Trends in Pharmacological Sciences 1991: Vol 12 Index

8 Pages·1991·2.4 MB·English

Author Index
compiled by Carol Smith
Abbott, Alison, 5-HT advances on four Simultaneous Ca** imaging and of human liver cytosolic
‘fronts 359 electrophysiological analysis sulfotransferases 255
Abbott, Alison, see Collingridge, Graham demonstrate source of Ca** for EAA Fasolato, Cristina, see Meldolesi, Jacopo
Abbott, Alison, see Catt, Kevin receptors 169 Feniuk, Wasyl, see Humphrey, Patrick P.A.
Abbott, Alison, NMDA receptor subunit Colman, Robert W., see DeLa Cadena, Ford-Hutchinson, Anthony W., FLAP: a
cloned 334 Raul A. novel drug target for inhibiting the
Allsop, David, see Hardy, John Colquhoun, David, Neher and Sakmann synthesis of leukotrienes 68
Anwyl, Roger, The role of the metabotropic win Nobel Prize for Patch-clamp work Frederiksen, Marilynn C., see Atkinson,
receptor in synaptic plasticity 324 449 Arthur J.
Atkinson, Jr., Arthur J., Ruo, Tsuen Ih and Connolly, John, see Deneris, Evan
Frederiksen, Marilynn C., Physiological Cook, Nigel S., see Rudin, Markus Garbers, David L., see Schulz, Stephanie
basis of multicompartmental models of Coote, John H., Pharmacological control of Garland, Lawrence G., see Thompson,
drug distribution 96 altitude sickness 450 Neil T.
Azevedo, |., see Osswald, W. Coy, David H., see Jensen, Robert T. Gatter, Kevin C., see McCarthy, Sean A.
Crawley, Jacqueline N., Cholecystokinin- Gilon, Chaim, see Levitzki, Alexander
Bagetta, G., Nisticd, G. and Bowery, N.G., dopamine interactions 232 Gonzales, Rueben and Hoffman,
Characteristics of tetanus toxin and its Curran, Tom, see Morgan, James I. Paula L. Receptor-gated ion channels
exploitation in neurodegenerative may be selective CNS targets for ethanol
studies 285 Dainty, lan A., see O'Connor, Steve E. 1
Bahouth, Suleiman W., Wang, Hsien-yu and Dattatreyamurty, Bosukonda, see Grasso, Patricia, see Reichert, Jr., Leo E.
Malbon, Craig C., Immunological Reichert, Jr., Leo E. Green, Allan, see Milligan, Graeme
approaches for probing receptor de Bie, J.E.G.M., see van Rossum, J.M. Gresele, Paolo, Deckmyn, Hans, Nenci,
structure and function 338 De Camilli, Pietro, Co-secretion of multiple Giuseppe G. and Vermylen, Jos,
Bansbach, Catherine C., see Chang, signal molecules from endocrine cells Thromboxane synthase inhibitors,
Joseph Y. via distinct exocytotic pathways 446 thromboxane receptor antagonists and
Beranek, Paul, see Bunce, Keith Deckmyn, Hans, see Gresele, Paolo dual blockers in thrombotic
Bicknell, Roy, see McCarthy, Sean A. DeLa Cadena, Raul A. and Colman, disorders 158
Birdsall, Nigel J.M., Cloning and structure- Robert W., Structure and functions of Griffiths, Roger and Dunlop, John, Cysteine
function of the H, histamine receptor 9 human kininogens 272 sulphinic acid as a candidate
Birdsall, Nigel J.M., Wheel on the sweet Deneris, Evan S., Connolly, John, Rogers, endogenous EAA ligand 94
smell of success 283 Scott W. and Duvoisin, Robert, Grootenhuis, Peter D.J., see van Boeckel,
Blundell, John, Pharmacological approaches Pharmacological and functional Constant A.A.
to appetite suppression 147 diversity of neuronal nicotinic Grouzmann, Eric, see Walker, Philippe
Bonser, Robert W., see Thompson, Neil T. acetylcholine receptors 34 Guengerich, F. Peter, Molecular advances for
Bowery, N.G., see Bagetta, G. Dingledine, Raymond, New wave of non- the cytochrome P-450 superfamily 281
Bredt, David S., see Snyder, Solomon H. NMDA excitatory amino acid receptors
Brien, James F., see Marks, Gerald S. 360 Haasnoot, Cornelis A.G., see van Boeckel,
Browning, Michael D., see Leidenheimer, Dixon, Richard A.F., see Tota, Michael R. Constant A.A.
