 177 11. Hepatobiliary Cancer 181 Brian Pham and Edward J. Kim Introduction 181 Case Summaries 181 Case 11.1: Metastatic Hepatocellular Carcinoma 181 Case 11.2: Locally Advanced Cholangiocarcinoma 184 Case 11.3: Metastatic Cholangiocarcinoma 186 Review Questions 188 Answers and Rationales 190 References 190 12. Colorectal Cancer 193 Brian Pham and Edward J. Kim Introduction 193 Case Summaries 194 viii Contents Case 12.1: Locally Advanced Colon Adenocarcinoma 194 Case 12.2: Locally Advanced Rectal Cancer 196 Case 12.3: Unresectable Metastatic Colon Adenocarcinoma 197 Review Questions 200 Answers and Rationales 203 References 204 13. Anal Cancer 207 Arathi Mohan and John C. Krauss Introduction 207 Case Summaries 208 Case 13.1: Locally Advanced Anal Cancer 208 Case 13.2: Very Early-Stage Anal Cancer Requiring Surgery Alone 210 Case 13.3: Metastatic Anal Cancer 211 Review Questions 212 Answers and Rationales 214 References 214 14. Prostate Cancer 217 Monica Tamil, Nagaishwarya Moka, Aihua Edward Yen, and Arpit Rao Introduction 217 Case Summaries 217 Case 14.1: Localized Prostate Cancer 217 Case 14.2: Biochemically Recurrent Prostate Cancer 220 Case 14.3: Metastatic Hormone-Sensitive Prostate Cancer 222 Review Questions 225 Answers and Rationales 228 References 229 15. Testicular Cancer 231 Thomas C. Westbrook, Eric B. Schwartz, and Zachery R. Reichert Introduction 231 Case Summaries 231 Case 15.1: Localized Testicular Cancer—Seminoma 231 Case 15.2: Advanced Testicular Cancer—Seminoma 233 Case 15.3: Locally Advanced Nonseminoma Testicular Cancer 236 Case 15.4: Metastatic Nonseminoma Testicular Cancer 237 Review Questions 240 Answers and Rationales 243 References 244 16. Renal Cancer 245 Eric Granowicz and Mamta Parikh Introduction 245 Case Summaries 245 Case 16.1: Early-Stage Renal Cell Carcinoma 245 Case 16.2: Metastatic Renal Cell Carcinoma 248 Case 16.3: Oligometastatic Disease 251 Review Questions 253 Contents ix Answers and Rationales 256 References 257 17. Bladder Cancer 259 Eric Granowicz and Mamta Parikh Introduction 259 Case Summaries 259 Case 17.1: Muscle-Invasive Bladder Cancer in a Surgical Candidate 259 Case 17.2: Muscle-Invasive Bladder Cancer in a Nonsurgical Candidate 262 Case 17.3: Metastatic Bladder Cancer 263 Case 17.4: Platinum-Refractory Metastatic Bladder Cancer 265 Review Questions 267 Answers and Rationales 270 References 271 18. Cervical Cancer 273 Alli M. Straubhar and Jean H. Siedel Introduction 273 Case Summaries 274 Case 18.1: Early Cervical Cancer 274 Case 18.2: Locally Advanced Cervical Cancer 277 Case 18.3: Distant Metastatic and Recurrent Cervical Cancer 278 Review Questions 281 Answers and Rationales 284 References 285 19. Uterine Cancer 289 Claire Hoppenot Introduction 289 Case Summaries 289 Case 19.1: Type 1 Endometrial Cancer 289 Case 19.2: Advanced Type 2 Endometrial Cancer 292 Case 19.3: Leiomyosarcoma 294 Review Questions 298 Answers and Rationales 300 References 300 20. Ovarian Cancer 303 Katelyn Tondo-Steele and Jean H. Siedel Introduction 303 Case Summaries 304 Case 20.1: Early Ovarian Cancer 304 Case 20.2: Borderline Ovarian Tumor 306 Case 20.3: P rimary Treatment: Neoadjuvant Treatment Versus Primary Cytoreductive Surgery 308 Case 20.4: Recurrent Ovarian Cancer 310 Case 20.5: Malignant Germ Cell Tumor 311 Review Questions 313 Answers and Rationales 316 References 318