Nancy J. Dunlop, John, see Griffiths, Roger Hadden, John W., Immunotherapy of
Bunce, Keith, Tyers, Michael and Beranek, Duvoisin, Robert, see Deneris, Evan human immunodeficiency virus
Paul, A clinical evaluation of 5-HT, infection 107
receptor antagonists as anti-emetics 46 Ellinor, Patrick T., see Tsien, Richard W. Hardy, John and Allsop, David, Amyloid
Burnier, Michel, see Walker, Philippe Endrenyi, Laszlo and Patel, Mayank, deposition as the central event in the
Evaluation of two assumptions: single aetiology of Alzheimer’s disease 383
Candelore, Marialuisa Rios, see Tota, straight line, and single normal Harris, R. Adron, see Leidenheimer,
Michael R. distribution 293 Nancy J.
Catt, Kevin and Abbott, Alison, Molecular Erd6, Sandor L., Excitatory amino acid Harrison, Jeffrey K., Pearson, William R.
cloning of angiotensin II receptors may receptors in the mammalian periphery and Lynch, Kevin R., Molecular
presage further receptor subtypes 279 426 characterization of «,- and
Challis, R.A. John, see Nicholson, David Erneux, Christophe and Takazawa, a,-adrenoceptors 62
Challiss, R.A. John, see Nahorski, Stefan R. Kazunaga, Intracellular control of Harvey, Alan, New influences of
Chang, Joseph Y., Sehgal, Suren N. and inositol phosphates by their biotechnology in drug discovery: is the
Bansbach, Catherine C., FK506 and metabolizing enzymes 174 rat an endangered species? 317
rapamycin: novel pharmacological Esterle, Teresa M. and Sanders-Bush, Elaine, Henley, Jeremy M. and Johnston, Graham
probes of the immune response 218 From neurotransmitter to gene: A.R., Vintage amino acids meeting
Chiu, Andrew T., see Timmermans, identifying the missing links 375 describes new tools for amino acid
Pieter B.M.W.M. Evans, Richard H., see Kilpatrick, lan C. research, subtypes of metabotropic
Clementi, Emilio, see Meldolesi, Jacopo receptors 357
Collingridge, Graham and Abbott, Alison, Falany, Charles N., Molecular enzymology Herblin, William F., see Timmermans,
477
Pieter B.M.W.M. Malbon, Craig C., see Bahouth, Suleiman W. O'Connor, Steve E., Dainty, lan A. and Leff,
Hickman, Dean, see Sim, Edith Man in’t Veld, Arie, see Saxena, Pramod R. Paul, Further subclassification of ATP
Hoffmann, Paula L., see Gonzales, Marks, Gerald S., Brien, James F., Nakatsu, receptors based on agonist studies 137
Rueben A. Kanji and McLaughlin, Brian E., Does O'Neill, Chris, A physiological role for PAF
Hoénack, Dagmar, see Léscher, Wolfgang carbon monoxide have a physiological in the stimulation of mammalian
Horne, William A., see Tsien, Richard W. function? 185 embryonic development 82
Hucho, Ferdinand, Jarv, Jaak and Weise, Matfield, Mark J., Animal liberation or Osswald, W. and Azevedo, I., Role of
Christoph, Substrate-binding sites in animal research? 411 adenosine in the trophic effects of
acetylcholinesterase 422 Matthews, Gary, lon channels that are sympathetic innervation 442
Humphrey, Patrick P.A. and Feniuk, Wasyl, directly activated by cyclic nucleotides
Mode of action of the anti-migraine drug 245 Palmer, Richard M.J., see Radomski,
sumatriptan 444 Max, B., This and That: scientific convictions Marek W.
and reflections on a cat's eye 248 Palmer, Richard M.]., see Moncada, Salvador
Insel, Thomas R. see Winslow, James T. Max, B., This and That: error, observation Parsons, Andrew A., 5-HT receptors in
Izquierdo, Ivan, Role of NMDA receptors in and education in pharmacology 176 human and animal cerebrovasculature
memory 128 Max, B., This and That: the 310
Izquierdo, Ivan and Medina, ethnopharmacology of simple Patel, Mayank, see Endrenyi, Laszlo
Jorge H. GABA, receptor modulation of phenethylamines, and the question of Paukovits, Walter R., see Moser,
memory: the role of endogenous cocaine and the human heart 329 Marie-Héleéne
benzodiazepines 260 Max, B., This and That: the neurotoxicity of Pearson, William R., see Harrison, Jeffrey K.
carbon dioxide 408 Petteway, Jr., Stephen R., Lambert,
Jenkinson, Donald H., How we describe McCarthy, Sean A., Kuzu, Isinsu, Gatter, Dennis M. and Metcalf, Brian W., The
competitive antagonists: three questions Kevin C. and Bicknell, Roy, chronically infected cell as a target for
of usage 53 Heterogeneity of the endothelial cell and the treatment of HIV infection and AIDS
Jensen, Robert T. and Coy, David H., its role in organ preference of tumour 28
Progress in the development of potent metastasis 462 Poetzsch, J., see Lutz, W.K.
bombesin receptor antagonists 13 McEwen, Bruce S., Non-genomic and Powis, Garth, Signalling targets for
Johnston, Graham A.R., see Henley, genomic effects of steroids on neural anticancer drug development 188
Jeremy M. activity 141 Pozzan, Tullio, see Meldolesi, Jacopo
McLaughlin, Brian E., see Marks, Gerald S.
Kalow, Werner, Interethnic variation of McMahon, Stephen B., see Koltzenburg, Radomski, Marek W., Palmer, Richard MJ.
drug metabolism 102 Martin and Moncada, Salvador, Modulation of
Karlsson, Karl-Anders, Glycobiology, a Medina, Jorge H., see Izquierdo, Ivan platelet aggregation by an L-arginine-
growing field for drug design 265 Meldolesi, Jacopo, Clementi, Emilio, nitric oxide pathway 87
Keen, Mary and Krane, Anke, Regulation of Fasolato, Cristina, Zacchetti, Daniele and Ragan, C. lan, see Nahorski, Stefan R.
G protein levels (Letter) 292 Pozzan, Tullio, Ca** influx following Reichert, Jr., Leo E., Dattatreyamurty,
Keen, Mary, Testing models of agonism for receptor activation 289 Bosukonda, Grasso, Patricia and
G protein-coupled receptors 371 Meldolesi, Jacopo and Magni, Michele, Santa-Coloma, Tomas A., Structure-
Kilpatrick, lan C., Waller, Sarah J. and Lipid metabolites and growth factor function relationships of the
Evans, Richard H., Uniform distribution action 362 glycoprotein hormones and their
of CSA undermines neurotransmitter Metcalf, Brian W., see Petteway Jr., receptors 199
role (Letter) 95 Stephen R. Rettig, Rainer and Unger, Thomas, The role
Koltzenburg, Martin and McMahon, Michel, Martin C., Receptors for of the kidney in the aetiology of
Stephen B., The enigmatic role of the neuropeptide Y: multiple subtypes and hypertension: renal transplantation
sympathetic nervous system in chronic multiple second messengers 389 studies in rats 243
pain 399 Miller, Richard J., Metabotropic excitatory Robinson, C. Jane, Multiple receptors found
Krane, Anke, see Keen, Mary amino acid receptors reveal their true for the growing FGF family 123
Kromer, Wolfgang, Receptor classification colors 365 Rogers, Scott W., see Deneris, Evan
using antagonists without determining Milligan, Graeme and Green, Allan, Agonist Rothwell, Nancy J., Functions and
pA, values 11 control of G-protein levels 207 mechanisms of interleukin 1 in the brain
Kuzu, Isinsu, see McCarthy, Sean A. Moncada, Salvador and Palmer, Richard 430
M.J., Inhibition of the induction of nitric Rudin, Markus, Zierhut, Wolfgang, Sauter,
Lambert, Dennis M., see Petteway, Jr., oxide synthase by glucocorticoids: yet André and Cook, Nigel S., New
Stephen R. another explanation for their anti- developments in cardiovascular
Leff, Paul, see O’Connor, Steve E. inflammatory effects 130 magnetic resonance imaging and
Leidenheimer, Nancy J., Browning, Moncada, Salvador, see Radomski, spectroscopy 416
Michael D. and Harris, R. Adron, Marek W. Ruo, Tsuen Ih, see Atkinson, Arthur J.
GABA, receptor phosphorylation: Morgan, James I. and Curren, Tom, Proto-
multiple sites, actions and artifacts 84 oncogene transcription factors and Sanders-Bush, Elaine, see Esterle, Teresa M.
Levitzki, Alexander and Gilon, Chaim, epilepsy 343 Santa-Coloma, Tomas A., see Reichert, Jr.,
Tyrphostins as molecular tools and Moser, Marie-Hélene and Paukovits, Leo E.
potential antiproliferative drugs 171 Walter R., Haemoprotection against Sarter, Martin, Taking stock of cognition
Linden, Joel, Tucker, Amy L. and Lynch, cytostatic drugs by stem cell inhibition enhancers 456
Kevin R., Molecular cloning of 304 Sauter, André, see Rudin, Markus
adenosine A, and A, receptors 326 Saxena, Pramod R. and Villalon, Carlos M.,
Léscher, Wolfgang and Hénack, Dagmar, Nahorski, Stefan R., Ragan, C. lan and 5-Hydroxytryptamine: a chameleon in
Responses to NMDA receptor Challiss, R.A. John, Lithium and the the heart 223
antagonists altered by epileptogenesis phosphoinositide cycle: an example of Saxena, Pramod R. and Man in’t Veld, Arie,
(Letter) 52 uncompetitive inhibition and its ACE inhibitors can reverse blood vessel
Liiddens, Hartmut and Wisden, William, pharmacological consequences 297 damage 239
Function and pharmacology of multiple Nakatsu, Kanji, see Marks, Gerald S. Scaf, Arnold H.J., Role of partial agonism in
GABA, receptor subunits Nelson, Nathan, Structure and selectivity of benzodiazepines 182
Lutz, W.K., Poetzsch, J., Schlatter, J. and pharmacology of the proton-ATPases 71 Schlatter, J., see Lutz, W.K.
Schlatter, C., The real role of risk Nenci, Giuseppe G., see Gresele, Paolo Schlatter, C., see Lutz, W.K.
assessment in cancer risk management Nicholson, C. David, Challis, R.A. John and Schoner, Wilhelm, Endogenous digitalis-like
214 Shahid, Mohammed, Differential factors 209
Lynch, Kevin R., see Harrison, Jeffrey K. modulation of tissue function and Schulz, Stephanie, Yuen, Peter S.T. and
Lynch, Kevin R., see Linden, Joel therapeutic potential of selective Garbers, David L., The expanding family
inhibitors of cyclic nucleotide of guanylyl cyclases 116
Mackay, Dennis, Receptor classification phosphodiesterase isoenzymes 19 Sehgal, Suren N., see Chang, Joseph Y.
using antagonists (Letter) 181 Nisticd, G., see Bagetta, G. Seydel, Joachim K., Nuclear magnetic
Magni, Michele, see Meldolesi, Jacopo resonance and differential scanning
478
calorimetry as tools for studying Christophe von Kiigelgen, Ivar, and Starke, Klaus,
drug-membrane interactions 368 Thompson, Neil T., Bonser, Robert W. and Noradrenaline-ATP co-transmission in
Shahid, Mohammed, see Nicholson, Garland, Lawrence G., Receptor-coupled the sympathetic nervous system 319
C. David phospholipase D and its inhibition 404
Shoaib, Mohammed, see Stolerman, lan P. Timmermans, Pieter B.M.W.M., Wong, Waeber, Bernard, see Walker, Philippe
Sibley, David R., Cloning of a “D,’ receptor Pancras C., Chiu, Andrew T. and Walker, Philippe, Grouzmann, Eric, Burnier,
subtype expands dopamine receptor Herblin, William F., Nonpeptide Michel and Waeber, Bernard, The role of
family 7 angiotensin Il receptor antagonists 55 neuropeptide Y in cardiovascular
Sim, Edith and Hickman, Dean, Tota, Michael R., Candelore, Marialuisa regulation 111
Polymorphism in human Rios, Dixon, Richard A.F. and Strader, Waller, Sarah J., see Kilpatrick, lan C.
N-acetyltransferase - the case of the Catherine D., Biophysical and genetic Wang, Hsien-yu, see Bahouth, Suleiman W.
missing allele 211 analysis of the ligand-binding site of the Webb, David J., Endothelin receptors
Sliskovic, Drago and White, Andrew D., §-adrenoceptor + cloned, endothelin converting enzyme
Therapeutic potential of ACAT Trendelenburg, Ullrich, The TiPS Lecture: characterized and pathophysiological
inhibitors as lipid lowering and anti- Functional aspects of the neuronal roles for endothelin proposed 43
atherosclerotic agents 194 uptake of noradrenaline 334 Weise, Christoph, see Jarv, Jaak
Smith, Peter A., Non-nicotinic mechanisms Tsien, Richard W., Ellinor, Patrick T. and White, Andrew D., see Sliskovic, Drago R.
in ganglionic transmission 397 Horne, William A., Molecular diversity Willner, Paul, Animal models as
Snyder, Solomon H. and Bredt, David S., of voltage-dependent Ca?* channels 349 simulations of depression 131
Nitric oxide as a neuronal Tucker, Amy L., see Linden, Joel Winslow, James T. and Insel, Thomas R.,
messenger 125 Tyers, Michael, see Bunce, Keith The infant rat separation paradigm: a
Starke, Klaus, Selectivity of ethanol on novel test for novel anxiolytics 402
ligand-gated ion channels 182 Unger, Thomas, see Rettig, Rainer Wisden, William, see Liiddens, Hartmut
Starke, Klaus, see von Kiigelgen, Ivar Wong, Pancras C., see Timmermans,
Stolerman, Ian P. and Shoaib, Mohammed, Vallance, Patrick, Seeking a role for the Pieter B.M.W.M.
The neurobiology of tobacco addiction clinical pharmacologist 79 Wormser, Uri, Toxicology of mustard gas
467 van Boeckel, Constant A.A., Grootenhuis, 164
Strader, Catherine, see Tota, Michael R. Peter D.J. and Haasnoot, Cornelis A.G.,
Strange, Philip G., D,;/D, dopamine Specificity in the recognition process Yuen, Peter S.T., see Schulz, Stephanie
receptor interaction at the biochemical between charged carbohydrates and
level 48 proteins 241 Zacchetti, Daniele, see Meldolesi, Jacopo
Sutherland, Robert, B-Lactamase inhibitors van Rossum, J.M. and de Bie, J.E.G.M., Zernig, Gerald, Clinical future for
and reversal of antibiotic resistance 227 Chaos and illusion 379 Ca?* antagonists looks more promising,
Vermylen, Jos, see Gresele, Paolo 439
Takazawa, Kazunaga, see Erneux, Villalon, Carlos M., see Saxena, Pramod R. Zierhut, Wolfgang, see Rudin, Markus
479

Subject Index
compiled by Alison Abbott
(P) Principles
(L) Letters
A65186 233 antibiotics 227 carozolol 4
ACAT (acetyl-CoA:cholesterol anticancer drugs 188 catechol O-methyltransferase 336
acetyltransferase) 194 antidepressants 27 cathine 152, 332
ACAT inhibitors 194 antithrombin III 241 (-)cathinone 152, 332
ACE 55, 239 al1-antitrypsin 242 CBM36773 457
ACE inhibitors 239 anxiety 233, 264, 402 CCK 151, 232, 256
aceclidine 457 AP3 365 CCK receptors 233
N-acetaminophen 256 AP4 365 cephalosporins 227
acetazolamide 452 AP5 129, 365 ceronapril 460
acetylcarnitine 457 AP7 129 ceruletide 151
acetylcholine 397, 457 apomorphine 150 CGRP 444
acetylcholine release 143 appetite 147 chaos 379
acetylcholinesterase 422 arecoline 457 chemical warfare 88
N-acetyltransferase 104, 211 aspirin (acetylsacicylic acid) 102, 159 cholesterol 194
trans-ACPD 324, 358, 365 asthma 26 choline 457
1s,3R-ACPD, see trans-ACPD ATP 137, 320, 443 C1976 196
AcSDKP 309 H*/Kt-ATPase 73 C1977 359
adenosine receptors 170, 208, 326, 442 ATP receptors, see P, purinoceptors C1979 457
adrenaline 256 atrial natriuretic peptide 117 C1988 233
ADEPT 464 atropine 150 cilazapril 239
ADPyS 137 AY26514 457 cilostamide 20
a-adrenoceptors 62, 328, 399 cis-trans peptidylprolyl isomerase 218
B-adrenoceptor kinase 86 Bacteriorhodopsin receptor 4 clavulanic acid 228
B-adrenoceptors 65, 338 benzene 214 clinical pharmacology 79
B-adrenoceptors, ligand binding site 4 benzidine 211 clonazepam 49
B,-adrenoceptors 317 benzodiazepine inverse agonists 152 clonidine 460
AFDX116 457 benzodiazepine site (GABA, receptor) 49 cocaine 151, 329, 336
agonism 371 (P) benzodiazepines (see also individual drugs) cognition enhancers 456
AIDS, see HIV infection 182 (P), 260 competitive antagonists 53 (P)
alcohol 154 bethanechol 457 congestive heart failure 26, 55
alcohol dehydrogenase 103 bifemeran 457 cyanopindolol 310
almitrine 452 biotechnology 317 cyclandelate 198
alphaxalone 143 BMAA 409 cyclic nucleotide-activated ion channels 245
altitude sickness 450 BMY25801 47 cyclic nucleotide phosphodiesterase (PDE)
Alzheimer’s disease 27, 383, 458 BOAA 409 isoenzymes 1
amiloride 192 bombesin 151 cyclophilin 221
bombesin receptor antagonists 13 cycloserine 460
p-amino benzoic acid 212
aminoacridines 190 BOP086 457 cyclosporin A 218
2-aminofluorene 211 bradykinin 401, 444 cytisine 36
4-aminopyridine 457 BRL42715 231
amiridin 457 a-bungarotoxin 34 Daltroban 161
amodiaquine 457 butyrylcholinesterase 424 DAU6285 360
AMPA receptors 169, 324, 357, 360 debrisoquine hydroxylase 104
amphetamine 150, 330, 377 Ca?* antagonists (see also individual drugs) decamethonium 425
amphetamine withdrawal 132 420, 439 dehydroepiandrosterone 256
ampligen 108 Ca?* channels, effect of ethanol 2 demethoxyviridin 407
B-amyloid 383 Ca?* channels, molecular biology 349, 439 denbufylline 20
ANAPP, 319 Ca?* imaging 169 depression 131
androsterone 256 Ca?*, intracellular levels 290 dequalinium 190
angina pectoris 226 calcitonin 151 desensitization 2
angiotensin converting enzyme, see ACE cancer 214, 462 desoxycorticosterone 142
angiotensin II 55, 443 captopril 55, 460 devazepide 233
angiotensin II receptor antagonists, B-carbolines 49, 261, 459 dexamethasone 452
nonpeptide 55, 279 carbon dioxide 408 diazepam 49, 106
angiotensin II receptors 239, 279 carbon monoxide 185 diethyldithiocarbamate 109
Animal Liberation Front 413 carbonic anhydrase 452 digitalis-like factors, endogenous 209
animal models 131, 243, 402 cardiovascular disorders, and endothelin 45 digoxin 210
animals in research 411 cardiovascular pharmacology 223, 239, 310, dihydropyridines 353
anorexia 147 418 11,13-dihydroxy-14-octadecaenoic acid 210
481
dihydroxycinnamate 192 GM-CSF 220, 309 lavendustin A 192
diltiazem 440 granisetron 46 learned helplessness 132
1,1-dimethyl-4-pheny|piperazinium 36 growth factors 28, 123, 188, 239, 241, 269, learning 127, 260
dipyridamole 20 308, 375 leukotrienes 68
distress calling 132 guanylyl cyclases, molecular biology 117 levodopa 155, 256
dizocilpine 128 LH 199
DMCM 49 Haemoprotection 304 LHRH release 143
DNA fingerprinting 251 haloperidol 152 5-lipoxy genase 68
DOI 152 hCG 199 lisuride 150
dopamine 256 heart failure 226 lithium 297
dopamine D, receptors 48, 375, 472 heme oxygenase 187 long-term depression 169, 324
dopamine D, receptors 48, 136, 375 heparin 241, 268 long-term potentiation 128, 169, 324
dopamine D, receptors 7 heptylphysostigmine 457 lophotoxin 37
dopamine receptor interaction 48 herbimycin A 192 lorglumide 233
dopamine receptors 7, 65, 328, 472 hexamethonium 37 lovastatin 198
dopamine receptors, nomenclature 8 histamine H, receptor, cloning 9 LTD, receptor antagonists 68
dopamine release 143 histamine receptors 9, 328, 391 LY171555 48
Down syndrome 387 histidine 152 LY262684 233
doxorubicin 190 HIV infection 28, 107 LY274614 359
drug resistance 227 HIV-1 protease inhibitors 30
drug screening 317 HMG CoA reductase 194 m-CPP 151
DuP753 57, 279 Hoe065 460 macrophage inflammatory proteinla 308
DuP996 457 Hoel175 460 malaria 441
HP029 457 manic depression 297
E2020 457
5-HT 223 mas 280
edrophonium 425, 457 5-HT receptors 65, 223, 310, 317 mazindol 150
EGF receptors 362 5-HT, receptor antagonists, as anti-emetics MC12016 460
ELAM-1 266 (see also individual drugs) 46 MDL72222 47, 223, 310
EMD54622 20 5-HT; receptors, effect of ethanol 3 a,B-MeATP 319
emesis 46 Huntington's disease 235 a,BmeATP 138
enalapril 55 huperazine A 457 meglumine 460
endothelin receptors 43 (-)-hydroxycitrate 150 melanin 251
endothelins 43 N-hydroxy-2-acetylaminofluorene 259 melinamide 196
endothelium-derived relaxing factor (EDRF) 12(R)-hydroxy-5,8,10,14-eicosatetraenoic membrane-drug interactions 368
(see also nitric oxide) 185 acid 210 memory, see learning
enkephalin 256 7-hydroxymethy1,12- 7-MEOTA 457
enoximone 20 methylbenz(a)anthracene 259 mephenytoin hydroxylase 104
enterogastrone 151 5-hydroxytryptamine, see 5-HT mercury 91
epilepsy 52 (L), 343 hypertension 27, 55, 239, 243 2-MeSATP 137
erbstatin 190 hypocholesterolaemic drugs 194 mesulergine 310
estrogens, see oestrogens metabotropic receptors 324, 365
estrone, see oestrone 1C1118233 20 metastasis 462
etazolate 20 1CS205930 46, 223, 310, 360, 460 metergoline 134
ethanol 1, 182 (L) imazodan 20 methanesulfonylfluoride 457
excitatory amino acid receptors, peripheral immunophilins 221 5-methoxytryptamine 223
426 immunotherapy 107 metitepine 310
exocytosis 446 ImReg-1 109 metoclopramide 47
indeloxazine 460 metrifonate 457
Factor VIII, see von Willibrand factor indolidan 20 migraine 313, 444
D-fenfluramine 151, 152 infant rat separation paradigm 402 milacemide 460
FGF receptors 123, 363 inflammatory bowel disease 68 milrinone 20
fibroblast growth factors (FGFs) 123 inositol phosphates 174, 189, 289, 297, 362 minoxidil 258
FK506 218 insulin 154 MK0886 68
FKS508 457 interferon-a 108 monoamine oxidase 336
FLAP (5-lipoxygenase-activating protein) 68 y-interferon 220 morphine 155
flumazenil 261 interleukin-1 266, 430 MRI 416
flunitrazepam 49 interleukin-2 108, 220, 269 multicompartment models of drug
fluoxetine 152 interleukins 220 distribution 96 (P)
fos 344, 375 IP,-3-kinase 174, 191 muscarinic acetylcholine receptors
FSH 199 IP,-5-phosphatase 174 11, 65, 373 (P)
isoarecoline 457 muscimol 151
G proteins 207, 292 (L) isoniazid 102 mustard gas 164
GABA, see also individual receptors isopreterenol 152
446, 457 isoprinosine 109 Na*/K*-ATPase 48, 73, 209, 330
GABA, receptor 141, 260, 287, 357 isradipine 420 NADPH diaphorase 126
GABA, receptor, effect of ethanol 1 naloxone 152, 460
GABA, receptor, molecular biology 49 Jo1784 460 NAT04152 198
GABA, receptor, phosphorylation 84 jun 344, 375 nefiracetam 457
GABA, receptors 357 Neher, Erwin 448
galantamine 457 K* channel openers (see also individual neosurugatoxin 37
Galileo 89 drugs) 421 neuroendocrine cells 446
gallamine 425 kainate receptors 357, 360 neuroleptics 8
gangliosides 460 Kaposi's sarcoma 123 neuromedin B 13
GAP 191 kelatorphan 43 neuronal uptake 334
gastrin-releasing peptide 13 khat 322 neuropeptide Y 111, 389, 397
gastrointestinal disorders 441 kininogens 272 neuropeptide Y receptors 112, 389
Giordano, Bruno 89 neutral endopeptidase-24.11 43
glucagon 152 L365260 233 neutropenia 309
glucocorticoids 130, 282 L669083 69 nicotine 36, 457, 467
a-glycerylphosphorylcholine 457 L670596 68 nicotinic acetylcholine receptor, muscle type
glycobiology 265 L689560 359 341
glycoconjugates 241 B-lactamase inhibitors 227 nicotinic acetylcholine receptors, neuronal
482
type 34, 471 pimobendan 20 SK&F82526 48
NIK247 457 pimozide 134 SK&F94120 20
nimodipine 460 pinaverium 441 SM19888 457
nitric oxide 87, 125 piroximone 20 smoking 215, 471
nitric oxide synthase, see NO synthase platelet aggregation 87, 275 somatostatin 151
NMDA receptor antagonists, and platelet-derived growth factor receptor, see spantide 13
epileptogenesis 52 (L) PDGF receptor 117 sperm acrosome reaction 142, 270
NMDA receptors 1, 170, 288, 324, 334, 449 polymorphism, genetic 211 spironolactone 452
NMDA receptors, memory 128 Porsolt forced swim test 133 SR163441 82
L-NMMA 87,125 prasterone 460 SR95531 357
NMR 368, 416 prazocin 62 statistical analysis 293 (P)
NO synthase 118, 125, 130 5a-pregnan-3a-ol-20-one 142 staurosporin 190
NO437 152 5a-pregnane-3a,21-diol-20-one 142 steroids 141
Nobel Prize 449 pregnenolone 144, 256 stomach cancer 123
nociception, see pain primaquine 102 substance K receptor 328
non-NMDA excitatory amino acid progesterone 142, 452 substance P 444
receptors, see AMPA and kainate prostaglandins 151, 161 substance P receptor antagonists 13
receptors protein kinase C 189 sulbactam 231
nootropics, see cognition enhancers proto-oncogenes 343 sulfotransferases 255
noradrenaline 256, 334 proton ATPases 71 sulphur amino acids 94 (L), 95 (L)
noradrenaline-ATP cotransmission pyridostigmine 457 sumatriptan 226, 310, 444
norpyridostigmine 457 suramin 190, 319
nucleotide receptors 140 Quinpirole 48
quipazine 150 Tamoxifen 190
Odorant receptors, see olfactory receptors taurine deficiency 248
oestrogens 143, 151 RA6 457 testosterone 256
oestrone 256 RA7 457 tetanus toxin 285
8-OH-DPAT 223, 312 raf-1 191 tetrahydrocannabinol 152
OKY046 161 rapamycin 218 TGF receptors 171
olfactory receptor 246, 284 RDC7 326 THA 457
ondansetron 46, 460 RDC8 326 thermolysin 43
k-opioid receptors 359 re-stenosis 240 thiazolidinedione 190
Org30029 20 receptor classification 11 (P), 181 (L) thiorphan 43
ORG31550 243 receptor regulation (see also individual THIP 151
Org6582 151 receptors) 2, 84 threochlorocitrate 150
ouabain 210 receptor structure 4, 338 thrombosis 27, 158
2-oxo-quazepam 49 Redi, Francesco 177 thromboxane receptor antagonists 68, 158
oxotremorine 457 regulatory nuclear binding proteins 220 thromboxane synthase inhibitors 158
oxymetazoline 62 renin-angiotensin system 55, 115, 239 thymic humoral factor 109
rhodopsin receptor 4 thymopentin 109
P-450 281 ridogrel 163 TJ23 457
P, purinoceptors 137, 319 risk assessment 214 TNF-a 220, 266, 309, 466
PAF, and embryonic development 82 Ro151788 49 tobacco 467
pain 399 Ro154513 1,49 transfection systems 317
pantolyl-GABA 457 Ro200083 150 transforming growth factor p 308
paraoxonase 104 Ro201724 20 TRH 151, 457
partial agonism 182 (P) Ro2200654 150 tricyclic antidepressants 134, 155
PD123177 57, 279 Ro318220 405 triiodothyronine 256
PDGF receptors 171, 362 Ro54864 262 tryptophan 150
pEEDCK 304 rolipram 20 TSH 199
penicillin 227 RS82856 20 (+)-tubocurarine 37, 425
cis-trans peptidylprolyl isomerase 218 RS86 457 tyrosine kinase 171
PETA 414 tyrphostins 171, 190
phantom limb 399 Sabeluzole 460
pharmacogenetics 102 SaH58035 196 UTP 138
pharmacokinetics 96 (P) Sakmann, Bert 449 UTP-sensitive receptors, see nucleotide
phenylethylamines 329 salbutamol 152 receptors
phenylpropanolamine 155 sangivamycin 190
phosphatidylcholine 457 saralasin 55 Vinpocetine 20, 456
phosphodiesterase, see cyclic nucleotide satietin 150 von Willibrand factor 462
phosphodiesterase SCH23390 152
phospholipase Cy 191, 362 schizophrenia 235 WAY100359 357
phospholipase D 404 SDZ205557 360 WB4101 62
phosphoramidon 43 SDZ210086 457 wortmannin 407
photoreceptor 246 SDZENA713 457
phylogenetic tree, and cationic amine SDZPCO400 421 Yohimbine 310
receptors 65, 328 secoverine 457
physostigmine 425, 457 selegiline 457 Zacopride 460
PI hydrolysis, see inositol phosphates separation models of depression 132 zaprinast 20, 87
piceatannol 192 sertraline 152 zardaverine 20
picotamide 163 simvastin 198 zidovudine 107
pilocarpine 457 SK&F38393 152 zolpidem 49
483